Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

308 works between 1967 and 2026
All (308) Journal Article (276) Conference Publication (26) Book Chapter (6)

41 - 60 of 308 works

2020

Journal Article

Antimicrobial resistance in ESKAPE pathogens

De Oliveira, David M. P., Forde, Brian M., Kidd, Timothy J., Harris, Patrick N. A., Schembri, Mark A., Beatson, Scott A., Paterson, David L. and Walker, Mark J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical Microbiology Reviews, 33 (3) e00181-19, e00181-19. doi: 10.1128/cmr.00181-19

Antimicrobial resistance in ESKAPE pathogens

2020

Journal Article

Update on group A streptococcal vaccine development

Dale, James B. and Walker, Mark J. (2020). Update on group A streptococcal vaccine development. Current Opinion in Infectious Diseases, 33 (3), 244-250. doi: 10.1097/QCO.0000000000000644

Update on group A streptococcal vaccine development

2020

Journal Article

All major cholesterol-dependent cytolysins use glycans as cellular receptors

Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926

All major cholesterol-dependent cytolysins use glycans as cellular receptors

2020

Journal Article

Multiple bactericidal mechanisms of the zinc ionophore PBT2

Harbison-Price, Nichaela, Ferguson, Scott A., Heikal, Adam, Taiaroa, George, Hards, Kiel, Nakatani, Yoshio, Rennison, David, Brimble, Margaret A., El-Deeb, Ibrahim M., Bohlmann, Lisa, McDevitt, Christopher A., von Itzstein, Mark, Walker, Mark J. and Cook, Gregory M. (2020). Multiple bactericidal mechanisms of the zinc ionophore PBT2. mSphere, 5 (2) e00157-20. doi: 10.1128/msphere.00157-20

Multiple bactericidal mechanisms of the zinc ionophore PBT2

2020

Journal Article

Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies

Rivera-Hernandez, Tania, Rhyme, Mira Syahira, Cork, Amanda J., Jones, Scott, Segui-Perez, Celia, Brunner, Livia, Richter, Johanna, Petrovsky, Nikolai, Lawrenz, Maria, Goldblatt, David, Collin, Nicolas and Walker, Mark J. (2020). Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies. mBio, 11 (2) e00122-20. doi: 10.1128/mbio.00122-20

Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies

2020

Journal Article

Updated emm-typing protocol for Streptococcus pyogenes

Frost, H. R., Davies, M. R., Velusamy, S., Delforge, V., Erhart, A., Darboe, S., Steer, A., Walker, M. J., Beall, B., Botteaux, A. and Smeesters, P. R. (2020). Updated emm-typing protocol for Streptococcus pyogenes. Clinical Microbiology and Infection, 26 (7) 946.e5, 946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026

Updated emm-typing protocol for Streptococcus pyogenes

2020

Journal Article

Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine

Xu, Zhenghui, Rivera-Hernandez, Tania, Chatterjee, Oishee, Walker, Mark J. and Moyle, Peter M. (2020). Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. Journal of Controlled Release, 317, 96-108. doi: 10.1016/j.jconrel.2019.11.018

Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine

2020

Journal Article

Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins

Frost, Hannah R., Davies, Mark R., Delforge, Valérie, Lakhloufi, Dalila, Sanderson-Smith, Martina, Srinivasan, Velusamy, Steer, Andrew C., Walker, Mark J., Beall, Bernard, Botteaux, Anne and Smeesters, Pierre R. (2020). Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins. mSphere, 5 (1) e00806. doi: 10.1128/mSphere.00806-19

Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins

2020

Book Chapter

Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement

Barnett, Timothy C., Daw, Jessica N., Walker, Mark J. and Brouwer, Stephan (2020). Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement. Group A Streptococcus: methods and protocols. (pp. 59-69) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_5

Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement

2020

Journal Article

Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2

Jen, Freda E.-C., Everest-Dass, Arun V., El-Deeb, Ibrahim M., Singh, Sanjesh, Haselhorst, Thomas, Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2020). Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2. ACS Infectious Diseases, 6 (1), 50-55. doi: 10.1021/acsinfecdis.9b00307

Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2

2020

Book Chapter

Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease

Rivera-Hernandez, Tania and Walker, Mark J. (2020). Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease. Group A Streptococcus: methods and protocols. (pp. 309-316) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_24

Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease

2020

Book Chapter

Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells

Indraratna, Anuk, De Oliveira, David M. P., Hartley-Tassell, Lauren E., Day, Christopher J., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2020). Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells. Group A Streptococcus: methods and protocols. (pp. 145-151) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY USA: Springer Nature. doi: 10.1007/978-1-0716-0467-0_10

Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells

2019

Journal Article

Increased incidence of scarlet fever — China, 1999−2018

You, Yuanhai, Qin, Ying, Walker, Mark J., Feng, Luzhao and Zhang, Jianzhong (2019). Increased incidence of scarlet fever — China, 1999−2018. China CDC Weekly, 1 (5), 63-66. doi: 10.46234/ccdcw2019.019

Increased incidence of scarlet fever — China, 1999−2018

2019

Journal Article

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

Ly, Diane, Donahue, Deborah, Walker, Mark J., Ploplis, Victoria A., McArthur, Jason D., Ranson, Marie, Castellino, Francis J. and Sanderson-Smith, Martina L. (2019). Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection, 21 (8-9), 412-417. doi: 10.1016/j.micinf.2019.04.004

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

2019

Journal Article

Scarlet fever changes its spots

Brouwer, Stephan, Lacey, Jake A., You, Yuanhai, Davies, Mark R. and Walker, Mark J. (2019). Scarlet fever changes its spots. Lancet Infectious Diseases, 19 (11), 1154-1155. doi: 10.1016/S1473-3099(19)30494-3

Scarlet fever changes its spots

2019

Journal Article

The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections

Brouwer, Stephan and Walker, Mark J. (2019). The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections. American Journal of Pathology, 189 (10), 1913-1915. doi: 10.1016/j.ajpath.2019.07.005

The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections

2019

Journal Article

Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells

De Oliveira, David M. P., Everest-Dass, Arun, Hartley-Tassell, Lauren, Day, Christopher J., Indraratna, Anuk, Brouwer, Stephan, Cleary, Ailish, Kautto, Liisa, Gorman, Jody, Packer, Nicolle H., Jennings, Michael P., Walker, Mark J. and Sanderson-Smith, Martina L. (2019). Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells. FASEB Journal, 33 (10), 10808-10818. doi: 10.1096/fj.201900559R

Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells

2019

Journal Article

Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (8), 1295-1295. doi: 10.1038/s41588-019-0482-z

Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

2019

Journal Article

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (6), 1035-1043. doi: 10.1038/s41588-019-0417-8

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

2019

Journal Article

Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

Osowicki, Joshua, Azzopardi, Kristy I., Baker, Ciara, Waddington, Claire S., Pandey, Manisha, Schuster, Tibor, Grobler, Anneke, Cheng, Allen C., Pollard, Andrew J., McCarthy, James S., Good, Michael F., Walker, Mark J., Dale, James B., Batzloff, Michael R., Carapetis, Jonathan R., Smeesters, Pierre R. and Steer, Andrew C. (2019). Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study. Vaccine, 37 (26), 3485-3494. doi: 10.1016/j.vaccine.2019.03.059

Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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