Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

308 works between 1967 and 2026
All (308) Journal Article (276) Conference Publication (26) Book Chapter (6)

101 - 120 of 308 works

2015

Journal Article

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

Zhang, May M., Ong, Cheryl-lynn, Walker, Mark J. and McEwan, Alastair G. (2015). Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?. Pathogens and Disease, 74 (2) ftv122, ftv122. doi: 10.1093/femspd/ftv122

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

2015

Journal Article

Streptococcal toxins: role in pathogenesis and disease

Barnett, Timothy C., Cole, Jason N., Rivera-Hernandez, Tania, Henningham, Anna, Paton, James C., Nizet, Victor and Walker, Mark J. (2015). Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17 (12), 1721-1741. doi: 10.1111/cmi.12531

Streptococcal toxins: role in pathogenesis and disease

2015

Journal Article

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

Ben Zakour, Nouri L., Davies, Mark R., You, Yuanhai, Chen, Jonathan H. K., Forde, Brian M., Stanton-Cook, Mitchell, Yang, Ruifu, Cui, Yujun, Barnett, Timothy C., Venturini, Carola, Ong, Cheryl-lynn Y., Tse, Herman, Dougan, Gordon, Zhang, Jianzhong, Yuen, Kwok-Yung, Beatson, Scott A. and Walker MJ (2015). Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone. Scientific Reports, 5 (1) 15877, 15877.1-15877.7. doi: 10.1038/srep15877

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

2015

Journal Article

Meet our editorial board member

Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11).

Meet our editorial board member

2015

Journal Article

Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses

Tsatsaronis, James A., Ly, Diane, Pupovac, Aleta, Goldmann, Oliver, Rohde, Manfred, Taylor, Jude M., Walker, Mark J., Medina, Eva and Sanderson-Smith, Martina L. (2015). Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses. Journal of Innate Immunity, 7 (6), 612-622. doi: 10.1159/000430498

Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses

2015

Journal Article

Host-pathogen interaction during bacterial vaccination

Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002

Host-pathogen interaction during bacterial vaccination

2015

Journal Article

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

Djoko, Karrera Y, Ong, Cheryl-lynn Y, Walker, Mark J and McEwan, Alastair G (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.. Journal of Biological Chemistry, 290 (31), 18954-18961. doi: 10.1074/jbc.R115.647099

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

2015

Journal Article

Molecular typing of Chinese Streptococcus pyogenes isolates

You, Yuanhai, Wang, Haibin, Bi, Zhenwang, Walker, Mark, Peng, Xianhui, Hu, Bin, Zhou, Haijian, Song, Yanyan, Tao, Xiaoxia, Kou, Zengqiang, Meng, Fanliang, Zhang, Menghan, Bi, Zhenqiang, Luo, Fengji and Zhang, Jianzhong (2015). Molecular typing of Chinese Streptococcus pyogenes isolates. Molecular and Cellular Probes, 29 (3), 172-176. doi: 10.1016/j.mcp.2015.03.009

Molecular typing of Chinese Streptococcus pyogenes isolates

2015

Journal Article

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

Ong, Cheryl-lynnY., Walker, Mark J. and McEwan, Alastair G. (2015). Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.. Scientific Reports, 5 (Art No.: 10799) 10799, 10799. doi: 10.1038/srep10799.

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

2015

Journal Article

Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase

Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764

Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase

2015

Journal Article

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

2015

Journal Article

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-José, Descorps-Declere, Stéphane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., Holden, Matthew T G., Poyart, Claire and Glaser, Philippe (2015). Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 6 (1) 6108. doi: 10.1038/ncomms7108

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

2015

Journal Article

Meet our editorial board member

Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11)

Meet our editorial board member

2015

Journal Article

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

Davies, Mark R., Holden, Matthew T., Coupland, Paul, Chen, Jonathan H. K., Venturini, Carola, Barnett, Timothy C., Ben Zakour, Nouri L., Tse, Herman, Dougan, Gordon, Yuen, Kwok-Yung and Walker, Mark J. (2015). Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance. Nature Genetics, 47 (1), 84-87+. doi: 10.1038/ng.3147

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

2015

Journal Article

Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak

Bartley, Paul B., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Muguli, Raghuram, Prado, Luis, Garnys, Vyt, Taylor, Katherine, Barnett, Timothy C., Pinna, Glen, Robson, Jennifer, Paterson, David L., Walker, Mark J., Schembri, Mark A. and Beatson, Scott A. (2015). Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak. Clinical Infectious Diseases, 62 (3), 273-279. doi: 10.1093/cid/civ870

Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak

2014

Journal Article

The contribution of non-human primate models to the development of human vaccines

Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.

The contribution of non-human primate models to the development of human vaccines

2014

Journal Article

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus

Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo,Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N. (2014). Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus. Journal of Biological Chemistry, 289 (46), 32303-32315. doi: 10.1074/jbc.M114.602847

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus

2014

Journal Article

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

Shewell, Lucy K., Harvey,Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C. and Jennings, Michael P. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.. Proceedings of the National Academy of Sciences of the United State of America, 111 (49), E5312-E5320. doi: 10.1073/pnas.1412703111

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

2014

Journal Article

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 (8), 1325-1338. doi: 10.1093/infdis/jiu260

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

2014

Journal Article

Tracking antibiotic resistance

Beatson, Scott A. and Walker, Mark J. (2014). Tracking antibiotic resistance. Science, 345 (6203), 1454-1455. doi: 10.1126/science.1260471

Tracking antibiotic resistance

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au