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2016 Journal Article Integration of summary data from GWAS and eQTL studies predicts complex trait gene targetsZhu, Zhihong, Zhang, Futao, Hu, Han, Bakshi, Andrew, Robinson, Matthew R., Powell, Joseph E., Montgomery,Grant W., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2016). Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics, 48 (5), 481-487. doi: 10.1038/ng.3538 |
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2016 Journal Article Corrigendum: The epigenetic clock and telomere length are independently associated with chronological age and mortality [Int J Epidemiol., 45, 2, (424-432)(2016)] DOI: 10.1093/ije/dyw041Marioni, Riccardo E., Harris, Sarah E., Shah, Sonia, McRae, Allan F., von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R., Visscher, Peter M. and Deary, Ian J. (2016). Corrigendum: The epigenetic clock and telomere length are independently associated with chronological age and mortality [Int J Epidemiol., 45, 2, (424-432)(2016)] DOI: 10.1093/ije/dyw041. International Journal of Epidemiology, 47 (1) dyx217, 356-356. doi: 10.1093/ije/dyx233 |
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2016 Journal Article The epigenetic clock and telomere length are independently associated with chronological age and mortalityMarioni, Riccardo E., Harris, Sarah E., Shah, Sonia, McRae, Allan F., von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R., Visscher, Peter M. and Deary, Ian J. (2016). The epigenetic clock and telomere length are independently associated with chronological age and mortality. International Journal of Epidemiology, 45 (2), 424-432. doi: 10.1093/ije/dyw041 |
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2016 Journal Article Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association studyHou, Liping, Heilbronner, Urs, Degenhardt, Franziska, Adli, Mazda, Akiyama, Kazufumi, Akula, Nirmala, Ardau, Raffaella, Arias, Bárbara, Backlund, Lena, Banzato, Claudio E. M., Benabarre, Antoni, Bengesser, Susanne, Bhattacharjee, Abesh Kumar, Biernacka, Joanna M., Birner, Armin, Brichant-Petitjean, Clara, Bui, Elise T., Cervantes, Pablo, Chen, Guo-Bo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Clark, Scott R., Colom, Francesc, Cousins, David A., Cruceanu, Cristiana, Czerski, Piotr M., Dantas, Clarissa R., Dayer, Alexandre ... Schulze, Thomas G. (2016). Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. The Lancet, 387 (10023), 1085-1093. doi: 10.1016/S0140-6736(16)00143-4 |
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2016 Journal Article Disease and polygenic architecture: avoid trio design and appropriately account for unscreened control subjects for common diseasePeyrot, Wouter J., Boomsma, Dorret I., Penninx, Brenda W. J. H. and Wray, Naomi R. (2016). Disease and polygenic architecture: avoid trio design and appropriately account for unscreened control subjects for common disease. American Journal of Human Genetics, 98 (2), 382-391. doi: 10.1016/j.ajhg.2015.12.017 |
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2016 Journal Article Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing studyHawi, Z., Cummins, T.D.R., Tong, J., Arcos-Burgos, M., Zhao, Q., Matthews, N., Newman, D. P., Johnson, B., Vance, A., Heussler, H. S., Levy, F., Easteal, S., Wray, N. R., Kenny, E., Morris, D., Kent, L., Gill, M. and Bellgrove, M. A. (2016). Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study. Molecular Psychiatry, 22 (4), 580-584. doi: 10.1038/mp.2016.117 |
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2016 Journal Article DNA methylation-based measures of biological age: meta-analysis predicting time to deathChen, Brian H., Marioni, Riccardo E., Colicino, Elena, Peters, Marjolein J., Ward-Caviness, Cavin K., Tsai, Pei-Chien, Roetker, Nicholas S., Just, Allan C., Demerath, Ellen W., Guan, Weihua, Bressler, Jan, Fornage, Myriam, Studenski, Stephanie, Vandiver, Amy R., Moore, Ann Zenobia, Tanaka, Toshiko, Kiel, Douglas P., Liang, Liming, Vokonas, Pantel, Schwartz, Joel, Lunetta, Kathryn L., Murabito, Joanne M., Bandinelli, Stefania, Hernandez, Dena G., Melzer, David, Nalls, Michael, Pilling, Luke C., Price, Timothy R., Singleton, Andrew B. ... Horvath, Steve (2016). DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging, 8 (9), 1844-1865. doi: 10.18632/aging.101020 |
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2015 Journal Article Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signalingZannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Roh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Bruckl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B. and Mehta, Divya (2015). Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biology, 16 (1) 266, 1-12. doi: 10.1186/s13059-015-0828-5 |
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2015 Journal Article Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illnessBigdeli, Tim B., Ripke, Stephan, Bacanu, Silviu-Alin, Lee, Sang Hong, Wray, Naomi R., Gejman, Pablo V., Rietschel, Marcella, Cichon, Sven, St Clair, David, Corvin, Aiden, Kirov, George, Mcquillin, Andrew, Gurling, Hugh, Rujescu, Dan, Andreassen, Ole A., Werge, Thomas, Blackwood, Douglas H.R., Pato, Carlos N., Pato, Michele T., Malhotra, Anil K., O'Donovan, Michael C., Kendler, Kenneth S. and Fanous, Ayman H. (2015). Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 (2), 276-289. doi: 10.1002/ajmg.b.32402 |
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2015 Journal Article Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysisLoh, Po-Ru, Bhatia, Gaurav, Gusev, Alexander, Finucane, Hilary K., Bulik-Sullivan, Brendan K., Pollack, Samuela J., de Candia, Teresa R., Lee, Sang Hong, Wray, Naomi R., Kendler, Kenneth S., O'Donovan, Michael C., Neale, Benjamin M., Patterson, Nick, Price, Alkes L., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Visscher, Peter M. and Mowry, Bryan J. (2015). Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics, 47 (12), 1385-1392. doi: 10.1038/ng.3431 |
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2015 Journal Article EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortexLim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015). EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 (21), 3746-3757. doi: 10.1242/dev.119909 |
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2015 Journal Article High loading of polygenic risk in cases with chronic schizophreniaMeier, S. M., Agerbo, E., Maier, R., Pedersen, C. B., Pedersen, C. B., Grove, J., Hollegaard, M. V., Demontis, D., Trabjerg, B. B., Hjorthoj, C., Ripke, S., Degenhardt, F., Nothen, M. M., Rujescu, D., Maier, W., Werge, T., Mors, O., Hougaard, D. M., Borglum, A. D., Wray, N. R., Rietschel, M., Nordentoft, M., Mortensen, P. B. and Mattheisen, M. (2015). High loading of polygenic risk in cases with chronic schizophrenia. Molecular Psychiatry, 21 (7), 1-6. doi: 10.1038/mp.2015.130 |
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2015 Journal Article Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass indexYang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A. E., Lee, Sang Hong, Robinson, Matthew R., Perry, John R. B., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, The LifeLines Cohort Study, Esko, Tonu, Milani, Lili, Maegi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C., Wray, Naomi R., Goddard, Michael E. and Visscher, Peter M. (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47 (10), 1114-1120. doi: 10.1038/ng.3390 |
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2015 Journal Article Evidence of CNIH3 involvement in opioid dependenceNelson, E. C., Agrawal, A., Heath, A. C., Bogdan, R., Sherva, R., Zhang, B., Al-Hasani, R., Bruchas, M. R., Chou, Y.-L., Demers, C. H., Carey, C. E., Conley, E. D., Fakira, A. K., Farrer, L. A., Goate, A., Gordon, S., Henders, A. K., Hesselbrock, V., Kapoor, M., Lynskey, M. T., Madden, P. A. F., Moron, J. A., Rice, J. P., Saccone, N. L., Schwab, S. G., Shand, F. L., Todorov, A. A., Wallace, L., Wang, T. ... Montgomery, G. W. (2015). Evidence of CNIH3 involvement in opioid dependence. Molecular Psychiatry, 21 (5), 608-614. doi: 10.1038/mp.2015.102 |
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2015 Journal Article The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936Marioni, Riccardo E., Shah, Sonia, McRae, Allan F., Ritchie, Stuart J., Muniz-Terrera, Graciela, Harris, Sarah E., Gibson, Jude, Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Taylor, Adele, Murphy, Lee, Starr, John M., Horvath, Steve, Visscher, Peter M., Wray, Naomi R. and Deary, Ian J. (2015). The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. International Journal of Epidemiology, 44 (4), 1388-1396. doi: 10.1093/ije/dyu277 |
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2015 Journal Article Improving phenotypic prediction by combining genetic and epigenetic associationsShah, Sonia, Bonder, Marc J., Marioni, Riccardo E., Zhu, Zhihong, McRae, Allan F., Zhernakova, Alexandra, Harris, Sarah E., Liewald, Dave, Henders, Anjali K., Mendelson, Michael M., Liu, Chunyu, Joehanes, Roby, Liang, Liming, Levy, Daniel, Martin, Nicholas G., Starr, John M., Wijmenga, Cisca, Wray, Naomi R., Yang, Jian, Montgomery, Grant W., Franke, Luke, Deary, Ian J., Visscher, Peter M. and BIOS Consortium (2015). Improving phenotypic prediction by combining genetic and epigenetic associations. American Journal of Human Genetics, 97 (1), 75-85. doi: 10.1016/j.ajhg.2015.05.014 |
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2015 Journal Article Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysisAgerbo, Esben, Sullivan, Patrick F., Vilhjalmsson, Bjarni J., Pedersen, Catsten B., Mors, Ole, Borglum, Anders D., Hougaard, David M., Hollegaard, Mads V., Meier, Sandra, Mattheisen, Manuel, Ripke, Stephen, Wray, Naomi R. and Mortensen, Preben B. (2015). Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysis. JAMA Psychiatry, 72 (7), 635-641. doi: 10.1001/jamapsychiatry.2015.0346 |
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2015 Journal Article The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjectsPeyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A., Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and Middeldorp, Christel (2015). The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects. Molecular Psychiatry, 20 (6), 735-743. doi: 10.1038/mp.2015.50 |
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2015 Journal Article C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosisHe, Ji, Tang, Lu, Benyamin, Beben, Shah, Sonia, Hemani, Gib, Liu, Rong, Ye, Shan, Liu, Xiaolu, Ma, Yan, Zhang, Huagang, Cremin, Katie, Leo, Paul, Wray, Naomi R., Visscher, Peter M., Xu, Huji, Brown, Matthew A., Bartlett, Perry F., Mangelsdorf, Marie and Fan, Dongsheng (2015). C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis. Neurobiology of Aging, 36 (9) 2660.e1, 2660.e1-2660.e8. doi: 10.1016/j.neurobiolaging.2015.06.002 |
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2015 Journal Article Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampusJhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015). Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience, 35 (21), 8132-8144. doi: 10.1523/JNEUROSCI.0504-15.2015 |
