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2019 Journal Article A divergent transcriptional landscape underpins the development and functional branching of MAIT cellsKoay, H-. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., Whyte, C. E., Konstantinov, I. E., d'Udekem, Y., Baldwin, T., Hickey, P. F., Berzins, S. P., Mak, J. Y. W., Sontani, Y., Roots, C. M., Sidwell, T., Kallies, A., Chen, Z., Nüssing, S., Kedzierska, K., Mackay, L. K., McColl, S. R., Deenick, E. K., Fairlie, D. P., McCluskey, J., Goodnow, C. C., Ritchie, M. E., Belz, G. T., Naik, S. H. ... Godfrey, D. I. (2019). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. Science Immunology, 4 (41) eaay6039, eaay6039. doi: 10.1126/sciimmunol.aay6039 |
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2019 Journal Article IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infectionWang, Huimeng, Kjer-Nielsen, Lars, Shi, Mai, D'Souza, Criselle, Pediongco, Troi J., Cao, Hanwei, Kostenko, Lyudmila, Lim, Xin Yi, Eckle, Sidonia B. G., Meehan, Bronwyn S., Zhu, Tianyuan, Wang, Bingjie, Zhao, Zhe, Mak, Jeffrey Y. W., Fairlie, David P., Teng, Michele W. L., Rossjohn, Jamie, Yu, Di, de St Groth, Barbara Fazekas, Lovrecz, George, Lu, Louis, McCluskey, James, Strugnell, Richard A., Corbett, Alexandra J. and Chen, Zhenjun (2019). IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. Science Immunology, 4 (41) eaaw0402, eaaw0402. doi: 10.1126/sciimmunol.aaw0402 |
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2019 Journal Article Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cellsLer, Geraldine J. M., Xu, Weijun, Mak, Jeffrey Y. W., Liu, Ligong, Bernhardt, Paul V. and Fairlie, David P (2019). Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells. Chemistry – A European Journal, 25 (68) chem.201903732, 15594-15608. doi: 10.1002/chem.201903732 |
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2019 Journal Article MAIT cells upregulate α4β7 in response to acute simian immunodeficiency virus/simian HIV infection but are resistant to peripheral depletion in pigtail macaquesJuno, Jennifer A., Wragg, Kathleen M., Amarasena, Thakshila, Meehan, Bronwyn S., Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., McCluskey, James, Eckle, Sidonia B. G. and Kent, Stephen J. (2019). MAIT cells upregulate α4β7 in response to acute simian immunodeficiency virus/simian HIV infection but are resistant to peripheral depletion in pigtail macaques. The Journal of Immunology, 202 (7), ji1801405-2120. doi: 10.4049/jimmunol.1801405 |
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2019 Conference Publication IL-23 co-stimulation drives antigen-specific MAIT cell activation and enables vaccination against bacterial infectionWang, H., Kjer-Nielsen, L., Shi, M., Souza, D. C., Pediongco, T., Cao, H., Kostenko, L., Lim, X., Eckle, S., Meeha, B., Wang, B., Zhu, T., Mak, J., Fairlie, D., Teng, M., Rossjohn, J., Yu, D., Groth, B., McCluskey, J., Strugnell, R., Corbett, A. and Chen, Z. (2019). IL-23 co-stimulation drives antigen-specific MAIT cell activation and enables vaccination against bacterial infection. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October, 2019. Weinheim, Germany: WILEY. doi: 10.1002/eji.201970400 |
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2018 Journal Article MAIT cells protect against pulmonary Legionella longbeachae infectionWang, Huimeng, D’Souza, Criselle, Lim, Xin Yi, Kostenko, Lyudmila, Pediongco, Troi J., Eckle, Sidonia B. G., Meehan, Bronwyn S., Shi, Mai, Wang, Nancy, Li, Shihan, Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Iwakura, Yoichiro, Gunnersen, Jennifer M., Stent, Andrew W., Godfrey, Dale I., Rossjohn, Jamie, Westall, Glen P., Kjer-Nielsen, Lars, Strugnell, Richard A., McCluskey, James, Corbett, Alexandra J., Hinks, Timothy S. C. and Chen, Zhenjun (2018). MAIT cells protect against pulmonary Legionella longbeachae infection. Nature Communications, 9 (1) 3350, 3350. doi: 10.1038/s41467-018-05202-8 |
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2018 Conference Publication Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colonVarelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. Immunology 2018™ Meeting, Austin, TX United States, 4-8 May 2018. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.200.supp.55.15 |
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2018 Journal Article An overview on the identification of MAIT cell antigensKjer-Nielsen, Lars, Corbett, Alexandra J., Chen, Zhenjun, Liu, Ligong, Mak, Jeffrey Y. W., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., McCluskey, James and Eckle, Sidonia B. G. (2018). An overview on the identification of MAIT cell antigens. Immunology and Cell Biology, 96 (6), 573-587. doi: 10.1111/imcb.12057 |
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2018 Journal Article Recipient mucosal-associated invariant T cells control GVHD within the colonVarelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646 |
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2018 Journal Article Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori InfectionD'Souza, Criselle, Pediongco, Troi, Wang, Huimeng, Scheerlinck, Jean-Pierre Y., Kostenko, Lyudmila, Esterbauer, Robyn, Stent, Andrew W., Eckle, Sidonia B. G., Meehan, Bronwyn S., Strugnell, Richard A., Cao, Hanwei, Liu, Ligong, Mak, Jeffrey Y. W., Lovrecz, George, Lu, Louis, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Every, Alison L., Chen, Zhenjun and Corbett, Alexandra J. (2018). Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection. Journal of Immunology, 200 (5), 1901-1916. doi: 10.4049/jimmunol.1701512 |
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2018 Conference Publication Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colonVarelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. Immunology Meeting, Austin Tx, 4-8 May 2018. Bethesda, MD United States: American Association of Immunologists. |
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2018 Conference Publication Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular cleftsStoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Alan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2018). Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts. 2018 Royal Society of Chemistry Twitter Conference, London, United Kingdom (held online), 6-7 March 2018. London, United Kingdom: Royal Society of Chemistry. |
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2017 Journal Article Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular CleftsStoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Allan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2017). Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts. European Journal of Organic Chemistry, 2017 (45), 6793-6796. doi: 10.1002/ejoc.201701319 |
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2017 Journal Article Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cellsKeller, Andrew N., Eckle, Sidonia B. G., Xu, Weijun, Liu, Ligong, Hughes, Victoria A., Mak, Jeffrey Y. W., Meehan, Bronwyn S., Pediongco, Troi, Birkinshaw, Richard W., Chen, Zhenjun, Wang, Huimeng, D'Souza, Criselle, Kjer-Nielsen, Lars, Gherardin, Nicholas A., Godfrey, Dale I., Kostenko, Lyudmila, Corbett, Alexandra J., Purcell, Anthony W., Fairlie, David P., McCluskey, James and Rossjohn, Jamie (2017). Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nature Immunology, 18 (4), 402-411. doi: 10.1038/ni.3679 |
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2017 Book Chapter Thiazoles in peptides and peptidomimeticsMak, Jeffrey Y. W., Xu, Weijun and Fairlie, David P. (2017). Thiazoles in peptides and peptidomimetics. Peptidomimetics I. (pp. 235-266) edited by William D. Lubell. Cham, Switzerland: Springer. doi: 10.1007/7081_2015_176 |
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2017 Conference Publication Vitamin B2 related molecules that activate T cellsMak, Jeffrey, Xu, Weijun, Reid, Robert, Corbett, Alexandra, Meehan, Bronwyn, Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong and Fairlie, David (2017). Vitamin B2 related molecules that activate T cells. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington DC, USA, 20-24 August 2017. Washington DC, USA: American Chemical Society. |
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2016 Conference Publication Common drugs modulate mucosal-associated invariant T cell functionKeller, A. N., Eckle, S. B. G., Xu, W., Liu, L., Hughes, V. A., Mak, J., Meehan, B., Pediongco, T., Birkinshaw, R. W., Chen, Z., Wang, H., Souza, C., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., McCluskey, J. and Rossjohn, J. (2016). Common drugs modulate mucosal-associated invariant T cell function. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Germany: Wiley. doi: 10.1002/eji.201670200 |
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2016 Journal Article PAR2 modulators derived from GB88Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306 |
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2016 Conference Publication Drugs/drug analogues modulate MAIT cell function in an MR1-dependent mannerEckle, S. B. G., Keller, A. N., Xu, W., Meehan, B., Pediongco, T., Liu, L., Hughes, V. A., Mak, J. Y. W., Birkinshaw, R. W., Chen, Z., Wang, H., D'Souza, C., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., Rossjohn, J. and McCluskey, J. (2016). Drugs/drug analogues modulate MAIT cell function in an MR1-dependent manner. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200 |
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2016 Conference Publication MAIT cells: Friend or Foe in recognising microbial vitamin metabolites presented by the MHC-I-related molecule MR1McCluskey, J., Corbett, A. J., Eckle, S. B. G., Chen, Z., Wang, H., Sun, S., D'Souza, C., Kostenko, L., Reantragoon, R., Meehan, B., Birkinshaw, R. W., Liu, L., Patel, O., Mahony, J., Cao, H., Jackson, D., Williamson, N. A., Strugnell, R. A., Mak, J. Y. W., Van Sinderen, D., Fairlie, D. P., Kjer-Nielsen, L., Godfrey, D., I and Rossjohn, J. (2016). MAIT cells: Friend or Foe in recognising microbial vitamin metabolites presented by the MHC-I-related molecule MR1. International Congress of Immunology (ICI), Melbourne, Australia, August 21-26, 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200 |
