Overview
Availability
- Professor Mark Walker is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Mark Walker’s works on UQ eSpace
2024
Journal Article
Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus
Lai, Chien-Yu, Xie, Jia-Xun, Lai, Meng-Chih, Wu, Zhao-Yi, Lin, Jr-Shiuan, Huang, Yu-Tsung, Chi, Chia-Yu, Chiang-Ni, Chuan, Walker, Mark J. and Chang, Yung-Chi (2024). Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus. npj Vaccines, 9 (1) 46. doi: 10.1038/s41541-024-00839-7
2024
Journal Article
M proteins of group A <i>Streptococcus</i> bind hyaluronic acid via arginine–arginine/serine–arginine motifs
McEwan, Tahnee B.‐D., De Oliveira, David M. P., Stares, Emily K., Hartley‐Tassell, Lauren E., Day, Christopher J., Proctor, Emma‐Jayne, Nizet, Victor, Walker, Mark J., Jennings, Michael P., Sluyter, Ronald and Sanderson‐Smith, Martina L. (2024). M proteins of group A Streptococcus bind hyaluronic acid via arginine–arginine/serine–arginine motifs. The FASEB Journal, 38 (20) e70123, e70123. doi: 10.1096/fj.202401301r
2024
Journal Article
A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes
Brouwer, Stephan, Das, Swairindhree, Hayes, Andrew J., Bertolla, Olivia M., Davies, Mark R., Walker, Mark J., Whiley, David M., Irwin, Adam D. and Tickner, Jacob A. (2024). A rapid molecular detection tool for toxigenic M1UK Streptococcus pyogenes. The Journal of Infectious Diseases. doi: 10.1093/infdis/jiae437
2024
Journal Article
Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model
Rivera-Hernandez, Tania, Carnathan, Diane G., Richter, Johanna, Marchant, Patrick, Cork, Amanda J., Elangovan, Gayathiri, Henningham, Anna, Cole, Jason N., Choudhury, Biswa, Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., Good, Michael F., Agarwal, Paresh, Kapoor, Neeraj, Nizet, Victor, Silvestri, Guido and Walker, Mark J. (2024). Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model. Vaccines, 12 (4) 382, 382. doi: 10.3390/vaccines12040382
2024
Journal Article
Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis
Xie, Ouli, Morris, Jacqueline M., Hayes, Andrew J., Towers, Rebecca J., Jespersen, Magnus G., Lees, John A., Ben Zakour, Nouri L., Berking, Olga, Baines, Sarah L., Carter, Glen P., Tonkin-Hill, Gerry, Schrieber, Layla, McIntyre, Liam, Lacey, Jake A., James, Taylah B., Sriprakash, Kadaba S., Beatson, Scott A., Hasegawa, Tadao, Giffard, Phil, Steer, Andrew C., Batzloff, Michael R., Beall, Bernard W., Pinho, Marcos D., Ramirez, Mario, Bessen, Debra E., Dougan, Gordon, Bentley, Stephen D., Walker, Mark J., Currie, Bart J. ... Davies, Mark R. (2024). Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis. Nature Communications, 15 (1) 2286, 1-14. doi: 10.1038/s41467-024-46530-2
2023
Journal Article
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
2023
Journal Article
Pathogenesis, epidemiology and control of Group A Streptococcus infection
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nature Reviews Microbiology, 21 (7), 431-447. doi: 10.1038/s41579-023-00865-7
2023
Journal Article
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4
2023
Journal Article
Streptolysin O deficiency in Streptococcus pyogenes M1T1 covR/S mutant strain attenuates virulence in In Vitro and In Vivo infection models
Langshaw, Emma L., Reynolds, Simone, Ozberk, Victoria, Dooley, Jessica, Calcutt, Ainslie, Zaman, Mehfuz, Walker, Mark J., Batzloff, Michael R., Davies, Mark R., Good, Michael F. and Pandey, Manisha (2023). Streptolysin O deficiency in Streptococcus pyogenes M1T1 covR/S mutant strain attenuates virulence in In Vitro and In Vivo infection models. mBio, 14 (1) e03488-22, e0348822. doi: 10.1128/mbio.03488-22
2023
Journal Article
Promiscuous evolution of Group A Streptococcal M and M-like proteins
Frost, Hannah R., Guglielmini, Julien, Duchêne, Sebastian, Lacey, Jake A., Sanderson-Smith, Martina, Steer, Andrew C., Walker, Mark J., Botteaux, Anne, Davies, Mark R. and Smeesters, Pierre R. (2023). Promiscuous evolution of Group A Streptococcal M and M-like proteins. Microbiology, 169 (1) 001280, 1-10. doi: 10.1099/mic.0.001280
2023
Journal Article
Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7)
Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7). Nature Reviews Microbiology, 21 (9), 619-619. doi: 10.1038/s41579-023-00939-6
2022
Journal Article
Vancomycin resistance in Enterococcus and Staphylococcus aureus
Li, Gen, Walker, Mark J. and De Oliveira, David M. P. (2022). Vancomycin resistance in Enterococcus and Staphylococcus aureus. Microorganisms, 11 (1) 24, 1-51. doi: 10.3390/microorganisms11010024
2022
Journal Article
Repurposing the ionophore, PBT2, for treatment of multidrug-resistant Neisseria gonorrhoeae infections
Jen, Freda E-C, Edwards, Jennifer L., El-Deeb, Ibrahim M., Walker, Mark J., von Itzstein, Mark and Jennings, Michael P. (2022). Repurposing the ionophore, PBT2, for treatment of multidrug-resistant Neisseria gonorrhoeae infections. Antimicrobial Agents and Chemotherapy, 66 (9), 1-4. doi: 10.1128/aac.02318-21
2022
Journal Article
Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion
Brouwer, Stephan, Jespersen, Magnus G., Ong, Cheryl-lynn Y., De Oliveira, David M. P., Keller, Bernhard, Cork, Amanda J., Djoko, Karrera Y., Davies, Mark R. and Walker, Mark J. (2022). Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion. mBio, 13 (3), e0067622. doi: 10.1128/mbio.00676-22
