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2025

Journal Article

Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older

Yu, Chenglong, Zhou, Zhen, Neumann, Johannes T., Lin, Tian, Robb, Catherine, Fransquet, Peter, McNeil, John J., Wray, Naomi R., Zoungas, Sophia and Lacaze, Paul (2025). Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older. Diabetes, Obesity and Metabolism. doi: 10.1111/dom.16579

Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older

2025

Journal Article

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

Lo, Chris Wai Hang, Gillett, Alexandra C., Iveson, Matthew H., Kamp, Michelle, Fabbri, Chiara, Wong, Win Lee Edwin, Handley, Dale, Pain, Oliver, Vassos, Evangelos, Wray, Naomi R., Whalley, Heather C., Li, Danyang, Young, Allan H., McIntosh, Andrew M. and Lewis, Cathryn M. (2025). Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics. Biological Psychiatry Global Open Science, 5 (4) 100502, 100502-4. doi: 10.1016/j.bpsgos.2025.100502

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

2025

Journal Article

White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis

Barker, Lauren F., McRae, Allan F., Yuen, Hok Pan, Henders, Anjali K., Wallace, Leanne M., Lin, Tian, Phassouliotis, Christina, Spark, Jessica, Kerr, Melissa, Byrne, Enda M., Amminger, G. Paul, Nelson, Barnaby, Wray, Naomi R. and McGorry, Patrick D. (2025). White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis. Biological Psychiatry Global Open Science 100546, 100546. doi: 10.1016/j.bpsgos.2025.100546

White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis

2025

Journal Article

Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study

Horsdal, Henriette Thisted, Albiñana, Clara, Zhu, Zhihong, Boelt, Sanne Grundvad, Borbye-Lorenzen, Nis, Cohen, Arieh S., Skogstrand, Kristin, Melgaard, Lars, MacSween, Nadia Jensen, Thorbek, Marta Jadwiga, Plana-Ripoll, Oleguer, Petersen, Liselotte Vogdrup, Bulik, Cynthia M., B⊘rglum, Anders D., Mors, Ole, Nordentoft, Merete, Werge, Thomas, Moen, Gunn-Helen, D'Urso, Shannon, Wray, Naomi R., Vilhjálmsson, Bjarni J., Agerbo, Esben, Pedersen, Carsten B⊘cker, Mortensen, Preben Bo and McGrath, John J. (2025). Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study. The Lancet Psychiatry, 12 (6), 410-420. doi: 10.1016/S2215-0366(25)00099-9

Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study

2025

Journal Article

Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

Wei, Dang, Freydenzon, Anna, Guinebretiere, Octave, Zaidi, Karim, Yang, Fen, Ye, Weimin, Hammar, Niklas, Modig, Karin, Wray, Naomi R., Feychting, Maria, Hamieh, Nadine, Ventelou, Bruno, Lekens, Beranger, Gantzer, Laurene, Durrleman, Stanley, McRae, Allan, Couvy-Duchesne, Baptiste, Fang, Fang and Nedelec, Thomas (2025). Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. eBioMedicine, 113 105585, 105585. doi: 10.1016/j.ebiom.2025.105585

Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

2025

Journal Article

Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile

Galligan, Dana E, Payne, Leanne, Sullivan, Daniel P, Bhadravathi Lokeshappa, Madhura, Ziser, Laura, Nunn, Lorelle, Wallace, Leanne M, Andersen, Isabella, Howarth, Sophie, Kato, Akina, Karunanithi, Mohan, Mingin, Cassandra, O’Scanaill, Sally, Aouira, Nisreen, Paramecwari, Ayu, Sanders, Matthew R, Cobham, Vanessa E, Wray, Naomi R, Henders, Anjali K, Byrne, Enda M, Heussler, Honey and Middeldorp, Christel M (2025). Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile. BMJ Open, 15 (3) e091676, e091676-3. doi: 10.1136/bmjopen-2024-091676

Improving Outcomes in Mental Health (IOMH)—an Australian longitudinal clinical study of families with children with neurodevelopmental problems: cohort profile

