|
2026 Journal Article Progress in understanding the biological basis of polygenic disordersWray, N. R., Lin, T., Li, A., de Almeida, V., Ziller, M. and Zeng, J. (2026). Progress in understanding the biological basis of polygenic disorders. Current Opinion in Genetics and Development, 97 102433, 102433-97. doi: 10.1016/j.gde.2025.102433 |
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2026 Journal Article Psychiatric Nosology Should Include Genetic SyndromesWray, Naomi R. and Owen, Michael J. (2026). Psychiatric Nosology Should Include Genetic Syndromes. Biological Psychiatry, 99 (7), 508-510. doi: 10.1016/j.biopsych.2026.01.008 |
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2026 Journal Article Genome-wide fine-mapping improves identification of causal variantsWu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Genome-wide fine-mapping improves identification of causal variants. Nature Genetics, 58 (4), 1-12. doi: 10.1038/s41588-026-02549-3 |
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2026 Journal Article Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese AdultsWang, Baihan, Morris, Sam, Fry, Hannah, Iona, Andri, Clarke, Jonathan, Lin, Kuang, Pupko, Igor, Kartsonaki, Christiana, Bennett, Derrick A., Chen, Yiping, Du, Huaidong, Yang, Ling, Avery, Daniel, Schmidt-Valle, Dan, Feng, Shixian, Sun, Dianjianyi, Yu, Canqing, Lv, Jun, Pei, Pei, Chen, Junshi, Kuchenbaecker, Karoline, Wray, Naomi R., Li, Liming, Walters, Robin G., Chen, Zhengming and Millwood, Iona Y. (2026). Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults. Biological Psychiatry Global Open Science, 6 (2) 100681, 100681. doi: 10.1016/j.bpsgos.2025.100681 |
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2026 Journal Article Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biologyJiang, Jiayue-Clara, Brianceau, Camille, Delzant, Elise, Colle, Romain, Bottemanne, Hugo, Corruble, Emmanuelle, Wray, Naomi R., Colliot, Olivier, Shah, Sonia and Couvy-Duchesne, Baptiste (2026). Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biology. Translational Psychiatry, 16 (1) 171, 1. doi: 10.1038/s41398-026-03889-8 |
|
2026 Journal Article Effects of 6-months of SSRI use on DNA-methylation and gene expression in bloodBarker, Lauren F., McRae, Allan F, Yuen, Hok Pan, Henders, Anjali K, Wallace, Leanne M, Lin, Tian, Davyson, Ella, Phassouliotis, Christina, Spark, Jessica, Kerr, Melissa, Street, Rebekah, Byrne, Enda M, Amminger, G.Paul, Nelson, Barnaby, Wray, Naomi R. and McGorry, Patrick D (2026). Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood. Brain, Behavior, and Immunity, 135 106520, 106520. doi: 10.1016/j.bbi.2026.106520 |
|
2026 Journal Article Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive DisorderWalker, Alicia, Mitchell, Brittany L., Lin, Tian, Crouse, Jacob J., Albinana, Clara, Yap, Chloe X., Lynall, Mary Ellen, Lind, Penelope A., Cipriani, Andrea, Byrne, Enda M., Medland, Sarah E., Martin, Nicholas G., Taquet, Maxime, Hickie, Ian B. and Wray, Naomi R. (2026). Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder. Jama Psychiatry, 83 (3), 247-258. doi: 10.1001/jamapsychiatry.2025.4372 |
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2026 Journal Article Atypical Depression Is Associated With a Distinct Clinical, Neurobiological, Treatment Response, and Polygenic Risk ProfileShin, Mirim, Crouse, Jacob J., Lin, Tian, Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope A., Parker, Richard, Mckenna, Sarah, Tonini, Emiliana, Carpenter, Joanne S., Merikangas, Kathleen R., Wray, Naomi R., Medland, Sarah E., Martin, Nicholas G. and Hickie, Ian B. (2026). Atypical Depression Is Associated With a Distinct Clinical, Neurobiological, Treatment Response, and Polygenic Risk Profile. Biological Psychiatry. doi: 10.1016/j.biopsych.2026.01.003 |
