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2026

Journal Article

Association between polygenic liability to depression and lifetime depression in at-risk adolescents

Byrne, Enda M., Gillespie, Nathan A., Najman, Jake M., Henders, Anjali K., Mitchell, Brittany L., Dwyer, Dominic, Hartmann, Simon, Cavve, Blake S., Amminger, G. Paul, Clark, Scott, Gao, Caroline, Lin, Ashleigh, Schmaal, Lianne, Thompson, Andrew, Wood, Stephen J., Wigman, J.T.W, Yung, Alison R., Medland, Sarah E., Crouse, Jacob J., Scott, Jan, Scott, James G., Williams, Gail M., Nelson, Barnaby, Martin, Nicholas G., Hickie, Ian B., Wray, Naomi R. and Middeldorp, Christel M. (2026). Association between polygenic liability to depression and lifetime depression in at-risk adolescents. Molecular Psychiatry, 1-9. doi: 10.1038/s41380-026-03917-5

Association between polygenic liability to depression and lifetime depression in at-risk adolescents

2026

Journal Article

ONE MODEL DOES NOT FIT ALL: HETEROGENEITY IN POLYGENIC PROFILES OF ADHD ACROSS FOUR DEVELOPMENTAL STAGES

Ge, Fenfen, Wang, Yue, Agerbo, Esben, Benros, Michael, Wray, Naomi, Demontis, Ditte, Musliner, Katherine, Bo Mortensen, Preben, Petersen, Liselotte and Vilhjalmsson, Bjarni (2026). ONE MODEL DOES NOT FIT ALL: HETEROGENEITY IN POLYGENIC PROFILES OF ADHD ACROSS FOUR DEVELOPMENTAL STAGES. European Neuropsychopharmacology, 111 112989, 112989. doi: 10.1016/j.euroneuro.2026.112989

ONE MODEL DOES NOT FIT ALL: HETEROGENEITY IN POLYGENIC PROFILES OF ADHD ACROSS FOUR DEVELOPMENTAL STAGES

2026

Journal Article

F117. GENETIC LIABILITY TO ANTIPSYCHOTIC MEDICATION SIDE-EFFECTS IN THE UK BIOBANK

Proctor, Sasha, McGrath, Isabelle, Halstead, Sean, Pillinger, Toby, Upthegrove, Rachel, Wray, Naomi and Yap, Chloe (2026). F117. GENETIC LIABILITY TO ANTIPSYCHOTIC MEDICATION SIDE-EFFECTS IN THE UK BIOBANK. European Neuropsychopharmacology, 111 113512, 113512. doi: 10.1016/j.euroneuro.2026.113512

F117. GENETIC LIABILITY TO ANTIPSYCHOTIC MEDICATION SIDE-EFFECTS IN THE UK BIOBANK

2026

Journal Article

F17. IMMUNE-BRAIN POLYGENIC RISK ARCHITECTURE AND CLINICAL HETEROGENEITY IN PSYCHIATRIC DISORDERS

Mellon-Whelan, Aisling, McGrath, Isabelle, Wray, Naomi and Lynall, Mary-Ellen (2026). F17. IMMUNE-BRAIN POLYGENIC RISK ARCHITECTURE AND CLINICAL HETEROGENEITY IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 111 113412, 113412. doi: 10.1016/j.euroneuro.2026.113412

F17. IMMUNE-BRAIN POLYGENIC RISK ARCHITECTURE AND CLINICAL HETEROGENEITY IN PSYCHIATRIC DISORDERS

2026

Journal Article

THE PREDICTION OF SYMPTOM SEVERITY IN CHILDREN AND PARENTS IN A CLINICAL COHORT OF FAMILIES WITH CHILDREN WITH NEURODEVELOPMENTAL PROBLEMS

Middeldorp, Christel M., Galligan, Dana, Gangaraju, Swathi, Wray, Naomi and Byrne, Enda (2026). THE PREDICTION OF SYMPTOM SEVERITY IN CHILDREN AND PARENTS IN A CLINICAL COHORT OF FAMILIES WITH CHILDREN WITH NEURODEVELOPMENTAL PROBLEMS. European Neuropsychopharmacology, 111 113018, 113018. doi: 10.1016/j.euroneuro.2026.113018

THE PREDICTION OF SYMPTOM SEVERITY IN CHILDREN AND PARENTS IN A CLINICAL COHORT OF FAMILIES WITH CHILDREN WITH NEURODEVELOPMENTAL PROBLEMS

2026

Journal Article

T8. DISENTANGLING CAUSAL AND CORRELATED IMMUNE SIGNALS IN PSYCHIATRIC DISORDERS USING MULTI-TISSUE FUNCTIONAL GENOMICS

McGrath, Isabelle, Mellon-Whelan, Aisling, Walker, Alicia, Zhou, Ruolan, Wray, Naomi and Lynall, Mary-Ellen (2026). T8. DISENTANGLING CAUSAL AND CORRELATED IMMUNE SIGNALS IN PSYCHIATRIC DISORDERS USING MULTI-TISSUE FUNCTIONAL GENOMICS. European Neuropsychopharmacology, 111 113265, 113265. doi: 10.1016/j.euroneuro.2026.113265

T8. DISENTANGLING CAUSAL AND CORRELATED IMMUNE SIGNALS IN PSYCHIATRIC DISORDERS USING MULTI-TISSUE FUNCTIONAL GENOMICS

2026

Journal Article

A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA

McGrath, Isabelle, Group, PGC-MDD Working, Wray, Naomi and Lynall, Mary-Ellen (2026). A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA. European Neuropsychopharmacology, 111 112983, 112983. doi: 10.1016/j.euroneuro.2026.112983

A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA

2026

Journal Article

THE SHARED GENETICS BETWEEN BRAIN STRUCTURE AND PSYCHIATRIC DISORDERS: FROM GWAS TO DEVELOPMENTAL MECHANISMS

He, Yuankai, Ebneabassi, Amir, Gu, Yuanjun, Riegis, Clara, Pearson, Bess, Polimanti, Renato, Grove, Jakob, Børglum, Anders, Astle, Duncan, Rittman, Tim, Wray, Naomi, Won, Hyejung, Bethlehem, Richard A.I., Bullmore, Edward and Warrier, Varun (2026). THE SHARED GENETICS BETWEEN BRAIN STRUCTURE AND PSYCHIATRIC DISORDERS: FROM GWAS TO DEVELOPMENTAL MECHANISMS. European Neuropsychopharmacology, 111 112978, 112978. doi: 10.1016/j.euroneuro.2026.112978

THE SHARED GENETICS BETWEEN BRAIN STRUCTURE AND PSYCHIATRIC DISORDERS: FROM GWAS TO DEVELOPMENTAL MECHANISMS

2026

Journal Article

67. MIND THE GAP: QUANTIFYING AND MITIGATING THE IMPACT OF VARIANT MISSINGNESS ON POLYGENIC SCORES WITHIN THE GENOPRED PIPELINE

Pain, Oliver, Wang, Xiaotong, Visscher, Peter and Wray, Naomi (2026). 67. MIND THE GAP: QUANTIFYING AND MITIGATING THE IMPACT OF VARIANT MISSINGNESS ON POLYGENIC SCORES WITHIN THE GENOPRED PIPELINE. European Neuropsychopharmacology, 111 113094, 113094. doi: 10.1016/j.euroneuro.2026.113094

67. MIND THE GAP: QUANTIFYING AND MITIGATING THE IMPACT OF VARIANT MISSINGNESS ON POLYGENIC SCORES WITHIN THE GENOPRED PIPELINE

2026

Journal Article

An Internal-Standard-Integrated Digital SERS Immunoassay for Accurate and Precise Trace-Level Cytokine Quantification in Plasma

Zhang, Yiwen, Farokhinejad, Fahimeh, Crouse, Jacob J., Shin, Mirim, Henders, Anjali K., Wallace, Leanne M., Lobb, Richard J., Antaw, Fiach, Wray, Naomi R., Hickie, Ian B., Wuethrich, Alain and Trau, Matt (2026). An Internal-Standard-Integrated Digital SERS Immunoassay for Accurate and Precise Trace-Level Cytokine Quantification in Plasma. Analytical Chemistry. doi: 10.1021/acs.analchem.6c03298

An Internal-Standard-Integrated Digital SERS Immunoassay for Accurate and Precise Trace-Level Cytokine Quantification in Plasma

2026

Conference Publication

Unsupervised Variant Clustering Identifies Genetic Subtypes of Disease

Mizikovsky, Dalia, Wray, Naomi, Shah, Sonia and Palpant, Nathan (2026). Unsupervised Variant Clustering Identifies Genetic Subtypes of Disease. HOBOKEN: WILEY.

Unsupervised Variant Clustering Identifies Genetic Subtypes of Disease

2026

Conference Publication

Developing and Evaluating a Cross-Cutting "Circadian Depression" Phenotype

Crouse, Jacob, Tonini, Emiliana, Carpenter, Joanne S., Shin, Mirim, Mitchell, Brittany L., Byrne, Enda M., Hockey, Samuel H., Wray, Naomi R., Lind, Penelope A., Medland, Sarah E., Merikangas, Kathleen R., Martin, Nicholas G., Scott, Jan, Scott, Elizabeth M. and Hickie, Ian B. (2026). Developing and Evaluating a Cross-Cutting "Circadian Depression" Phenotype. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.

Developing and Evaluating a Cross-Cutting "Circadian Depression" Phenotype

2026

Conference Publication

Rethinking Covariate Adjustment in Psychiatric Biomarker Research: A Framework Applied to UK Biobank Blood Samples

Shin, Mirim, Crouse, Jacob J., Hickie, Ian B., Wray, Naomi and Albinana, Clara (2026). Rethinking Covariate Adjustment in Psychiatric Biomarker Research: A Framework Applied to UK Biobank Blood Samples. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.

Rethinking Covariate Adjustment in Psychiatric Biomarker Research: A Framework Applied to UK Biobank Blood Samples

2026

Conference Publication

Heterogeneity in Sleep-Wake and Circadian Rhythm Disturbance Profiles in Young People With Emerging Mood Disorders: Clinical and Genetic Correlates

Shin, Mirim, Carpenter, Joanne S., Tonini, Emiliana, Lin, Tian, Scott, Elizabeth M., Wray, Naomi, Scott, Jan, Crouse, Jacob J. and Hickie, Ian (2026). Heterogeneity in Sleep-Wake and Circadian Rhythm Disturbance Profiles in Young People With Emerging Mood Disorders: Clinical and Genetic Correlates. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.

Heterogeneity in Sleep-Wake and Circadian Rhythm Disturbance Profiles in Young People With Emerging Mood Disorders: Clinical and Genetic Correlates

2026

Conference Publication

Cohort Profile: The First 400 Children, Adolescents, and Young Adults in the Neurobiology Youth Follow-Up Study

Shin, Mirim, Nichles, Alissa, Zmicerevska, Natalia, Song, Yun Ju, Phung, Elizabeth, Janiszewski, Connie, Park, Minji, Carpenter, Joanne, Tonini, Emiliana, Iorfino, Frank, Lin, Tian, Wray, Naomi R., Scott, Elizabeth M. and Crouse, Jacob J. (2026). Cohort Profile: The First 400 Children, Adolescents, and Young Adults in the Neurobiology Youth Follow-Up Study. HOBOKEN: WILEY.

Cohort Profile: The First 400 Children, Adolescents, and Young Adults in the Neurobiology Youth Follow-Up Study

2026

Conference Publication

Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study

Graczyk, M. M., Albinana, C., Lee, A., Christodoulou, M. D., Deak, J. D., Burgess, S., Wray, N. R., Gelernter, J. and Topiwala, A. (2026). Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study. 37th World Congress of Neuropsychopharmacology (CINP) / Joint Meeting of the Scandinavian-College-of-Neuropsychopharmacology, Glasgow Scotland, Jun 26-29, 2026. OXFORD: OXFORD UNIV PRESS. doi: 10.1093/ijnp/pyag040.436

Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study

2026

Journal Article

Atypical depression is associated with a distinct clinical, neurobiological, treatment response, and polygenic risk profile

Shin, Mirim, Crouse, Jacob J., Lin, Tian, Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope A., Parker, Richard, Mckenna, Sarah, Tonini, Emiliana, Carpenter, Joanne S., Merikangas, Kathleen R., Wray, Naomi R., Medland, Sarah E., Martin, Nicholas G. and Hickie, Ian B. (2026). Atypical depression is associated with a distinct clinical, neurobiological, treatment response, and polygenic risk profile. Biological Psychiatry, 100 (5), 525-535. doi: 10.1016/j.biopsych.2026.01.003

Atypical depression is associated with a distinct clinical, neurobiological, treatment response, and polygenic risk profile

2026

Journal Article

Optimizing study design for clinically useful peripheral molecular biomarker discovery in psychiatry: a review

Yap, Chloe X., Henders, Anjali K., Wray, Naomi R. and Upthegrove, Rachel (2026). Optimizing study design for clinically useful peripheral molecular biomarker discovery in psychiatry: a review. JAMA Psychiatry. doi: 10.1001/jamapsychiatry.2026.2299

Optimizing study design for clinically useful peripheral molecular biomarker discovery in psychiatry: a review

2026

Journal Article

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder

ter Kuile, Abigail R., Mitchell, Brittany L., Lee, Sang Hyuck, Morneau-Vaillancourt, Geneviève, Skelton, Megan, Coleman, Jonathan R. I., Davies, Helena L., Mundy, Jessica, Peel, Alicia J., Hübel, Christopher, Davies, Molly R., Fürtjes, Anna E., Ahmad, Zain, Lin, Yuhao, Adey, Brett N., McGregor, Thomas, Palmos, Alish, Zvrskovec, Johan, Hotopf, Matthew, Kalsi, Gursharan, Smith, Daniel J., Veale, David, Walters, James T. R., Armour, Chérie, Hirsch, Colette R., McIntosh, Andrew M., Wray, Naomi R., Medland, Sarah E., Byrne, Enda M. ... Eley, Thalia C. (2026). Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder. Molecular Psychiatry, 1-14. doi: 10.1038/s41380-026-03677-2

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder

2026

Journal Article

Correction: “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians

Nathan, Vaishnavi, Akbar, Heena, McInerney-Leo, Aideen, Gilroy, Deborah, Henders, Anjali, Naresh, Reema, Choudhury, Nahid, Waqar, Maleeha, Shah, Sonia, Yanes, Tatiane, on behalf of the South Asian Genes and Health in Australia (SAGHA) research team, Atherton, John, Greaves, Kim, McGaughran, Julie, McInerney-Leo, Aideen, Mehta, Divya, Villani, Rehan Marie, Wallis, Katharine and Wray, Naomi R. (2026). Correction: “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians. European Journal of Human Genetics, 34 (8), 1190-1190. doi: 10.1038/s41431-026-02157-z

Correction: “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians