Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

308 works between 1967 and 2026
All (308) Journal Article (276) Conference Publication (26) Book Chapter (6)

61 - 80 of 308 works

2019

Journal Article

An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model

Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2019). An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model. mBio, 10 (2) e00693-19. doi: 10.1128/mBio.00693-19

An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model

2019

Journal Article

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Edgar, Rebecca J., van Hensbergen, Vincent P., Ruda, Alessandro, Turner, Andrew G., Deng, Pan, Le Breton, Yoann, El-Sayed, Najib M., Belew, Ashton T., McIver, Kevin S., McEwan, Alastair G., Morris, Andrew J., Lambeau, Gérard, Walker, Mark J., Rush, Jeffrey S., Korotkov, Konstantin V., Widmalm, Göran, van Sorge, Nina M. and Korotkova, Natalia (2019). Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nature Chemical Biology, 15 (5), 463-471. doi: 10.1038/s41589-019-0251-4

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

2019

Journal Article

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

Turner, Andrew G., Djoko, Karrera Y., Ong, Cheryl-Lynn Y., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2019). Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress. Biochemical Journal, 476 (3), 595-611. doi: 10.1042/BCJ20180902

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

2019

Journal Article

A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?

Osowicki, Joshua, Azzopardi, Kristy I., McIntyre, Liam, Rivera-Hernandez, Tania, Ong, Cheryl-Lynn Y., Baker, Ciara, Gillen, Christine M., Walker, Mark J., Smeesters, Pierre R., Davies, Mark R. and Steer, Andrew C. (2019). A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?. mSphere, 4 (1) e00647-18, e00647-18. doi: 10.1128/mSphere.00647-18

A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?

2019

Journal Article

Detection of epidemic scarlet fever group A Streptococcus in Australia

Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099

Detection of epidemic scarlet fever group A Streptococcus in Australia

2019

Conference Publication

Achievable Stereo Vision Depth Accuracy with Changing Camera Baseline

Sasiadek, Jurek Z. and Walker, Mark J. (2019). Achievable Stereo Vision Depth Accuracy with Changing Camera Baseline. 24th International Conference on Methods and Models in Automation and Robotics (MMAR), Miedzyzdroje Poland, Aug 26-29, 2019. NEW YORK: IEEE. doi: 10.1109/mmar.2019.8864723

Achievable Stereo Vision Depth Accuracy with Changing Camera Baseline

2018

Journal Article

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18, 1-12. doi: 10.1128/mBio.02391-18

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

2018

Journal Article

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18. doi: 10.1128/mbio.02391-18

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

2018

Journal Article

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Imai, Takashi, Matsumura, Takayuki, Mayer-Lambertz, Sabine, Wells, Christine A., Ishikawa, Eri, Butcher, Suzanne K., Barnett, Timothy C., Walker, Mark J., Imamura, Akihiro, Ishida, Hideharu, Ikebe, Tadayoshi, Miyamoto, Tomofumi, Ato, Manabu, Ohga, Shouichi, Lepenies, Bernd, van Sorge, Nina M. and Yamasaki, Sho (2018). Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proceedings of the National Academy of Sciences of the United States of America, 115 (45), E10662-E10671. doi: 10.1073/pnas.1809100115

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

2018

Journal Article

Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker

Walker, M. J. A., Hayes, E. S., Saint, D. A., Adaikan, G., Abraham, S., Goldin, A. L., Beatch, G. N., MacLeod, B. A., Wall, R. A. and Pugsley, M. K. (2018). Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker. Biomedicine & Pharmacotherapy, 106, 510-522. doi: 10.1016/j.biopha.2018.06.157

Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker

2018

Journal Article

Hypotheses for the resurgence of scarlet fever in China

You, Yuanhai, Davies, Mark R, Walker, Mark J and Zhang, Jianzhong (2018). Hypotheses for the resurgence of scarlet fever in China. The Lancet Infectious Diseases, 18 (9), 942-943. doi: 10.1016/S1473-3099(18)30470-5

Hypotheses for the resurgence of scarlet fever in China

2018

Journal Article

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment

Kawasaki, Minami, Delamare-Deboutteville, Jerome, Bowater, Rachel O, Walker, Mark J., Beatson, Scott, Ben Zakour, Nouri L. and Barnes, Andrew C. (2018). Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment. Applied and Environmental Microbiology, 84 (16) e00859-18, AEM.00859-18. doi: 10.1128/aem.00859-18

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment

2018

Journal Article

A host proteome atlas of Streptococcus pyogenes infection

Soderholm, Amelia T. and Walker, Mark J. (2018). A host proteome atlas of Streptococcus pyogenes infection. Cell Systems, 6 (5), 536-538. doi: 10.1016/j.cels.2018.05.003

A host proteome atlas of Streptococcus pyogenes infection

2018

Journal Article

Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP

Soderholm, Amelia T., Barnett, Timothy C., Korn, Othmar, Rivera-Hernandez, Tania, Seymour, Lisa M., Schulz, Benjamin L., Nizet, Victor, Wells, Christine A., Sweet, Matthew J. and Walker, Mark J. (2018). Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Frontiers in Cellular and Infection Microbiology, 8 (MAY) 160, 160. doi: 10.3389/fcimb.2018.00160

Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP

2018

Journal Article

Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing

You, Yuanhai, Kou, Yongjun, Niu, Longfei, Jia, Qiong, Liu, Yahui, Davies, Mark R., Walker, Mark J., Zhu, Jiaqiang and Zhang, Jianzhong (2018). Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing. Genome Announcements, 6 (18) e00389-18, e00389-18. doi: 10.1128/genomeA.00389-18

Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing

2018

Journal Article

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)

Turcot, Valerie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tonu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M. ... Loos, Ruth J. F. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017). Nature Genetics, 50 (5), 765-766. doi: 10.1038/s41588-018-0050-y

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017)

2018

Journal Article

The role of zinc acquisition and zinc tolerance in group A streptococcal infection

Ong, Cheryl-Lynn Y., Berking, Olga, Walker, Mark J. and McEwan, Alastair G. (2018). The role of zinc acquisition and zinc tolerance in group A streptococcal infection. Infection and Immunity, 86 (6) e00048-18, e00048-18. doi: 10.1128/IAI.00048-18

The role of zinc acquisition and zinc tolerance in group A streptococcal infection

2018

Journal Article

Scarlet fever makes a comeback

Walker, Mark J. and Brouwer, Stephan (2018). Scarlet fever makes a comeback. The Lancet Infectious Diseases, 18 (2), 128-129. doi: 10.1016/S1473-3099(17)30694-1

Scarlet fever makes a comeback

2018

Journal Article

Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis

You, Yuanhai, Davies, Mark R, Protani, Melinda, McIntyre, Liam, Walker, Mark J and Zhang, Jianzhong (2018). Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis. EBioMedicine, 28, 128-135. doi: 10.1016/j.ebiom.2018.01.010

Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis

2018

Journal Article

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

Henningham, Anna, Davies, Mark R., Uchiyama, Satoshi, van Sorge, Nina M., Lund, Sean, Chen, Kelsey T., Walker, Mark J., Cole, Jason N. and Nizet, Victor (2018). Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus. mBio, 9 (1) e02294-17, 1-12. doi: 10.1128/mBio.02294-17

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2026
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2027
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2026
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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