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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Peptide mimic for influenza vaccination using nonnatural combinatorial chemistryMiles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J., Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A. and Sewell, Andrew K. (2018). Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation, 128 (4), 1569-1580. doi: 10.1172/JCI91512 |
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2018 Journal Article Transcriptome and toxin family analysis of the paralysis tick, Ixodes holocyclusRodriguez-Valle, Manuel, Moolhuijzen, Paula, Barrero, Roberto A., Ong, Chian Teng, Busch, Greta, Karbanowicz, Thomas, Booth, Mitchell, Clark, Richard, Koehbach, Johannes, Ijaz, Hina, Broady, Kevin, Agnew, Kim, Knowles, Aleta G., Bellgard, Matthew I. and Tabor, Ala E. (2018). Transcriptome and toxin family analysis of the paralysis tick, Ixodes holocyclus. International Journal for Parasitology, 48 (1), 71-82. doi: 10.1016/j.ijpara.2017.07.007 |
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2017 Journal Article G-Protein Coupled Receptors Targeted by Analgesic Venom PeptidesDaniel, James T. and Clark, Richard J. (2017). G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides. Toxins, 9 (11) 372, 1-26. doi: 10.3390/toxins9110372 |
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2017 Journal Article Helminth immunomodulation in autoimmune diseaseSmallwood, Taylor B., Giacomin, Paul R., Loukas, Alex, Mulvenna, Jason P., Clark, Richard J. and Miles, John J. (2017). Helminth immunomodulation in autoimmune disease. Frontiers in Immunology, 8 (APR) 453, 453. doi: 10.3389/fimmu.2017.00453 |
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2016 Journal Article Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxinCarstens, Bodil B., Swedberg, Joakim, Berecki, Geza, Adams, David J., Craik, David J. and Clark, Richard J. (2016). Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxin. Biopolymers, 106 (6), 864-875. doi: 10.1002/bip.22848 |
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2016 Journal Article Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysisKoehbach, Johannes and Clark, Richard J. (2016). Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysis. Biopolymers, 106 (6), 774-783. doi: 10.1002/bip.22858 |
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2016 Journal Article Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer compositionZhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016). Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41, 264-272. doi: 10.1016/j.actbio.2016.05.034 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructuredDaly, Norelle L., Gunasekera, Sunithi, Clark, Richard J., Lin, Feng, Wade, John D., Anderson, Marilyn and Craik, David J. (2016). The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured. Biopolymers, 106 (6), 825-833. doi: 10.1002/bip.22977 |
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2016 Journal Article Tick holocyclotoxins trigger host paralysis by presynaptic inhibitionChand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016). Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 (1) 29446, 29446. doi: 10.1038/srep29446 |
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2016 Journal Article Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional MotifCarstens, Bodil B., Berecki, Géza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie, 128 (15), 4770-4774. doi: 10.1002/ange.201600297 |
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2016 Journal Article Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional MotifCarstens, Bodil B., Berecki, Geza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie - International Edition, 55 (15), 4692-4696. doi: 10.1002/anie.201600297 |
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2015 Journal Article Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxinsAkcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699 |
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2015 Journal Article Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barrettiCarstens, Bodil B., Rosengren, K. Johan, Gunasekera, Sunithi, Schempp, Stefanie, Bohlin, Lars, Dahlstrom, Mia, Clark, Richard J. and Goransson, Ulf (2015). Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti. Journal of Natural Products, 78 (8), 1886-1893. doi: 10.1021/acs.jnatprod.5b00210 |
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2015 Journal Article Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinumHellinger, Roland, Koehbach, Johannes, Puigpinos, Albert, Clark, Richard J., Tarrago, Teresa, Giralt, Ernest and Gruber, Christian W. (2015). Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum. Journal of Natural Products, 78 (5), 1073-1082. doi: 10.1021/np501061t |
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2015 Journal Article In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclizationMalik, U., Silva, O. N., Fensterseifer, I. C. M., Chan, A., Clark, R. J., Franco, O. L., Daly, N. L. and Craik, D. J. (2015). In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization. Antimicrobial Agents and Chemotherapy, 59 (4), 2113-2121. doi: 10.1128/AAC.04324-14 |
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2015 Journal Article Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonistKompella, Shiva N., Hung, Andrew, Clark, Richard J., Mari, Frank and Adams, David J. (2015). Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. Journal of Biological Chemistry, 290 (2), 1039-1048. doi: 10.1074/jbc.M114.605592 |
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2014 Journal Article Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activationBerecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J. and Adams, David J. (2014). Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. Journal of General Physiology, 143 (4), 465-479. doi: 10.1085/jgp.201311104 |
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2013 Journal Article Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r)Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J. and Olson, James M. (2013). Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r). Journal of Medicinal Chemistry, 56 (23), 9807-9807. doi: 10.1021/jm4016119 |
