Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Not available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Group A streptococcus pathogenesis and vaccine development

    Prof. Walker's research focuses on the mechanism by which group A streptococcus causes disease outbreaks and the development of a vaccine to prevent group A streptococcus infection and disease.

Search Professor Mark Walker’s works on UQ eSpace

260 works between 1987 and 2026
All (260) Journal Article (244) Conference Publication (10) Book Chapter (6)

161 - 180 of 260 works

2011

Journal Article

Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae

Seymour, Lisa M., Falconer, Linda, Deutscher, Ania T., Minion, F. Chris, Padula, Matthew P., Nicholas E. Dixon,, Djordjevic, Steven P. and Walker, Mark J. (2011). Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae. Journal of Biological Chemistry, 286 (12), 10097-10104. doi: 10.1074/jbc.M110.208140

Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae

2011

Conference Publication

How group A streptococcus alpha-enolase interacts with human plasmin(ogen)

Ericsson, Daniel, Cork, Amanda J., Valkov, Eugene, Stamp, Anna, Aquilina, Andrew, Walker, Mark J. and Kobe, Bostjan (2011). How group A streptococcus alpha-enolase interacts with human plasmin(ogen). CHESTER: INT UNION CRYSTALLOGRAPHY. doi: 10.1107/S010876731109221X

How group A streptococcus alpha-enolase interacts with human plasmin(ogen)

2010

Journal Article

A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin

Treweek, TM, Rekas, A, Walker, MJ and Carver, JA (2010). A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin. Experimental Eye Research, 91 (5), 691-699. doi: 10.1016/j.exer.2010.08.015

A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin

2010

Journal Article

A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia

Seymour, Lisa M., Deutscher, Ania T., Jenkins, Cheryl, Kuit, Tracey A., Falconer, Linda, Minion, F. Chris, Crossett, Ben, Padula, Matthew, Dixon, Nicholas E., Djordjevic, Steven P. and Walker, Mark J. (2010). A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia. Journal of Biological Chemistry, 285 (44), 33971-33978. doi: 10.1074/jbc.M110.104463

A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia

2010

Journal Article

Parameters governing invasive disease propensity of non-M1 serotype group A streptococci

Maamary, PG, Sanderson-Smith, ML, Aziz, RK, Hollands, A, Cole, JN, Mckay, FC, McArthur, JD, Kirk, JK, Cork, AJ, Keefe, RJ, Kansal, RG, Sun, H, Taylor, WL, Chhatwal, GS, Ginsburg, D, Nizet, V, Kotb, M and Walker, MJ (2010). Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. Journal of Innate Immunology, 2 (6), 596-606. doi: 10.1159/000317640

Parameters governing invasive disease propensity of non-M1 serotype group A streptococci

2010

Journal Article

Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia

Deutscher, Ania T., Jenkins, Cheryl, Minion, F. Chris, Seymour, Lisa M., Padula, Matthew P., Dixon, Nicholas E., Walker, Mark J. and Djordjevic, Steven P. (2010). Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia. Molecular Microbiology, 78 (2), 444-458. doi: 10.1111/j.1365-2958.2010.07345.x

Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia

2010

Journal Article

Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin

Dawes, Faye E., Kuzevski, Alexander, Bettelheim, Karl A., Hornitzky, Michael A., Djordjevic, Steven P. and Walker, Mark J. (2010). Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin. PLoS One, 5 (9) e12754, e12754-1-e12754-6. doi: 10.1371/journal.pone.0012754

Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin

2010

Journal Article

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus

Cole, JN, Pence, MA, von Kockritz-Blickwede, M, Hollands, A, Gallo, RL, Walker, MJ and Nizet, V (2010). M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus. mBio, 1 (4) e00191-10, e00191-10-1-e00191-10-8. doi: 10.1128/mBio.00191-10

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus

2010

Journal Article

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone

Hollands, Andrew, Pence, Morgan A., Timmer, Anjuli M., Osvath, Sarah R., Turnbull, Lynne, Whitchurch, Cynthia B., Walker, Mark J. and Nizet, Victor (2010). Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone. Journal of Infectious Diseases, 202 (1), 11-19. doi: 10.1086/653124

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone

2010

Journal Article

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM)

Figuera-Losada, M., Ranson, M., Sanderson-Smith, M.L., Walker, M. J., Castellino, F. J. and Prorok, M. (2010). Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). BBA - Proteins and Proteomics, 1804 (6), 1342-1349. doi: 10.1016/j.bbapap.2010.01.019

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM)

2010

Journal Article

Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence

Aziz, Ramy K., Kansal, Rita, Aronow, Bruce J., Taylor, William L., Rowe, Sarah L., Kubal, Michael, Chhatwal, Gursharan S., Walker, Mark J. and Kotb, Malak (2010). Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence. PLoS One, 5 (4) e9798, e9798. doi: 10.1371/journal.pone.0009798

Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence

2010

Journal Article

Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid

Venturini, C, Beatson, SA, Djordjevic, SP and Walker, MJ (2010). Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid. The FASEB Journal, 24 (4), 1160-1166. doi: 10.1096/fj.09-144972

Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid

2009

Journal Article

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

2009

Journal Article

Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium

Matic, Jake N., Terry, Tamsin D., Van Bockel, David, Maddocks, Tracy, Tinworth, David, Jennings, Michael P., Djordjevic, Steven P. and Walker, Mark J. (2009). Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium. Infection and Immunity, 77 (5), 1817-1826. doi: 10.1128/IAI.01301-08

Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium

2009

Journal Article

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

Wilton, Jody, Jenkins, Cheryl, Cordwell, Stuart J., Falconer, Linda, Minion, F. Chris, Oneal, David C., Djordjevic, Michael A., Connolly, Angela, Barchia, Idris, Walker, Mark J. and Djordjevic, Steven P. (2009). Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Molecular Microbiology, 71 (3), 566-582. doi: 10.1111/j.1365-2958.2008.06546.x

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

2008

Journal Article

Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity

Morris, Amie M., Treweek, Teresa M., Aquilina, J. A., Carver, John A. and Walker, Mark J. (2008). Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity. FEBS Journal, 275 (23), 5885-5898. doi: 10.1111/j.1742-4658.2008.06719.x

Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity

2008

Journal Article

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

Hollands, Andrew, Aziz, Ramy K., Kansal, Rita, Kotb, Malak, Nizet, Victor and Walker, Mark J. (2008). A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One, 3 (12 Article # e4102) e4102, e4102. doi: 10.1371/journal.pone.0004102

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

2008

Journal Article

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

McArthur, Jason D., McKay, Fiona C., Ramachandran, Vidiya, Shyam, Priya, Cork, Amanda J., Sanderson-Smith, Martina L., Cole, Jason N., Ringdahl, Ulrika, Sjobring, Ulf, Ranson, Marie and Walker, Mark J. (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. Faseb Journal, 22 (9), 3146-3153. doi: 10.1096/fj.08-109348

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

2008

Journal Article

M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate

Sanderson-Smith, M. L., Dinkla, K., Cole, J. N., Cork, A. J., Maamary, P. G., McArthur, J. D., Chhatwal, G. S. and Walker, M. J. (2008). M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. The FASEB Journal, 22 (8), 2715-2722. doi: 10.1096/fj.07-105643

M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate

2008

Journal Article

Human pathogenic streptococcal proteomics and vaccine development

Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008). Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 (3), 387-410. doi: 10.1002/prca.200780048

Human pathogenic streptococcal proteomics and vaccine development

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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