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2021 Journal Article Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonistsLi, Xaria X., Clark, Richard J. and Woodruff, Trent M. (2021). Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists. International Immunopharmacology, 100 108074, 108074. doi: 10.1016/j.intimp.2021.108074 |
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2021 Journal Article LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesityLu, Xuehan, Huang, Lili, Huang, Zhengxiang, Feng, Dandan, Clark, Richard J. and Chen, Chen (2021). LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesity. Frontiers in Endocrinology, 12 717544, 717544. doi: 10.3389/fendo.2021.717544 |
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2021 Journal Article Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivoSmallwood, Taylor B., Navarro, Severine, Cristofori-Armstrong, Ben, Watkins, Thomas S., Tungatt, Katie, Ryan, Rachael Y.M., Haigh, Oscar L., Lutzky, Viviana P., Mulvenna, Jason P., Rosengren, K. Johan, Loukas, Alex, Miles, John J. and Clark, Richard J. (2021). Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1) 100834, 1-14. doi: 10.1016/j.jbc.2021.100834 |
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2021 Journal Article Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal painMuratspahić, Edin, Tomašević, Nataša, Koehbach, Johannes, Duerrauer, Leopold, Hadžić, Seid, Castro, Joel, Schober, Gudrun, Sideromenos, Spyridon, Clark, Richard J., Brierley, Stuart M., Craik, David J. and Gruber, Christian W. (2021). Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00158, 9042-9055. doi: 10.1021/acs.jmedchem.1c00158 |
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2021 Journal Article Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087 |
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2021 Journal Article Advances in venom peptide drug discovery: where are we at and where are we heading?Smallwood, Taylor B. and Clark, Richard J. (2021). Advances in venom peptide drug discovery: where are we at and where are we heading?. Expert Opinion on Drug Discovery, 16 (10) 17460441.2021.1922386, 1-11. doi: 10.1080/17460441.2021.1922386 |
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2021 Journal Article A chameleonic macrocyclic peptide with drug delivery applicationsPayne, Colton D., Franke, Bastian, Fisher, Mark F., Hajiaghaalipour, Fatemeh, McAleese, Courtney E., Song, Angela, Eliasson, Carl, Zhang, Jingjing, Jayasena, Achala S., Vadlamani, Grishma, Clark, Richard J., Minchin, Rodney F., Mylne, Joshua S. and Rosengren, K. Johan (2021). A chameleonic macrocyclic peptide with drug delivery applications. Chemical Science, 12 (19), 6670-6683. doi: 10.1039/d1sc00692d |
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2021 Journal Article ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutationsMoral-Sanz, Javier, Fernandez-Rojo, Manuel A., Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., Alewood, Paul F., Waddell, Nicola, Miles, John J., Mulvenna, Jason P. and Ikonomopoulou, Maria P. (2021). ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations. Toxins, 13 (2) 146, 1-19. doi: 10.3390/toxins13020146 |
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2021 Journal Article Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidinsGoncalves Monteiro, Daniela, van Dijk, Johannes W. A., Aliyanto, Randy, Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas, Rosengren, Johan and Clark, Richard J. (2021). Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidins. Biomedicines, 9 (2) 164, 1-14. doi: 10.3390/biomedicines9020164 |
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2021 Journal Article The “C3aR Antagonist” SB290157 is a partial C5aR2 agonistLi, Xaria X., Kumar, Vinod, Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). The “C3aR Antagonist” SB290157 is a partial C5aR2 agonist. Frontiers in Pharmacology, 11 591398, 591398. doi: 10.3389/fphar.2020.591398 |
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2021 Journal Article Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplanGorman, Declan M., Lee, John, Payne, Colton D., Woodruff, Trent M. and Clark, Richard J. (2021). Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan. Amino Acids, 53 (1), 143-147. doi: 10.1007/s00726-020-02921-5 |
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2020 Journal Article Defining the familial fold of the vicilin-buried peptide familyPayne, Colton D., Vadlamani, Grishma, Fisher, Mark F., Zhang, Jingjing, Clark, Richard J., Mylne, Joshua S. and Rosengren, K. Johan (2020). Defining the familial fold of the vicilin-buried peptide family. Journal of Natural Products, 83 (10), 3030-3040. doi: 10.1021/acs.jnatprod.0c00594 |
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2020 Journal Article Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonistsLee, Han Siean, Wang, Shu Hui, Daniel, James T., Hossain, Mohammed Akhter, Clark, Richard J., Bathgate, Ross A. D. and Rosengren, K. Johan (2020). Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonists. Biomedicines, 8 (10) 415, 1-16. doi: 10.3390/biomedicines8100415 |
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2020 Journal Article Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and functionLi, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology, 180 114156, 114156. doi: 10.1016/j.bcp.2020.114156 |
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2020 Journal Article C5aR2 activation broadly modulates the signaling and function of primary human macrophagesLi, Xaria X., Clark, Richard J. and Woodruff, Trent M. (2020). C5aR2 activation broadly modulates the signaling and function of primary human macrophages. Journal of Immunology, 205 (4), 1-11. doi: 10.4049/jimmunol.2000407 |
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2020 Journal Article Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffoldsLee, Han Siean, Postan, Michael, Song, Angela, Clark, Richard J., Bathgate, Ross A. D., Haugaard-Kedström, Linda M. and Rosengren, K. Johan (2020). Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffolds. Frontiers in Chemistry, 8 87, 87. doi: 10.3389/fchem.2020.00087 |
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2020 Journal Article Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735 |
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2019 Journal Article Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChREl Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577 |
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2018 Journal Article Discovery of peptide probes to modulate oxytocin-type receptors of insectsKeov, Peter, Liutkevičiūtė, Zita, Hellinger, Roland, Clark, Richard J. and Gruber, Christian W. (2018). Discovery of peptide probes to modulate oxytocin-type receptors of insects. Scientific reports, 8 (1) 10020, 10020. doi: 10.1038/s41598-018-28380-3 |
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2018 Journal Article Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1Sadeghi, Mahsa, Carstens, Bodil B., Callaghan, Brid P., Daniel, James T., Tae, Han Shen, O'Donnell, Tracey, Castro, Joel, Brierley, Stuart M., Adams, David J., Craik, David J. and Clark, Richard J. (2018). Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13 (6), 1577-1587. doi: 10.1021/acschembio.8b00190 |
