|
2026 Journal Article “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South AsiansNathan, Vaishnavi, Akbar, Heena, McInerney-Leo, Aideen, Gilroy, Deborah, Henders, Anjali, Naresh, Reema, Choudhury, Nahid, Waqar, Maleeha, Shah, Sonia, Yanes, Tatiane, on behalf of the South Asian Genes and Health in Australia (SAGHA) research team, Atherton, John, Greaves, Kim, McGaughran, Julie, Mehta, Divya, Villani, Rehan Marie, Wallis, Katharine and Wray, Naomi R. (2026). “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians. European Journal of Human Genetics. doi: 10.1038/s41431-026-02129-3 |
|
2026 Journal Article Extensive antagonistic variants across the human genomeBian, Beilei, Hivert, Valentin, Wray, Naomi R. and McRae, Allan F. (2026). Extensive antagonistic variants across the human genome. Nature Communications. doi: 10.1038/s41467-026-71215-3 |
|
2026 Journal Article Poor mood after oral contraceptive use is associated with increased vulnerability to peripartum depression, premenstrual dysphoric disorder, and higher genetic risk for depressionKiewa, Jacqueline, Lind, Penelope A., Hickie, Ian B., Medland, Sarah E., Mitchell, Brittany E., Middeldorp, Christel M., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2026). Poor mood after oral contraceptive use is associated with increased vulnerability to peripartum depression, premenstrual dysphoric disorder, and higher genetic risk for depression. Archives of Womens Mental Health, 29 (3) 71, 1-13. doi: 10.1007/s00737-026-01708-z |
|
2026 Journal Article Empirical evaluation of analytic validity of polygenic scoresLin, Tian, Zeng, Jian, Gordon, Scott D., Wallace, Leanne, Ziser, Laura, Shah, Sonia, Pain, Oliver, Nolte, Ilja M., Snieder, Harold, Lifelines Cohort Study, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A, Lopera Maya, Esteban A, Sanna, Serena, Swertz, Morris A, Vonk, Judith M, Wijmenga, Cisca, James, Paul A., Martin, Nicholas G., Visscher, Peter M., Lee, Eric, Yengo, Loic, Henders, Anjali K. and Wray, Naomi R. (2026). Empirical evaluation of analytic validity of polygenic scores. Genome Medicine. doi: 10.1186/s13073-026-01654-6 |
|
2026 Journal Article Cohort profile: investigating antidepressant response within generation ScotlandCalnan, Megan, Edmondson – Stait, Amelia, Milbourn, Hannah, Elsden, Esme, Henders, Anjali K., Ball, Emily L., Iveson, Matthew H., AMBER Research Team, AMBER Lived Experience Advisory Panel, Generation Scotland Team, Wray, Naomi R., Shah, Sonia, Lewis, Cathryn M. and McIntosh, Andrew M. (2026). Cohort profile: investigating antidepressant response within generation Scotland. Wellcome Open Research, 11 210. doi: 10.12688/wellcomeopenres.26056.1 |
|
2026 Journal Article Psychiatric Nosology Should Include Genetic SyndromesWray, Naomi R. and Owen, Michael J. (2026). Psychiatric Nosology Should Include Genetic Syndromes. Biological Psychiatry, 99 (7), 508-510. doi: 10.1016/j.biopsych.2026.01.008 |
|
2026 Journal Article Genome-wide fine-mapping improves identification of causal variantsWu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Genome-wide fine-mapping improves identification of causal variants. Nature Genetics, 58 (4), 940-951. doi: 10.1038/s41588-026-02549-3 |
|
