Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Not available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Group A streptococcus pathogenesis and vaccine development

    Prof. Walker's research focuses on the mechanism by which group A streptococcus causes disease outbreaks and the development of a vaccine to prevent group A streptococcus infection and disease.

Search Professor Mark Walker’s works on UQ eSpace

260 works between 1987 and 2026
All (260) Journal Article (244) Conference Publication (10) Book Chapter (6)

181 - 200 of 260 works

2008

Journal Article

Human pathogenic streptococcal proteomics and vaccine development

Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008). Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 (3), 387-410. doi: 10.1002/prca.200780048

Human pathogenic streptococcal proteomics and vaccine development

2008

Journal Article

Isolation and solubilization of gram-positive bacterial cell wall-associated proteins

Cole, Jason N, Djordjevic, Steven P and Walker, Mark J (2008). Isolation and solubilization of gram-positive bacterial cell wall-associated proteins. Methods in molecular biology (Clifton, N.J.), 425, 295-311.

Isolation and solubilization of gram-positive bacterial cell wall-associated proteins

2007

Journal Article

Role of group A Streptococcus HtrA in the maturation of SpeB protease

Cole, Jason N., Aquilina, John A., Hains, Peter G., Henningham, Anna, Sriprakash, Kadaba S., Caparon, Michael G., Nizet, Victor, Kotb, Malak, Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2007). Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics, 7 (24), 4488-4498. doi: 10.1002/pmic.200700626

Role of group A Streptococcus HtrA in the maturation of SpeB protease

2007

Journal Article

Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation

Treweek, Teresa M., Ecroyd, Heath, Williams, Danielle M., Meehan, Sarah, Carver, John A. and Walker, Mark J. (2007). Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation. PLoS One, 2 (Article # e1046) e1046, e1046. doi: 10.1371/journal.pone.0001046

Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation

2007

Journal Article

New understanding of the group A Streptococcus pathogenesis cycle

Tart, Anne H., Walker, Mark J. and Musser, James M. (2007). New understanding of the group A Streptococcus pathogenesis cycle. Trends in Microbiology, 15 (7), 318-325. doi: 10.1016/j.tim.2007.05.001

New understanding of the group A Streptococcus pathogenesis cycle

2007

Journal Article

Characterization of mesophilic bacilli in faeces of feedlot cattle

Wu, X. -Y., Walker, M., Vanselow, B., Chao, R. -L. and Chin, J. (2007). Characterization of mesophilic bacilli in faeces of feedlot cattle. Journal of Applied Microbiology, 102 (3), 872-879. doi: 10.1111/j.1365-2672.2006.03106.x

Characterization of mesophilic bacilli in faeces of feedlot cattle

2007

Conference Publication

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

Sanderson-Smith, Martina L., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2007). The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues. Washington, DC, United States: American Society for Microbiology. doi: 10.1128/JB.01218-06

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

2007

Journal Article

Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs

Wu, Xi-Yang, Chapman, Toni, Trott, Darren J., Bettelheim, Karl, Do, Thuy N., Driesen, Steve, Walker, Mark J. and Chin, James (2007). Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs. Applied and Environmental Microbiology, 73 (1), 83-91. doi: 10.1128/AEM.00990-06

Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs

2007

Book Chapter

Gene expression and tagging of streptococcal proteins

Cole, J. N., Sanderson-Smith, M. L., Cork, A. J., Henningham, A., Conlan, F., Ranson, M., McArthur, J. D. and Walker, M. J. (2007). Gene expression and tagging of streptococcal proteins. Molecular Biology of Streptococci. (pp. 359-378) edited by Regine Hakenbeck and Singh Chhatwal. Norfold, United Kingdom: Horizon Bioscience.

Gene expression and tagging of streptococcal proteins

2006

Journal Article

Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence

Timmer, Anjuli M., Kristian, Sascha A., Datta, Vivekanand, Jeng, Arthur, Gillen, Christine M., Walker, Mark J., Beall, Bernard and Nizet, Victor (2006). Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Molecular Microbiology, 62 (1), 15-25. doi: 10.1111/j.1365-2958.2006.05337.x

Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence

2006

Journal Article

The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains

Sanderson-Smith, Martina L., Walker, Mark J. and Ranson, Marie (2006). The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains. Journal of Biological Chemistry, 281 (36), 25965-25971. doi: 10.1074/jbc.M603846200

The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains

2006

Journal Article

Trigger for group A streptococcal M1T1 invasive disease

Cole, Jason N., McArthur, Jason D., McKay, Fiona C., Sanderson-Smith, Martina L., Cork, Amanda J., Ranson, Marie, Rohde, Manfred, Itzek, Andreas, Sun, Hongmin, Ginsburg, David, Kotb, Malak, Nizet, Victor, Chhatwal, GS and Walker, Mark J. (2006). Trigger for group A streptococcal M1T1 invasive disease. FASEB Journal, 20 (10), E1139-E1145. doi: 10.1096/fj.06-5804fje

Trigger for group A streptococcal M1T1 invasive disease

2006

Journal Article

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

Poljak, Anne, Grant, Ross, Austin, Chris J. D., Jamie, Joanne F., Willows, Robert D., Takikawa, Osamu, Littlejohn, Tamantha K., Truscott, Roger J. W., Walker, Mark J., Sachdev, Perminder and Smythe, George A. (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450 (1), 9-19. doi: 10.1016/j.abb.2006.03.003

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

2006

Journal Article

P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells

Burnett, Tracey A., Dinkla, Katrin, Rohde, Manfred, Chhatwal, Gursharan S., Uphoff, Cord, Srivastava, Mukesh, Cordwell, Stuart J., Geary, Steven, Liao, Xiaofen, Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2006). P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells. Molecular Microbiology, 60 (3), 669-686. doi: 10.1111/j.1365-2958.2006.05139.x

P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells

2006

Journal Article

Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants

Sanderson-Smith, Martina, Batzloff, Michael, Sriprakash, Kabada S., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2006). Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants. Journal of Biological Chemistry, 281 (6), 3217-3226. doi: 10.1074/jbc.M508758200

Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants

2006

Journal Article

Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin

Jenkins, Cheryl, Wilton, Jody L., Minion, F. Chris, Falconer, Linda, Walker, Mark J. and Djordjevic, Steven P. (2006). Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin. Infection and Immunity, 74 (1), 481-487. doi: 10.1128/IAI.74.1.481-487.2006

Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin

2006

Journal Article

Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development

McArthur, Jason D. and Walker, Mark J. (2006). Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development. Molecular Microbiology, 59 (1), 1-4. doi: 10.1111/j.1365-2958.2005.04967.x

Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development

2006

Journal Article

Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance

Wu, Xi-Yang, Walker, Mark J., Hornitzky, Michael and Chin, James (2006). Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance. Journal of Microbiological Methods, 64 (1), 107-119. doi: 10.1016/j.mimet.2005.04.021

Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance

2005

Journal Article

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

Walker, Mark J., McArthur, Jason D., McKay, Fiona and Ranson, Marie (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor?. Trends in Microbiology, 13 (7), 308-313. doi: 10.1016/j.tim.2005.05.006

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

2005

Journal Article

Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

Cole, Jason N., Ramirez, Ruben D., Currie, Bart J., Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2005). Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus. Infection and Immunity, 73 (5), 3137-3146. doi: 10.1128/IAI.73.5.3137-3146.2005

Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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