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2025

Journal Article

Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile

Galligan, Dana E, Payne, Leanne, Sullivan, Daniel P, Bhadravathi Lokeshappa, Madhura, Ziser, Laura, Nunn, Lorelle, Wallace, Leanne M, Andersen, Isabella, Howarth, Sophie, Kato, Akina, Karunanithi, Mohan, Mingin, Cassandra, O’Scanaill, Sally, Aouira, Nisreen, Paramecwari, Ayu, Sanders, Matthew R, Cobham, Vanessa E, Wray, Naomi R, Henders, Anjali K, Byrne, Enda M, Heussler, Honey and Middeldorp, Christel M (2025). Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile. BMJ Open, 15 (3) e091676, e091676-3. doi: 10.1136/bmjopen-2024-091676

Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile

2025

Journal Article

Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

Wei, Dang, Freydenzon, Anna, Guinebretiere, Octave, Zaidi, Karim, Yang, Fen, Ye, Weimin, Hammar, Niklas, Modig, Karin, Wray, Naomi R., Feychting, Maria, Hamieh, Nadine, Ventelou, Bruno, Lekens, Beranger, Gantzer, Laurene, Durrleman, Stanley, McRae, Allan, Couvy-Duchesne, Baptiste, Fang, Fang and Nedelec, Thomas (2025). Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. eBioMedicine, 113 105585, 105585. doi: 10.1016/j.ebiom.2025.105585

Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

2025

Journal Article

Insights from a methylome-wide association study of antidepressant exposure

Davyson, E., Shen, X., Huider, F., Adams, M. J., Borges, K., McCartney, D. L., Barker, L. F., van Dongen, J., Boomsma, D. I., Weihs, A., Grabe, H. J., Kühn, L., Teumer, A., Völzke, H., Zhu, T., Kaprio, J., Ollikainen, M., David, F. S., Meinert, S., Stein, F., Forstner, A. J., Dannlowski, U., Kircher, T., Tapuc, A., Czamara, D., Binder, E. B., Brückl, T., Kwong, A. S. F., Yousefi, P. ... McIntosh, A. M. (2025). Insights from a methylome-wide association study of antidepressant exposure. Nature Communications, 16 (1) 1908, 1. doi: 10.1038/s41467-024-55356-x

Insights from a methylome-wide association study of antidepressant exposure

2025

Journal Article

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

Crouse, Jacob J., Park, Shin Ho, Mitchell, Brittany L., Byrne, Enda M., Medland, Sarah E., Lin, Tian, Scott, Jan, de Haan, Zsofi, Tonini, Emiliana, Iorfino, Frank, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2025). Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression. European Psychiatry, 68 (1) e41, 1-34. doi: 10.1192/j.eurpsy.2025.20

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

2025

Journal Article

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity

Yao, Shuyang, Harder, Arvid, Darki, Fahimeh, Chang, Yu-Wei, Li, Ang, Nikouei, Kasra, Volpe, Giovanni, Lundström, Johan N., Zeng, Jian, Wray, Naomi R., Lu, Yi, Sullivan, Patrick F. and Hjerling-Leffler, Jens (2025). Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity. Nature Communications, 16 (1) 395, 395. doi: 10.1038/s41467-024-55611-1

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity

2025

Journal Article

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Adams, Mark J., Streit, Fabian, Meng, Xiangrui, Awasthi, Swapnil, Adey, Brett N., Choi, Karmel W., Chundru, V. Kartik, Coleman, Jonathan R.I., Ferwerda, Bart, Foo, Jerome C., Gerring, Zachary F., Giannakopoulou, Olga, Gupta, Priya, Hall, Alisha S.M., Harder, Arvid, Howard, David M., Hübel, Christopher, Kwong, Alex S.F., Levey, Daniel F., Mitchell, Brittany L., Ni, Guiyan, Ota, Vanessa K., Pain, Oliver, Pathak, Gita A., Schulte, Eva C., Shen, Xueyi, Thorp, Jackson G., Walker, Alicia, Yao, Shuyang ... McIntosh, Andrew M. (2025). Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell, 188 (3), 640-652.e9. doi: 10.1016/j.cell.2024.12.002

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

2024

Journal Article

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Stahl, Eli A., Domenici, Enrico, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Blackwood, Douglas H. R., Borglum, Anders D., Bramon, Elvira, Bruggeman, Richard ... Ziller, Michael J. (2024). Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications , 15 (1) 5534. doi: 10.1038/s41467-024-49338-2

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

2024

Journal Article

Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases

Jiang, Jiayue-Clara, Singh, Kritika, Nitin, Rachana, Davis, Lea K., Wray, Naomi R. and Shah, Sonia (2024). Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases. Circulation: Genomic and Precision Medicine, 17 (6) e004685, 1-12. doi: 10.1161/circgen.124.004685

Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases

2024

Journal Article

Genome-wide copy number variation association study in anorexia nervosa

Walker, Alicia, Karlsson, Robert, Szatkiewicz, Jin P., Thornton, Laura M., Yilmaz, Zeynep, Leppä, Virpi M., Savva, Androula, Lin, Tian, Sidorenko, Julia, McRae, Allan, Kirov, George, Davies, Helena L., Fundín, Bengt T., Chawner, Samuel J. R. A., Song, Jie, Borg, Stina, Wen, Jia, Watson, Hunna J., Munn-Chernoff, Melissa A., Baker, Jessica H., Gordon, Scott, Berrettini, Wade H., Brandt, Harry, Crawford, Steven, Halmi, Katherine A., Kaplan, Allan S., Kaye, Walter H., Mitchell, James, Strober, Michael ... Wray, Naomi R. (2024). Genome-wide copy number variation association study in anorexia nervosa. Molecular Psychiatry, 1-8. doi: 10.1038/s41380-024-02811-2

Genome-wide copy number variation association study in anorexia nervosa

2024

Conference Publication

Latest Insights From Multi-ancestry Fine-mapping In Psychiatric Disorders

Koromina, Maria and Wray, Naomi (2024). Latest Insights From Multi-ancestry Fine-mapping In Psychiatric Disorders. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.033

Latest Insights From Multi-ancestry Fine-mapping In Psychiatric Disorders

2024

Conference Publication

The Application Of Mendelian Randomization Method To Exposure-outcome Pairs With A Non-linear Relationship

Zhu, Zhihong, Wray, Naomi, McGrath, John and Vilhjálmsson, Bjarni (2024). The Application Of Mendelian Randomization Method To Exposure-outcome Pairs With A Non-linear Relationship. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.032

The Application Of Mendelian Randomization Method To Exposure-outcome Pairs With A Non-linear Relationship

2024

Conference Publication

Genome-wide Fine-mapping Improves Identification Of Causal Variants

Zeng, Jian, Wu, Yang, Zheng, Zhili, Thibaut, Loic, Goddard, Michael, Wray, Naomi and Visscher, Peter (2024). Genome-wide Fine-mapping Improves Identification Of Causal Variants. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.037

Genome-wide Fine-mapping Improves Identification Of Causal Variants

2024

Conference Publication

AMBER: Antidepressant Medications: Biology, Exposure And Response

Lewis, Cathryn, Fletcher-Watson, Sue, Whalley, Heather, Shah, Sonia, Pain, Oliver, Wray, Naomi and McIntosh, Andrew (2024). AMBER: Antidepressant Medications: Biology, Exposure And Response. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.452

AMBER: Antidepressant Medications: Biology, Exposure And Response

2024

Conference Publication

Cohort Profile: Improving Outcomes Of Mental Health (IOMH) A Longitudinal Clinical Study Of Families With Children With Neurodevelopmental Problems

Galligan, Dana, Payne, Leanne, Sullivan, Daniel, Bhadravathi Lokeshappa, Madhura, Ziser, Laura, Nunn, Lorelle, Wallace, Leanne, Sanders, Matthew, Cobham, Vanessa, Wray, Naomi, Henders, Anjali, Byrne, Enda, Heussler, Helen and Middeldorp, Christel M. (2024). Cohort Profile: Improving Outcomes Of Mental Health (IOMH) A Longitudinal Clinical Study Of Families With Children With Neurodevelopmental Problems. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.469

Cohort Profile: Improving Outcomes Of Mental Health (IOMH) A Longitudinal Clinical Study Of Families With Children With Neurodevelopmental Problems

2024

Conference Publication

A Multi-omic QTL Analysis Of Major Depressive Disorder

Nisbet, Laurence, Shen, Xueyi, Wray, Naomi and McIntosh, Andrew (2024). A Multi-omic QTL Analysis Of Major Depressive Disorder. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.357

A Multi-omic QTL Analysis Of Major Depressive Disorder

2024

Conference Publication

Mendelian Randomization – What Are The Promises?

Schwab, Sibylle and Wray, Naomi (2024). Mendelian Randomization – What Are The Promises?. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.028

Mendelian Randomization – What Are The Promises?

2024

Journal Article

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

Adams, Mark J., Thorp, Jackson G., Jermy, Bradley S., Kwong, Alex S. F., Kõiv, Kadri, Grotzinger, Andrew D., Nivard, Michel G., Marshall, Sally, Milaneschi, Yuri, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W. J. H., Boomsma, Dorret I., Levinson, Douglas F., Breen, Gerome, Pistis, Giorgio, Grabe, Hans J., Tiemeier, Henning, Berger, Klaus, Rietschel, Marcella, Magnusson, Patrik K., Uher, Rudolf, Hamilton, Steven P., Lucae, Susanne, Lehto, Kelli, Li, Qingqin S., Byrne, Enda M., Hickie, Ian B., Martin, Nicholas G. ... Derks, Eske M. (2024). Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts. Psychological Medicine, 54 (12), 3459-3468. doi: 10.1017/s0033291724001880

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

2024

Journal Article

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Scott, Jan, Medland, Sarah E., Lin, Tian, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2024). Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. Molecular Psychiatry, 29 (9), 2765-2773. doi: 10.1038/s41380-024-02492-x

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

2024

Conference Publication

Sex Matters in Cardiovascular Research: A Higher Genetic Risk of Depression is a Greater Risk Factor for Cardiovascular Diseases in Females

Jiang, J., Singh, K., Nitin, R., Davis, L., Wray, N. and Shah, S. (2024). Sex Matters in Cardiovascular Research: A Higher Genetic Risk of Depression is a Greater Risk Factor for Cardiovascular Diseases in Females. 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.412

Sex Matters in Cardiovascular Research: A Higher Genetic Risk of Depression is a Greater Risk Factor for Cardiovascular Diseases in Females

2024

Journal Article

R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores

Momin, Md. Moksedul, Wray, Naomi R. and Lee, S. Hong (2024). R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores. Human Genetics, 143 (9-10), 1193-1205. doi: 10.1007/s00439-024-02682-1

R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores