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2025

Journal Article

Decoding PDI diversity: insights into structure, domains, and functionality in sorghum

López-Gómez, Carla F., Morris, Marc T., Massel, Karen, Smith, Millicent, Crisp, Peter, Schenk, Gerhard and Godwin, Ian D. (2025). Decoding PDI diversity: insights into structure, domains, and functionality in sorghum. doi: 10.1101/2025.06.06.658324

Decoding PDI diversity: insights into structure, domains, and functionality in sorghum

2025

Journal Article

Iron–sulfur cluster enzymes of the methylerythritol phosphate pathway: IspG and IspH

Douw, Andrew, Perez-Gil, Jordi, Schenk, Gerhard and Vickers, Claudia E. (2025). Iron–sulfur cluster enzymes of the methylerythritol phosphate pathway: IspG and IspH. Biochemistry, 64 (12), 2544-2555. doi: 10.1021/acs.biochem.4c00714

Iron–sulfur cluster enzymes of the methylerythritol phosphate pathway: IspG and IspH

2025

Journal Article

A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity

Guddat, Luke William, Lin, Xin, Kurz, Julia L., Li, Yong-Hong, Wun, Shun Jie, Lonhienne, Thierry, McGeary, Ross P., West, Nicholas P., Schenk, Gerhard and Wang, Jian-Guo (2025). A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity. Chemistry – A European Journal, 31 (36) e202501158, e202501158. doi: 10.1002/chem.202501158

A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity

2025

Journal Article

The circular phosphorus economy: agronomic performance of recycled fertilizers and target crops

Walsh, Michael, Schenk, Gerhard, Robinson, Nicole, John, Samuel, Dayananda, Buddhi, Krishnan, Vithya, Adam, Christian, Hermann, Ludwig and Schmidt, Susanne (2025). The circular phosphorus economy: agronomic performance of recycled fertilizers and target crops. Journal of Plant Nutrition and Soil Science, 188 (3), 408-421. doi: 10.1002/jpln.202400299

The circular phosphorus economy: agronomic performance of recycled fertilizers and target crops

2024

Journal Article

Phage anti-pycsar proteins efficiently degrade β-lactam antibiotics

Joshi, Pallav, Krco, Stefan, Davis, Samuel J., Asser, Lachlan, Brück, Thomas, Soo, Rochelle M., Bodén, Mikael, Hugenholtz, Philip, Wilson, Liam A., Schenk, Gerhard and Morris, Marc T. (2024). Phage anti-pycsar proteins efficiently degrade β-lactam antibiotics. Applied Biosciences, 3 (4), 438-449. doi: 10.3390/applbiosci3040028

Phage anti-pycsar proteins efficiently degrade β-lactam antibiotics

2024

Journal Article

Structure-guided engineering unveils deeper substrate channel in processive endoglucanase EG5C-1 contributing to enhanced catalytic efficiency and processivity

Wang, Jialing, Chen, Jie, Lv, Kemin, Gao, Zhen, Li, Jiahuang, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering unveils deeper substrate channel in processive endoglucanase EG5C-1 contributing to enhanced catalytic efficiency and processivity. ACS Synthetic Biology, 13 (12), 4131-4142. doi: 10.1021/acssynbio.4c00562

Structure-guided engineering unveils deeper substrate channel in processive endoglucanase EG5C-1 contributing to enhanced catalytic efficiency and processivity

2024

Journal Article

Synthesis, characterization, and structures of mononuclear and phenoxo-/acetato-bridged trinuclear zinc(II) complexes from salan ligands: study of their hydrolytic activity

Dinda, Rupam, Mohanty, Monalisa, Wilson, Liam, Roy, Satabdi, Mohapatra, Deepika, Patra, Sushree Aradhana, Schenk, Gerhard, Pessoa, João Costa, Sasamori, Takahiro and Aurelien, Crochet (2024). Synthesis, characterization, and structures of mononuclear and phenoxo-/acetato-bridged trinuclear zinc(II) complexes from salan ligands: study of their hydrolytic activity. Journal of Molecular Structure, 1308 138106, 1-10. doi: 10.1016/j.molstruc.2024.138106

Synthesis, characterization, and structures of mononuclear and phenoxo-/acetato-bridged trinuclear zinc(II) complexes from salan ligands: study of their hydrolytic activity

2024

Journal Article

Structural characterization of enzymatic interactions with functional nicotinamide cofactor biomimetics

Rocha, Raquel A., Wilson, Liam A., Schwartz, Brett D., Warden, Andrew C., Guddat, Luke W., Speight, Robert E., Malins, Lara, Schenk, Gerhard and Scott, Colin (2024). Structural characterization of enzymatic interactions with functional nicotinamide cofactor biomimetics. Catalysts, 14 (7) 399, 1-17. doi: 10.3390/catal14070399

Structural characterization of enzymatic interactions with functional nicotinamide cofactor biomimetics

2024

Journal Article

Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase

Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958

Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase

2024

Journal Article

Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering

Lv, Kemin, Li, Xiaozhou, Chen, Kequan, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering. ACS Catalysis, 14 (9), 6856-6867. doi: 10.1021/acscatal.4c01083

Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering

2024

Journal Article

Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539

Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

2024

Journal Article

Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades

Teshima, Mariko, Sutiono, Samuel, Döring, Manuel, Beer, Barbara, Boden, Mikael, Schenk, Gerhard and Sieber, Volker (2024). Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades. ChemSusChem, 17 (4) e202301132, 1-13. doi: 10.1002/cssc.202301132

Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades

2024

Journal Article

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

Huang, Xiao-Lan, Harmer, Jeffrey R., Schenk, Gerhard and Southam, Gordon (2024). Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology. Frontiers in Chemistry, 12 1349020, 1349020. doi: 10.3389/fchem.2024.1349020

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

2024

Journal Article

Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines

Wang, Jialing, Huang, Zhuangzhuang, Xu, Haodong, Nian, Yong, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines. ChemSusChem, 17 (9) e202301735, e202301735. doi: 10.1002/cssc.202301735

Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines

2024

Journal Article

Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem

Lv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303

Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem

2023

Journal Article

Realising the circular phosphorus economy delivers for sustainable development goals

Walsh, Michael, Schenk, Gerhard and Schmidt, Susanne (2023). Realising the circular phosphorus economy delivers for sustainable development goals. npj Sustainable Agriculture, 1 (1) 2, 1-15. doi: 10.1038/s44264-023-00002-0

Realising the circular phosphorus economy delivers for sustainable development goals

2023

Journal Article

Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization

Cheah, Li Chen, Liu, Lian, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Vickers, Claudia E. and Sainsbury, Frank (2023). Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization. Advanced Science, 10 (32) e2303415, 1-10. doi: 10.1002/advs.202303415

Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization

2023

Journal Article

Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

Kurz, Julia L., Monteiro Pedroso, Marcelo, Richard, Emmanuelle, McGeary, Ross P. and Schenk, Gerhard (2023). Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorganic and Medicinal Chemistry Letters, 92 129387, 1-5. doi: 10.1016/j.bmcl.2023.129387

Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

2023

Journal Article

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

Krco, Stefan, Davis, Samuel J., Joshi, Pallav, Wilson, Liam A., Monteiro Pedroso, Marcelo, Douw, Andrew, Schofield, Christopher J., Hugenholtz, Philip, Schenk, Gerhard and Morris, Marc T. (2023). Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance. Frontiers in Chemistry, 11 1196073, 1196073. doi: 10.3389/fchem.2023.1196073

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

2023

Journal Article

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches