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2026 Journal Article Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapiesKoch, Elise, Puusepp, Tuuli, Einarsson, Guðmundur, Mitchell, Brittany L., Harder, Arvid, Lin, Yuhao, García-Marín, Luis M., Krebs, Kristi, Shadrin, Alexey A., Xiong, Ying, Estonian Biobank Research Team, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Nelis, Mari, Hudjashov, Georgi, Frei, Oleksandr, Lu, Yi, Hägg, Sara, Rentería, Miguel E., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G., Hübel, Christopher, Breen, Gerome, Thorgeirsson, Thorgeir, Stefánsson, Hreinn, Stefánsson, Kári, Lehto, Kelli ... O’Connell, Kevin S. (2026). Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies. Molecular Psychiatry, 31 (4), 2005-2013. doi: 10.1038/s41380-025-03357-7 |
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2026 Journal Article Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3)Wu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3). Nature Genetics, 58 (6), 1446-1446. doi: 10.1038/s41588-026-02627-6 |
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2025 Journal Article Clinical trials in depression: integrated collection across EU and US registriesStewart, Kate, Schindler, Louise, Bevan, Robert, Rehman, Samrina, Iveson, Matthew H., McIntosh, Andrew M., Wray, Naomi R. and Lewis, Cathryn M. (2025). Clinical trials in depression: integrated collection across EU and US registries. Wellcome Open Research, 10 670, 1-19. doi: 10.12688/wellcomeopenres.25126.1 |
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2025 Journal Article Mapping the genetic landscape across 14 psychiatric disordersGrotzinger, Andrew D., Werme, Josefin, Peyrot, Wouter J., Frei, Oleksandr, de Leeuw, Christiaan, Bicks, Lucy K., Guo, Qiuyu, Margolis, Michael P., Coombes, Brandon J., Batzler, Anthony, Pazdernik, Vanessa, Biernacka, Joanna M., Andreassen, Ole A., Anttila, Verneri, Børglum, Anders D., Breen, Gerome, Cai, Na, Demontis, Ditte, Edenberg, Howard J., Faraone, Stephen V., Franke, Barbara, Gandal, Michael J., Gelernter, Joel, Hatoum, Alexander S., Hettema, John M., Johnson, Emma C., Jonas, Katherine G., Knowles, James A., Koenen, Karestan C. ... Smoller, Jordan W. (2025). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649 (8096), 406-415. doi: 10.1038/s41586-025-09820-3 |
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2025 Journal Article Population-representative inference for primary and secondary outcomes in extended case-cohort designsWimberley, Theresa, Plana-Ripoll, Oleguer, Pedersen, Carsten B., Pedersen, Marianne G., Dreier, Julie W., Christensen, Jakob, Horsdal, Henriette Thisted, Astrup, Aske, Thompson, Wesley K., Helenius, Dorte, McGrath, John J., Wray, Naomi R., Petersen, Liselotte Vogdrup, Vilhjálmsson, Bjarni, Mortensen, Preben B. and Agerbo, Esben (2025). Population-representative inference for primary and secondary outcomes in extended case-cohort designs. Discover Public Health, 22 (1) 599, 1-13. doi: 10.1186/s12982-025-00888-w |
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2025 Journal Article Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapyBye, Christopher R., Qian, Elizabeth, Lim, Katherine, Daniszewski, Maciej, Garton, Fleur C., Trần-Lê, Bảo C., Liang, Helena H., Lin, Tian, Lock, John G., Crombie, Duncan E., Morgan, Steven, Hu, Yi, Barton, Samantha K., Palmer, Lucy M., Djouma, Elvan, Kodikara, Saritha, Lê Cao, Kim-Anh, Dharmadasa, Thanuja, Henders, Anjali K., Ziser, Laura A., Kiernan, Matthew C., Talbot, Kevin, Needham, Merrilee, Fletcher, Susan, Talman, Paul, Mathers, Susan, Wray, Naomi R., Hewitt, Alex W., Pebay, Alice and Turner, Bradley J. (2025). Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. Nature Neuroscience, 29 (1), 40-52. doi: 10.1038/s41593-025-02118-7 |
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2025 Journal Article From variants to mechanisms: neurogenomics in the post-GWAS eraMargolis, Michael P., Tang, Miao, Gagliardi, Miriam, Wen, Cindy, Wu, Yeda, Wray, Naomi R., Ziller, Michael J. and Gandal, Michael J. (2025). From variants to mechanisms: neurogenomics in the post-GWAS era. Neuron, 113 (21), 3509-3529. doi: 10.1016/j.neuron.2025.10.014 |
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2025 Journal Article Familial co-aggregation and shared heritability between neurodevelopmental problems and cardiometabolic conditionsLi, Yiran, Zhou, Yiling, Vos, Melissa, Bos, Martje, Steen, Olivier, Wray, Naomi R., Hartman, Catharina A. and Snieder, Harold (2025). Familial co-aggregation and shared heritability between neurodevelopmental problems and cardiometabolic conditions. Nature Mental Health, 3 (12), 1545-1554. doi: 10.1038/s44220-025-00535-y |
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2025 Journal Article Epigenetic profiles of tissue informative CpGs inform ALS disease status and progressionCaggiano, Christa, Morselli, Marco, Qian, Xiaoyu, Celona, Barbara, Thompson, Michael J., Wani, Shivangi, Tosevska, Anela, Taraszka, Kodi, Heuer, Galen, Ngo, Shyuan T., Steyn, Frederick J., Nestor, Peter J., Wallace, Leanne, Mccombe, Pamela, Heggie, Susan, Thorpe, Kathryn, Mcelligott, Caitlin, English, Gemyka, Henders, Anjali, Henderson, Robert, Lomen-Hoerth, Catherine, Wray, Naomi R., Mcrae, Allan F., Pellegrini, Matteo, Garton, Fleur C. and Zaitlen, Noah (2025). Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression. Genome Medicine, 17 (1) 115, 1-20. doi: 10.1186/s13073-025-01542-5 |
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2025 Journal Article Polygenic and developmental profiles of autism differ by age at diagnosisZhang, Xinhe, Grove, Jakob, Gu, Yuanjun, Buus, Cornelia K., Nielsen, Lea K., Neufeld, Sharon A. S., Koko, Mahmoud, Malawsky, Daniel S., Wade, Emma M., Verhoef, Ellen, Gui, Anna, Hegemann, Laura, APEX Consortium, Allison, Carrie, Tsompanidis, Alex, Adhya, Deep, Holt, Rosemary, Al-Rubaie, Omar, Ghoddousi, Ramin Ali Marandi, Heazell, Alexander E. P., Mill, Jonathan, Franklin, Alice, Bamford, Rosie, Hurles, Matthew E., Mousa, Mahmoud, Rowitch, David H., Niakan, Kathy K., Burton, Graham J., Cindrova-Davies, Tereza ... Warrier, Varun (2025). Polygenic and developmental profiles of autism differ by age at diagnosis. Nature, 646 (8087), 1146-1155. doi: 10.1038/s41586-025-09542-6 |
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2025 Journal Article Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genesvan der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 2427-2435. doi: 10.1038/s41588-025-02295-y |
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2025 Journal Article Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genesvan der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 1-1. doi: 10.1038/s41588-025-02383-z |
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2025 Journal Article Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working GroupColbert, Sarah M. C., Monson, Eric T., Andreassen, Ole A., Ayinde, Olatunde O., Barr, Peter B., Bejan, Cosmin A., Ceja, Zuriel, Coon, Hilary, DiBlasi, Emily, Edenberg, Howard J., Gelernter, Joel, Hatoum, Alexander, Izotova, Anastasia, Johnson, Emma C., Kaufman, Erin A., Kranzler, Henry R., Koromina, Maria, Lehto, Kelli, Myung, Woojae, Nurnberger, John I., Serretti, Alessandro, Smoller, Jordan W., Stein, Murray B., Zai, Clement C., Erlangsen, Annette, Gaine, Marie, Martorell, Lourdes, Sud, Reeteka, Toma, Claudio ... Zillich, Lea (2025). Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. Molecular Psychiatry, 30 (12), 6144-6154. doi: 10.1038/s41380-025-03271-y |
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2025 Journal Article A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparisonShen, Xueyi, Barbu, Miruna, Caramaschi, Doretta, Arathimos, Ryan, Czamara, Darina, David, Friederike S., Dearman, Anna, Dilkes, Evelyn, Herrera-Rivero, Marisol, Huider, Floris, Kuhn, Luise, Lu, Kuan-Chen, Palviainen, Teemu, Schowe, Alicia M., Shireby, Gemma, Weihs, Antoine, Wong, Chloe C. Y., Davyson, Eleanor, Casey, Hannah, Adams, Mark J., Allgaier, Antje-Kathrin, Barber, Michael, Burrage, Joe, Caspi, Avshalom, Costeira, Ricardo, Dunn, Erin C., Feldmann, Lisa, Frank, Josef, Freisleder, Franz J. ... PGC MDD Working Group (2025). A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison. Nature Mental Health, 3 (10), 1152-1167. doi: 10.1038/s44220-025-00486-4 |
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2025 Journal Article White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosisBarker, Lauren F., McRae, Allan F., Yuen, Hok Pan, Henders, Anjali K., Wallace, Leanne M., Lin, Tian, Phassouliotis, Christina, Spark, Jessica, Kerr, Melissa, Byrne, Enda M., Amminger, G. Paul, Nelson, Barnaby, Wray, Naomi R. and McGorry, Patrick D. (2025). White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis. Biological Psychiatry Global Open Science, 5 (5) 100546, 1-11. doi: 10.1016/j.bpsgos.2025.100546 |
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2025 Journal Article Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and olderYu, Chenglong, Zhou, Zhen, Neumann, Johannes T., Lin, Tian, Robb, Catherine, Fransquet, Peter, McNeil, John J., Wray, Naomi R., Zoungas, Sophia and Lacaze, Paul (2025). Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older. Diabetes, Obesity and Metabolism, 27 (9), 5259-5268. doi: 10.1111/dom.16579 |
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2025 Journal Article Sex-stratified genome-wide association meta-analysis of major depressive disorderThomas, Jodi T., Thorp, Jackson G., Huider, Floris, Grimes, Poppy Z., Wang, Rujia, Youssef, Pierre, Coleman, Jonathan R. I., Byrne, Enda M., Adams, Mark, BIONIC consortium, van Loo, Hanna M., Penninx, Brenda W. J. H., The GLAD Study, Medland, Sarah E., Hickie, Ian B., Olsen, Catherine M., Whiteman, David C., Whalley, Heather C., Penninx, Brenda W.J.H., van Loo, Hanna M., Derks, Eske M., Eley, Thalia C., Breen, Gerome, Boomsma, Dorret I., Wray, Naomi R., Martin, Nicholas G. and Mitchell, Brittany L. (2025). Sex-stratified genome-wide association meta-analysis of major depressive disorder. Nature Communications, 16 (1) 7960, 1-15. doi: 10.1038/s41467-025-63236-1 |
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2025 Journal Article Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smokingHe, Weixiong, van der Most, Peter J., Ong, Jue-Sheng, Hwang, Liang-Dar, Wu, Yeda, Magnø, Morten S., Vehof, Jelle, Krebs, Kristi, Mauring, Laura, Õunap, Katrin, Abner, Erik, Martin, Nicholas G., Plotnikov, Denis, Jiang, Chen, Melles, Ronald B., Gharahkhani, Puya, Snieder, Harold, Palumaa, Teele, Kaljurand, Kuldar, Guggenheim, Jeremy A., Mackey, David A., Engle, Elizabeth C., Choquet, Hélène, MacGregor, Stuart, Lifelines Cohort Study, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A. ... Wray, Naomi (2025). Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. Nature Communications, 16 (1) 7890, 1-14. doi: 10.1038/s41467-025-62456-9 |
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2025 Journal Article Insulin resistance as an early marker in youth with mood disordersShin, Mirim, Crouse, Jacob J., Weger, Meltem, McKenna, Sarah, Wray, Naomi R., Scott, Elizabeth M., Hickie, Ian B. and Gachon, Frédéric (2025). Insulin resistance as an early marker in youth with mood disorders. Nature Mental Health, 3 (9), 1-3. doi: 10.1038/s44220-025-00472-w |
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2025 Journal Article Genomic risk prediction for depression in a large prospective study of older adults of European descentYu, Chenglong, Bakshi, Andrew, Agustini, Bruno, Walker, Alicia, Lin, Tian, Lotfaliany, Mojtaba, Williams, Lana J., McNeil, John J., Wray, Naomi R., Berk, Michael and Lacaze, Paul (2025). Genomic risk prediction for depression in a large prospective study of older adults of European descent. Molecular Psychiatry, 30 (12), 1-8. doi: 10.1038/s41380-025-03145-3 |
