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2025

Conference Publication

Biobank-scale proteomic estimates of circadian dysregulation increase risk of bipolar disorder, schizophrenia and depression

Albinana, Clara, Zeng, Yanni, Crouse, Jacob J., Hickie, Ian B., Gachon, Frederic and Wray, Naomi (2025). Biobank-scale proteomic estimates of circadian dysregulation increase risk of bipolar disorder, schizophrenia and depression. World Congress of Psychiatric Genetics (WCPG), Cancun, Mexico, 19-23 October 2025. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2025.08.177

Biobank-scale proteomic estimates of circadian dysregulation increase risk of bipolar disorder, schizophrenia and depression

2025

Conference Publication

GENETICS AND GENOMICS OF ANTIDEPRESSANT ACTION AND RESPONSE

Wray, Naomi, Murray, Graham and Mcintosh, Andrew (2025). GENETICS AND GENOMICS OF ANTIDEPRESSANT ACTION AND RESPONSE. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2025.08.501

GENETICS AND GENOMICS OF ANTIDEPRESSANT ACTION AND RESPONSE

2025

Conference Publication

Refined mitochondrial DNA copy number (MTDNA-CN) calling and analysis pipeline reveals nuclear genetic regulation of MTDNA-CN in blood and its lack of association with mood disorders

Wang, Xiaotong, McGrath, Isabelle, Li, Ang and Wray, Naomi (2025). Refined mitochondrial DNA copy number (MTDNA-CN) calling and analysis pipeline reveals nuclear genetic regulation of MTDNA-CN in blood and its lack of association with mood disorders. World Congress of Psychiatric Genetics (WCPG), Cancun, Mexico, 19-23 October 2025. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2025.08.402

Refined mitochondrial DNA copy number (MTDNA-CN) calling and analysis pipeline reveals nuclear genetic regulation of MTDNA-CN in blood and its lack of association with mood disorders

2025

Conference Publication

Multi-ancestry conditional and joint analysis (MANC-COJO) of GWAS summary statistics

Wang, Xiaotong, Wang, Yong, Visscher, Peter, Wray, Naomi and Yengo, Loic (2025). Multi-ancestry conditional and joint analysis (MANC-COJO) of GWAS summary statistics. World Congress of Psychiatric Genetics (WCPG), Cancun, Mexico, 19-23 October 2025. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2025.08.136

Multi-ancestry conditional and joint analysis (MANC-COJO) of GWAS summary statistics

2025

Conference Publication

BENCHMARKING METHODS INTEGRATING GWAS AND SINGLE-CELL TRANSCRIPTOMIC DATA FOR MAPPING TRAIT-CELL TYPE ASSOCIATIONS

Li, Ang, Wray, Naomi and Zeng, Jian (2025). BENCHMARKING METHODS INTEGRATING GWAS AND SINGLE-CELL TRANSCRIPTOMIC DATA FOR MAPPING TRAIT-CELL TYPE ASSOCIATIONS. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2025.08.394

BENCHMARKING METHODS INTEGRATING GWAS AND SINGLE-CELL TRANSCRIPTOMIC DATA FOR MAPPING TRAIT-CELL TYPE ASSOCIATIONS

2025

Conference Publication

Functional genomic investigation of the immune hypothesis of mental illness

McGrath, Isabelle, Wray, Naomi and Lynall, Mary-Ellen (2025). Functional genomic investigation of the immune hypothesis of mental illness. World Congress of Psychiatric Genetics (WCPG), Cancun, Mexico, 19-23 October 2025. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2025.08.210

Functional genomic investigation of the immune hypothesis of mental illness

2025

Journal Article

Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

van der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 1-1. doi: 10.1038/s41588-025-02383-z

Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

2025

Journal Article

Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

van der Laan, Camiel M., Ip, Hill F., Schipper, Marijn, Hottenga, Jouke-Jan, St Pourcain, Beate, Zayats, Tetyana, Pool, René, Krapohl, Eva M. L., Brikell, Isabell, Soler Artigas, María, Cabana-Domínguez, Judit, Llonga, Natalia, Nolte, Ilja M., Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Gordon, Scott, Aliev, Fazil, Burt, S. Alexandra, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S. ... Boomsma, Dorret I. (2025). Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes. Nature Genetics, 57 (10), 2427-2435. doi: 10.1038/s41588-025-02295-y

Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

2025

Journal Article

A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison

Shen, Xueyi, Barbu, Miruna, Caramaschi, Doretta, Arathimos, Ryan, Czamara, Darina, David, Friederike S., Dearman, Anna, Dilkes, Evelyn, Herrera-Rivero, Marisol, Huider, Floris, Kuhn, Luise, Lu, Kuan-Chen, Palviainen, Teemu, Schowe, Alicia M., Shireby, Gemma, Weihs, Antoine, Wong, Chloe C. Y., Davyson, Eleanor, Casey, Hannah, Adams, Mark J., Allgaier, Antje-Kathrin, Barber, Michael, Burrage, Joe, Caspi, Avshalom, Costeira, Ricardo, Dunn, Erin C., Feldmann, Lisa, Frank, Josef, Freisleder, Franz J. ... PGC MDD Working Group (2025). A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison. Nature Mental Health, 3 (10), 1152-1167. doi: 10.1038/s44220-025-00486-4

A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison

2025

Journal Article

White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis

Barker, Lauren F., McRae, Allan F., Yuen, Hok Pan, Henders, Anjali K., Wallace, Leanne M., Lin, Tian, Phassouliotis, Christina, Spark, Jessica, Kerr, Melissa, Byrne, Enda M., Amminger, G. Paul, Nelson, Barnaby, Wray, Naomi R. and McGorry, Patrick D. (2025). White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis. Biological Psychiatry Global Open Science, 5 (5) 100546, 1-11. doi: 10.1016/j.bpsgos.2025.100546

White blood cell proportions are associated with response to psychosocial therapy in young people at ultra-high risk for psychosis

2025

Journal Article

Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older

Yu, Chenglong, Zhou, Zhen, Neumann, Johannes T., Lin, Tian, Robb, Catherine, Fransquet, Peter, McNeil, John J., Wray, Naomi R., Zoungas, Sophia and Lacaze, Paul (2025). Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older. Diabetes, Obesity and Metabolism, 27 (9), 5259-5268. doi: 10.1111/dom.16579

Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older

2025

Conference Publication

Distinct Clinical, Metabolic-Inflammatory-Genetic Characteristics and Treatment Responses of Atypical Depression

Shin, Mirim, Crouse, Jacob J., Lin, Tian, Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope A., Parker, Richard, McKenna, Sarah, Tonini, Emiliana, Carpenter, Joanne S., Wray, Naomi, Medland, Sarah E., Martin, Nicholas G. and Hickie, Ian B. (2025). Distinct Clinical, Metabolic-Inflammatory-Genetic Characteristics and Treatment Responses of Atypical Depression. HOBOKEN: WILEY.

Distinct Clinical, Metabolic-Inflammatory-Genetic Characteristics and Treatment Responses of Atypical Depression

2025

Conference Publication

Mental Health and Sleep Correlates of Self-Reported Outdoor Daylight Exposure in Over 13,000 Adults With Depression

Crouse, Jacob, Park, Shin Ho, Mitchell, Brittany, Byrne, Enda, Medland, Sarah, Lin, Tian, Scott, Jan, de Haan, Zsofi, Tonini, Emiliana, Iorfino, Frank, Wray, Naomi, Martin, Nicholas and Hickie, Ian (2025). Mental Health and Sleep Correlates of Self-Reported Outdoor Daylight Exposure in Over 13,000 Adults With Depression. HOBOKEN: WILEY.

Mental Health and Sleep Correlates of Self-Reported Outdoor Daylight Exposure in Over 13,000 Adults With Depression

2025

Journal Article

Sex-stratified genome-wide association meta-analysis of major depressive disorder

Thomas, Jodi T., Thorp, Jackson G., Huider, Floris, Grimes, Poppy Z., Wang, Rujia, Youssef, Pierre, Coleman, Jonathan R. I., Byrne, Enda M., Adams, Mark, BIONIC consortium, van Loo, Hanna M., Penninx, Brenda W. J. H., The GLAD Study, Medland, Sarah E., Hickie, Ian B., Olsen, Catherine M., Whiteman, David C., Whalley, Heather C., Penninx, Brenda W.J.H., van Loo, Hanna M., Derks, Eske M., Eley, Thalia C., Breen, Gerome, Boomsma, Dorret I., Wray, Naomi R., Martin, Nicholas G. and Mitchell, Brittany L. (2025). Sex-stratified genome-wide association meta-analysis of major depressive disorder. Nature Communications, 16 (1) 7960, 1-15. doi: 10.1038/s41467-025-63236-1

Sex-stratified genome-wide association meta-analysis of major depressive disorder

2025

Journal Article

Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking

He, Weixiong, van der Most, Peter J., Ong, Jue-Sheng, Hwang, Liang-Dar, Wu, Yeda, Magnø, Morten S., Vehof, Jelle, Krebs, Kristi, Mauring, Laura, Õunap, Katrin, Abner, Erik, Martin, Nicholas G., Plotnikov, Denis, Jiang, Chen, Melles, Ronald B., Gharahkhani, Puya, Snieder, Harold, Palumaa, Teele, Kaljurand, Kuldar, Guggenheim, Jeremy A., Mackey, David A., Engle, Elizabeth C., Choquet, Hélène, MacGregor, Stuart, Lifelines Cohort Study, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A. ... Wray, Naomi (2025). Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. Nature Communications, 16 (1) 7890, 1-14. doi: 10.1038/s41467-025-62456-9

Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking

2025

Journal Article

Insulin resistance as an early marker in youth with mood disorders

Shin, Mirim, Crouse, Jacob J., Weger, Meltem, McKenna, Sarah, Wray, Naomi R., Scott, Elizabeth M., Hickie, Ian B. and Gachon, Frédéric (2025). Insulin resistance as an early marker in youth with mood disorders. Nature Mental Health, 3 (9), 1-3. doi: 10.1038/s44220-025-00472-w

Insulin resistance as an early marker in youth with mood disorders

2025

Journal Article

Genomic risk prediction for depression in a large prospective study of older adults of European descent

Yu, Chenglong, Bakshi, Andrew, Agustini, Bruno, Walker, Alicia, Lin, Tian, Lotfaliany, Mojtaba, Williams, Lana J., McNeil, John J., Wray, Naomi R., Berk, Michael and Lacaze, Paul (2025). Genomic risk prediction for depression in a large prospective study of older adults of European descent. Molecular Psychiatry, 30 (12), 1-8. doi: 10.1038/s41380-025-03145-3

Genomic risk prediction for depression in a large prospective study of older adults of European descent

2025

Journal Article

Chronic tinnitus is quietened by sound therapy using a novel cross-frequency de-correlating stimulus modulation

Yukhnovich, E. A., Harrison, S., Wray, N., Alter, K. and Sedley, W. (2025). Chronic tinnitus is quietened by sound therapy using a novel cross-frequency de-correlating stimulus modulation. Hearing Research, 464 109335, 11-13. doi: 10.1016/j.heares.2025.109335

Chronic tinnitus is quietened by sound therapy using a novel cross-frequency de-correlating stimulus modulation

2025

Journal Article

Absolute and relative risks of mental disorders in families: a Danish register-based study

Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Antonsen, Sussie, Pedersen, Emil Michael, Horsdal, Henriette Thisted, Debost, Jean-Christophe, Mortensen, Preben Bo, Petersen, Liselotte Vogdrup, Vilhjálmsson, Bjarni J., Nielsen, Jørgen Feldbæk, Due, Jeppe Klok, Søgaard, Anders, Igel, Christian, Thompson, Wesley K., Fan, Chun Chieh, Wray, Naomi R., McGrath, John J. and Agerbo, Esben (2025). Absolute and relative risks of mental disorders in families: a Danish register-based study. The Lancet Psychiatry, 12 (8), 590-599. doi: 10.1016/S2215-0366(25)00196-8

Absolute and relative risks of mental disorders in families: a Danish register-based study

2025

Journal Article

Antidepressant switching as a proxy phenotype for drug nonresponse: investigating clinical, demographic, and genetic characteristics

Lo, Chris Wai Hang, Gillett, Alexandra C., Iveson, Matthew H., Kamp, Michelle, Fabbri, Chiara, Wong, Win Lee Edwin, Handley, Dale, Pain, Oliver, Vassos, Evangelos, Wray, Naomi R., Whalley, Heather C., Li, Danyang, Young, Allan H., McIntosh, Andrew M. and Lewis, Cathryn M. (2025). Antidepressant switching as a proxy phenotype for drug nonresponse: investigating clinical, demographic, and genetic characteristics. Biological Psychiatry Global Open Science, 5 (4) 100502, 1-11. doi: 10.1016/j.bpsgos.2025.100502

Antidepressant switching as a proxy phenotype for drug nonresponse: investigating clinical, demographic, and genetic characteristics