2018 Journal Article PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infectionAshhurst, Anneliese S, Parumasivam, Thaigarajan, Chan, John Gar Yan, Lin, Leon C W, Flórido, Manuela, West, Nicholas P, Chan, Hak-Kim and Britton, Warwick J (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PLoS One, 13 (3) e0194620, e0194620. doi: 10.1371/journal.pone.0194620 |
2018 Journal Article The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenesBrouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17 |
2017 Journal Article Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coliPhan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204 |
2017 Journal Article Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosisNg, Benjamin Y. C., Wee, Eugene J. H., Woods, Kyra, Anderson, Will, Antaw, Fiach, Tsang, Hennes Z. H., West, Nicholas P. and Trau, Matt (2017). Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosis. Analytical Chemistry, 89 (17), 9017-9022. doi: 10.1021/acs.analchem.7b01685 |
2017 Journal Article The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenesTurner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17 |
2017 Journal Article Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesisTran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017). Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 (1) 14414, 14414. doi: 10.1038/ncomms14414 |
2016 Journal Article Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease modelsRivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16 |
2016 Journal Article Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985 |
2016 Journal Article Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid SynthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985 |
2015 Journal Article Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case findingNg, Benjamin Y. C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding. ACS Sensors, 1 (2), 173-178. doi: 10.1021/acssensors.5b00171 |
2015 Journal Article Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold NanoparticlesNg, Benjamin Y. C., Xiao, Wei, West, Nicholas P., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2015). Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Analytical Chemistry, 87 (20), 10613-10618. doi: 10.1021/acs.analchem.5b03121 |
2015 Journal Article Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosisNg, Benjamin Y.C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis. Scientific Reports, 5 (1) 15027, 15027.1-15027.7. doi: 10.1038/srep15027 |
2015 Journal Article Host-pathogen interaction during bacterial vaccinationBarnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002 |
2015 Journal Article First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activityEng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611 |
2015 Journal Article Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulenceTurner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15 |
2014 Journal Article The contribution of non-human primate models to the development of human vaccinesRivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322. |
2014 Journal Article ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamicsMarteyn, Benoit S., Karimova, Gouzel, Fenton, Andrew K., Gazi, Anastasia D., West, Nicholas, Touqui, Lhousseine, Prevost, Marie-Christine, Betton, Jean-Michel, Poyraz, Oemer, Ladant, Daniel, Gerdes, Kenn, Sansonetti, Philippe J. and Tang, Christoph M. (2014). ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. mBio, 5 (2) e00022-14. doi: 10.1128/mBio.00022-14 |
2014 Journal Article Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killingLy, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754 |
2013 Journal Article Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU)Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J. and Payne, R. J. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11 (46), 8113-8126. doi: 10.1039/c3ob41896k |
2013 Journal Article TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccinesTyne, Anneliese S., Chan, John Gar Yan, Shanahan, Erin R., Atmosukarto, Ines, Chan, Hak-Kim, Britton, Warwick J. and West, Nicholas P. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31 (40), 4322-4329. doi: 10.1016/j.vaccine.2013.07.022 |