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Professor David Clark
Professor

David Clark

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Overview

Background

Professor David A Clark

Royal Brisbane and Women’s Hospital, and University of Queensland, Australia

Prof Clark is a visiting colorectal surgeon at the Royal Brisbane and Women’s Hospital. He qualified from the University of QLD in 1991, trained in surgery in Brisbane, and undertook colorectal fellowships in the United Kingdom. He was admitted as a Fellow of the Royal College of Surgeons at Edinburgh in January 2002.

He is a Professor for the University of QLD and runs a busy clinical practice at the St Vincent's Private Hospital Northside. He has a strong interest in inflammatory bowel disease and the IBD Unit at the RBWH has an active academic program. Prof Clark has presented internationally in the field of IBD and minimally invasive colorectal surgery.

The colorectal unit based at the RBWH has a commitment to education and runs a regular laparoscopic colorectal training course and now supports 3 colorectal fellows and a research co-ordinator. He is a board member of the ANZ Training Board in Colorectal Surgery (ANZTBCRS) and the recent convenor for the Society and Section scientific meetings.

Prof Clark heads the Brisbane Colorectal Reseacrh Unit (CRU) and completed a PhD at the University of Sydney in June 2022. He concurrently supervised 4 PhD candidates through UQ. He is widely published in the fields of minimally invasive surgery and inflammaory bowel disease.

Brisbane is renowned for minimally invasive colorectal surgery and training and teaching are a passion.

Availability

Professor David Clark is:
Available for supervision

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, University of Sydney
  • Board Member, Australia and New Zealand Training Board in Colorectal Surgery, Australia and New Zealand Training Board in Colorectal Surgery
  • Member, Colorectal Surgical Society of Australia and New Zealand, Colorectal Surgical Society of Australia and New Zealand
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh

Research interests

  • Early Surgery for Ileal Crohn's Disease

    Surgery as a therapeutic option vs trial of multiple medical therapies.

  • Surgery for Acute Severe Ulcerative Colitis

    Refining the minimally invasive technique for these acutely unwell patients and optimizing the ultimate restorative procedure.

  • Minimally invasive colorectal surgery

    Regular masterclasses showcasing advances in minimally invasive approaches to colorectal surgery.

  • Modified Kono S anastomosis after ileocolic resection for Crohn's disease

    An RCT out of the RBWH and recruiting 2023.

  • Colorectal cancer organoids for predicting response to chemotherapy

    QIMR research project to collect specimens and enhance the pipeline to grow and test organoids in a clinically actionable timeframe.

Research impacts

Professor Clark's publications in the field of drain fluid biomarkers of anastomotic leak have seen the uptake of the research methodology in numerous centres around the world. Indeed the measurement of drain fluid amylase is an inexpensive and readily availble test that should be the standard of care in the peri-operative period of ileal pouch surgery when a diverting ileostomy is not incorporated. Further development of novel drain fluid biomarkers are under investigation to support the post-operative care in the setting of rectal cancer surgery.

Research in the field of organoids has the potential to translate to precision medicine in a clinically actionable timeframe.

Publications from the colorectal sub-committee in colorectal cancer through the Queensland Cancer Control and Analysis Team (QCCAT) are produced to report on multiple aspects of service delivery and quality throughout Queensland with the goal of enhancing patient outcomes throughout the state.

Works

Search Professor David Clark’s works on UQ eSpace

97 works between 1999 and 2025

41 - 60 of 97 works

2022

Journal Article

Drain fluid amylase as a biomarker for the detection of anastomotic leakage after rectal resection without a diverting ileostomy

Clark, David A., Edmundson, Aleksandra, Steffens, Daniel, Harris, Craig, Stevenson, Andrew and Solomon, Michael (2022). Drain fluid amylase as a biomarker for the detection of anastomotic leakage after rectal resection without a diverting ileostomy. ANZ Journal of Surgery, 92 (4), 813-818. doi: 10.1111/ans.17461

Drain fluid amylase as a biomarker for the detection of anastomotic leakage after rectal resection without a diverting ileostomy

