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2025 Journal Article Microfluidic-assisted evolution of a robust NAD+-dependent enzyme with improved isobutanol tolerance at elevated temperaturesTeshima, Mariko, Genth, Robert, Bayaraa, Tenuun, Döring, Manuel, Beer, Barbara, Schenk, Gerhard and Sieber, Volker (2025). Microfluidic-assisted evolution of a robust NAD+-dependent enzyme with improved isobutanol tolerance at elevated temperatures. ChemSusChem, 18 (20) 2501120. doi: 10.1002/cssc.202501120 |
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2025 Journal Article Deep-learning-guided mining and clustering of remote amino acid residues for the simultaneous engineering of the catalytic activity and thermostability of a processive endoglucanaseWu, Mujunqi, Huang, Yuzhen, He, Xinyan, Chen, Kequan, Wu, Bin and Schenk, Gerhard (2025). Deep-learning-guided mining and clustering of remote amino acid residues for the simultaneous engineering of the catalytic activity and thermostability of a processive endoglucanase. ACS Synthetic Biology, 14 (10), 4047-4058. doi: 10.1021/acssynbio.5c00454 |
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2025 Journal Article Exploiting the geranylgeranyl-pyrophosphate-sensing N-terminal domain of HMG-CoA reductase 2 to regulate farnesyl pyrophosphate synthase (Erg20p) for improved monoterpene production in Saccharomyces cerevisiaeLu, Zeyu, Evans, Samuel, McDonnell, Liam, Bandari, Naga Chandra, Weng, Yilun, Jin, Wanli, Speight, Robert, Schenk, Gerhard, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2025). Exploiting the geranylgeranyl-pyrophosphate-sensing N-terminal domain of HMG-CoA reductase 2 to regulate farnesyl pyrophosphate synthase (Erg20p) for improved monoterpene production in Saccharomyces cerevisiae. Yeast, 42 (8-10), 169-180. doi: 10.1002/yea.4005 |
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2025 Journal Article Boosting amidation of Ortho-substituted anilines with esters or acids via hinge and tunnel engineering of lipaseWang, Jialing, Wang, Wenwen, Ma, Peipei, Liu, Gaofei, Gao, Zhen, Wu, Hongli, Wu, Bin, He, Bingfang and Schenk, Gerhard (2025). Boosting amidation of Ortho-substituted anilines with esters or acids via hinge and tunnel engineering of lipase. Chemical Engineering Journal, 519 165291, 1-11. doi: 10.1016/j.cej.2025.165291 |
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2025 Journal Article Tailoring regioselectivity-controlled UDP-glycosyltransferase for bidirectional glycosylation of tyrosol via free energy-driven pocket reshaping and tunnel engineeringZhang, Ziyu, Chen, Jingyi, Liang, Zuozhi, Shao, Wenming, Gao, Zhen, Wu, Bin, He, Bingfang and Schenk, Gerhard (2025). Tailoring regioselectivity-controlled UDP-glycosyltransferase for bidirectional glycosylation of tyrosol via free energy-driven pocket reshaping and tunnel engineering. Advanced Science, 12 (40) e09814. doi: 10.1002/advs.202509814 |
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2025 Journal Article Decoding PDI diversity: insights into structure, domains, and functionality in sorghumLópez-Gómez, Carla F., Morris, Marc T., Massel, Karen, Smith, Millicent, Crisp, Peter, Schenk, Gerhard and Godwin, Ian D. (2025). Decoding PDI diversity: insights into structure, domains, and functionality in sorghum. Computational and Structural Biotechnology Journal, 27, 3328-3336. doi: 10.1016/j.csbj.2025.07.035 |
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2025 Journal Article Decoding PDI diversity: insights into structure, domains, and functionality in sorghumLópez-Gómez, Carla F., Morris, Marc T., Massel, Karen, Smith, Millicent, Crisp, Peter, Schenk, Gerhard and Godwin, Ian D. (2025). Decoding PDI diversity: insights into structure, domains, and functionality in sorghum. doi: 10.1101/2025.06.06.658324 |
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2025 Journal Article Iron–sulfur cluster enzymes of the methylerythritol phosphate pathway: IspG and IspHDouw, Andrew, Perez-Gil, Jordi, Schenk, Gerhard and Vickers, Claudia E. (2025). Iron–sulfur cluster enzymes of the methylerythritol phosphate pathway: IspG and IspH. Biochemistry, 64 (12), 2544-2555. doi: 10.1021/acs.biochem.4c00714 |
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2025 Journal Article A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activityGuddat, Luke William, Lin, Xin, Kurz, Julia L., Li, Yong-Hong, Wun, Shun Jie, Lonhienne, Thierry, McGeary, Ross P., West, Nicholas P., Schenk, Gerhard and Wang, Jian-Guo (2025). A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity. Chemistry – A European Journal, 31 (36) e202501158, e202501158. doi: 10.1002/chem.202501158 |
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2025 Journal Article The circular phosphorus economy: agronomic performance of recycled fertilizers and target cropsWalsh, Michael, Schenk, Gerhard, Robinson, Nicole, John, Samuel, Dayananda, Buddhi, Krishnan, Vithya, Adam, Christian, Hermann, Ludwig and Schmidt, Susanne (2025). The circular phosphorus economy: agronomic performance of recycled fertilizers and target crops. Journal of Plant Nutrition and Soil Science, 188 (3), 408-421. doi: 10.1002/jpln.202400299 |
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2024 Journal Article Phage anti-pycsar proteins efficiently degrade β-lactam antibioticsJoshi, Pallav, Krco, Stefan, Davis, Samuel J., Asser, Lachlan, Brück, Thomas, Soo, Rochelle M., Bodén, Mikael, Hugenholtz, Philip, Wilson, Liam A., Schenk, Gerhard and Morris, Marc T. (2024). Phage anti-pycsar proteins efficiently degrade β-lactam antibiotics. Applied Biosciences, 3 (4), 438-449. doi: 10.3390/applbiosci3040028 |
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2024 Journal Article Structure-guided engineering unveils deeper substrate channel in processive endoglucanase EG5C-1 contributing to enhanced catalytic efficiency and processivityWang, Jialing, Chen, Jie, Lv, Kemin, Gao, Zhen, Li, Jiahuang, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering unveils deeper substrate channel in processive endoglucanase EG5C-1 contributing to enhanced catalytic efficiency and processivity. ACS Synthetic Biology, 13 (12), 4131-4142. doi: 10.1021/acssynbio.4c00562 |
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2024 Journal Article Synthesis, characterization, and structures of mononuclear and phenoxo-/acetato-bridged trinuclear zinc(II) complexes from salan ligands: study of their hydrolytic activityDinda, Rupam, Mohanty, Monalisa, Wilson, Liam, Roy, Satabdi, Mohapatra, Deepika, Patra, Sushree Aradhana, Schenk, Gerhard, Pessoa, João Costa, Sasamori, Takahiro and Aurelien, Crochet (2024). Synthesis, characterization, and structures of mononuclear and phenoxo-/acetato-bridged trinuclear zinc(II) complexes from salan ligands: study of their hydrolytic activity. Journal of Molecular Structure, 1308 138106, 1-10. doi: 10.1016/j.molstruc.2024.138106 |
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2024 Journal Article Structural characterization of enzymatic interactions with functional nicotinamide cofactor biomimeticsRocha, Raquel A., Wilson, Liam A., Schwartz, Brett D., Warden, Andrew C., Guddat, Luke W., Speight, Robert E., Malins, Lara, Schenk, Gerhard and Scott, Colin (2024). Structural characterization of enzymatic interactions with functional nicotinamide cofactor biomimetics. Catalysts, 14 (7) 399, 1-17. doi: 10.3390/catal14070399 |
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2024 Journal Article Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineeringLv, Kemin, Li, Xiaozhou, Chen, Kequan, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering. ACS Catalysis, 14 (9), 6856-6867. doi: 10.1021/acscatal.4c01083 |
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2024 Journal Article Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomeraseLin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958 |
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2024 Journal Article Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnologyWilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539 |
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2024 Journal Article Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascadesTeshima, Mariko, Sutiono, Samuel, Döring, Manuel, Beer, Barbara, Boden, Mikael, Schenk, Gerhard and Sieber, Volker (2024). Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades. ChemSusChem, 17 (4) e202301132, 1-13. doi: 10.1002/cssc.202301132 |
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2024 Journal Article Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biologyHuang, Xiao-Lan, Harmer, Jeffrey R., Schenk, Gerhard and Southam, Gordon (2024). Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology. Frontiers in Chemistry, 12 1349020, 1349020. doi: 10.3389/fchem.2024.1349020 |
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2024 Journal Article Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystemLv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303 |