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2025 Journal Article Integrating multi-omics summary data identifies candidate molecular mechanisms for major depressionNisbet, Laurence, Wu, Yang, Adams, Mark, Lynall, Mary-Ellen, Hjerling-Leffler, Jens, Wray, Naomi R., McIntosh, Andrew M. and Shen, Xueyi (2025). Integrating multi-omics summary data identifies candidate molecular mechanisms for major depression. Biological Psychiatry. doi: 10.1016/j.biopsych.2025.11.024 |
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2025 Journal Article Clinical trials in depression: integrated collection across EU and US registriesStewart, Kate, Schindler, Louise, Bevan, Robert, Rehman, Samrina, Iveson, Matthew H., McIntosh, Andrew M., Wray, Naomi R. and Lewis, Cathryn M. (2025). Clinical trials in depression: integrated collection across EU and US registries. Wellcome Open Research, 10 670, 1-19. doi: 10.12688/wellcomeopenres.25126.1 |
|
2025 Journal Article Mapping the genetic landscape across 14 psychiatric disordersGrotzinger, Andrew D., Werme, Josefin, Peyrot, Wouter J., Frei, Oleksandr, de Leeuw, Christiaan, Bicks, Lucy K., Guo, Qiuyu, Margolis, Michael P., Coombes, Brandon J., Batzler, Anthony, Pazdernik, Vanessa, Biernacka, Joanna M., Andreassen, Ole A., Anttila, Verneri, Børglum, Anders D., Breen, Gerome, Cai, Na, Demontis, Ditte, Edenberg, Howard J., Faraone, Stephen V., Franke, Barbara, Gandal, Michael J., Gelernter, Joel, Hatoum, Alexander S., Hettema, John M., Johnson, Emma C., Jonas, Katherine G., Knowles, James A., Koenen, Karestan C. ... Smoller, Jordan W. (2025). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649 (8096), 406-415. doi: 10.1038/s41586-025-09820-3 |
|
2025 Journal Article Population-representative inference for primary and secondary outcomes in extended case-cohort designsWimberley, Theresa, Plana-Ripoll, Oleguer, Pedersen, Carsten B., Pedersen, Marianne G., Dreier, Julie W., Christensen, Jakob, Horsdal, Henriette Thisted, Astrup, Aske, Thompson, Wesley K., Helenius, Dorte, McGrath, John J., Wray, Naomi R., Petersen, Liselotte Vogdrup, Vilhjálmsson, Bjarni, Mortensen, Preben B. and Agerbo, Esben (2025). Population-representative inference for primary and secondary outcomes in extended case-cohort designs. Discover Public Health, 22 (1) 599, 1-13. doi: 10.1186/s12982-025-00888-w |
|
2025 Journal Article Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapyBye, Christopher R., Qian, Elizabeth, Lim, Katherine, Daniszewski, Maciej, Garton, Fleur C., Trần-Lê, Bảo C., Liang, Helena H., Lin, Tian, Lock, John G., Crombie, Duncan E., Morgan, Steven, Hu, Yi, Barton, Samantha K., Palmer, Lucy M., Djouma, Elvan, Kodikara, Saritha, Lê Cao, Kim-Anh, Dharmadasa, Thanuja, Henders, Anjali K., Ziser, Laura A., Kiernan, Matthew C., Talbot, Kevin, Needham, Merrilee, Fletcher, Susan, Talman, Paul, Mathers, Susan, Wray, Naomi R., Hewitt, Alex W., Pebay, Alice and Turner, Bradley J. (2025). Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience, 29 (1), 40-52. doi: 10.1038/s41593-025-02118-7 |
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2025 Journal Article Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapiesKoch, Elise, Puusepp, Tuuli, Einarsson, Guðmundur, Mitchell, Brittany L., Harder, Arvid, Lin, Yuhao, García-Marín, Luis M., Krebs, Kristi, Shadrin, Alexey A., Xiong, Ying, Estonian Biobank Research Team, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Nelis, Mari, Hudjashov, Georgi, Frei, Oleksandr, Lu, Yi, Hägg, Sara, Rentería, Miguel E., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G., Hübel, Christopher, Breen, Gerome, Thorgeirsson, Thorgeir, Stefánsson, Hreinn, Stefánsson, Kári, Lehto, Kelli ... O’Connell, Kevin S. (2025). Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies. Molecular Psychiatry, 31 (4), 2005-2013. doi: 10.1038/s41380-025-03357-7 |
|
2025 Journal Article From variants to mechanisms: neurogenomics in the post-GWAS eraMargolis, Michael P., Tang, Miao, Gagliardi, Miriam, Wen, Cindy, Wu, Yeda, Wray, Naomi R., Ziller, Michael J. and Gandal, Michael J. (2025). From variants to mechanisms: neurogenomics in the post-GWAS era. Neuron, 113 (21), 3509-3529. doi: 10.1016/j.neuron.2025.10.014 |
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2025 Journal Article Familial co-aggregation and shared heritability between neurodevelopmental problems and cardiometabolic conditionsLi, Yiran, Zhou, Yiling, Vos, Melissa, Bos, Martje, Steen, Olivier, Wray, Naomi R., Hartman, Catharina A. and Snieder, Harold (2025). Familial co-aggregation and shared heritability between neurodevelopmental problems and cardiometabolic conditions. Nature Mental Health, 3 (12), 1545-1554. doi: 10.1038/s44220-025-00535-y |
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2025 Journal Article Epigenetic profiles of tissue informative CpGs inform ALS disease status and progressionCaggiano, Christa, Morselli, Marco, Qian, Xiaoyu, Celona, Barbara, Thompson, Michael J., Wani, Shivangi, Tosevska, Anela, Taraszka, Kodi, Heuer, Galen, Ngo, Shyuan T., Steyn, Frederick J., Nestor, Peter J., Wallace, Leanne, Mccombe, Pamela, Heggie, Susan, Thorpe, Kathryn, Mcelligott, Caitlin, English, Gemyka, Henders, Anjali, Henderson, Robert, Lomen-Hoerth, Catherine, Wray, Naomi R., Mcrae, Allan F., Pellegrini, Matteo, Garton, Fleur C. and Zaitlen, Noah (2025). Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression. Genome Medicine, 17 (1) 115, 1-20. doi: 10.1186/s13073-025-01542-5 |
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2025 Journal Article Polygenic and developmental profiles of autism differ by age at diagnosisZhang, Xinhe, Grove, Jakob, Gu, Yuanjun, Buus, Cornelia K., Nielsen, Lea K., Neufeld, Sharon A. S., Koko, Mahmoud, Malawsky, Daniel S., Wade, Emma M., Verhoef, Ellen, Gui, Anna, Hegemann, Laura, APEX Consortium, Allison, Carrie, Tsompanidis, Alex, Adhya, Deep, Holt, Rosemary, Al-Rubaie, Omar, Ghoddousi, Ramin Ali Marandi, Heazell, Alexander E. P., Mill, Jonathan, Franklin, Alice, Bamford, Rosie, Hurles, Matthew E., Mousa, Mahmoud, Rowitch, David H., Niakan, Kathy K., Burton, Graham J., Cindrova-Davies, Tereza ... Warrier, Varun (2025). Polygenic and developmental profiles of autism differ by age at diagnosis. Nature, 646 (8087), 1146-1155. doi: 10.1038/s41586-025-09542-6 |
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2025 Journal Article Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genesvan der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 2427-2435. doi: 10.1038/s41588-025-02295-y |
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2025 Journal Article Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genesvan der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 1-1. doi: 10.1038/s41588-025-02383-z |
