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2025 Journal Article Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channelsAdegoke, Victoria A., Dongol, Yashad, Gonzalez, Tye, Song, Angela, Clark, Richard J., Lewis, Richard J., Conibear, Anne C. and Rosengren, K. Johan (2025). Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels. Australian Journal of Chemistry, 78 (9) CH25071. doi: 10.1071/ch25071 |
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2025 Conference Publication Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membraneSun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969 |
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2025 Conference Publication Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptorsClark, Richard, Dent, Joshua, Gorman, Declan, Li, Xaria, Wu, Xiaosa, Cui, Cedric, Fung, Jenny, Lee, John, Rosengren, Johan and Woodruff, Trent (2025). Development of novel peptide ligands with improved selectivity and pharmacological properties for complement system receptors. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153001 |
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2025 Conference Publication Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1Cao, Yuzhihan, Pietrogrande, Giovanni, Pars, Selin, Clark, Richard, Wolvetang, Ernst, Woodruff, Trent and Albornoz, Eduardo (2025). Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153008 |
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2025 Journal Article Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signalingDehkhoda, Farhad, Ringuet, Mitchell T., Whitfield, Emily A., Mutunduwe, Keith, Whelan, Fiona, Nowell, Cameron J., Misganaw, Desye, Xu, Zheng, Piper, Noah B. C., Clark, Richard J., Hossain, Mohammed Akhter, Fothergill, Linda J., McDougall, Stuart J., Furness, John B. and Furness, Sebastian G. B. (2025). Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling. Molecular Cell, 85 (11), 2246-2260.e10. doi: 10.1016/j.molcel.2025.05.005 |
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2025 Journal Article Colon‐targeted complement C5a<sub>1</sub> receptor inhibition using pH‐sensitive nanoparticles ameliorates experimental colitisCui, Cedric S., Lerskiatiphanich, Titaya, Li, Xaria X., Giri, Rabina, Liu, Ning, Kumar, Vinod, Whittaker, Andrew K., Han, Felicity Y., Clark, Richard J., Begun, Jakob, Lee, John D. and Woodruff, Trent M. (2025). Colon‐targeted complement C5a1 receptor inhibition using pH‐sensitive nanoparticles ameliorates experimental colitis. British Journal of Pharmacology, 182 (16), 3852-3869. doi: 10.1111/bph.70056 |
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2025 Journal Article Molecular determinants of the selectivity and potency of α-conotoxin Vc1.1 for human nicotinic acetylcholine receptorsTae, Han-Shen, Hung, Andrew, Clark, Richard J. and Adams, David J. (2025). Molecular determinants of the selectivity and potency of α-conotoxin Vc1.1 for human nicotinic acetylcholine receptors. Journal of Biological Chemistry, 301 (1) 108017, 1-13. doi: 10.1016/j.jbc.2024.108017 |
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2024 Journal Article The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisationBudusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175 |
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2024 Journal Article Chemical synthesis of grafted cyclotides using a “plug and play” approachKoehbach, Johannes, Muratspahić, Edin, Ahmed, Zakaria M., White, Andrew M., Tomašević, Nataša, Durek, Thomas, Clark, Richard J., Gruber, Christian W. and Craik, David J. (2024). Chemical synthesis of grafted cyclotides using a “plug and play” approach. RSC Chemical Biology, 5 (6), 567-571. doi: 10.1039/d4cb00008k |
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2024 Journal Article Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypesWu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909 |
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2024 Journal Article Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killingLi, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5) e2314627121, 1-10. doi: 10.1073/pnas.2314627121 |
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2024 Journal Article Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analoguesSmallwood, Taylor B., Krumpe, Lauren R. H., Payne, Colton D., Klein, Victoria G., O'Keefe, Barry R., Clark, Richard J., Schroeder, Christina I. and Rosengren, K. Johan (2024). Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues. Chemical Science, 15 (33), 13227-13233. doi: 10.1039/d4sc01976h |
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2023 Journal Article Special Issue in Honor of Professor Mary Garson AMBlanchfield, Joanne T., Nonato, Maribel G. and Clark, Richard J. (2023). Special Issue in Honor of Professor Mary Garson AM. Journal of Natural Products, 86 (3), 473-474. doi: 10.1021/acs.jnatprod.3c00088 |
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2023 Journal Article TLQP-21 is a low potency partial C3aR activator on human primary macrophagesLi, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673 |
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2022 Conference Publication WS1.4: Biostimulation of bacteria for streamlined identification of new antimicrobial compoundsMirzaee, Hooman, Ariens, Emily, Booth, James, Carvalhais, Lilia C., Blaskovich, Mark A.T., Clark, Richard J. and Schenk, Peer M. (2022). WS1.4: Biostimulation of bacteria for streamlined identification of new antimicrobial compounds. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, WA Australia, 27 – 30 November 2022. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/s2213-7165(22)00272-7 |
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2022 Journal Article Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibitionChand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2022). Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 12 (1) 20636, 1-1. doi: 10.1038/s41598-022-24528-4 |
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2022 Journal Article Engineering peptide inhibitors of the HFE–transferrin receptor 1 complexGoncalves Monteiro, Daniela Goncalves, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan and Clark, Richard J. (2022). Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex. Molecules, 27 (19) 6581, 1-13. doi: 10.3390/molecules27196581 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923 |
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2022 Conference Publication Identification of potent small peptides targeting human C3a receptorDeerain, Nick, Kumar, Vinod, Clark, Richard and Woodruff, Trent (2022). Identification of potent small peptides targeting human C3a receptor. ICW – 2021 Virtual Workshop of the International Complement Society (ICS), Virtual, 7-10 December 2021. Oxford, United Kingdom: Elsevier. |
