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2023 Journal Article Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymesJayasinghe-Arachchige, Vindi M., Serafim, Leonardo F., Hu, Qiaoyu, Ozen, Cihan, Moorkkannur, Sreerag N., Schenk, Gerhard and Prabhakar, Rajeev (2023). Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes. ACS Catalysis, 13 (5), 3131-3147. doi: 10.1021/acscatal.2c05758 |
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2023 Journal Article Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligandCosta, Luel M.O., Reis, Iago S., Fernandes, Christiane, Marques, Marcelo M., Resende, Jackson A.L.C., Krenske, Elizabeth H., Schenk, Gerhard, Gahan, Lawrence R. and Horn, Adolfo (2023). Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand. Journal of Inorganic Biochemistry, 239 112064, 1-13. doi: 10.1016/j.jinorgbio.2022.112064 |
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2023 Journal Article Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticusBayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140 |
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2023 Journal Article Biomimetics for purple acid phosphatases: a historical perspectiveWilson, Liam A., Pedroso, Marcelo M., Peralta, Rosely A., Gahan, Lawrence R. and Schenk, Gerhard (2023). Biomimetics for purple acid phosphatases: a historical perspective. Journal of Inorganic Biochemistry, 238 112061, 112061. doi: 10.1016/j.jinorgbio.2022.112061 |
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2022 Journal Article Structural basis of resistance to herbicides that target acetohydroxyacid synthaseLonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x |
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2022 Journal Article Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphataseSatta, Alessandro, Esquirol, Lygie, Ebert, Birgitta E., Newman, Janet, Peat, Thomas S., Plan, Manuel, Schenk, Gerhard and Vickers, Claudia E. (2022). Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase. The FEBS Journal, 289 (21), 6672-6693. doi: 10.1111/febs.16556 |
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2022 Journal Article Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymesCheah, L. C., Liu, L., Plan, M. R., Peng, B., Lu, Z., Schenk, G., Vickers, C. E. and Sainsbury, F. (2022). Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes. BioRxiv. doi: 10.1101/2022.11.24.517869 |
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2022 Journal Article Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633 |
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2022 Journal Article Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform ChemicalsLv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011 |
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2022 Journal Article Metabolomics of non-saccharomyces yeasts in fermented beveragesEllis, Daniel J., Kerr, Edward D., Schenk, Gerhard and Schulz, Benjamin L. (2022). Metabolomics of non-saccharomyces yeasts in fermented beverages. Beverages, 8 (3) 41, 1-14. doi: 10.3390/beverages8030041 |
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2022 Journal Article Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide developmentShah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073 |
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2022 Journal Article Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistanceBayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927 |
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2022 Journal Article Efficient green light acclimation of the green algae Picochlorum sp. triggering geranylgeranylated chlorophyllsPaper, Michael, Glemser, Matthias, Haack, Martina, Lorenzen, Jan, Mehlmer, Norbert, Fuchs, Tobias, Schenk, Gerhard, Garbe, Daniel, Weuster-Botz, Dirk, Eisenreich, Wolfgang, Lakatos, Michael and Brueck, Thomas B. (2022). Efficient green light acclimation of the green algae Picochlorum sp. triggering geranylgeranylated chlorophylls. Frontiers in Bioengineering and Biotechnology, 10 885977. doi: 10.3389/fbioe.2022.885977 |
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2022 Journal Article Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinolRingel, Marion, Dimos, Nicole, Himpich, Stephanie, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Schenk, Gerhard, Loll, Bernhard and Brück, Thomas (2022). Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microbial Cell Factories, 21 (1) 64, 64. doi: 10.1186/s12934-022-01791-8 |
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2022 Journal Article Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratasesMelse, Okke, Sutiono, Samuel, Haslbeck, Magdalena, Schenk, Gerhard, Antes, Iris and Sieber, Volker (2022). Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratases. ChemBioChem, 23 (10) e202200088, e202200088. doi: 10.1002/cbic.202200088 |
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2022 Journal Article LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibioticsStroek, Rozanne, Wilson, Liam, Goracke, William, Kang, Taeuk, Vermue, Febe, Krco, Stefan, Mendels, Yonatan, Douw, Andrew, Morris, Marc, Knaven, Esmee G., Mitić, Nataša, Gutierrez, Maria C.R., Schenk, Elaine B., Clark, Alice, Garcia, David, Monteiro Pedroso, Marcelo and Schenk, Gerhard (2022). LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibiotics. Journal of Inorganic Biochemistry, 226 111637, 1-4. doi: 10.1016/j.jinorgbio.2021.111637 |
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2021 Journal Article Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leadsLow, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9 |
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2021 Journal Article Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acidWilson, Liam A., Knaven, Esmée G., Morris, Marc T., Monteiro Pedroso, Marcelo, Schofield, Christopher J., Brück, Thomas, Boden, Mikael, Waite, David W., Hugenholtz, Philip, Guddat, Luke and Schenk, Gerhard (2021). Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid. Antimicrobial Agents and Chemotherapy, 65 (10) e00936-21, e0093621. doi: 10.1128/aac.00936-21 |
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2021 Journal Article Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilisWang, Lijuan, Cao, Kun, Pedroso, Marcelo Monteiro, Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis. Journal of Biological Chemistry, 297 (5) 101262, 101262. doi: 10.1016/j.jbc.2021.101262 |
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2021 Journal Article Rational design of potent inhibitors of a metallohydrolase using a fragment-based approachFeder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486 |
