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Featured 2024 Journal Article Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent immunomodulators developed from an unstable bacterial metabolite of vitamin B2 biosynthesis. Angewandte Chemie (International Edition), 63 (31) e202400632, e202400632. doi: 10.1002/anie.202400632 |
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2021 Journal Article Chemical modulators of mucosal associated Invariant T cellsMak, Jeffrey Y.W., Liu, Ligong and Fairlie, David P. (2021). Chemical modulators of mucosal associated Invariant T cells. Accounts of Chemical Research, 54 (17) acs.accounts.1c00359, 3462-3475. doi: 10.1021/acs.accounts.1c00359 |
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Featured 2021 Journal Article HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamatesMak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967 |
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2020 Journal Article Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigensMcWilliam, Hamish E. G., Mak, Jeffrey Y. W., Awad, Wael, Zorkau, Matthew, Cruz-Gomez, Sebastian, Lim, Hui Jing, Yan, Yuting, Wormald, Sam, Dagley, Laura F., Eckle, Sidonia B. G., Corbett, Alexandra J., Liu, Haiyin, Li, Shihan, Reddiex, Scott J. J., Mintern, Justine D., Liu, Ligong, McCluskey, James, Rossjohn, Jamie, Fairlie, David P. and Villadangos, Jose A. (2020). Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens. Proceedings of the National Academy of Sciences, 117 (40), 1-12. doi: 10.1073/pnas.2011260117 |
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2017 Journal Article Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cellsMak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong and Fairlie, David P. (2017). Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nature Communications, 8 (1) 14599, 14599. doi: 10.1038/ncomms14599 |
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2014 Journal Article Natural Products with Anti-Bredt and Bridgehead Double BondsMak, Jeffrey Y. W., Pouwer, Rebecca H. and Williams, Craig M. (2014). Natural Products with Anti-Bredt and Bridgehead Double Bonds. Angewandte Chemie International Edition, 53 (50), 13664-13688. doi: 10.1002/anie.201400932 |
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2014 Journal Article T-cell activation by transitory neo-antigens derived from distinct microbial pathwaysCorbett, Alexandra J., Eckle, Sidonia B. G., Birkinshaw, Richard W., Liu, Ligong, Patel, Onisha, Mahony, Jennifer, Chen, Zhenjun, Reantragoon, Rangsima, Meehan, Bronwyn, Cao, Hanwei, Williamson, Nicholas A., Strugnell, Richard A., Van Sinderen, Douwe, Mak, Jeffrey Y. W., Fairlie, David P., Kjer-Nielsen, Lars, Rossjohn, Jamie and McClusky, James (2014). T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 509 (7500), 361-365. doi: 10.1038/nature13160 |
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2012 Journal Article Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin GMak, Jeffrey Y.W. and Williams, Craig M. (2012). Enantioselective total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G. Chemical Communications, 48 (2), 287-289. doi: 10.1039/c1cc15995j |
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2024 Journal Article Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responsesPurohit, Shivam K., Stern, Lauren, Corbett, Alexandra J., Mak, Jeffrey Y.W., Fairlie, David P., Slobedman, Barry and Abendroth, Allison (2024). Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. PLoS Pathogens, 20 (8 August) e1012372, e1012372. doi: 10.1371/journal.ppat.1012372 |
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2024 Journal Article Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 BiosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis. Angewandte Chemie, 136 (31). doi: 10.1002/ange.202400632 |
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2024 Journal Article MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitisZheng, Yichao, Han, Fei, Wu, Zhengyu, Wang, Bingjie, Chen, Xingchi, Boulouis, Caroline, Jiang, Yuebin, Ho, Amanda, He, Dan, Sia, Wan Rong, Mak, Jeffrey Y. W., Fairlie, David P., Wang, Lin-Fa, Sandberg, Johan K., Lobie, Peter E., Ma, Shaohua and Leeansyah, Edwin (2024). MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis. Science Advances, 10 (24) eadn6331, eadn6331. doi: 10.1126/sciadv.adn6331 |
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2024 Journal Article MAIT cell-MR1 reactivity is highly conserved across multiple divergent speciesEdmans, Matthew D., Connelley, Timothy K., Morgan, Sophie, Pediongco, Troi J., Jayaraman, Siddharth, Juno, Jennifer A., Meehan, Bronwyn S., Dewar, Phoebe M., Maze, Emmanuel A., Roos, Eduard O., Paudyal, Basu, Mak, Jeffrey YW., Liu, Ligong, Fairlie, David P., Wang, Huimeng, Corbett, Alexandra J., McCluskey, James, Benedictus, Lindert, Tchilian, Elma, Klenerman, Paul and Eckle, Sidonia BG. (2024). MAIT cell-MR1 reactivity is highly conserved across multiple divergent species. Journal of Biological Chemistry, 300 (6) 107338, 107338. doi: 10.1016/j.jbc.2024.107338 |
