Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

250 works between 1987 and 2025
All (250) Journal Article (236) Book Chapter (6) Conference Publication (7) Other Outputs (1)

161 - 180 of 250 works

2010

Journal Article

Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence

Aziz, Ramy K., Kansal, Rita, Aronow, Bruce J., Taylor, William L., Rowe, Sarah L., Kubal, Michael, Chhatwal, Gursharan S., Walker, Mark J. and Kotb, Malak (2010). Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence. PLoS One, 5 (4) e9798, e9798. doi: 10.1371/journal.pone.0009798

Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence

2010

Journal Article

Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid

Venturini, C, Beatson, SA, Djordjevic, SP and Walker, MJ (2010). Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid. The FASEB Journal, 24 (4), 1160-1166. doi: 10.1096/fj.09-144972

Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid

2009

Journal Article

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

2009

Journal Article

Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium

Matic, Jake N., Terry, Tamsin D., Van Bockel, David, Maddocks, Tracy, Tinworth, David, Jennings, Michael P., Djordjevic, Steven P. and Walker, Mark J. (2009). Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium. Infection and Immunity, 77 (5), 1817-1826. doi: 10.1128/IAI.01301-08

Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium

2009

Journal Article

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

Wilton, Jody, Jenkins, Cheryl, Cordwell, Stuart J., Falconer, Linda, Minion, F. Chris, Oneal, David C., Djordjevic, Michael A., Connolly, Angela, Barchia, Idris, Walker, Mark J. and Djordjevic, Steven P. (2009). Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Molecular Microbiology, 71 (3), 566-582. doi: 10.1111/j.1365-2958.2008.06546.x

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

2008

Journal Article

Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity

Morris, Amie M., Treweek, Teresa M., Aquilina, J. A., Carver, John A. and Walker, Mark J. (2008). Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity. FEBS Journal, 275 (23), 5885-5898. doi: 10.1111/j.1742-4658.2008.06719.x

Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity

2008

Journal Article

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

Hollands, Andrew, Aziz, Ramy K., Kansal, Rita, Kotb, Malak, Nizet, Victor and Walker, Mark J. (2008). A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One, 3 (12 Article # e4102) e4102, e4102. doi: 10.1371/journal.pone.0004102

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

2008

Journal Article

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

McArthur, Jason D., McKay, Fiona C., Ramachandran, Vidiya, Shyam, Priya, Cork, Amanda J., Sanderson-Smith, Martina L., Cole, Jason N., Ringdahl, Ulrika, Sjobring, Ulf, Ranson, Marie and Walker, Mark J. (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. Faseb Journal, 22 (9), 3146-3153. doi: 10.1096/fj.08-109348

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

2008

Journal Article

M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate

Sanderson-Smith, M. L., Dinkla, K., Cole, J. N., Cork, A. J., Maamary, P. G., McArthur, J. D., Chhatwal, G. S. and Walker, M. J. (2008). M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. The FASEB Journal, 22 (8), 2715-2722. doi: 10.1096/fj.07-105643

M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate

2008

Journal Article

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete

Gillen, Christine M., Courtney, Harry S., Schulze, Kai, Rohde, Manfred, Wilson, Mark R., Timmer, Anjulli M., Guzman, Carlos A., Nizet, Victor, Chhatwal, G. s. and Walker, Mark J. (2008). Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. Journal of Biological Chemistry, 283 (10), 6359-6366. doi: 10.1074/jbc.M706739200

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete

2008

Journal Article

Human pathogenic streptococcal proteomics and vaccine development

Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008). Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 (3), 387-410. doi: 10.1002/prca.200780048

Human pathogenic streptococcal proteomics and vaccine development

2008

Journal Article

Isolation and solubilization of gram-positive bacterial cell wall-associated proteins

Cole, Jason N, Djordjevic, Steven P and Walker, Mark J (2008). Isolation and solubilization of gram-positive bacterial cell wall-associated proteins. Methods in molecular biology (Clifton, N.J.), 425, 295-311.

Isolation and solubilization of gram-positive bacterial cell wall-associated proteins

2007

Journal Article

Role of group A Streptococcus HtrA in the maturation of SpeB protease

Cole, Jason N., Aquilina, John A., Hains, Peter G., Henningham, Anna, Sriprakash, Kadaba S., Caparon, Michael G., Nizet, Victor, Kotb, Malak, Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2007). Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics, 7 (24), 4488-4498. doi: 10.1002/pmic.200700626

Role of group A Streptococcus HtrA in the maturation of SpeB protease

2007

Journal Article

Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation

Treweek, Teresa M., Ecroyd, Heath, Williams, Danielle M., Meehan, Sarah, Carver, John A. and Walker, Mark J. (2007). Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation. PLoS One, 2 (Article # e1046) e1046, e1046. doi: 10.1371/journal.pone.0001046

Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation

2007

Journal Article

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

Walker, Mark J., Hollands, Andrew, Sanderson-Smith, Martina L., Cole, Jason N., Kirk, Joshua K., Henningham, Anna, McArthur, Jason D., Dinkla, Katrin, Aziz, Ramy K., Kansal, Rita G., Simpson, Amelia J., Buchanan, John T., Chhatwal, Gursharan S., Kotb, Malak and Nizet, Malak (2007). DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nature Medicine, 13 (8), 981-985. doi: 10.1038/nm1612

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

2007

Journal Article

New understanding of the group A Streptococcus pathogenesis cycle

Tart, Anne H., Walker, Mark J. and Musser, James M. (2007). New understanding of the group A Streptococcus pathogenesis cycle. Trends in Microbiology, 15 (7), 318-325. doi: 10.1016/j.tim.2007.05.001

New understanding of the group A Streptococcus pathogenesis cycle

2007

Journal Article

Characterization of mesophilic bacilli in faeces of feedlot cattle

Wu, X. -Y., Walker, M., Vanselow, B., Chao, R. -L. and Chin, J. (2007). Characterization of mesophilic bacilli in faeces of feedlot cattle. Journal of Applied Microbiology, 102 (3), 872-879. doi: 10.1111/j.1365-2672.2006.03106.x

Characterization of mesophilic bacilli in faeces of feedlot cattle

2007

Conference Publication

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

Sanderson-Smith, Martina L., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2007). The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues. Washington, DC, United States: American Society for Microbiology. doi: 10.1128/JB.01218-06

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

2007

Journal Article

Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs

Wu, Xi-Yang, Chapman, Toni, Trott, Darren J., Bettelheim, Karl, Do, Thuy N., Driesen, Steve, Walker, Mark J. and Chin, James (2007). Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs. Applied and Environmental Microbiology, 73 (1), 83-91. doi: 10.1128/AEM.00990-06

Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs

2007

Book Chapter

Gene expression and tagging of streptococcal proteins

Cole, J. N., Sanderson-Smith, M. L., Cork, A. J., Henningham, A., Conlan, F., Ranson, M., McArthur, J. D. and Walker, M. J. (2007). Gene expression and tagging of streptococcal proteins. Molecular Biology of Streptococci. (pp. 359-378) edited by Regine Hakenbeck and Singh Chhatwal. Norfold, United Kingdom: Horizon Bioscience.

Gene expression and tagging of streptococcal proteins

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2025
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2025
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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