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2021 Journal Article Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomeraseLin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665 |
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2021 Journal Article Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesisLv, Kemin, Shao, Wenyu, Pedroso, Marcelo Monteiro, Peng, Jiayu, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2021). Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesis. International Journal of Biological Macromolecules, 168, 442-452. doi: 10.1016/j.ijbiomac.2020.12.060 |
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2021 Journal Article Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leadsKandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919 |
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2021 Journal Article Recent advances in heterogeneous catalytic systems containing metal ions for phosphate ester hydrolysisGomes, Marco Antonio G. B., Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo (2021). Recent advances in heterogeneous catalytic systems containing metal ions for phosphate ester hydrolysis. Chemistry: A European Journal, 27 (3) chem.202002333, 877-887. doi: 10.1002/chem.202002333 |
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2020 Journal Article Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganismsSelleck, Christopher, Pedroso, Marcelo Monteiro, Wilson, Liam, Krco, Stefan, Knaven, Esmée Gianna, Miraula, Manfredi, Mitić, Nataša, Larrabee, James A., Brück, Thomas, Clark, Alice, Guddat, Luke W. and Schenk, Gerhard (2020). Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms. Scientific Reports, 10 (1) 12882, 12882. doi: 10.1038/s41598-020-68612-z |
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2020 Journal Article Dinuclear copper(II) complexes with derivative triazine ligands as biomimetic models for catechol oxidases and nucleasesSilva, Marcos P., Saibert, Cristine, Bortolotto, Tiago, Bortoluzzi, Adailton J., Schenk, Gerhard, Peralta, Rosely A., Terenzi, Hernán and Neves, Ademir (2020). Dinuclear copper(II) complexes with derivative triazine ligands as biomimetic models for catechol oxidases and nucleases. Journal of Inorganic Biochemistry, 213 111249, 111249. doi: 10.1016/j.jinorgbio.2020.111249 |
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2020 Journal Article Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganismsWun, Shun Jie, Johnson, Lambro A., You, Lv, McGeary, Ross P., Brueck, Thomas, Schenk, Gerhard and Guddat, Luke W. (2020). Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Archives of Biochemistry and Biophysics, 692 108516, 108516. doi: 10.1016/j.abb.2020.108516 |
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2020 Journal Article Towards a sustainable generation of pseudopterosin-type bioactivesRingel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g |
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2020 Journal Article Structures of fungal and plant acetohydroxyacid synthasesLonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3 |
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2020 Journal Article Towards high-throughput optimization of microbial lipid production: from strain development to process monitoringAwad, Dania, Younes, Samer, Glemser, Matthias, Wagner, Franz M., Schenk, Gerhard, Mehlmer, Norbert and Brueck, Thomas (2020). Towards high-throughput optimization of microbial lipid production: from strain development to process monitoring. Sustainable Energy and Fuels, 4 (12), 5958-5969. doi: 10.1039/d0se00540a |
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2020 Journal Article Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diversePedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4 |
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2020 Journal Article Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reactionWilson, Liam A., Garcia, David, Pedroso, Marcelo Monteiro, Schulz, Benjamin L., Guddat, Luke W. and Schenk, Gerhard (2020). Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction. Analytical Biochemistry, 595 113618, 113618. doi: 10.1016/j.ab.2020.113618 |
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2020 Journal Article Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitorBayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899 |
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2020 Journal Article Enabling the direct enzymatic dehydration of d-Glycerate to pyruvate as the key step in synthetic enzyme cascades used in the cell-free production of fine chemicalsSutiono, Samuel, Teshima, Mariko, Beer, Barbara, Schenk, Gerhard and Sieber, Volker (2020). Enabling the direct enzymatic dehydration of d-Glycerate to pyruvate as the key step in synthetic enzyme cascades used in the cell-free production of fine chemicals. ACS Catalysis, 10 (5), 3110-3118. doi: 10.1021/acscatal.9b05068 |
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2020 Journal Article Effect of chemically distinct substrates on the mechanism and reactivity of a highly promiscuous metallohydrolaseSharma, Gaurav, Jayasinghe-Arachchige, Vindi M., Hu, Qiaoyu, Schenk, Gerhard and Prabhakar, Rajeev (2020). Effect of chemically distinct substrates on the mechanism and reactivity of a highly promiscuous metallohydrolase. ACS Catalysis, 10 (6), 3684-3696. doi: 10.1021/acscatal.9b04847 |
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2020 Journal Article Polynuclear zinc(II) complexes of thiosemicarbazone: synthesis, X-ray structure and biological evaluationSaswati, Mohanty, Monalisa, Banerjee, Atanu, Biswal, Sonaleen, Horn, Adolfo, Schenk, Gerhard, Brzezinski, Krzysztof, Sinn, Ekkehard, Reuter, Hans and Dinda, Rupam (2020). Polynuclear zinc(II) complexes of thiosemicarbazone: synthesis, X-ray structure and biological evaluation. Journal of Inorganic Biochemistry, 203 110908, 110908. doi: 10.1016/j.jinorgbio.2019.110908 |
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2020 Journal Article Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in cropsFeder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2020). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. Plant Science, 294 110445, 110445. doi: 10.1016/j.plantsci.2020.110445 |
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2020 Journal Article Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspectiveUribe, Elena, Reyes, María-Belen, Martínez, Ignacio, Mella, Kelly, Salas, Mónica, Tarifeño-Saldivia, Estefanía, López, Vasthi, García-Robles, María, Martínez-Oyanedel, José, Figueroa, Maximiliano, Carvajal, Nelson and Schenk, Gerhard (2020). Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective. Journal of Inorganic Biochemistry, 202 110812, 110812. doi: 10.1016/j.jinorgbio.2019.110812 |
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2020 Journal Article Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agentsImran, Muhammad, Javed, Tariq, Jabeen, Asma, Mehnaz, Gul, Ullah, Kalim, Shaheen, Nusrat, Khalid, Sofia, Amirzada, Muhammad Imran, Yameen, Muhammad Arafat, Hasan, S. M. Farid, Shah, Sajid Hussain, Rauf, Khalid, Schenk, Gary, McGeary, Ross, Pieters, Luc, Latif, Muhammad, Al-Kahraman, Yasser Msa and Hassan Bin Asad, Muhammad Hassham (2020). Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents. Pakistan Journal of Pharmaceutical Sciences, 33 (1 Supplement), 385-392. doi: 10.36721/PJPS.2020.33.1.SUP.385-392.1 |
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2020 Journal Article Engineering proton conductivity in melanin using metal dopingMostert, A. Bernardus, Rienecker, Shermiyah B., Sheliakina, Margarita, Zierep, Paul, Hanson, Graeme R., Harmer, Jeffrey R., Schenk, Gerhard and Meredith, Paul (2020). Engineering proton conductivity in melanin using metal doping. Journal of Materials Chemistry B, 8 (35), 8050-8060. doi: 10.1039/d0tb01390k |