2026 Journal Article Genetic and phenotypic associations With sustained antidepressant use in major depressive disorderWalker, Alicia, Mitchell, Brittany L., Lin, Tian, Crouse, Jacob J., Albinana, Clara, Yap, Chloe X., Lynall, Mary Ellen, Lind, Penelope A., Cipriani, Andrea, Byrne, Enda M., Medland, Sarah E., Martin, Nicholas G., Taquet, Maxime, Hickie, Ian B. and Wray, Naomi R. (2026). Genetic and phenotypic associations With sustained antidepressant use in major depressive disorder. Jama Psychiatry, 83 (3), 247-258. doi: 10.1001/jamapsychiatry.2025.4372 |
|
2026 Journal Article Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese AdultsWang, Baihan, Morris, Sam, Fry, Hannah, Iona, Andri, Clarke, Jonathan, Lin, Kuang, Pupko, Igor, Kartsonaki, Christiana, Bennett, Derrick A., Chen, Yiping, Du, Huaidong, Yang, Ling, Avery, Daniel, Schmidt-Valle, Dan, Feng, Shixian, Sun, Dianjianyi, Yu, Canqing, Lv, Jun, Pei, Pei, Chen, Junshi, Kuchenbaecker, Karoline, Wray, Naomi R., Li, Liming, Walters, Robin G., Chen, Zhengming and Millwood, Iona Y. (2026). Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults. Biological Psychiatry Global Open Science, 6 (2) 100681, 100681. doi: 10.1016/j.bpsgos.2025.100681 |
|
2026 Journal Article Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biologyJiang, Jiayue-Clara, Brianceau, Camille, Delzant, Elise, Colle, Romain, Bottemanne, Hugo, Corruble, Emmanuelle, Wray, Naomi R., Colliot, Olivier, Shah, Sonia and Couvy-Duchesne, Baptiste (2026). Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biology. Translational Psychiatry, 16 (1) 171. doi: 10.1038/s41398-026-03889-8 |
|
2026 Journal Article Effects of 6-months of SSRI use on DNA-methylation and gene expression in bloodBarker, Lauren F., McRae, Allan F, Yuen, Hok Pan, Henders, Anjali K, Wallace, Leanne M, Lin, Tian, Davyson, Ella, Phassouliotis, Christina, Spark, Jessica, Kerr, Melissa, Street, Rebekah, Byrne, Enda M, Amminger, G.Paul, Nelson, Barnaby, Wray, Naomi R. and McGorry, Patrick D (2026). Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood. Brain, Behavior, and Immunity, 135 106520, 106520. doi: 10.1016/j.bbi.2026.106520 |
|
2026 Journal Article Progress in understanding the biological basis of polygenic disordersWray, Naomi R., Lin, Tian, Li, A., de Almeida, Valéria Correia, Ziller, Michael Johannes and Zeng, Jian (2026). Progress in understanding the biological basis of polygenic disorders. Current Opinion in Genetics and Development, 97 102433. doi: 10.1016/j.gde.2025.102433 |
|
2026 Journal Article Atypical Depression Is Associated With a Distinct Clinical, Neurobiological, Treatment Response, and Polygenic Risk ProfileShin, Mirim, Crouse, Jacob J., Lin, Tian, Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope A., Parker, Richard, Mckenna, Sarah, Tonini, Emiliana, Carpenter, Joanne S., Merikangas, Kathleen R., Wray, Naomi R., Medland, Sarah E., Martin, Nicholas G. and Hickie, Ian B. (2026). Atypical Depression Is Associated With a Distinct Clinical, Neurobiological, Treatment Response, and Polygenic Risk Profile. Biological Psychiatry. doi: 10.1016/j.biopsych.2026.01.003 |
|
2026 Journal Article Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3)Wu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3). Nature Genetics. doi: 10.1038/s41588-026-02627-6 |
|
2025 Journal Article Integrating multi-omics summary data identifies candidate molecular mechanisms for major depressionNisbet, Laurence, Wu, Yang, Adams, Mark, Lynall, Mary-Ellen, Hjerling-Leffler, Jens, Wray, Naomi R., McIntosh, Andrew M. and Shen, Xueyi (2025). Integrating multi-omics summary data identifies candidate molecular mechanisms for major depression. Biological Psychiatry. doi: 10.1016/j.biopsych.2025.11.024 |
