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2010 Journal Article Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activityHuang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010). Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 (14), 10797-10805. doi: 10.1074/jbc.M109.089854 |
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2010 Journal Article Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteinsClark, Richard J. and Craik, David J. (2010). Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins. Biopolymers, 94 (4), 414-422. doi: 10.1002/bip.21372 |
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2009 Journal Article Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survivalLattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012 |
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2009 Journal Article A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonistsArmishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A. and Jensen, Anders A. (2009). A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. Journal of Biological Chemistry, 285 (3), 1809-1821. doi: 10.1074/jbc.M109.071183 |
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2009 Journal Article Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptorHalai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J. and Craik, David J. (2009). Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptor. Journal of Biological Chemistry, 284 (30), 20275-20284. doi: 10.1074/jbc.M109.015339 |
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2009 Journal Article Dissecting the oxidative folding of circular cystine knot miniproteinsGunasekera, Sunithi, Daly, Norelle L., Clark, Richard J. and Craik, David J. (2009). Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants and Redox Signalling, 11 (5), 971-980. doi: 10.1089/ars.2008.2295 |
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2009 Journal Article Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivativesArmishaw, Christopher, Jensen, Anders A., Balle, Thomas, Clark, Richard J., Harpsøe, Kasper, Skonberg, Christian, Liljefors, Tommy and Strømgaard, Kristian (2009). Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives. Journal of Biological Chemistry, 284 (14), 9498-9512. doi: 10.1074/jbc.M806136200 |
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2009 Journal Article Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analoguesMillard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009). Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 (8), 4944-4951. doi: 10.1074/jbc.M804950200 |
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2008 Journal Article Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activationCallaghan, Brid, Haythornthwaite, Alison R., Berecki, Geza, Clark, Richard J., Craik, David J. and Adams, David J. (2008). Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation. The Journal of Neuroscience, 28 (43), 10943-10951. doi: 10.1523/JNEUROSCI.3594-08.2008 |
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2008 Journal Article Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotidesGunasekera, Sunithi, Foley, Fiona M., Clark, Richard J., Sando, Lillian, Fabri, Louis J., Craik, David J. and Daly, Norelle L. (2008). Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry, 51 (24), 7697-7704. doi: 10.1021/jm800704e |
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2008 Journal Article Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMRWestermann, Jan, Clark, Richard J. and Craik, David J. (2008). Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR. Protein And Peptide Letters, 15 (9), 910-914. doi: 10.2174/092986608785849335 |
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2008 Journal Article The three-dimensional structure of the analgesic alpha-conotoxin, RgIAClark, Richard J., Daly, Norelle L., Halai, Reena, Nevin, Simon T., Adams, David J. and Craik, David J. (2008). The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Letters, 582 (5), 597-602. doi: 10.1016/j.febslet.2008.01.027 |
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2008 Journal Article The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicityHerrman, Anders, Burman, Robert, Mylne, Joshua S., Karlsson, Gustav, Gullbo, Joachim, Craik, David J., Clark, Richard J. and Goransson, Ulf (2008). The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry, 69 (4), 939-952. doi: 10.1016/j.phytochem.2007.10.023 |
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2008 Journal Article Cyclotides and conotoxins ultra-stable disulfide-rich peptidesCraik, David J., Clark, Richard J. and Daly, Norelle L. (2008). Cyclotides and conotoxins ultra-stable disulfide-rich peptides. Chimica Oggi -Chemistry Today, 26 (4), 20-22. |
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2008 Journal Article Utlra-stable peptide scaffolds for protein engineering synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2Aboye, T, Clark, Richard J., Craik, David J. and Goransson, U (2008). Utlra-stable peptide scaffolds for protein engineering synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. ChemBioChem, 9 (1), 103-113. doi: 10.1002/cbic.200700357 |
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2007 Journal Article Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?Nevin, Simon T., Clark, Richard J., Klimis, H., Christie, M. J., Craik, David J. and Adams, David J. (2007). Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?. Molecular Pharmacology, 72 (6), 1406-1410. doi: 10.1124/mol.107.040568 |
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2007 Journal Article Structure of alpha-conotoxin BuIA: Influences of disulfide connectivity on structural dynamicsJin, Ai-Hua, Brandstaetter, Hemma, Nevin, Simon T., Tan, Chia Chia, Clark, Richard J., Adams, David J., Alewood, Paul F., Craik, David J. and Daly, Norelle L. (2007). Structure of alpha-conotoxin BuIA: Influences of disulfide connectivity on structural dynamics. BMC Structural Biology, 7 (28) 28, 1-13. doi: 10.1186/1472-6807-7-28 |
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2007 Journal Article Potential therapeutic applications of the cyclotides and related cystine knot mini-proteinsCraik, D. J, Clark, R. J and Daly, N. L (2007). Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins. Expert Opinion On Investigational Drugs, 16 (5), 595-604. doi: 10.1517/13543784.16.5.595 |
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2007 Journal Article The cyclotide fingerprint in Oldenlandia affinis: Elucidation of chemically modified, linear and novel macrocyclic peptidesPlan, M. R. R, Goransson, U, Clark, R. J, Daly, N. L, Colgrave, M. L and Craik, D.J (2007). The cyclotide fingerprint in Oldenlandia affinis: Elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem, 8 (9), 1001-1011. doi: 10.1002/cbic.200700097 |
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2007 Journal Article A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteinsGruber, C. W, Cemazar, M., Clark, R. .J, Horibe, T, Renda, R. F., Anderson, M. A. and Craik, D. J. (2007). A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. Journal of Biological Chemistry, 282 (28), 20435-20446. doi: 10.1074/jbc.M700018200 |
