Overview
Background
Dr Andy Kuo is a Senior Research Officer and Centre Manager at the Centre for Integrated Preclinical Drug Development (CIPDD), a Tier 2 Infrastructure Centre located in the School of Biomedical Sciences at UQ. With expertise in preclinical translational research, in the last ten years Dr Kuo in the role of Study Director, has managed the conduct of numerous R&D contract-funded and collaborative research grant-funded studies that are/have been undertaken in accordance with the requirements of CIPDD’s electronic Quality Management System (eQMS), which is rare in Australia.
To date he has successfully conducted/managed over 60 research projects, conducted in accordance with the requirements of CIPDD’s eQMS framework. His extensive experience encompasses experimental procedures and the management of preclinical studies, particularly in the areas of animal model development/validation, pharmacodynamic readouts, pharmacokinetics, and toxicology.
Despite the demands of working in an NCRIS (National Collaborative Research Infrastructure Strategy)-funded National Centre that is a key partner in Therapeutic Innovation Australia’s (TIA) Small Molecule Therapeutics Capability focused on IP-sensitive research, he has sustained a robust publication record, with 32 publications and 2 book chapters. Additionally, he has submitted 46 commercial-in-confidence study reports to industry and academic collaborators contributing significantly to the field of novel therapeutics innovation.
Availability
- Dr Andy Kuo is:
- Available for supervision
Works
Search Professor Andy Kuo’s works on UQ eSpace
2024
Journal Article
J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine
Kuo, A., Imam, M. Z., Li, R., Lin, L., Raboczyj, A., Bohmer, A. E., Nicholson, J. R., Corradini, L. and Smith, M. T. (2024). J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine. Frontiers in Pharmacology, 15 1346801. doi: 10.3389/fphar.2024.1346801
2023
Journal Article
seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation
Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333
2023
Journal Article
In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes
Imam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6
2023
Journal Article
Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695
2023
Journal Article
CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. Pharmacological Reports, 75 (3), 634-646. doi: 10.1007/s43440-023-00446-8
2022
Journal Article
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915
2022
Book Chapter
Side effects of central analgesic drugs
Imam, M. Z., Kuo, A. and Smith, M. T. (2022). Side effects of central analgesic drugs. Drug discovery and evaluation: safety and pharmacokinetic assays. (pp. 1-24) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-73317-9_70-1
2021
Journal Article
Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy
Kuo, Andy, Corradini, Laura, Nicholson, Janet R. and Smith, Maree T. (2021). Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy. Biomolecules, 11 (7) 940, 1-17. doi: 10.3390/biom11070940
2021
Journal Article
Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402
2020
Journal Article
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
2020
Journal Article
Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain
Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8
2020
Journal Article
Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP)
Kuo, Andy, Lourdesamy, Jacintha, Nicholson, Janet R., Corradini, Laura and Maree, Smith T. (2020). Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). Clinical and Experimental Pharmacology and Physiology, 47 (12) 1440-1681.13383, 1912-1922. doi: 10.1111/1440-1681.13383
2020
Journal Article
In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile
Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947
2020
Journal Article
Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918
2020
Journal Article
Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants
Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1
2019
Journal Article
Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain
Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165
2019
Journal Article
J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056
2019
Journal Article
Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods
Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology, 27 (2), 387-396. doi: 10.1007/s10787-018-00551-8
2019
Journal Article
Cyclooctatetraene: a bioactive cubane paradigm complement
Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
2018
Journal Article
In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats
Kuo, Andy and Smith, Maree T. (2018). In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats. Clinical and Experimental Pharmacology & Physiology, 45 (10), 1056-1066. doi: 10.1111/1440-1681.12972
Supervision
Availability
- Dr Andy Kuo is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model
Associate Advisor
Other advisors: Professor Mark Walker, Dr Suzanne Parker, Dr David De Oliveira, Emeritus Professor Maree Smith
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Doctor Philosophy
A novel treatment for chronic pain
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Trent Woodruff, Dr Amanda Kijas, Dr Felicity Han
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Doctor Philosophy
Novel long-acting and orally delivered conotoxin-based peptides with both analgesic efficacy and disease modifying potential
Associate Advisor
Other advisors: Associate Professor Richard Clark, Emeritus Professor Maree Smith
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Doctor Philosophy
Discovery and Pharmacological Evaluation of Novel Analgesics for the Relief of Ross River Virus Induced Chronic Pain
Associate Advisor
Other advisors: Professor Kate Schroder, Emeritus Professor Maree Smith, Dr Mohammad Zafar Imam
Completed supervision
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2019
Doctor Philosophy
Analgesic efficacy of novel opioid compounds relative to adverse effects in rats
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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2019
Doctor Philosophy
Chronic low back pain: pathobiological investigations towards improved treatments
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
-
2018
Doctor Philosophy
Establishment, optimization and characterization of a rat model of breast cancer induced bone pain
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Irina Vetter
Media
Enquiries
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