|
2025 Journal Article Clinical trials in depression: integrated collection across EU and US registriesStewart, Kate, Schindler, Louise, Bevan, Robert, Rehman, Samrina, Iveson, Matthew H., McIntosh, Andrew M., Wray, Naomi R. and Lewis, Cathryn M. (2025). Clinical trials in depression: integrated collection across EU and US registries. Wellcome Open Research, 10 670, 1-19. doi: 10.12688/wellcomeopenres.25126.1 |
|
2025 Journal Article Mapping the genetic landscape across 14 psychiatric disordersGrotzinger, Andrew D., Werme, Josefin, Peyrot, Wouter J., Frei, Oleksandr, de Leeuw, Christiaan, Bicks, Lucy K., Guo, Qiuyu, Margolis, Michael P., Coombes, Brandon J., Batzler, Anthony, Pazdernik, Vanessa, Biernacka, Joanna M., Andreassen, Ole A., Anttila, Verneri, Børglum, Anders D., Breen, Gerome, Cai, Na, Demontis, Ditte, Edenberg, Howard J., Faraone, Stephen V., Franke, Barbara, Gandal, Michael J., Gelernter, Joel, Hatoum, Alexander S., Hettema, John M., Johnson, Emma C., Jonas, Katherine G., Knowles, James A., Koenen, Karestan C. ... Smoller, Jordan W. (2025). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649 (8096), 406-415. doi: 10.1038/s41586-025-09820-3 |
|
2025 Journal Article Population-representative inference for primary and secondary outcomes in extended case-cohort designsWimberley, Theresa, Plana-Ripoll, Oleguer, Pedersen, Carsten B., Pedersen, Marianne G., Dreier, Julie W., Christensen, Jakob, Horsdal, Henriette Thisted, Astrup, Aske, Thompson, Wesley K., Helenius, Dorte, McGrath, John J., Wray, Naomi R., Petersen, Liselotte Vogdrup, Vilhjálmsson, Bjarni, Mortensen, Preben B. and Agerbo, Esben (2025). Population-representative inference for primary and secondary outcomes in extended case-cohort designs. Discover Public Health, 22 (1) 599, 1-13. doi: 10.1186/s12982-025-00888-w |
|
2025 Journal Article Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapyBye, Christopher R., Qian, Elizabeth, Lim, Katherine, Daniszewski, Maciej, Garton, Fleur C., Trần-Lê, Bảo C., Liang, Helena H., Lin, Tian, Lock, John G., Crombie, Duncan E., Morgan, Steven, Hu, Yi, Barton, Samantha K., Palmer, Lucy M., Djouma, Elvan, Kodikara, Saritha, Lê Cao, Kim-Anh, Dharmadasa, Thanuja, Henders, Anjali K., Ziser, Laura A., Kiernan, Matthew C., Talbot, Kevin, Needham, Merrilee, Fletcher, Susan, Talman, Paul, Mathers, Susan, Wray, Naomi R., Hewitt, Alex W., Pebay, Alice and Turner, Bradley J. (2025). Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience, 29 (1), 40-52. doi: 10.1038/s41593-025-02118-7 |
|
2025 Journal Article Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapiesKoch, Elise, Puusepp, Tuuli, Einarsson, Guðmundur, Mitchell, Brittany L., Harder, Arvid, Lin, Yuhao, García-Marín, Luis M., Krebs, Kristi, Shadrin, Alexey A., Xiong, Ying, Estonian Biobank Research Team, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Nelis, Mari, Hudjashov, Georgi, Frei, Oleksandr, Lu, Yi, Hägg, Sara, Rentería, Miguel E., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G., Hübel, Christopher, Breen, Gerome, Thorgeirsson, Thorgeir, Stefánsson, Hreinn, Stefánsson, Kári, Lehto, Kelli ... O’Connell, Kevin S. (2025). Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies. Molecular Psychiatry, 31 (4), 2005-2013. doi: 10.1038/s41380-025-03357-7 |
