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2020 Journal Article Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surfaceAwad, Milena M., Hutton, Melanie L., Quek, Adam J., Klare, William P., Mileto, Steven J., Mackin, Kate, Ly, Diane, Oorschot, Viola, Bosnjak, Marijana, Jenkin, Grant, Conroy, Paul J., West, Nick, Fulcher, Alex, Costin, Adam, Day, Christopher J., Jennings, Michael P., Medcalf, Robert L., Sanderson-Smith, Martina, Cordwell, Stuart J., Law, Ruby H.P., Whisstock, James C. and Lyras, Dena (2020). Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surface. Gastroenterology, 159 (4), 1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032 |
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2020 Journal Article Structures of fungal and plant acetohydroxyacid synthasesLonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3 |
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2020 Conference Publication Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineeringLee, Brendon, Almeida, Deepak, Afriat-Jurnou, Livnat, Aung, Htin, Forde, Brian, Harold, Liam, Hards, Kiel, Pidot, Sacha, Ahmed, Hafna, Mohamed, Elaaf, Taylor, Mathew, West, Nicholas, Stinear, Timothy, Greening, Chris, Beatson, Scott, Cook, Gregory, Nuermberger, Eric and Jackson, Colin (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. Annual Meeting on Experimental Biology, San Diego, CA, United States, 4-7 April 2020. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1096/fasebj.2020.34.s1.04923 |
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2020 Journal Article Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitorBayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899 |
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2020 Journal Article Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineeringLee, Brendon M., Harold, Liam K., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Nuermberger, Eric L., Cook, Gregory M. and Jackson, Colin J. (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathogens, 16 (2) e1008287, e1008287. doi: 10.1371/journal.ppat.1008287 |
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2020 Journal Article Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and SolubilityAng, Chee Wei, Tan, Lendl, Sykes, Melissa L., Abugharbiyeh, Neda, Debnath, Anjan, Reid, Janet C., West, Nicholas P., Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. Journal of Medicinal Chemistry, 63 (24), 15726-15751. doi: 10.1021/acs.jmedchem.0c01372 |
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2019 Journal Article Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolismSerafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019). Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362 |
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2019 Journal Article Total synthesis of the antimalarial ascidian natural product albopunctatonePullella, Glenn A., Wdowiak, Adam P., Sykes, Melissa L., Lucantoni, Leonardo, Sukhoverkov, Kirill V., Zulfiqar, Bilal, Sobolev, Alexandre N., West, Nicholas P., Mylne, Joshua S., Avery, Vicky M. and Piggott, Matthew J. (2019). Total synthesis of the antimalarial ascidian natural product albopunctatone. Organic Letters, 21 (14), 5519-5523. doi: 10.1021/acs.orglett.9b01838 |
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2019 Book Chapter Nucleic Acid Detection of Tuberculosis Via Innovative Point-of-Care Nanotechnologies Targeted for Low Resource SettingsNg, Benjamin Y.C., Wee, Eugene J.H., West, Nicholas P. and Trau, Matt (2019). Nucleic Acid Detection of Tuberculosis Via Innovative Point-of-Care Nanotechnologies Targeted for Low Resource Settings. Revolutionizing Tropical Medicine. (pp. 584-599) Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119282686.ch33 |
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2018 Journal Article Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activityJarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T. and Cooper, Matthew A. (2018). Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry, 61 (24) acs.jmedchem.8b01578, 11349-11371. doi: 10.1021/acs.jmedchem.8b01578 |
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2018 Journal Article Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferaseEng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018). Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159, 10-22. doi: 10.1016/j.ejmech.2018.09.039 |
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2018 Journal Article Thioamide derivative of the potent antitubercular 2-(decylsulfonyl) acetamide is less active against mycobacterium tuberculosis, but a more potent antistaphylococcal agentSun, Hsien-Kuo, Pang, Angel, Farr, Dylan C., Mosaiab, Tamim, Britton, Warwick J., Anoopkumar-Dukie, Shailendra, Grice, I. Darren, Kiefel, Milton J., West, Nick P., Grant, Gary D. and Houston, Todd A. (2018). Thioamide derivative of the potent antitubercular 2-(decylsulfonyl) acetamide is less active against mycobacterium tuberculosis, but a more potent antistaphylococcal agent. Australian Journal of Chemistry, 71 (9), 716-719. doi: 10.1071/CH18206 |
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2018 Journal Article Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning methodTan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018). Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 (6) e5146, e5146. doi: 10.7717/peerj.5146 |
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2018 Journal Article Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosisStrong, Emily J. and West, Nicholas P. (2018). Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 (1) 5604, 5604. doi: 10.1038/s41598-018-23893-3 |
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2018 Journal Article PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infectionAshhurst, Anneliese S, Parumasivam, Thaigarajan, Chan, John Gar Yan, Lin, Leon C W, Flórido, Manuela, West, Nicholas P, Chan, Hak-Kim and Britton, Warwick J (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PLoS One, 13 (3) e0194620, e0194620. doi: 10.1371/journal.pone.0194620 |
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2018 Journal Article The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenesBrouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17 |
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2017 Journal Article Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coliPhan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204 |
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2017 Journal Article Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosisNg, Benjamin Y. C., Wee, Eugene J. H., Woods, Kyra, Anderson, Will, Antaw, Fiach, Tsang, Hennes Z. H., West, Nicholas P. and Trau, Matt (2017). Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosis. Analytical Chemistry, 89 (17), 9017-9022. doi: 10.1021/acs.analchem.7b01685 |
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2017 Journal Article The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenesTurner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17 |
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2017 Journal Article Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesisTran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017). Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 (1) 14414, 14414. doi: 10.1038/ncomms14414 |