2022

Journal Article

Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy

Clark, David A., Edmundson, Aleksandra, Steffens, Daniel, Radford-Smith, Graham and Solomon, Michael (2022). Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy. Diseases of the Colon & Rectum, 65 (11), 1335-1341. doi: 10.1097/dcr.0000000000002376

Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy

2022

Journal Article

Surgical management and long‐term functional outcomes after anastomotic leak in patients undergoing minimally invasive restorative rectal resection and without a diverting ileostomy

McGiffin, Tony, Clark, David A., Edmundson, Aleks, Steffens, Daniel, Stevenson, Andrew and Solomon, Michael (2022). Surgical management and long‐term functional outcomes after anastomotic leak in patients undergoing minimally invasive restorative rectal resection and without a diverting ileostomy. ANZ Journal of Surgery, 92 (4), 806-812. doi: 10.1111/ans.17475

Surgical management and long‐term functional outcomes after anastomotic leak in patients undergoing minimally invasive restorative rectal resection and without a diverting ileostomy

2022

Journal Article

Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response

Zaborowski, Alexandra M., Abdile, Ahmed, Adamina, Michel, Aigner, Felix, D'Allens, Laura, Allmer, Caterina, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D., Buchwald, Pamela, Burger, Jacobus W. A., Burlov, Nikita, Campanelli, Michela ... Winter, Des C. (2022). Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response. British Journal of Surgery, 109 (3), 251-255. doi: 10.1093/bjs/znab437

Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response

2022

Journal Article

Ileal Crohn's disease fistulating into a Meckel's diverticulum

Zammit, Andrew Philip, Miller, Gregory, Satchwell, Joshua and Clark, David (2022). Ileal Crohn's disease fistulating into a Meckel's diverticulum. ANZ Journal of Surgery, 92 (11), 3103-3104. doi: 10.1111/ans.17572

Ileal Crohn's disease fistulating into a Meckel's diverticulum

2022

Journal Article

The National Aeronautics and Space Administration-task load index: NASA-TLX: evaluation of its use in surgery

Bell, Stephen W., Kong, Joseph C. H., Clark, David A., Carne, Peter, Skinner, Stewart, Pillinger, Stephen, Burton, Paul and Brown, Wendy (2022). The National Aeronautics and Space Administration-task load index: NASA-TLX: evaluation of its use in surgery. ANZ Journal of Surgery, 92 (11), 3022-3028. doi: 10.1111/ans.17830

The National Aeronautics and Space Administration-task load index: NASA-TLX: evaluation of its use in surgery

2022

Journal Article

Does an ileostomy cover the surgeon or the anastomosis?

Clark, David A., Stevenson, Andrew, Lumley, John, Petersen, Damien, Harris, Craig, Steffens, Daniel and Solomon, Michael (2022). Does an ileostomy cover the surgeon or the anastomosis?. ANZ Journal of Surgery, 92 (1-2), 19-20. doi: 10.1111/ans.17364

Does an ileostomy cover the surgeon or the anastomosis?

2021

Journal Article

Incisional hernia following ileostomy closure: who's at risk? The Gold Coast experience

Bloomfield, Ian, Dobson, Benjamin, Von Papen, Michael and Clark, David (2021). Incisional hernia following ileostomy closure: who's at risk? The Gold Coast experience. ANZ Journal of Surgery, 92 (1-2), 146-150. doi: 10.1111/ans.17359

Incisional hernia following ileostomy closure: who's at risk? The Gold Coast experience

2021

Journal Article

Geographical variation in the use of diverting loop ileostomy in Australia and New Zealand Colorectal Surgeons

Clark, David A., Stephensen, Bree, Edmundson, Aleksandra, Steffens, Daniel and Solomon, Michael (2021). Geographical variation in the use of diverting loop ileostomy in Australia and New Zealand Colorectal Surgeons. Annals of Coloproctology, 37 (5), 337-345. doi: 10.3393/ac.2020.09.14.1

Geographical variation in the use of diverting loop ileostomy in Australia and New Zealand Colorectal Surgeons

2021

Journal Article

Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer

Cuda, Tahleesa J., He, Yaowu, Kryza, Thomas, Khan, Tashbib, Tse, Brian W., Sokolowski, Kamil A., Liu, Cheng, Lyons, Nicholas, Gough, Madeline, Snell, Cameron E., Wyld, David K., Rose, Stephen, Riddell, Andrew D., Stevenson, Andrew R. L., Thomas, Paul A., Clark, David A., Puttick, Simon and Hooper, John D. (2021). Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer. Contrast Media and Molecular Imaging, 2021 3153278, 3153278. doi: 10.1155/2021/3153278

Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer

2021

Journal Article

An umbrella systematic review of drain fluid analysis in colorectal surgery for the detection of anastomotic leak: not yet ready to translate research studies into clinical practice

Clark, David A, Steffens, Daniel and Solomon, Michael (2021). An umbrella systematic review of drain fluid analysis in colorectal surgery for the detection of anastomotic leak: not yet ready to translate research studies into clinical practice. Colorectal Disease, 23 (11) codi.15844, 2795-2805. doi: 10.1111/codi.15844

An umbrella systematic review of drain fluid analysis in colorectal surgery for the detection of anastomotic leak: not yet ready to translate research studies into clinical practice

2021

Journal Article

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review

Zaborowski, Alexandra M., Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d'Allens, Laura, Allmer, Caterina, Alvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D., Buchwald, Pamela ... REACCT Collaborative (2021). Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review. JAMA Surgery, 156 (9), 865-874. doi: 10.1001/jamasurg.2021.2380

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review

2021

Journal Article

Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase

Caycedo-Marulanda, Antonio, Nadeau, Kara, Verschoor, Chris P., Sands, Dana, Spinelli, Antonino, Ashamalla, Shady, Patel, Sunil V., Di Candido, Francesca, Mujukian, Angela, Zaghiyan, Karen, Stevenson, Grant, Wolthuis, Albert, Clark, David A., D’Hoore, Andre, Stevenson, Andrew and Wexner, Steven D. (2021). Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase. Surgery, 169 (4), 774-781. doi: 10.1016/j.surg.2020.10.018

Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase

2021

Journal Article

Palpable head on digital rectal examination: a rare case of uterine incarceration causing obstruction and perforation of an ileal pouch in mid‐term pregnancy

Mizumoto, Ryo, Moloney, Jayson and Clark, David (2021). Palpable head on digital rectal examination: a rare case of uterine incarceration causing obstruction and perforation of an ileal pouch in mid‐term pregnancy. ANZ Journal of Surgery, 91 (9) ans.16641, E629-E630. doi: 10.1111/ans.16641

Palpable head on digital rectal examination: a rare case of uterine incarceration causing obstruction and perforation of an ileal pouch in mid‐term pregnancy

2021

Journal Article

Reply to Gachabayov et al. ‘Consensus statement on TaTME: other thoughts’

Hompes, Roel, Adamina, Michel, Aigner, Felix, Araujo, Sergio, Arezzo, Alberto, Ashamalla, Shady, deBeche-Adams, Teresa, Bell, Stephen, Bemelman, Willem, Brown, Carl, Brunner, Walter, Buchs, Nicolas, Caycedo, Antonio, Chadi, Sami, Chan, Park Sung, Clark, David, Denost, Quentin, D'Hoore, André, Fearnhead, Nicola, Francis, Nader, de Graaf, Eelco, Hasegawa, Suguru, Hayes, Julian, Heriot, Alexander, Hompes, Roel, Houben, Bert, Ito, Masaaki, Katory, Mark, Kleijnen, Jos ... the TaTME Guidance Group representing the ESCP (European Society of Coloproctology), in collaboration with ASCRS (American Society of Colon, Rectum Surgeons) et al (2021). Reply to Gachabayov et al. ‘Consensus statement on TaTME: other thoughts’. Colorectal Disease, 23 (2), 553-555. doi: 10.1111/codi.15434

Reply to Gachabayov et al. ‘Consensus statement on TaTME: other thoughts’

2021

Journal Article

Transanal mesorectal excision: early outcomes in Australia and New Zealand

Lau, S., Kong, J., Bell, S., Heriot, A., Stevenson, A., Moloney, J., Hayes, J., Merrie, A., Eglinton, T., Guest, G., Clark, D. and Warrier, S. (2021). Transanal mesorectal excision: early outcomes in Australia and New Zealand. British Journal of Surgery, 108 (2), 214-219. doi: 10.1093/bjs/znaa098

Transanal mesorectal excision: early outcomes in Australia and New Zealand

2020

Journal Article

Return to work following laparoscopic-assisted resection or open resection for rectal cancer: findings from AlaCaRT—Australasian Laparoscopic Cancer of the Rectum Trial

Law, Chi Kin, Brewer, Kate, Brown, Chris, Wilson, Kate, Bailey, Lisa, Hague, Wendy, Simes, John R., Stevenson, Andrew, Solomon, Michael, Morton, Rachael L., Australasian Gastro-Intestinal Trials Group (AGITG) and Clark, David (Australasian Gastro-Intestinal Trials Group member) (2020). Return to work following laparoscopic-assisted resection or open resection for rectal cancer: findings from AlaCaRT—Australasian Laparoscopic Cancer of the Rectum Trial. Cancer Medicine, 10 (2), 552-562. doi: 10.1002/cam4.3623

Return to work following laparoscopic-assisted resection or open resection for rectal cancer: findings from AlaCaRT—Australasian Laparoscopic Cancer of the Rectum Trial

2020

Journal Article

Amylase quantification in the terminal Ileum following formation of an Ileostomy

Clark, D. A., Cuda, T., Pretorius, C., Edmundson, A., Solomon, M. and Riddell, A. D. (2020). Amylase quantification in the terminal Ileum following formation of an Ileostomy. Scientific Reports, 10 (1) 19368, 19368. doi: 10.1038/s41598-020-76349-y

Amylase quantification in the terminal Ileum following formation of an Ileostomy

2020

Journal Article

PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer

Cuda, Tahleesa J., Riddell, Andrew D., Liu, Cheng, Whitehall, Vicki L., Borowsky, Jennifer, Wyld, David K., Burge, Matthew E., Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas J. R., Rose, Stephen E., Clark, David A., Stevenson, Andrew R. L., Hooper, John D., Puttick, Simon and Thomas, Paul A. (2020). PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer. The Journal of Nuclear Medicine, 61 (11), 1576-1579. doi: 10.2967/jnumed.119.233312

PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer

2020

Journal Article

Argument for taTME

Lauder, Christopher and Clark, David (2020). Argument for taTME. Annals of Laparoscopic and Endoscopic Surgery, 5 44. doi: 10.21037/ales.2020.03.10

Argument for taTME

Supervision

Availability

Professor David Clark is:
Available for supervision

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Available projects

  • Ileostomy app to reduce readmission with dehydration

Supervision history

Current supervision

  • Doctor Philosophy

    Novel theranostic targets for metastatic colorectal cancer

    Associate Advisor

  • Doctor Philosophy

    Novel Theranostic Targets for Colorectal Cancer

    Associate Advisor

  • Doctor Philosophy

    Improving the management decisions for patients diagnosed with a colorectal malignant polyp

    Associate Advisor

  • Doctor Philosophy

    Reducing post-operative Crohn's disease recurrence

    Associate Advisor

    Other advisors: Associate Professor Jakob Begun, Dr Rabina Giri

  • Doctor Philosophy

    Improving the management decisions for patients diagnosed with a colorectal malignant polyp

    Associate Advisor

  • Doctor Philosophy

    Personalised Medicine for Colorectal Cancer

    Associate Advisor

    Other advisors: Honorary Professor Vicki Whitehall

  • Doctor Philosophy

    Improving Immunotherapy Efficacy for Colorectal Cancer

    Associate Advisor

    Other advisors: Honorary Professor Vicki Whitehall

Completed supervision

Media

Enquiries

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