Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Not available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Group A streptococcus pathogenesis and vaccine development

    Prof. Walker's research focuses on the mechanism by which group A streptococcus causes disease outbreaks and the development of a vaccine to prevent group A streptococcus infection and disease.

Search Professor Mark Walker’s works on UQ eSpace

260 works between 1987 and 2026
All (260) Journal Article (244) Conference Publication (10) Book Chapter (6)

241 - 260 of 260 works

1996

Journal Article

Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica

McMillan, DJ, Shojaei, M, Chhatwal, GS, Guzman, CA and Walker, MJ (1996). Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica. Microbial Pathogenesis, 21 (5), 379-394. doi: 10.1006/mpat.1996.0069

Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica

1996

Journal Article

Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates

Partridge, Sally R., Baker, Mark S., Walker, Mark J. and Wilson, Mark R. (1996). Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates. Infection and Immunity, 64 (10), 4324-4329. doi: 10.1128/IAI.64.10.4324-4329.1996

Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates

1996

Journal Article

Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique

Smith, AM and Walker, MJ (1996). Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique. Microbial Pathogenesis, 20 (5), 263-273. doi: 10.1006/mpat.1996.0025

Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique

1996

Journal Article

Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia

Fagan, Peter K., Djordjevic, Steven P., Eamens, Graeme J., Chin, James and Walker, Mark J. (1996). Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia. Infection and Immunity, 64 (3), 1060-1064. doi: 10.1128/IAI.64.3.1060-1064.1996

Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia

1996

Journal Article

Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase

Southan, MD, Truscott, RJW, Jamie, JF, Pelosi, L, Walker, MJ, Maeda, H, Iwamoto, Y and Tone, S (1996). Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase. Medicinal Chemistry Research, 6 (5), 343-352.

Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase

1994

Journal Article

A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System

Guzman, CA, Piatti, G, Walker, MJ, Guardati, MC and Pruzzo, C (1994). A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System. Gene, 148 (1), 171-172. doi: 10.1016/0378-1119(94)90254-2

A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System

1994

Journal Article

Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant

Gohmann, S, Manning, PA, Alpert, CA, Walker, MJ and Timmis, KN (1994). Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant. Microbial Pathogenesis, 16 (1), 53-64. doi: 10.1006/mpat.1994.1005

Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant

1993

Journal Article

Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid

Guzman, Carlos A., Molinari, Gabriella, Fountain, Michael W., Rohde, Manfred, Timmis, Kenneth N. and Walker, Mark J. (1993). Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid. Infection and Immunity, 61 (2), 573-579. doi: 10.1128/IAI.61.2.573-579.1993

Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid

1993

Conference Publication

Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route

Guzman, CA, Timmis, KN and Walker, MJ (1993). Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route. NATO Advanced Research Workshop on Biology of Salmonella, Portorosa Italy, May 11-15, 1992. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.

Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route

1992

Journal Article

Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit

Walker, Mark J., Rohde, Manfred, Timmis, Kenneth N. and Guzman, Carlos A. (1992). Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit. Infection and Immunity, 60 (10), 4260-4268. doi: 10.1128/IAI.60.10.4260-4268.1992

Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit

1992

Journal Article

Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System

Guzman, CA, Walker, MJ, Rohde, M and Timmis, KN (1992). Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System. Microbial Pathogenesis, 12 (5), 383-389. doi: 10.1016/0882-4010(92)90101-S

Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System

1991

Journal Article

Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis

Guzman, Carlos A., Brownlie, Robert M., Kadurugamuwa, Jagath, Walker, Mark J. and Timmis, Kenneth N. (1991). Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis. Infection and Immunity, 59 (12), 4391-4397.

Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis

1991

Journal Article

Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica

Walker, Mark J., Rohde, Manfred, Wehland, Jurgen and Timmis, Kenneth N. (1991). Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica. Infection and Immunity, 59 (11), 4238-4248. doi: 10.1128/IAI.59.11.4238-4248.1991

Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica

1991

Journal Article

Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells

Walker, Mark J., Wehland, Jurgen, Timmis, Kenneth N., Raupach, Barbel and Schmidt, M. A. (1991). Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells. Infection and Immunity, 59 (11), 4249-4251. doi: 10.1128/IAI.59.11.4249-4251.1991

Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells

1991

Journal Article

Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa

Guzman, Carlos A., Walker, Mark J., Rohde, Manfred and Timmis, Kenneth N. (1991). Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa. Infection and Immunity, 59 (10), 3787-3795.

Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa

1991

Journal Article

Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals

Walker, Mark J., Guzman, Carlos A., Rohde, Manfred and Timmis, Kenneth N. (1991). Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals. Infection and Immunity, 59 (5), 1739-1746. doi: 10.1128/IAI.59.5.1739-1746.1991

Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals

1990

Journal Article

Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures

Walker, MJ, Rohde, M, Brownlie, RM and Timmis, KN (1990). Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures. Molecular Microbiology, 4 (1), 39-47. doi: 10.1111/j.1365-2958.1990.tb02013.x

Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures

1988

Journal Article

Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca

Walker, MJ, Birch, RG and Pemberton, JM (1988). Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca. Molecular Microbiology, 2 (4), 443-454. doi: 10.1111/j.1365-2958.1988.tb00050.x

Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca

1988

Journal Article

Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria

Walker, MJ and Pemberton, JM (1988). Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria. Current Microbiology, 17 (2), 69-75. doi: 10.1007/BF01568788

Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria

1987

Journal Article

Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca

Walker, MJ and Pemberton, JM (1987). Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca. Archives of Microbiology, 146 (4), 390-395. doi: 10.1007/BF00410941

Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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