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2015

Journal Article

Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model

Moser, Gerhard, Lee, Sang Hong, Hayes, Ben J., Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2015). Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model. PLoS Genetics, 11 (4) e1004969, 1-22. doi: 10.1371/journal.pgen.1004969

Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model

2015

Journal Article

Quantitative genetics of disease traits

Wray, N. R. and Visscher, P. M. (2015). Quantitative genetics of disease traits. Journal of Animal Breeding and Genetics, 132 (2), 198-203. doi: 10.1111/jbg.12153

Quantitative genetics of disease traits

2015

Journal Article

Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke

Holliday, Elizabeth G., Traylor, Matthew, Malik, Rainer, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C., Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C., Boerwinkle, Eric, Boncoraglio, Giorgio B., Clarke, Robert, Cole, John W., Fornage, Myriam, Furie, Karen L., Ikram, M. Arfan, Jannes, Jim, Kittner, Steven J., Lincz, Lisa F., Maguire, Jane M., Meschia, James F., Mosley, Thomas H., Nalls, Mike A., Oldmeadow, Christopher, Parati, Eugenio A., Psaty, Bruce M., Rothwell, Peter M., Seshadri, Sudha, Scott, Rodney J. ... Wray, Naomi R. (2015). Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke. Stroke, 46 (3), 615-615. doi: 10.1161/STROKEAHA.114.007930

Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke

2015

Journal Article

Lifetime Stress Accelerates Epigenetic Aging

Zannas, A., Carrillo-Roa, T., Iurato, S., Ressler, K., Nemeroff, C., Smith, A., Lange, J., Bradley, B., Heim, C., Brückl, T., Ising, M., Wray, N., Erhardt, A., Binder, E. and Mehta, D. (2015). Lifetime Stress Accelerates Epigenetic Aging. European Psychiatry, 30. doi: 10.1016/s0924-9338(15)31949-0

Lifetime Stress Accelerates Epigenetic Aging

2015

Journal Article

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

Maier, Robert, Moser, Gerhard, Chen, Guo-Bo, Ripke, Stephan, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell, William, Potash, James B., Scheftner, William A., Shi, Jianxin, Weissman, Myrna M., Hultman, Christina M., Landen, Mikael, Levinson, Douglas F., Kendler, Kenneth S., Smoller, Jordan W., Wray, Naomi R. and Lee, S. Hong (2015). Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics, 96 (2), 283-294. doi: 10.1016/j.ajhg.2014.12.006

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

2015

Journal Article

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, Enda M, Raheja, Uttam K, Stephens, Sarah H, Heath, Andrew C, Madden, Pamela A, Vaswani, Dipika, Nijjar, Gagan V, Ryan, Kathleen A, Youssufi, Hassaan, Gehrman, Philip R, Shuldiner, Alan R, Martin, Nicholas G, Montgomery, Grant W, Wray, Naomi R, Nelson, Elliot C, Mitchell, Braxton D, Postolache, Teodor T, Psychiatric Genetics Consortium Major Depressive Disorder Working Group and Middeldorp, Christel (2015). Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 76 (2), 128-134. doi: 10.4088/JCP.14m08981

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

2015

Journal Article

Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins

Mills, Natalie T., Wright, Margaret J., Henders, Anjali K., Eyles, Darryl W., Baune, Bernhard T., McGrath, John J., Byrne, Edna M., Hansell, Narelle K., Birosova, Eva, Scott, James G., Martin, Nicholas G., Montgomery, Grant W., Wray, Naomi R. and Vinkhuyzen, Anna A. E. (2015). Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins. Twin Research and Human Genetics, 18 (1), 28-35. doi: 10.1017/thg.2014.70

Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins

2015

Journal Article

Cohort profile update: the Mater-University of Queensland Study of Pregnancy (MUSP)

Najman, Jake M., Alati, Rosa, Bor, William, Clavarino, Alexandra, Mamun, Abdullah, McGrath, John J., McIntyre, David, O'Callaghan, Michael, Scott, James, Shuttlewood, Greg, Williams, Gail M. and Wray, Naomi (2015). Cohort profile update: the Mater-University of Queensland Study of Pregnancy (MUSP). International Journal of Epidemiology, 44 (1), 78-78f. doi: 10.1093/ije/dyu234

Cohort profile update: the Mater-University of Queensland Study of Pregnancy (MUSP)

2015

Journal Article

DNA methylation age of blood predicts all-cause mortality in later life

Marioni, Riccardo E., Shah, Sonia, McRae, Allan F., Chen, Brian H., Colicino, Elena, Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G., Montgomery, Grant W., Feinberg, Andrew P., Fallin, M. Daniele, Multhaup, Michael L., Jaffe, Andrew E., Joehanes, Roby, Schwartz, Joel, Just, Allan C., Lunetta, Kathryn L., Murabito, Joanne M., Starr, John M., Horvath, Steve, Baccarelli, Andrea A., Levy, Daniel, Visscher, Peter M. ... Deary, Ian J. (2015). DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology, 16 (1) 25, 25.1-25.12. doi: 10.1186/s13059-015-0584-6

DNA methylation age of blood predicts all-cause mortality in later life

2015

Journal Article

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O'Dushlaine, Colm, Rossin, Lizzy, Lee, Phil H., Duncan, Laramie, Parikshak, Neelroop N., Newhouse, Stephen, Ripke, Stephan, Neale, Benjamin M., Purcell, Shaun M., Posthuma, Danielle, Nurnberger, John I., Lee, S. Hong, Faraone, Stephen V., Perlis, Roy H., Mowry, Bryan J, Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H. ... Breen, Gerome (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18 (2), 199-209. doi: 10.1038/nn.3922

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

2015

Journal Article

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

Lee, S. Hong, Byrne, Enda M., Hultman, Christina M., Kahler, Anna, Vinkhuyzen, Anna A. E., Ripke, Stephan, Andreassen, Ole A., Frisell, Thomas, Gusev, Alexander, Hu, Xinli, Karlsson, Robert, Mantzioris, Vasilis X., McGrath, John J., Mehta, Divya, Stahl, Eli A., Zhao, Qiongyi, Kendler, Kenneth S., Sullivan, Patrick F., Price, Alkes L., O'Donovan, Michael, Okada, Yukinori, Mowry, Bryan J., Raychaudhuri, Soumya, Wray, Naomi R., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Rheumatoid Arthritis Consortium International and Visscher, Peter M . (2015). New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44 (5) dyv136, 1-16. doi: 10.1093/ije/dyv136

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

2014

Journal Article

The contribution of genetic variants to disease depends on the ruler

Witte, John S., Visscher, Peter M. and Wray, Naomi R. (2014). The contribution of genetic variants to disease depends on the ruler. Nature Reviews Genetics, 15 (11), 765-776. doi: 10.1038/nrg3786

The contribution of genetic variants to disease depends on the ruler

2014

Journal Article

Genetic and environmental exposures constrain epigenetic drift over the human life course

Shah, Sonia, McRae, Allan F., Marioni, Riccardo E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G., Montgomery, Grant W., Starr, John M., Wray, Naomi R., Deary, Ian J. and Visscher, Peter M. (2014). Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Research, 24 (11), 1725-1733. doi: 10.1101/gr.176933.114

Genetic and environmental exposures constrain epigenetic drift over the human life course

