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2024

Journal Article

Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics

Rocha, Raquel A., Wilson, Liam A., Schwartz, Brett D., Warden, Andrew C., Guddat, Luke W., Speight, Robert E., Malins, Lara, Schenk, Gerhard and Scott, Colin (2024). Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics. Catalysts, 14 (7) ARTN 399, 399. doi: 10.3390/catal14070399

Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics

2024

Journal Article

Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering

Lv, Kemin, Li, Xiaozhou, Chen, Kequan, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering. ACS Catalysis, 14 (9), 6856-6867. doi: 10.1021/acscatal.4c01083

Improving the catalytic efficiency of a GH5 processive endoglucanase by a combinatorial strategy using consensus mutagenesis and loop engineering

2024

Journal Article

Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase

Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958

Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase

2024

Journal Article

Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539

Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

2024

Journal Article

Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity

Dinda, Rupam, Mohanty, Monalisa, Wilson, Liam, Roy, Satabdi, Mohapatra, Deepika, Patra, Sushree Aradhana, Schenk, Gerhard, Pessoa, João Costa, Sasamori, Takahiro and Aurelien, Crochet (2024). Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity. Journal of Molecular Structure, 1308 138106, 138106. doi: 10.1016/j.molstruc.2024.138106

Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity

2024

Journal Article

Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades

Teshima, Mariko, Sutiono, Samuel, Döring, Manuel, Beer, Barbara, Boden, Mikael, Schenk, Gerhard and Sieber, Volker (2024). Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades. ChemSusChem, 17 (4) e202301132, 1-13. doi: 10.1002/cssc.202301132

Development of a highly selective NAD+‐dependent glyceraldehyde dehydrogenase and its application in minimal cell‐free enzyme cascades

2024

Journal Article

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

Huang, Xiao-Lan, Harmer, Jeffrey R., Schenk, Gerhard and Southam, Gordon (2024). Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology. Frontiers in Chemistry, 12 ARTN 1349020. doi: 10.3389/fchem.2024.1349020

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

2024

Journal Article

Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem

Lv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303

Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem

2024

Journal Article

Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines

Wang, Jialing, Huang, Zhuangzhuang, Xu, Haodong, Nian, Yong, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines. ChemSusChem, 17 (9) e202301735. doi: 10.1002/cssc.202301735

Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines

2023

Journal Article

Realising the circular phosphorus economy delivers for sustainable development goals

Walsh, Michael, Schenk, Gerhard and Schmidt, Susanne (2023). Realising the circular phosphorus economy delivers for sustainable development goals. npj Sustainable Agriculture, 1 (1) 2, 1-15. doi: 10.1038/s44264-023-00002-0

Realising the circular phosphorus economy delivers for sustainable development goals

2023

Journal Article

Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization

Cheah, Li Chen, Liu, Lian, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Vickers, Claudia E. and Sainsbury, Frank (2023). Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization. Advanced Science, 10 (32) e2303415, 1-10. doi: 10.1002/advs.202303415

Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization

2023

Journal Article

Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

Kurz, Julia L., Monteiro Pedroso, Marcelo, Richard, Emmanuelle, McGeary, Ross P. and Schenk, Gerhard (2023). Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorganic and Medicinal Chemistry Letters, 92 129387, 1-5. doi: 10.1016/j.bmcl.2023.129387

Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

2023

Journal Article

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

Krco, Stefan, Davis, Samuel J., Joshi, Pallav, Wilson, Liam A., Monteiro Pedroso, Marcelo, Douw, Andrew, Schofield, Christopher J., Hugenholtz, Philip, Schenk, Gerhard and Morris, Marc T. (2023). Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance. Frontiers in Chemistry, 11 1196073, 1196073. doi: 10.3389/fchem.2023.1196073

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

2023

Journal Article

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

2023

Journal Article

Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation

Cheah, Li Chen, Liu, Lian, Stark, Terra, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Sainsbury, Frank and Vickers, Claudia E. (2023). Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation. Metabolic Engineering, 77, 143-151. doi: 10.1016/j.ymben.2023.03.012

Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation

2023

Journal Article

Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase

Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528

Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase

2023

Journal Article

Gas fermentation for microbial sustainable aviation fuel production

Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008

Gas fermentation for microbial sustainable aviation fuel production

2023

Journal Article

Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes

Jayasinghe-Arachchige, Vindi M., Serafim, Leonardo F., Hu, Qiaoyu, Ozen, Cihan, Moorkkannur, Sreerag N., Schenk, Gerhard and Prabhakar, Rajeev (2023). Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes. ACS Catalysis, 13 (5), 3131-3147. doi: 10.1021/acscatal.2c05758

Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes

2023

Journal Article

Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus

Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140

Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus

2023

Journal Article

Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand

Costa, Luel M.O., Reis, Iago S., Fernandes, Christiane, Marques, Marcelo M., Resende, Jackson A.L.C., Krenske, Elizabeth H., Schenk, Gerhard, Gahan, Lawrence R. and Horn, Adolfo (2023). Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand. Journal of Inorganic Biochemistry, 239 112064, 1-13. doi: 10.1016/j.jinorgbio.2022.112064

Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand