
Overview
Background
Stephan Brouwer (ORCiD: 0000-0002-9777-2992) is a postdoctoral research fellow at the University of Queensland. With expertise in bacterial pathogenesis, encompassing both Gram-negative and Gram-positive human pathogens, his research explores the interaction between infectious disease agents and the human host. Much of his work focuses on understanding and preventing disease caused by the human pathogen Group A Streptococcus (GAS; Streptococcus pyogenes). He is at the forefront of the global effort to characterise a scarlet fever outbreak which began in North Asia in 2011, and his current research themes centre around the emergence of new hypervirulent GAS lineages that pose a major public health threat. Stephan utilises modern molecular technologies to study host-pathogen interactions and identify the genetic requirements for GAS to cause disease, with the aim to pursue the development of life-saving therapeutic and preventative advances. He has published his findings in Top Tier journals and helped to establish a sentinel hospital surveillance system in Australia to monitor the importation of GAS isolates causing epidemic scarlet fever.
Stephan completed his PhD in 2015 at one of Germany’s most respected research institutes, Helmholtz Centre for Infection Research (HZI), where he conducted research on post-transcriptional regulatory mechanisms in the human pathogen Pseudomonas aeruginosa. He then moved to Australia to join the group of Prof. Mark Walker at the Institute for Molecular Bioscience, University of Queensland, where he is working eversince.
Availability
- Dr Stephan Brouwer is:
- Available for supervision
Qualifications
- Masters (Coursework) of Science, Berufsakademie Oldenburg
- Doctor of Philosophy, Technische Universitat Braunschweig
Works
Search Professor Stephan Brouwer’s works on UQ eSpace
2025
Journal Article
A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes
Brouwer, Stephan, Das, Swairindhree, Hayes, Andrew J., Bertolla, Olivia M., Davies, Mark R., Walker, Mark J., Whiley, David M., Irwin, Adam D. and Tickner, Jacob A. (2025). A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes. The Journal of Infectious Diseases, 231 (2), e375-e384. doi: 10.1093/infdis/jiae437
2025
Journal Article
Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1 UK lineage
Richter, Johanna, Cork, Amanda J., Ong, Yvette, Keller, Nadia, Hayes, Andrew J., Schembri, Mark A., Jennison, Amy V., Davies, Mark R., Schroder, Kate, Walker, Mark J. and Brouwer, Stephan (2025). Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1 UK lineage. mBio, 16 (2) e0336624, e0336624. doi: 10.1128/mbio.03366-24
2024
Journal Article
Clinical Snapshot of Group A Streptococcal Isolates from an Australian Tertiary Hospital
Shaw, Phoebe K., Hayes, Andrew J., Langton, Maree, Berkhout, Angela, Grimwood, Keith, Davies, Mark R., Walker, Mark J. and Brouwer, Stephan (2024). Clinical Snapshot of Group A Streptococcal Isolates from an Australian Tertiary Hospital. Pathogens, 13 (11) 956, 956. doi: 10.3390/pathogens13110956
2023
Journal Article
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
2023
Journal Article
Pathogenesis, epidemiology and control of Group A Streptococcus infection
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nature Reviews Microbiology, 21 (7), 431-447. doi: 10.1038/s41579-023-00865-7
2023
Journal Article
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4
2023
Journal Article
Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7)
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7). Nature Reviews Microbiology, 21 (9), 619-619. doi: 10.1038/s41579-023-00939-6
2022
Journal Article
Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion
Brouwer, Stephan, Jespersen, Magnus G., Ong, Cheryl-lynn Y., De Oliveira, David M. P., Keller, Bernhard, Cork, Amanda J., Djoko, Karrera Y., Davies, Mark R. and Walker, Mark J. (2022). Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion. mBio, 13 (3), e0067622. doi: 10.1128/mbio.00676-22
2022
Journal Article
Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria
De Oliveira, David M. P., Keller, Bernhard, Hayes, Andrew J., Ong, Cheryl-Lynn Y., Harbison-Price, Nichaela, El-Deeb, Ibrahim M., Li, Gen, Keller, Nadia, Bohlmann, Lisa, Brouwer, Stephan, Turner, Andrew G., Cork, Amanda J., Jones, Thomas R., Paterson, David L., McEwan, Alastair G., Davies, Mark R., McDevitt, Christopher A., Itzstein, Mark von and Walker, Mark J. (2022). Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria. Antibiotics, 11 (4) 449, 449. doi: 10.3390/antibiotics11040449
2022
Journal Article
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection
De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21
2021
Journal Article
Streptococcal superantigens and the return of scarlet fever
Hurst, Jacklyn R., Brouwer, Stephan, Walker, Mark J. and McCormick, John K. (2021). Streptococcal superantigens and the return of scarlet fever. PLOS Pathogens, 17 (12) e1010097, e1010097. doi: 10.1371/journal.ppat.1010097
2021
Journal Article
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection
Richter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499
2021
Journal Article
Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease
Richter, Johanna, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease. Cellular Microbiology, 23 (9) e13373, 1-9. doi: 10.1111/cmi.13373
2020
Journal Article
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M. P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nature Communications, 11 (1) 5018, 5018. doi: 10.1038/s41467-020-18700-5
2020
Journal Article
Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes
Stewart, Louisa J., Ong, Cheryl-Lynn Y., Zhang, May M., Brouwer, Stephan, McIntyre, Liam, Davies, Mark R., Walker, Mark J., McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2020). Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio, 11 (6) e02804-20, 1-19. doi: 10.1128/mBio.02804-20
2020
Journal Article
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis
De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791
2020
Journal Article
All major cholesterol-dependent cytolysins use glycans as cellular receptors
Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926
2020
Other Outputs
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M.P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. doi: 10.1101/2020.05.17.095000
2020
Book Chapter
Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement
Barnett, Timothy C., Daw, Jessica N., Walker, Mark J. and Brouwer, Stephan (2020). Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement. Group A Streptococcus: methods and protocols. (pp. 59-69) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_5
2019
Journal Article
Scarlet fever changes its spots
Brouwer, Stephan, Lacey, Jake A., You, Yuanhai, Davies, Mark R. and Walker, Mark J. (2019). Scarlet fever changes its spots. Lancet Infectious Diseases, 19 (11), 1154-1155. doi: 10.1016/S1473-3099(19)30494-3
Funding
Current funding
Supervision
Availability
- Dr Stephan Brouwer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK
Associate Advisor
Other advisors: Professor Mark Walker
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Doctor Philosophy
Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism
Associate Advisor
Other advisors: Professor Kate Schroder, Professor Mark Walker
-
Doctor Philosophy
Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation
Associate Advisor
Other advisors: Professor Mark Walker
Media
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