2014

Journal Article

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Gusev, Alexander, Lee, S. Hong, Trynka, Gosia, Finucane, Hilary, Vilhjálmsson, Bjarni J., Xu, Han, Zang, Chongzhi, Ripke, Stephan, Bulik-Sullivan, Brendan, Stahl, Eli, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kaehler, Anna K., Hultman, Christina M., Purcell, Shaun M., McCarroll, Steven A., Daly, Mark, Pasaniuc, Bogdan, Sullivan, Patrick F., Neale, Benjamin M., Wray, Naomi R., Raychaudhuri, Soumya, Price, Alkes L., Visscher, Peter M., Mowry, Bryan J., Psychosis Endophenotypes International Consortium and Wellcome Trust Case Control Consortium (2014). Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases. American Journal of Human Genetics, 95 (5), 535-552. doi: 10.1016/j.ajhg.2014.10.004

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

2014

Journal Article

Novel directions for G × E analysis in psychiatry

Vinkhuyzen, A. A. E. and Wray, N. R. (2014). Novel directions for G × E analysis in psychiatry. Epidemiology and Psychiatric Sciences, 24 (1), 12-19. doi: 10.1017/S2045796014000584

Novel directions for G × E analysis in psychiatry

2014

Journal Article

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

Levinson, Douglas F., Mostafavi, Sara, Milaneschi, Yuri, Rivera, Margarita, Ripke, Stephan, Wray, Naomi R. and Sullivan, Patrick F. (2014). Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?. Biological Psychiatry, 76 (7), 510-512. doi: 10.1016/j.biopsych.2014.07.029

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

2014

Journal Article

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

Chen, Guo-Bo, Lee, Sang Hong, Brion, Marie-Jo A., Montgomery, Grant W., Wray, Naomi R., Radford-Smith, Graham L., Visscher, Peter M., The International IBD Genetics Consortium, Australia and New Zealand IBDGC, Belgium Genetic Consortium, Initiative on Crohn and Colitis, NIDDK IBDGC, United Kingdom IBDGC and Wellcome Trust Case Control Consortium (2014). Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. Human Molecular Genetics, 23 (17) ddu174, 4710-4720. doi: 10.1093/hmg/ddu174

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

2014

Journal Article

A comparative study of techniques for differential expression analysis on RNA-seq data

Zhang, Zong Hong, Jhaveri, Dhanisha J., Marshall, Vikki M., Bauer, Denis C., Edson, Janette, Narayanan, Ramesh K., Robinson, Gregory J., Lundberg, Andreas E., Bartlett, Perry F., Wray, Naomi R. and Zhao, Qiong-Yi (2014). A comparative study of techniques for differential expression analysis on RNA-seq data. PLoS One, 9 (8) e103207, 1-11. doi: 10.1371/journal.pone.0103207

A comparative study of techniques for differential expression analysis on RNA-seq data

2014

Journal Article

The association between family history of mental disorders and general cognitive ability

McGrath, J. J., Wray, N. R., Pedersen, C. B., Mortensen, P. B., Greve, A. N. and Petersen, L. (2014). The association between family history of mental disorders and general cognitive ability. Translational Psychiatry, 4 (e412) e412, 1-6. doi: 10.1038/tp.2014.60

The association between family history of mental disorders and general cognitive ability

2014

Journal Article

Applying polygenic risk scores to postpartum depression

Byrne, Edna M., Carrillo-Roa, Tania, Penninx, Brenda W. J. H., Sallis, Hannah M., Viktorin, Alexander, Chapman, Brett, Henders, Anjali K., Pergadia, Michele L., Heath, Andrew C., Madden, Pamela A. F., Sullivan, Patrick F., Boschloo, Lynn, van Grootheest, Gerard, McMahon, George, Lawlor, Debbie A., Landen, Mikael, Lichtenstein, Paul, Magnusson, Patrik K. E., Evans, David M., Montgomery, Grant W., Boomsma, Dorret I., Martin, Nicholas G., Meltzer-Brody, Samantha and Wray, Naomi R. (2014). Applying polygenic risk scores to postpartum depression. Archives of Women's Mental Health, 17 (6), 519-528. doi: 10.1007/s00737-014-0428-5

Applying polygenic risk scores to postpartum depression