Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

247 works between 1987 and 2025
All (247) Journal Article (234) Book Chapter (6) Conference Publication (7)

101 - 120 of 247 works

2015

Journal Article

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

2015

Journal Article

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-José, Descorps-Declere, Stéphane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., Holden, Matthew T G., Poyart, Claire and Glaser, Philippe (2015). Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 6 (1) 6108. doi: 10.1038/ncomms7108

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

2015

Journal Article

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

Davies, Mark R., Holden, Matthew T., Coupland, Paul, Chen, Jonathan H. K., Venturini, Carola, Barnett, Timothy C., Ben Zakour, Nouri L., Tse, Herman, Dougan, Gordon, Yuen, Kwok-Yung and Walker, Mark J. (2015). Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance. Nature Genetics, 47 (1), 84-87+. doi: 10.1038/ng.3147

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

2015

Journal Article

Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak

Bartley, Paul B., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Muguli, Raghuram, Prado, Luis, Garnys, Vyt, Taylor, Katherine, Barnett, Timothy C., Pinna, Glen, Robson, Jennifer, Paterson, David L., Walker, Mark J., Schembri, Mark A. and Beatson, Scott A. (2015). Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak. Clinical Infectious Diseases, 62 (3), 273-279. doi: 10.1093/cid/civ870

Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak

2015

Journal Article

Meet our editorial board member

Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11)

Meet our editorial board member

2014

Journal Article

The contribution of non-human primate models to the development of human vaccines

Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.

The contribution of non-human primate models to the development of human vaccines

2014

Journal Article

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus

Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo,Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N. (2014). Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus. Journal of Biological Chemistry, 289 (46), 32303-32315. doi: 10.1074/jbc.M114.602847

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus

2014

Journal Article

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

Shewell, Lucy K., Harvey,Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C. and Jennings, Michael P. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.. Proceedings of the National Academy of Sciences of the United State of America, 111 (49), E5312-E5320. doi: 10.1073/pnas.1412703111

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

2014

Journal Article

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 (8), 1325-1338. doi: 10.1093/infdis/jiu260

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

2014

Journal Article

Tracking antibiotic resistance

Beatson, Scott A. and Walker, Mark J. (2014). Tracking antibiotic resistance. Science, 345 (6203), 1454-1455. doi: 10.1126/science.1260471

Tracking antibiotic resistance

2014

Journal Article

Host responses to group A Streptococcus: cell death and inflammation

Tsatsaronis, James A., Walker, Mark J. and Sanderson-Smith, Martina L. (2014). Host responses to group A Streptococcus: cell death and inflammation. PLoS Pathogens, 10 (8) e1004266, e1004266.1-e1004266.7. doi: 10.1371/journal.ppat.1004266

Host responses to group A Streptococcus: cell death and inflammation

2014

Journal Article

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-Jose, Descorps-Declere, Stephane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., The DEVANI Consortium, Holden, Matthew T. G. ... Glaser, Philippe (2014). Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5 (1) 4544, 4544.1-4544.11. doi: 10.1038/ncomms5544

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

2014

Journal Article

Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs

Woolley, Lauren K., Fell, Shayne A., Gonsalves, Jocelyn R., Raymond, Benjamin B. A., Collins, Damian, Kuit, Tracey A., Walker, Mark J., Djordjevic, Steven P., Eamens, Graeme J. and Jenkins, Cheryl (2014). Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs. Vaccine, 32 (34), 4333-4341. doi: 10.1016/j.vaccine.2014.06.008

Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs

2014

Journal Article

Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop

Moreland, Nicole J., Waddington, Claire S., Williamson, Deborah A., Sriskandan, Shiranee, Smeesters, Pierre R., Proft, Thomas, Steer, Andrew C., Walker, Mark J., Baker, Edward N., Baker, Michael G., Lennon, Diana, Dunbar, Rod and Fraser, John D. (2014). Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop. Vaccine, 32 (30), 3713-3720. doi: 10.1016/j.vaccine.2014.05.017

Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop

2014

Journal Article

The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design

van Sorge, Nina M., Cole, Jason N., Kuipers, Kristen, Henningham, Anna, Aziz, Ramy K., Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien T. M., Davies, Mark R., Dougan, Gordon, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph A., Hutter, Julia, Lepenies, Bernd, Rooijakkers, Suzan H. M., Malley, Richard, Walker, Mark J., Shattil, Sanford J., Schlievert, Patrick M., Choudhury, Biswa and Nizet, Victor (2014). The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host and Microbe, 15 (6), 729-740. doi: 10.1016/j.chom.2014.05.009.

The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design

2014

Journal Article

An antimicrobial role for zinc in innate immune defence against group A streptococcus

Ong, Cheryl-lynn Y., Gillen, Christine M., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2014). An antimicrobial role for zinc in innate immune defence against group A streptococcus. Journal of Infectious Diseases, 209 (10), 1500-1508. doi: 10.1093/infdis/jiu053

An antimicrobial role for zinc in innate immune defence against group A streptococcus

2014

Journal Article

Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants

Cook, Simon M., Skora, Amanda, Walker, Mark J., Sanderson-Smith, Martina L. and McArthur, Jason D. (2014). Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants. Biochemical Journal, 458 (1), 23-31. doi: 10.1042/BJ20131305

Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants

2014

Journal Article

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

2014

Conference Publication

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

Cole, Jason, van Sorge, Nina, Kuipers, Kirsten, Henningham, Anna, Aziz, Ramy, Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien, Davies, Mark, Dougan, Gordan, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph, Rooijakkers, Suzan, Malley, Richard, Walker, Mark, Shattil, Sanford, Schlievert, Patrick, Choudhury, Biswa and Nizet, Victor (2014). Genetics and virulence role of the classical group A Streptococcus Lancefield antigen. Experimental Biology Meeting, San Diego Ca, 26-30 April 2014. Federation of American Societies for Experimental Biology.

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

2014

Journal Article

Disease manifestations and pathogenic mechanisms of group A Streptococcus

Walker, Mark J., Barnett, Timothy C., McArthur, Jason D., Cole, Jason N., Gillen, Christine M., Henningham, Anna, Sriprakash, K. S., Sanderson-Smith, Martina L. and Nizet, Victor (2014). Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clinical Microbiology Reviews, 27 (2), 264-301. doi: 10.1128/CMR.00101-13

Disease manifestations and pathogenic mechanisms of group A Streptococcus

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2025
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2025
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price

  • Doctor Philosophy

    Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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