2025

Journal Article

Insights from a methylome-wide association study of antidepressant exposure

Davyson, E., Shen, X., Huider, F., Adams, M. J., Borges, K., McCartney, D. L., Barker, L. F., van Dongen, J., Boomsma, D. I., Weihs, A., Grabe, H. J., Kühn, L., Teumer, A., Völzke, H., Zhu, T., Kaprio, J., Ollikainen, M., David, F. S., Meinert, S., Stein, F., Forstner, A. J., Dannlowski, U., Kircher, T., Tapuc, A., Czamara, D., Binder, E. B., Brückl, T., Kwong, A. S. F., Yousefi, P. ... McIntosh, A. M. (2025). Insights from a methylome-wide association study of antidepressant exposure. Nature Communications, 16 (1) 1908. doi: 10.1038/s41467-024-55356-x

Insights from a methylome-wide association study of antidepressant exposure

2025

Journal Article

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

Crouse, Jacob J., Park, Shin Ho, Mitchell, Brittany L., Byrne, Enda M., Medland, Sarah E., Lin, Tian, Scott, Jan, de Haan, Zsofi, Tonini, Emiliana, Iorfino, Frank, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2025). Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression. European Psychiatry, 68 (1) e41, 1-34. doi: 10.1192/j.eurpsy.2025.20

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

2025

Journal Article

Grey‐Matter Structure Markers of Alzheimer's Disease, Alzheimer's Conversion, Functioning and Cognition: A Meta‐Analysis Across 11 Cohorts

Couvy‐Duchesne, Baptiste, Frouin, Vincent, Bouteloup, Vincent, Koussis, Nikitas, Sidorenko, Julia, Jiang, Jiyang, Wink, Alle Meije, Lorenzini, Luigi, Barkhof, Frederik, Trollor, Julian N., Mangin, Jean‐François, Sachdev, Perminder S., Brodaty, Henry, Lupton, Michelle K., Breakspear, Michael, Colliot, Olivier, Visscher, Peter M., Wray, Naomi R., for the Alzheimer's Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, the Alzheimer's Disease Repository Without Borders Investigators and the MEMENTO cohort Study Group (2025). Grey‐Matter Structure Markers of Alzheimer's Disease, Alzheimer's Conversion, Functioning and Cognition: A Meta‐Analysis Across 11 Cohorts. Human Brain Mapping, 46 (2) e70089, e70089. doi: 10.1002/hbm.70089

Grey‐Matter Structure Markers of Alzheimer's Disease, Alzheimer's Conversion, Functioning and Cognition: A Meta‐Analysis Across 11 Cohorts

2025

Journal Article

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity

Yao, Shuyang, Harder, Arvid, Darki, Fahimeh, Chang, Yu-Wei, Li, Ang, Nikouei, Kasra, Volpe, Giovanni, Lundström, Johan N., Zeng, Jian, Wray, Naomi R., Lu, Yi, Sullivan, Patrick F. and Hjerling-Leffler, Jens (2025). Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity. Nature Communications, 16 (1) 395, 1-18. doi: 10.1038/s41467-024-55611-1

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity

2025

Journal Article

Genome-wide copy number variation association study in anorexia nervosa

Walker, Alicia, Karlsson, Robert, Szatkiewicz, Jin P., Thornton, Laura M., Yilmaz, Zeynep, Leppä, Virpi M., Savva, Androula, Lin, Tian, Sidorenko, Julia, McRae, Allan, Kirov, George, Davies, Helena L., Fundín, Bengt T., Chawner, Samuel J. R. A., Song, Jie, Borg, Stina, Wen, Jia, Watson, Hunna J., Munn-Chernoff, Melissa A., Baker, Jessica H., Gordon, Scott, Berrettini, Wade H., Brandt, Harry, Crawford, Steven, Halmi, Katherine A., Kaplan, Allan S., Kaye, Walter H., Mitchell, James, Strober, Michael ... Wray, Naomi R. (2025). Genome-wide copy number variation association study in anorexia nervosa. Molecular Psychiatry, 30 (5) 867, 2009-2016. doi: 10.1038/s41380-024-02811-2

Genome-wide copy number variation association study in anorexia nervosa

2025

Journal Article

Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort

Bos, Martje, Monden, Rei, Wray, Naomi R., Zhou, Yiling, Kendler, Kenneth S., Rosmalen, Judith G. M., van Loo, Hanna M. and Snieder, Harold (2025). Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort. Psychological Medicine, 55 e126, e126-55. doi: 10.1017/s003329172500100x

Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort

2025

Journal Article

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Adams, Mark J., Streit, Fabian, Meng, Xiangrui, Awasthi, Swapnil, Adey, Brett N., Choi, Karmel W., Chundru, V. Kartik, Coleman, Jonathan R.I., Ferwerda, Bart, Foo, Jerome C., Gerring, Zachary F., Giannakopoulou, Olga, Gupta, Priya, Hall, Alisha S.M., Harder, Arvid, Howard, David M., Hübel, Christopher, Kwong, Alex S.F., Levey, Daniel F., Mitchell, Brittany L., Ni, Guiyan, Ota, Vanessa K., Pain, Oliver, Pathak, Gita A., Schulte, Eva C., Shen, Xueyi, Thorp, Jackson G., Walker, Alicia, Yao, Shuyang ... McIntosh, Andrew M. (2025). Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell, 188 (3), 640-652.e9. doi: 10.1016/j.cell.2024.12.002

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

2024

Journal Article

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Stahl, Eli A., Domenici, Enrico, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Blackwood, Douglas H. R., Borglum, Anders D., Bramon, Elvira, Bruggeman, Richard ... Ziller, Michael J. (2024). Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications, 15 (1) 5534, 1-28. doi: 10.1038/s41467-024-49338-2

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

2024

Journal Article

Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases

Jiang, Jiayue-Clara, Singh, Kritika, Nitin, Rachana, Davis, Lea K., Wray, Naomi R. and Shah, Sonia (2024). Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases. Circulation: Genomic and Precision Medicine, 17 (6) e004685, 1-12. doi: 10.1161/circgen.124.004685

Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases

2024

Journal Article

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

Adams, Mark J., Thorp, Jackson G., Jermy, Bradley S., Kwong, Alex S. F., Kõiv, Kadri, Grotzinger, Andrew D., Nivard, Michel G., Marshall, Sally, Milaneschi, Yuri, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W. J. H., Boomsma, Dorret I., Levinson, Douglas F., Breen, Gerome, Pistis, Giorgio, Grabe, Hans J., Tiemeier, Henning, Berger, Klaus, Rietschel, Marcella, Magnusson, Patrik K., Uher, Rudolf, Hamilton, Steven P., Lucae, Susanne, Lehto, Kelli, Li, Qingqin S., Byrne, Enda M., Hickie, Ian B., Martin, Nicholas G. ... Derks, Eske M. (2024). Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts. Psychological Medicine, 54 (12), 3459-3468. doi: 10.1017/s0033291724001880

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

2024

Journal Article

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Scott, Jan, Medland, Sarah E., Lin, Tian, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2024). Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. Molecular Psychiatry, 29 (9), 2765-2773. doi: 10.1038/s41380-024-02492-x

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

2024

Journal Article

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

Adams, Mark J., Thorp, Jackson G., Jermy, Bradley S., Kwong, Alex S. F., Koiv, Kadri, Grotzinger, Andrew D., Nivard, Michel G., Marshall, Sally, Milaneschi, Yuri, Baune, Bernhard T., Mueller-Myhsok, Bertram, Penninx, Brenda W. J. H., Boomsma, Dorret I., Levinson, Douglas F., Breen, Gerome, Pistis, Giorgio, Grabe, Hans J., Tiemeier, Henning, Berger, Klaus, Rietschel, Marcella, Magnusson, Patrik K., Uher, Rudolf, Hamilton, Steven P., Lucae, Susanne, Lehto, Kelli, Li, Qingqin S., Byrne, Enda M., Hickie, Ian B., Martin, Nicholas G. ... Derks, Eske M. (2024). Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts. Psychological Medicine, 54 (12), 3459-3468. doi: 10.1017/S0033291724001880

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

2024

Journal Article

R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores

Momin, Md. Moksedul, Wray, Naomi R. and Lee, S. Hong (2024). R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores. Human Genetics, 143 (9-10), 1193-1205. doi: 10.1007/s00439-024-02682-1

R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores

2024

Journal Article

Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain

Chauquet, Solal, Willis, Emily F., Grice, Laura, Harley, Samuel B. R., Powell, Joseph E., Wray, Naomi R., Nguyen, Quan, Ruitenberg, Marc J., Shah, Sonia and Vukovic, Jana (2024). Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain. Aging Cell, 23 (7) e14172, e14172. doi: 10.1111/acel.14172

Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain