
Overview
Background
Stephan Brouwer (ORCiD: 0000-0002-9777-2992) is a postdoctoral research fellow at the University of Queensland. With expertise in bacterial pathogenesis, encompassing both Gram-negative and Gram-positive human pathogens, his research explores the interaction between infectious disease agents and the human host. Much of his work focuses on understanding and preventing disease caused by the human pathogen Group A Streptococcus (GAS; Streptococcus pyogenes). He is at the forefront of the global effort to characterise a scarlet fever outbreak which began in North Asia in 2011, and his current research themes centre around the emergence of new hypervirulent GAS lineages that pose a major public health threat. Stephan utilises modern molecular technologies to study host-pathogen interactions and identify the genetic requirements for GAS to cause disease, with the aim to pursue the development of life-saving therapeutic and preventative advances. He has published his findings in Top Tier journals and helped to establish a sentinel hospital surveillance system in Australia to monitor the importation of GAS isolates causing epidemic scarlet fever.
Stephan completed his PhD in 2015 at one of Germany’s most respected research institutes, Helmholtz Centre for Infection Research (HZI), where he conducted research on post-transcriptional regulatory mechanisms in the human pathogen Pseudomonas aeruginosa. He then moved to Australia to join the group of Prof. Mark Walker at the Institute for Molecular Bioscience, University of Queensland, where he is working eversince.
Availability
- Dr Stephan Brouwer is:
- Available for supervision
Qualifications
- Masters (Coursework) of Science, Berufsakademie Oldenburg
- Doctor of Philosophy, Technische Universitat Braunschweig
Works
Search Professor Stephan Brouwer’s works on UQ eSpace
2019
Journal Article
Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells
De Oliveira, David M. P., Everest-Dass, Arun, Hartley-Tassell, Lauren, Day, Christopher J., Indraratna, Anuk, Brouwer, Stephan, Cleary, Ailish, Kautto, Liisa, Gorman, Jody, Packer, Nicolle H., Jennings, Michael P., Walker, Mark J. and Sanderson-Smith, Martina L. (2019). Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells. FASEB Journal, 33 (10), 10808-10818. doi: 10.1096/fj.201900559R
2019
Journal Article
The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections
Brouwer, Stephan and Walker, Mark J. (2019). The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections. American Journal of Pathology, 189 (10), 1913-1915. doi: 10.1016/j.ajpath.2019.07.005
2019
Journal Article
Detection of epidemic scarlet fever group A Streptococcus in Australia
Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099
2018
Journal Article
Scarlet fever makes a comeback
Walker, Mark J. and Brouwer, Stephan (2018). Scarlet fever makes a comeback. The Lancet Infectious Diseases, 18 (2), 128-129. doi: 10.1016/S1473-3099(17)30694-1
2018
Journal Article
The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes
Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17
2016
Journal Article
Streptococcus pyogenes adhesion and colonization
Brouwer, Stephan, Barnett, Timothy C., Rivera-Hernandez, Tania, Rohde, Manfred and Walker, Mark J. (2016). Streptococcus pyogenes adhesion and colonization. FEBS Letters, 590 (21), 3739-3757. doi: 10.1002/1873-3468.12254
2014
Journal Article
The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms
Brouwer, Stephan, Pustelny, Christian, Ritter, Christiane, Klinkert, Birgit, Narberhaus, Franz and Häussler, Susanne (2014). The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA isoforms. Journal of Bacteriology, 196 (23), 4163-4171. doi: 10.1128/JB.02000-14
Funding
Current funding
Supervision
Availability
- Dr Stephan Brouwer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism
Associate Advisor
Other advisors: Professor Kate Schroder, Professor Mark Walker
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Doctor Philosophy
Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation
Associate Advisor
Other advisors: Professor Mark Walker
-
Doctor Philosophy
The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK
Associate Advisor
Other advisors: Professor Mark Walker
Media
Enquiries
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