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2024 Journal Article Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracilCiacchi, Lisa, Mak, Jeffrey Y.W., Le, Jeremy P., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie and Awad, Wael (2024). Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil. Journal of Biological Chemistry, 300 (5) 107229, 107229. doi: 10.1016/j.jbc.2024.107229 |
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2024 Journal Article Sulfated bile acid is a host-derived ligand for MAIT cellsIto, Emi, Inuki, Shinsuke, Izumi, Yoshihiro, Takahashi, Masatomo, Dambayashi, Yuki, Ciacchi, Lisa, Awad, Wael, Takeyama, Ami, Shibata, Kensuke, Mori, Shotaro, Mak, Jeffrey Y. W., Fairlie, David P., Bamba, Takeshi, Ishikawa, Eri, Nagae, Masamichi, Rossjohn, Jamie and Yamasaki, Sho (2024). Sulfated bile acid is a host-derived ligand for MAIT cells. Science Immunology, 9 (91) ARTN eade6924, eade6924. doi: 10.1126/sciimmunol.ade6924 |
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2023 Journal Article Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomaliesKammann, Tobias, Gorin, Jean-Baptiste, Parrot, Tiphaine, Gao, Yu, Ponzetta, Andrea, Emgård, Johanna, Maleki, Kimia T., Sekine, Takuya, Rivera-Ballesteros, Olga, Gredmark-Russ, Sara, Rooyackers, Olav, Skagerberg, Magdalena, Eriksson, Lars I., Norrby-Teglund, Anna, Mak, Jeffrey Y. W., Fairlie, David P., Björkström, Niklas K., Klingström, Jonas, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus, Strålin, Kristoffer, Sandberg, Johan K. and Karolinska COVID-19 Study Group (2023). Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomalies. The Journal of Immunology, 212 (3), 389-396. doi: 10.4049/jimmunol.2300639 |
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2023 Journal Article Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivoNelson, Adam G., Wang, Huimeng, Dewar, Phoebe M., Eddy, Eleanor M., Li, Songyi, Lim, Xin Yi, Patton, Timothy, Zhou, Yuchen, Pediongco, Troi J., Meehan, Lucy J., Meehan, Bronwyn S., Mak, Jeffrey Y. W., Fairlie, David P., Stent, Andrew W., Kjer-Nielsen, Lars, McCluskey, James, Eckle, Sidonia B. G., Corbett, Alexandra J., Souter, Michael N. T. and Chen, Zhenjun (2023). Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo. Frontiers in Immunology, 14 1109759, 1-15. doi: 10.3389/fimmu.2023.1109759 |
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2023 Journal Article Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and diseaseWang, Yizhuo, Abrol, Rishika, Mak, Jeffrey Y. W., Das Gupta, Kaustav, Ramnath, Divya, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2023). Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease. The FEBS Journal, 290 (11), 2805-2832. doi: 10.1111/febs.16437 |
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2022 Journal Article Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1Wang, Carl J.H., Awad, Wael, Liu, Ligong, Mak, Jeffrey Y.W., Veerapen, Natacha, Illing, Patricia T., Purcell, Anthony W., Eckle, Sidonia B.G., McCluskey, James, Besra, Gurdyal S., Fairlie, David P., Rossjohn, Jamie and Le Nours, Jérôme (2022). Quantitative affinity measurement of small molecule ligand binding to Major Histocompatibility Complex class-I related protein 1 MR1. Journal of Biological Chemistry, 298 (12) 102714, 1-12. doi: 10.1016/j.jbc.2022.102714 |
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2022 Journal Article A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cellsLim, Hui Jing, Wubben, Jacinta M., Garcia, Cristian Pinero, Cruz-Gomez, Sebastian, Deng, Jieru, Mak, Jeffrey Y.W., Hachani, Abderrahman, Anderson, Regan J., Painter, Gavin F., Goyette, Jesse, Amarasinghe, Shanika L., Ritchie, Matthew E., Roquilly, Antoine, Fairlie, David P., Gaus, Katharina, Rossjohn, Jamie, Villadangos, Jose A. and McWilliam, Hamish E.G. (2022). A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. Journal of Cell Biology, 221 (12) e202110125. doi: 10.1083/jcb.202110125 |
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2022 Journal Article CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cellsSouter, Michael N.T., Awad, Wael, Li, Shihan, Pediongco, Troi J., Meehan, Bronwyn S., Meehan, Lucy J., Tian, Zehua, Zhao, Zhe, Wang, Huimeng, Nelson, Adam, Le Nours, Jérôme, Khandokar, Yogesh, Praveena, T., Wubben, Jacinta, Lin, Jie, Sullivan, Lucy C., Lovrecz, George O., Mak, Jeffrey Y.W., Liu, Ligong, Kostenko, Lyudmila, Kedzierska, Katherine, Corbett, Alexandra J., Fairlie, David P., Brooks, Andrew G., Gherardin, Nicholas A., Uldrich, Adam P., Chen, Zhenjun, Rossjohn, Jamie, Godfrey, Dale I. ... Eckle, Sidonia B.G. (2022). CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells. Journal of Experimental Medicine, 219 (9) e20210828, 1-30. doi: 10.1084/jem.20210828 |
