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Dr Stephan Brouwer
Dr

Stephan Brouwer

Email: 
Phone: 
+61 7 344 36274

Overview

Background

Stephan Brouwer (ORCiD: 0000-0002-9777-2992) is a postdoctoral research fellow at the University of Queensland. With expertise in bacterial pathogenesis, encompassing both Gram-negative and Gram-positive human pathogens, his research explores the interaction between infectious disease agents and the human host. Much of his work focuses on understanding and preventing disease caused by the human pathogen Group A Streptococcus (GAS; Streptococcus pyogenes). He is at the forefront of the global effort to characterise a scarlet fever outbreak which began in North Asia in 2011, and his current research themes centre around the emergence of new hypervirulent GAS lineages that pose a major public health threat. Stephan utilises modern molecular technologies to study host-pathogen interactions and identify the genetic requirements for GAS to cause disease, with the aim to pursue the development of life-saving therapeutic and preventative advances. He has published his findings in Top Tier journals and helped to establish a sentinel hospital surveillance system in Australia to monitor the importation of GAS isolates causing epidemic scarlet fever.

Stephan completed his PhD in 2015 at one of Germany’s most respected research institutes, Helmholtz Centre for Infection Research (HZI), where he conducted research on post-transcriptional regulatory mechanisms in the human pathogen Pseudomonas aeruginosa. He then moved to Australia to join the group of Prof. Mark Walker at the Institute for Molecular Bioscience, University of Queensland, where he is working eversince.

Availability

Dr Stephan Brouwer is:
Available for supervision

Qualifications

  • Masters (Coursework) of Science, Berufsakademie Oldenburg
  • Doctor of Philosophy, Technische Universitat Braunschweig

Works

Search Professor Stephan Brouwer’s works on UQ eSpace

24 works between 2014 and 2024

21 - 24 of 24 works

2018

Journal Article

Scarlet fever makes a comeback

Walker, Mark J. and Brouwer, Stephan (2018). Scarlet fever makes a comeback. The Lancet Infectious Diseases, 18 (2), 128-129. doi: 10.1016/S1473-3099(17)30694-1

Scarlet fever makes a comeback

2018

Journal Article

The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes

Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17

The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes

2016

Journal Article

Streptococcus pyogenes adhesion and colonization

Brouwer, Stephan, Barnett, Timothy C., Rivera-Hernandez, Tania, Rohde, Manfred and Walker, Mark J. (2016). Streptococcus pyogenes adhesion and colonization. FEBS Letters, 590 (21), 3739-3757. doi: 10.1002/1873-3468.12254

Streptococcus pyogenes adhesion and colonization

2014

Journal Article

The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms

Brouwer, Stephan, Pustelny, Christian, Ritter, Christiane, Klinkert, Birgit, Narberhaus, Franz and Häussler, Susanne (2014). The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms. Journal of Bacteriology, 196 (23), 4163-4171. doi: 10.1128/JB.02000-14

The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms

Funding

Current funding

  • 2023 - 2025
    Characterising a novel toxin regulatory mechanism from the new hypervirulent Streptococcal pyogenes M1uk lineage in Australia (NHMRC Ideas Grant administered by University of Wollongong).
    University of Wollongong
    Open grant

Supervision

Availability

Dr Stephan Brouwer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Associate Advisor

    Other advisors: Professor Mark Walker

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Associate Advisor

    Other advisors: Professor Mark Walker

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Associate Advisor

    Other advisors: Professor Kate Schroder, Professor Mark Walker

Media

Enquiries

For media enquiries about Dr Stephan Brouwer's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au