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2017 Journal Article Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascadeHohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203 |
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2017 Journal Article Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost communityPedroso, Marcelo Monteiro, Selleck, Christopher, Enculescu, Charmaine, Harmer, Jeffrey R., Mitic, Natasa, Craig, Whitney R., Helweh, Waleed, Hugenholtz, Philip, Tyson, Gene W., Tierney, David L., Larrabee, James A. and Schenk, Gerhard (2017). Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics, 9 (8), 1157-1168. doi: 10.1039/c7mt00195a |
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2017 Journal Article Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenesPedroso, Marcelo M., Ely, Fernanda, Carpenter, Margaret C., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Wilcox, Dean E. and Schenk, Gerhard (2017). Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Biochemistry, 56 (26), 3328-3336. doi: 10.1021/acs.biochem.6b01200 |
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2017 Journal Article High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolaseSelleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013 |
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2017 Journal Article Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitorMcGeary, Ross P., Tan, Daniel T. C., Selleck, Christopher, Monteiro Pedroso, Marcelo, Sidjabat, Hanna E. and Schenk, Gerhard (2017). Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor. European Journal of Medicinal Chemistry, 137, 351-364. doi: 10.1016/j.ejmech.2017.05.061 |
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2017 Journal Article Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agentsMonteiro Pedroso, Marcelo, Selleck, Christopher, Bilyj, Jessica, Harmer, Jeffrey R. , Gahan, Lawrence R. , Mitić, Natasa, Standish, Alistair J. , Tierney, David L. , Larrabee, James A. and Schenk, Gerhard (2017). Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents. Dalton Transactions, 46 (39), 13194-13201. doi: 10.1039/c7dt01350g |
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2017 Journal Article Progress toward inhibitors of metallo-β-lactamasesMcGeary, Ross P., Tan, Daniel T. C. and Schenk, Gerhard (2017). Progress toward inhibitors of metallo-β-lactamases. Future Medicinal Chemistry, 9 (7), 673-691. doi: 10.4155/fmc-2017-0007 |
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2017 Journal Article Is CuII coordinated to patellamides inside Prochloron cells?Comba, Peter, Eisenschmidt, Annika, Gahan, Lawrence R., Herten, Dirk-Peter , Nette, Geoffrey, Schenk, Gerhard and Seefeld, Martin (2017). Is CuII coordinated to patellamides inside Prochloron cells?. Chemistry - A European Journal, 23 (50), 12264-12274. doi: 10.1002/chem.201700895 |
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2017 Journal Article Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzymeSelleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866 |
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2017 Journal Article Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studiesMöhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028 |
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2017 Journal Article Insights into an evolutionary strategy leading to antibiotic resistanceHou, Chun-Feng D., Liu, Jian-wei, Collyer, Charles, Mitić, Natasha, Pedroso, Marcelo Monteiro, Schenk, Gerhard and Ollis, David L. (2017). Insights into an evolutionary strategy leading to antibiotic resistance. Scientific Reports, 7 (1) 40357, 40357.1-40357.13. doi: 10.1038/srep40357 |
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2017 Journal Article Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolasesRomero, Nicol, Benitez, José, Garcia, David, Gonzalez, Arlette, Bennun, Leonardo, Garcia-Robles, María A., Lopez, Vasthi, Wilson, Liam A., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2017). Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases. Journal of Inorganic Biochemistry, 166, 122-125. doi: 10.1016/j.jinorgbio.2016.11.015 |
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2016 Journal Article AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibilitySelleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762 |
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2016 Journal Article Product release is rate-limiting for catalytic processing by the Dengue virus proteaseShannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539 |
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2016 Journal Article New strategies to combat tuberculosisSchenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53. |
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2016 Journal Article Metallohydrolase biomimetics with catalytic and structural flexibilityMendes, Luisa L., Englert, Daniel, Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo Jr. (2016). Metallohydrolase biomimetics with catalytic and structural flexibility. Dalton Transactions, 45 (46), 18510-18521. doi: 10.1039/c6dt03200a |
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2016 Journal Article PrefaceGahan, Lawrence, Comba, Peter, Schenk, Gerhard, Daumann, Lena, Hambley, Trevor and Berners-Price, Sue (2016). Preface. Journal of Inorganic Biochemistry, 162, 162-163. doi: 10.1016/j.jinorgbio.2016.09.011 |
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2016 Journal Article Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networksMiraula, Manfredi, Schenk, Gerhard and Mitic, Natasa (2016). Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks. Journal of Inorganic Biochemistry, 162, 366-375. doi: 10.1016/j.jinorgbio.2015.12.014 |
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2016 Journal Article Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediationSchenk, Gerhard, Mateen, Irsa, Ng, Tee-Kheang, Pedroso, Marcelo M., Mitic, Natasa, Jafelicci, Miguel, Marques, Rodrigo F. C., Gahan, Lawrence R. and Ollis, David L. (2016). Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediation. Coordination Chemistry Reviews, 317, 122-131. doi: 10.1016/j.ccr.2016.03.006 |
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2016 Journal Article Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomeraseTadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620 |