2022
Journal Article
Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria
De Oliveira, David M. P., Keller, Bernhard, Hayes, Andrew J., Ong, Cheryl-Lynn Y., Harbison-Price, Nichaela, El-Deeb, Ibrahim M., Li, Gen, Keller, Nadia, Bohlmann, Lisa, Brouwer, Stephan, Turner, Andrew G., Cork, Amanda J., Jones, Thomas R., Paterson, David L., McEwan, Alastair G., Davies, Mark R., McDevitt, Christopher A., Itzstein, Mark von and Walker, Mark J. (2022). Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria. Antibiotics, 11 (4) 449, 449. doi: 10.3390/antibiotics11040449
2022
Journal Article
An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii
De Oliveira, David M.P. and Walker, Mark J. (2022). An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii. Microbial Cell, 9 (3), 69-71. doi: 10.15698/MIC2022.03.772
2022
Journal Article
The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection
Li, Gen, De Oliveira, David M.P. and Walker, Mark J. (2022). The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection. Journal of Inorganic Biochemistry, 227 111661, 111661. doi: 10.1016/j.jinorgbio.2021.111661
2022
Journal Article
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection
De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21
2022
Journal Article
Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W. and McDevitt, Christopher A. (2022). Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model. Cell Reports, 38 (2) 110202, 1-18. doi: 10.1016/j.celrep.2021.110202
2021
Journal Article
Streptococcal superantigens and the return of scarlet fever
Hurst, Jacklyn R., Brouwer, Stephan, Walker, Mark J. and McCormick, John K. (2021). Streptococcal superantigens and the return of scarlet fever. PLOS Pathogens, 17 (12) e1010097, e1010097. doi: 10.1371/journal.ppat.1010097
Funding
Current funding
Past funding
Supervision
Availability
- Professor Mark Walker is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
Principal Advisor
Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price
-
Doctor Philosophy
Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism
Principal Advisor
Other advisors: Professor Kate Schroder, Dr Stephan Brouwer
-
Doctor Philosophy
Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation
Principal Advisor
Other advisors: Dr Stephan Brouwer
-
Doctor Philosophy
Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira
-
Doctor Philosophy
Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens
Principal Advisor
Other advisors: Dr David De Oliveira
-
Doctor Philosophy
The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK
Principal Advisor
Other advisors: Dr Stephan Brouwer
-
Doctor Philosophy
Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
Associate Advisor
Other advisors: Professor Gabrielle Belz
-
Doctor Philosophy
Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model
Associate Advisor
Other advisors: Dr Suzanne Parker, Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith
Completed supervision
-
2023
Doctor Philosophy
Characterisation of the interaction of M1 Group A Streptococcus with the inflammasome pathway
Principal Advisor
Other advisors: Professor Kate Schroder
-
2018
Doctor Philosophy
The Group A Streptococcus M1T1 clone post-transcriptionally modifies innate immune signalling to promote infection
Principal Advisor
Other advisors: Professor Matt Sweet
-
2018
Doctor Philosophy
Investigation of metal stress response and regulation in Group A Streptococcus
Principal Advisor
Other advisors: Professor Matt Sweet
-
2017
Doctor Philosophy
Understanding the role of caveolae in the uptake process of Streptococcus pyogenes into non-phagocytic host cells
Principal Advisor
Other advisors: Professor Robert Parton
-
2012
Doctor Philosophy
Evolution of group A streptococci: impact on virulence capacity
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2022
Doctor Philosophy
Disseminated Tuberculosis; Defining Pathogen Encoded Mechanisms
Associate Advisor
Other advisors: Professor Nicholas West
-
2022
Doctor Philosophy
A bitter taste in your heart: the role of T2Rs in cardiovascular physiology and pathophysiology
Associate Advisor
Other advisors: Professor Mark Schembri, Professor Wally Thomas
-
2020
Doctor Philosophy
Site-specific Bioconjugation of Toll-like Receptor Ligands onto Folded Recombinant Protein Antigens Using Enzyme-mediated Ligation
Associate Advisor
Other advisors: Associate Professor Peter Moyle
-
2019
Doctor Philosophy
A pan genome reverse vaccinology approach to prevent Streptococcus agalactiae infection in farmed tilapia
Associate Advisor
Other advisors: Professor Andrew Barnes
-
2016
Doctor Philosophy
Evolution of Streptococcus iniae after vaccination and molecular underpinnings of capsular antigenicity
Associate Advisor
Other advisors: Professor Andrew Barnes
Media
Enquiries
Contact Professor Mark Walker directly for media enquiries about:
- Cellulitis
- Disease
- Impetigo
- Invasive disease
- Pharyngitis
- Scarlet fever
- Skin infections
- Streptococcal toxic shock syndrome
- Streptococcus
- Toxic shock syndrome
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: