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2016

Conference Publication

Development of peptide therapeutics for iron disorders

Goncalves, Daniela, Rishi, Gautam, Aliyanto, Randy, Rosengren, Johan, Subramaniam, Nathan, Frazer, David and Clark, Richard (2016). Development of peptide therapeutics for iron disorders. 6th Meeting of the International BioIron Society, Zhejiang University, Hangzhou, China, 8-10 September 2015. Hoboken, NJ, United States: John Wiley & Sons.

Development of peptide therapeutics for iron disorders

2015

Journal Article

Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins

Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699

Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins

2015

Journal Article

Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti

Carstens, Bodil B., Rosengren, K. Johan, Gunasekera, Sunithi, Schempp, Stefanie, Bohlin, Lars, Dahlstrom, Mia, Clark, Richard J. and Goransson, Ulf (2015). Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti. Journal of Natural Products, 78 (8), 1886-1893. doi: 10.1021/acs.jnatprod.5b00210

Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti

2015

Journal Article

Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum

Hellinger, Roland, Koehbach, Johannes, Puigpinos, Albert, Clark, Richard J., Tarrago, Teresa, Giralt, Ernest and Gruber, Christian W. (2015). Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum. Journal of Natural Products, 78 (5), 1073-1082. doi: 10.1021/np501061t

Inhibition of human prolyl oligopeptidase activity by the cyclotide psysol 2 isolated from Psychotria solitudinum

2015

Journal Article

In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization

Malik, U., Silva, O. N., Fensterseifer, I. C. M., Chan, A., Clark, R. J., Franco, O. L., Daly, N. L. and Craik, D. J. (2015). In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization. Antimicrobial Agents and Chemotherapy, 59 (4), 2113-2121. doi: 10.1128/AAC.04324-14

In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization

2015

Journal Article

Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist

Kompella, Shiva N., Hung, Andrew, Clark, Richard J., Mari, Frank and Adams, David J. (2015). Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. Journal of Biological Chemistry, 290 (2), 1039-1048. doi: 10.1074/jbc.M114.605592

Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist

2015

Conference Publication

Exploring the chemistry and pharmacological potential of bioactive peptides from insects

Koehbach, Johannes and Clark, Richard J. (2015). Exploring the chemistry and pharmacological potential of bioactive peptides from insects. 14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, August 3–7, 2015. Wien, Austria: Springer Wien. doi: 10.1007/s00726-015-2016-z

Exploring the chemistry and pharmacological potential of bioactive peptides from insects

2014

Journal Article

Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation

Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J. and Adams, David J. (2014). Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. Journal of General Physiology, 143 (4), 465-479. doi: 10.1085/jgp.201311104

Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation

2014

Conference Publication

A new target for the alpha-conotoxins: the gaba(b) receptor

Clark, R. J., Carstens, B. B., Berecki, G., Callaghan, B., Adams, D. J. and Craik, D. J. (2014). A new target for the alpha-conotoxins: the gaba(b) receptor. Oxford, United Kingdom: John Wiley & Sons.

A new target for the alpha-conotoxins: the gaba(b) receptor

2014

Conference Publication

Applications of conotoxins for the treatment of pain

Craik, David J., Clark, Richard J. and Poth, Aaron (2014). Applications of conotoxins for the treatment of pain. 247th National Spring Meeting of the American Chemical Society (ACS), Dallas, TX, United States, March 16-20, 2014. Washington, DC, United States: American Chemical Society.

Applications of conotoxins for the treatment of pain

2013

Journal Article

Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r)

Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J. and Olson, James M. (2013). Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r). Journal of Medicinal Chemistry, 56 (23), 9807-9807. doi: 10.1021/jm4016119

Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r)

2013

Journal Article

Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors

Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J. and Adams, David J. (2013). Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288 (48), 34428-34442. doi: 10.1074/jbc.M113.512582

Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors

2013

Journal Article

Novel inhibitor cystine knot peptides from momordica charantia

He, Wen-Jun, Chan, Lai Yue, Clark, Richard J., Tang, Jun, Zeng, Guang-Zhi, Franco, Octavio L., Cantacessi, Cinzia, Craik, David J., Daly, Norelle L. and Tan, Ning-Hua (2013). Novel inhibitor cystine knot peptides from momordica charantia. PLoS ONE, 8 (10) e75334, e75334.1-e75334.10. doi: 10.1371/journal.pone.0075334

Novel inhibitor cystine knot peptides from momordica charantia

2013

Journal Article

Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin

Clark, Richard J., Preza, Gloria C., Tan, Chia Chia, van Dijk, Johannes W. A., Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2013). Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers: Peptide Science, 100 (5), 519-526. doi: 10.1002/bip.22350

Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin

2013

Conference Publication

alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency

Kompella, Shiva N., Hung, Andrew, Clark, Richard J. and Adams, David J. (2013). alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency. 57th Annual Meeting of the Biophysical Society, Philadelphia Pa, 02-06 February 2013. Maryland Heights, MO United States: Cell Press. doi: 10.1016/j.bpj.2012.11.3505

alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency

2013

Conference Publication

Development of analgesic alpha-conotoxins for treatment of chronic pain

Adams, D. J., Berecki, G., Clark, R. and Craik, D. J. (2013). Development of analgesic alpha-conotoxins for treatment of chronic pain. 4th Meeting of the Australia Chinese Association for Biomedical Sciences Inc (ACABS), Hangzhou Peoples R China, 10-13 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/1440-1681.12170

Development of analgesic alpha-conotoxins for treatment of chronic pain

2012

Journal Article

Cyclization of conotoxins to improve their biopharmaceutical properties

Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012). Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 (4), 446-455. doi: 10.1016/j.toxicon.2010.12.003

Cyclization of conotoxins to improve their biopharmaceutical properties

2012

Journal Article

Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38)

Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2012). Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38). Current Pharmaceutical Design, 18 (8) doi: 10.2174/138161212799315858

Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38)

2012

Conference Publication

Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds

Chan, L. A., Gunasekera, S., Henriques, S. T., Worth, N. F., Le, S., Clark, R. J., Campbell, J. H., Craik, D. J. and Daly, N. L. (2012). Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2448

Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds

2012

Journal Article

Engineering cyclic peptide toxins

Clark, Richard J. and Craik, David J. (2012). Engineering cyclic peptide toxins. Methods in Enzymology, 503, 57-74. doi: 10.1016/B978-0-12-396962-0.00003-3

Engineering cyclic peptide toxins