Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

247 works between 1987 and 2025
All (247) Journal Article (234) Book Chapter (6) Conference Publication (7)

181 - 200 of 247 works

2006

Journal Article

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

Poljak, Anne, Grant, Ross, Austin, Chris J. D., Jamie, Joanne F., Willows, Robert D., Takikawa, Osamu, Littlejohn, Tamantha K., Truscott, Roger J. W., Walker, Mark J., Sachdev, Perminder and Smythe, George A. (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450 (1), 9-19. doi: 10.1016/j.abb.2006.03.003

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

2006

Journal Article

P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells

Burnett, Tracey A., Dinkla, Katrin, Rohde, Manfred, Chhatwal, Gursharan S., Uphoff, Cord, Srivastava, Mukesh, Cordwell, Stuart J., Geary, Steven, Liao, Xiaofen, Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2006). P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells. Molecular Microbiology, 60 (3), 669-686. doi: 10.1111/j.1365-2958.2006.05139.x

P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells

2006

Journal Article

Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants

Sanderson-Smith, Martina, Batzloff, Michael, Sriprakash, Kabada S., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2006). Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants. Journal of Biological Chemistry, 281 (6), 3217-3226. doi: 10.1074/jbc.M508758200

Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants

2006

Journal Article

Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance

Wu, Xi-Yang, Walker, Mark J., Hornitzky, Michael and Chin, James (2006). Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance. Journal of Microbiological Methods, 64 (1), 107-119. doi: 10.1016/j.mimet.2005.04.021

Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance

2006

Journal Article

Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin

Jenkins, Cheryl, Wilton, Jody L., Minion, F. Chris, Falconer, Linda, Walker, Mark J. and Djordjevic, Steven P. (2006). Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin. Infection and Immunity, 74 (1), 481-487. doi: 10.1128/IAI.74.1.481-487.2006

Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin

2006

Journal Article

Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development

McArthur, Jason D. and Walker, Mark J. (2006). Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development. Molecular Microbiology, 59 (1), 1-4. doi: 10.1111/j.1365-2958.2005.04967.x

Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development

2005

Journal Article

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

Walker, Mark J., McArthur, Jason D., McKay, Fiona and Ranson, Marie (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor?. Trends in Microbiology, 13 (7), 308-313. doi: 10.1016/j.tim.2005.05.006

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

2005

Journal Article

Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

Cole, Jason N., Ramirez, Ruben D., Currie, Bart J., Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2005). Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus. Infection and Immunity, 73 (5), 3137-3146. doi: 10.1128/IAI.73.5.3137-3146.2005

Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

2005

Journal Article

R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable

Treweek, Teresa M., Rekas, Agata, Lindner, Robyn A., Walker, Mark J., Aquilina, J. Andrew, Robinson, Carol V., Horwitz, Joseph, Perng, Ming Der, Quinlan, Roy A. and Carver, John A. (2005). R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable. FEBS Journal, 272 (3), 711-724. doi: 10.1111/j.1742-4658.2004.04507.x

R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable

2004

Journal Article

Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model

McArthur, J., Medina, E., Mueller, A., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S. and Walker, M. J. (2004). Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model. Infection and Immunity, 72 (12), 7342-7345. doi: 10.1128/IAI.72.12.7342-7345.2004

Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model

2004

Journal Article

Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes

Ramachandran, V., McArthur, J. D., Behm, C. E., Gutzeit, C., Dowton, M., Fagan, P. K., Towers, R., Currie, B., Sriprakash, K. S. and Walker, M. J. (2004). Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes. Journal of Bacteriology, 186 (22), 7601-7609. doi: 10.1128/JB.186.22.7601-7609.2004

Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes

2004

Journal Article

Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci

Towers, Rebecca J., Gal, Daniel, McMillan, David, Sriprakash, Kadaba S., Currie, Bart J., Walker, Mark J., Chhatwal, Gursharan S. and Fagan, Peter K. (2004). Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci. Journal of Clinical Microbiology, 42 (11), 5357-5361. doi: 10.1128/JCM.42.11.5357-5361.2004

Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci

2004

Journal Article

Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice

McArthur, J., Schulze, K., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S., Guzmán, C. A. and Walker, M. J. (2004). Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice. Indian Journal of Medical Research, Supplement, 119 (MAY), 115-120.

Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice

2004

Journal Article

Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection

McKay, Fiona C., McArthur, Jason D., Sanderson-Smith, Marina L., Gardam, Sandra, Currie, Bart J., Sriprakash, Kadaba S., Fagan, Peter K., Towers, Rebecca J., Batzloff, Michael R., Chhatwal, Gursharan S., Ranson, Marie and Walker, Mark J. (2004). Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity, 72 (1), 364-370. doi: 10.1128/IAI.72.1.364-370.2004

Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection

2003

Journal Article

Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure

Towers, R. J., Fagan, P. K., Talay, S. R., Currie, B. J., Sriprakash, K. S., Walker, M. J. and Chhatwal, G. S. (2003). Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure. Journal of Clinical Microbiology, 41 (12), 5398-5406. doi: 10.1128/JCM.41.12.5398-5406.2003

Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure

2003

Journal Article

Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources

Ramachandran, V., Brett, K., Hornitzky, M. A., Dowton, M., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources. Journal of Clinical Microbiology, 41 (11), 5022-5032. doi: 10.1128/JCM.41.11.5022-5032.2003

Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources

2003

Journal Article

The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement

Matic, JN, Wilton, JL, Towers, RJ, Scarman, AL, Minion, FC, Walker, MJ and Djordjevic, SP (2003). The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement. Gene, 319, 99-106. doi: 10.1016/S0378-1119(03)000798-4

The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement

2003

Journal Article

Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

Littlejohn, TK, Takikawa, O, Truscott, RJW and Walker, MJ (2003). Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. Journal of Biological Chemistry, 278 (32), 29525-29531. doi: 10.1074/jbc.M301700200

Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

2003

Journal Article

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes

Brett, K. N., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes. Journal of Clinical Microbiology, 41 (6), 2716-2722. doi: 10.1128/JCM.41.6.2716-2722.2003

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes

2003

Journal Article

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2025
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2025
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price

  • Doctor Philosophy

    Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au