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2024 Journal Article The fall of the mycobacterial cell wall: interrogating peptidoglycan synthesis for novel anti-TB agentsChiang, Cheng-Yu and West, Nicholas P. (2024). The fall of the mycobacterial cell wall: interrogating peptidoglycan synthesis for novel anti-TB agents. PeerJ, 12 (11) e18404. doi: 10.7717/peerj.18404 |
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2024 Journal Article Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosisWang, XinYue, Jowsey, William J., Cheung, Chen-Yi, Smart, Caitlan J., Klaus, Hannah R., Seeto, Noon EJ, Waller, Natalie JE, Chrisp, Michael T., Peterson, Amanda L., Ofori-Anyinam, Boatema, Strong, Emily, Nijagal, Brunda, West, Nicholas P., Yang, Jason H., Fineran, Peter C., Cook, Gregory M., Jackson, Simon A. and McNeil, Matthew B. (2024). Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Nature Communications, 15 (1) 9791, 9791. doi: 10.1038/s41467-024-54072-w |
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2024 Journal Article Phenotypic‐Based Discovery and Exploration of a Resorufin Scaffold with Activity against <i>Mycobacterium tuberculosis</i>Tran, Eric, Cheung, Chen‐Yi, Li, Lucy, Carter, Glen P., Gable, Robert W., West, Nicholas P., Kaur, Amandeep, Gee, Yi Sing, Cook, Gregory M., Baell, Jonathan B. and Jörg, Manuela (2024). Phenotypic‐Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis. ChemMedChem, 19 (24) e202400482, e202400482. doi: 10.1002/cmdc.202400482 |
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2024 Journal Article A chimeric ORF fusion phenotypic reporter for Cryptococcus neoformansPhillips-Rose, Louis S., Yu, Chendi K., West, Nicholas P. and Fraser, James A. (2024). A chimeric ORF fusion phenotypic reporter for Cryptococcus neoformans. Journal of Fungi, 10 (8) 567. doi: 10.3390/jof10080567 |
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2024 Journal Article Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillusPidot, Sacha J., Klatt, Stephan, Ates, Louis S., Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R., Porter, Jessica L., Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M., West, Nicholas, Tobias, Nicholas J., Fuerst, John A., Stutz, Michael D., Pellegrini, Marc, McConville, Malcolm, Brosch, Roland and Stinear, Timothy P. (2024). Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus. PLoS Pathogens, 20 (8) e1012440, e1012440. doi: 10.1371/journal.ppat.1012440 |
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2024 Journal Article Identification of axinellamines A and B as anti-tubercular agentsStrong, Emily J., Tan, Lendl, Hayes, Sasha, Whyte, Hayden, Davis, Rohan A. and West, Nicholas P. (2024). Identification of axinellamines A and B as anti-tubercular agents. Marine Drugs, 22 (7) 298, 298. doi: 10.3390/md22070298 |
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2024 Journal Article Synthesis of steroidal inhibitors for Mycobacterium tuberculosisChurchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479 |
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2024 Journal Article TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infectionStupar, Miljan, Tan, Lendl, Kerr, Edward D., De Voss, Christopher J., Forde, Brian M., Schulz, Benjamin L. and West, Nicholas P. (2024). TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection. Nature Communications, 15 (1) 1615, 1-14. doi: 10.1038/s41467-024-45343-7 |
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2024 Journal Article Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamidesFarr, Dylan C., Haselhorst, Thomas, Tan, Lendl, Furness, Juanelle, Strong, Emily, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2024). Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamides. European Journal of Medicinal Chemistry, 264 115983, 1-12. doi: 10.1016/j.ejmech.2023.115983 |
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2024 Journal Article Mycobacterium tuberculosis deficient in PdtaS cytosolic histidine kinase displays attenuated growth and affords protective efficacy against Aerosol M. tuberculosis infection in micePrendergast, Kelly A., Nagalingam, Gayathri, West, Nicholas P. and Triccas, James A. (2024). Mycobacterium tuberculosis deficient in PdtaS cytosolic histidine kinase displays attenuated growth and affords protective efficacy against Aerosol M. tuberculosis infection in mice. Vaccines, 12 (1) 50, 50. doi: 10.3390/vaccines12010050 |
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2023 Journal Article seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluationKong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333 |
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2023 Journal Article Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycinFarr, Dylan C., Tan, Lendl, Furness, Juanelle, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2023). Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin. Australian Journal of Chemistry, 76 (11), 812-820. doi: 10.1071/ch23154 |
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2023 Journal Article Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteriaMu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w |
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2023 Journal Article Discovery of anti‐tubercular analogues of bedaquiline with modified A‐, B‐ and C‐ring subunitsBarbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Priebbenow, Daniel and Baell, Jonathan B. (2023). Discovery of anti‐tubercular analogues of bedaquiline with modified A‐, B‐ and C‐ring subunits. ChemMedChem, 18 (1) e202200533, e202200533. doi: 10.1002/cmdc.202200533 |
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2022 Journal Article Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infectionAng, Chee Wei, Lee, Brendon M., Jackson, Colin J., Wang, Yuehong, Franzblau, Scott G., Francisco, Amanda F., Kelly, John M., Bernhardt, Paul V., Tan, Lendl, West, Nicholas P., Sykes, Melissa L., Hinton, Alexandra O., Bolisetti, Raghu, Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A.T. (2022). Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection. Journal of Medicinal Chemistry, 65 (19), 13125-13142. doi: 10.1021/acs.jmedchem.2c00972 |
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2022 Journal Article Two‐component sensor histidine kinases of Mycobacterium tuberculosis: beacons for niche navigationStupar, Miljan, Furness, Juanelle, De Voss, Christopher J., Tan, Lendl and West, Nicholas P. (2022). Two‐component sensor histidine kinases of Mycobacterium tuberculosis: beacons for niche navigation. Molecular Microbiology, 117 (5), 973-985. doi: 10.1111/mmi.14899 |
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2021 Journal Article Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazolesAng, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807 |
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2021 Journal Article Macrophage and neutrophil death programs differentially confer resistance to tuberculosisStutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P. and Pellegrini, Marc (2021). Macrophage and neutrophil death programs differentially confer resistance to tuberculosis. Immunity, 54 (8), 1758-1771.e7. doi: 10.1016/j.immuni.2021.06.009 |
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2021 Journal Article Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomeraseLin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665 |
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2021 Journal Article Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leadsKandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919 |
