Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

250 works between 1987 and 2025
All (250) Journal Article (236) Book Chapter (6) Conference Publication (7) Other Outputs (1)

201 - 220 of 250 works

2003

Journal Article

Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

Littlejohn, TK, Takikawa, O, Truscott, RJW and Walker, MJ (2003). Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. Journal of Biological Chemistry, 278 (32), 29525-29531. doi: 10.1074/jbc.M301700200

Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

2003

Journal Article

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes

Brett, K. N., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes. Journal of Clinical Microbiology, 41 (6), 2716-2722. doi: 10.1128/JCM.41.6.2716-2722.2003

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes

2003

Journal Article

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

2003

Journal Article

stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle

Brett, K. N., Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle. Journal of Clinical Microbiology, 41 (3), 926-936. doi: 10.1128/JCM.41.3.926-936.2003

stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle

2003

Conference Publication

Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea

Wu, X. Y., Chapman, T., Gordon, D., Do, N. T., Driesen, S., Walker, M. and Chin, J. (2003). Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea. The Ninth Biennial Conference of the Australasian Pig Science Association, Fremantle, WA, 23 - 26 Nov 2003. Werribee, Victoria: Australian Pig Science Association.

Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea

2003

Conference Publication

Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE)

Wu, X.Y., Chapman, T., Tan, M.K., Trott, D. J., Walker, M. and Chin, J. (2003). Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE). Australasian Pig Science Assoc (Inc) Conference, Fremantle, WA, 23-26 November 2003. Fremantle, WA: Australasian Pig Science Assoc..

Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE)

2002

Journal Article

Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis

Littlejohn, Tamantha K., Takikawa, Osamu, Jamie, Joanne F., Walker, Mark J. and Truscott, Roger J.W (2002). Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis. International Congress Series, 1233 (C), 157-160. doi: 10.1016/S0531-5131(02)00312-6

Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis

2002

Journal Article

Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci

Erdogan, Sezgin, Fagan, Peter K., Talay, Susanne R., Rohde, Manfred, Ferrieri, Patricia, Flores, Aurea E., Guzman, Carlos A., Walker, Mark J. and Chhatwal, Gursharan S. (2002). Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci. Infection and Immunity, 70 (2), 803-811. doi: 10.1128/IAI.70.2.803-811.2002

Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci

2002

Journal Article

Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia

Delvecchio, A., Currie, B. J., McArthur, J. D., Walker, M. J. and Sriprakash, K. S. (2002). Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia. Epidemiology and Infection, 128 (3), 391-396. doi: 10.1017/S0950268802006787

Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia

2002

Journal Article

Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor

Gillen, Christine M., Towers, Rebecca J., McMillan, David J., Delvecchio, Armando, Sriprakash, Kadaba S., Currie, Bart, Kreikemeyer, Berndt, Chhatwal, Gurusharan S. and Walker, Mark J. (2002). Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor. Microbiology, 148 (1), 169-178. doi: 10.1099/00221287-148-1-169

Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor

2001

Journal Article

The virulence factors of Bordetella pertussis: a matter of control

Smith, AM, Guzman, CA and Walker, MJ (2001). The virulence factors of Bordetella pertussis: a matter of control. Fems Microbiology Reviews, 25 (3), 309-333. doi: 10.1111/j.1574-6976.2001.tb00580.x

The virulence factors of Bordetella pertussis: a matter of control

2001

Journal Article

The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type

Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2001). The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. Journal of Clinical Microbiology, 39 (5), 1932-1937. doi: 10.1128/JCM.39.5.1932-1937.2001

The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type

2001

Journal Article

Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs

Fagan, PK, Walker, MJ, Chin, J, Eamens, GJ and Djordjevic, SP (2001). Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs. Microbial Pathogenesis, 30 (2), 101-110. doi: 10.1006/mpat.2000.0412

Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs

2000

Conference Publication

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract

Takikawa, O., Littlejohn, T., Jamie, J. F., Walker, M. J. and Truscott, R. J.W. (2000). Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract.

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract

2000

Journal Article

Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli

Smith, AM, Yan, H, Groves, N, Dalla Pozza, T and Walker, MJ (2000). Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli. Fems Microbiology Letters, 191 (2), 177-182. doi: 10.1016/S0378-1097(00)00386-4

Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli

2000

Journal Article

Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence

West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A. and Walker, Mark J. (2000). Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infection and Immunity, 68 (8), 4673-4680. doi: 10.1128/IAI.68.8.4673-4680.2000

Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence

2000

Journal Article

Expression and purification of recombinant human indoleamine 2,3-dioxygenase

Littlejohn, TK, Takikawa, O, Skylas, D, Jamie, JF, Walker, MJ and Truscott, RJW (2000). Expression and purification of recombinant human indoleamine 2,3-dioxygenase. Protein Expression and Purification, 19 (1), 22-29. doi: 10.1006/prep.2000.1214

Expression and purification of recombinant human indoleamine 2,3-dioxygenase

1999

Journal Article

Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

McMillan, DJ, Medina, E, Guzman, CA and Walker, MJ (1999). Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract. Fems Microbiology Letters, 178 (1), 7-11. doi: 10.1111/j.1574-6968.1999.tb13752.x

Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

1999

Journal Article

Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae

San Gil, F, Turner, B, Walker, MJ, Djordjevic, SP and Chin, JC (1999). Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae. Microbiology-Uk, 145 (9), 2595-2603. doi: 10.1099/00221287-145-9-2595

Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae

1998

Journal Article

A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence

Jungnitz, Heidrun, West, Nicholas P., Walker, Mark J., Chhatwal, Gursharan S. and Guzman, Carlos A. (1998). A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence. Infection and Immunity, 66 (10), 4640-4650.

A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2025
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2025
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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