Professor Mark Walker
Professor

Mark Walker

Email: 
Phone: 
+61 7 334 61623

Availability

Professor Mark Walker is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medical microbiology Microbiology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Mark Walker’s works on UQ eSpace

250 works between 1987 and 2025
All (250) Journal Article (236) Book Chapter (6) Conference Publication (7) Other Outputs (1)

121 - 140 of 250 works

2014

Journal Article

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

2014

Conference Publication

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

Cole, Jason, van Sorge, Nina, Kuipers, Kirsten, Henningham, Anna, Aziz, Ramy, Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien, Davies, Mark, Dougan, Gordan, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph, Rooijakkers, Suzan, Malley, Richard, Walker, Mark, Shattil, Sanford, Schlievert, Patrick, Choudhury, Biswa and Nizet, Victor (2014). Genetics and virulence role of the classical group A Streptococcus Lancefield antigen. Experimental Biology Meeting, San Diego Ca, 26-30 April 2014. Federation of American Societies for Experimental Biology.

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

2014

Journal Article

Disease manifestations and pathogenic mechanisms of group A Streptococcus

Walker, Mark J., Barnett, Timothy C., McArthur, Jason D., Cole, Jason N., Gillen, Christine M., Henningham, Anna, Sriprakash, K. S., Sanderson-Smith, Martina L. and Nizet, Victor (2014). Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clinical Microbiology Reviews, 27 (2), 264-301. doi: 10.1128/CMR.00101-13

Disease manifestations and pathogenic mechanisms of group A Streptococcus

2013

Journal Article

The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication

Barnett, Timothy C., Liebl, David, Seymour, Lisa M., Gillen, Christine M., Lim, Jin Yan, LaRock, Christopher N., Davies, Mark R., Schulz, Benjamin L., Nizet, Victor, Teasdale, Rohan D. and Walker, Mark J. (2013). The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication. Cell Host and Microbe, 14 (6), 675-682. doi: 10.1016/j.chom.2013.11.003

The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication

2013

Journal Article

Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts

Venturini, Carola, Hassan, Karl A., Chowdhury, Piklu Roy, Paulsen, Ian T., Walker, Mark J. and Djordjevic, Steven P. (2013). Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts. PLoS ONE, 8 (11) e78862, e78862.1-e78862.14. doi: 10.1371/journal.pone.0078862

Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts

2013

Journal Article

Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification

Towers, Rebecca J., Carapetis, Jonathan R., Currie, Bart J., Davies, Mark R., Walker, Mark J., Dougan, Gordon and Giffard, Philip M. (2013). Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification. PLoS One, 8 (9) e73851, e73851.1-e73851.6. doi: 10.1371/journal.pone.0073851

Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification

2013

Journal Article

Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus

Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13

Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus

2013

Journal Article

Molecular characterization of endocarditis-associated Staphylococcus aureus

Nethercott, Cara, Mabbett, Amanda N., Totsika, Makrina, Peters, Paul, Ortiz, Juan C., Nimmo, Graeme R., Coombs, Geoffrey W., Walker, Mark J. and Schembri, Mark A. (2013). Molecular characterization of endocarditis-associated Staphylococcus aureus. Journal of Clinical Microbiology, 51 (7), 2131-2138. doi: 10.1128/JCM.00651-13

Molecular characterization of endocarditis-associated Staphylococcus aureus

2013

Journal Article

A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection

Sanderson-Smith, Martina L., Zhang, Yueling, Ly, Diane, Donahue, Deborah, Hollands, Andrew, Nizet, Victor, Ranson, Marie, Ploplis, Victoria A., Walker, Mark J. and Castellino, Francis J. (2013). A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection. PLoS Pathogens, 9 (7) e1003469, e1003469.1-e1003469.9. doi: 10.1371/journal.ppat.1003469

A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection

2013

Journal Article

Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370

Venturini, Carola, Ong, Cheryl-Iynn Y., Gillen, Christine M., Ben-Zakour, Nouri L., Maamary, Peter G., Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2013). Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370. Infection and Immunity, 81 (6), 2062-2069. doi: 10.1128/IAI.00192-13

Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370

2013

Journal Article

Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR

Ong, Cheryl-lynn Y., Potter, Adam J., Trappetti, Claudia, Walker, Mark J., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infection and Immunity, 81 (2), 421-429. doi: 10.1128/IAI.00805-12

Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR

2013

Book Chapter

Group A streptococcal vaccine candidates: potential for the development of a human vaccine

Henningham, Anna, Gillen, Christine M. and Walker, Mark J. (2013). Group A streptococcal vaccine candidates: potential for the development of a human vaccine. Host-pathogen interactions in streptococcal diseases. (pp. 207-242) edited by G. Singh Chhatwal. New York, NY, United States: Springer. doi: 10.1007/82_2012_284

Group A streptococcal vaccine candidates: potential for the development of a human vaccine

2013

Journal Article

Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus

Tsatsaronis, James A., Hollands, Andrew, Cole, Jason N., Maamary, Peter G., Gillen, Christine M., Ben Zakour, Nouri L., Kotb, Malak, Nizet, Victor, Beatson, Scott A., Mark J. Walker and Sanderson-Smith, Martina L. (2013). Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus. FASEB Journal, 27 (7), 2633-2643. doi: 10.1096/fj.12-226662

Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus

2012

Journal Article

Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates

Woolley, Lauren K., Fell, Shayne, Gonsalves, Jocelyn R., Walker, Mark J., Djordjevic, Steven P., Jenkins, Cheryl and Eamens, Graeme J. (2012). Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates. Veterinary Microbiology, 161 (1-2), 186-195. doi: 10.1016/j.vetmic.2012.07.025

Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates

2012

Journal Article

Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis

Cook, Simon M., Skora, Amanda, Gillen, Christine M., Walker, Mark J. and McArthur, Jason D. (2012). Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis. Molecular Microbiology, 86 (5), 1052-1062. doi: 10.1111/mmi.12037

Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis

2012

Journal Article

Outsmarting outbreaks

Walker, Mark J. and Beatson, Scott A. (2012). Outsmarting outbreaks. Science, 338 (6111), 1161-1162. doi: 10.1126/science.1232327

Outsmarting outbreaks

2012

Journal Article

Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone

Maamary, Peter G., Ben Zakour, Nouri L., Cole, Jason N., Hollands, Andrew, Aziz, Ramy K., Barnett, Timothy C., Cork, Amanda J., Henningham, Anna, Sanderson-Smith, Martina, McArthur, Jason D., Venturini, Carola, Gillen, Christine M., Kirk, Joshua K., Johnson, Dwight R., Taylor, William L., Kaplan, Edward L., Kotb, Malak, Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2012). Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB Journal, 26 (11), 4675-4684. doi: 10.1096/fj.12-212142

Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone

2012

Journal Article

Molecular characterization of the 2011 Hong Kong scarlet fever outbreak

Tse, Herman, Bao, Jessie Y. J., Davies, Mark R., Maamary, Peter, Tsoi, Hoi-Wah, Tong, Amy H. Y., Ho, Tom C. C., Lin, Chi-Ho, Gillen, Christine M., Barnett, Timothy C., Chen, Jonathan H. K., Lee, Mianne, Yam, Wing-Cheong, Wong, Chi-Kin, Ong, Cheryl-lynn Y., Chan, Yee-Wai, Wu, Cheng-Wei, Ng, Tony, Lim, Wilina W. L., Tsang, Thomas H. F., Tse, Cindy W. S., Dougan, Gordon, Walker, Mark J., Lok, Si and Yuen, Kwok-Yung (2012). Molecular characterization of the 2011 Hong Kong scarlet fever outbreak. The Journal of Infectious Diseases, 206 (3), 341-351. doi: 10.1093/infdis/jis362

Molecular characterization of the 2011 Hong Kong scarlet fever outbreak

2012

Journal Article

Pathogenesis of group A streptococcal infections

Henningham, Anna, Barnett, Timothy C., Maamary, Peter G. and Walker, Mark J. (2012). Pathogenesis of group A streptococcal infections. Discovery Medicine, 13 (72), 329-342.

Pathogenesis of group A streptococcal infections

2012

Journal Article

Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography

Bogema, Daniel R., Deutscher, Ania T., Woolley, Lauren K., Seymour, Lisa M., Raymond, Benjamin B. A., Tacchi, Jessica L., Padula, Matthew P., Dixon, Nicholas E., Minion, F. Chris, Jenkins, Cheryl, Walker, Mark J. and Djordjevic, Steven P. (2012). Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography. mBio, 3 (2) e00282-11, e00282.1-e00282.11. doi: 10.1128/mBio.00282-11

Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography

Current funding

  • 2026 - 2030
    Guiding Group A Streptococcus vaccines into clinical development.
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Novel ionophore combination therapeutic treatment (CARB-X grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2024 - 2026
    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
    NHMRC Development Grant
    Open grant
  • 2024 - 2025
    Screening experimental adjuvants in non-human primates for improved Group A Streptococcus (GAS) vaccine efficacy
    The University of Queensland in America, Inc
    Open grant
  • 2023 - 2025
    Breaking drug resistance in community acquired bacterial pneumonia (CABP) (NHMRC Development grant administered by University of Melbourne)
    University of Melbourne
    Open grant
  • 2022 - 2026
    Mining the host-pathogen interface to deliver a drug pipeline for treating intractable and emerging infections
    NHMRC Synergy Grants
    Open grant
  • 2021 - 2028
    Development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
    ModernaTX, Inc
    Open grant
  • 2021 - 2025
    Scarlet fever pandemic and reversing antibiotic resistance
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2022
    Testing of prototype GSK vaccines in a mouse model of GAS invasive disease.
    GSK Vaccines Institute for Global Health
    Open grant
  • 2020 - 2023
    Breaking antibiotic resistance in high priority Gram-negative sepsis pathogens
    NHMRC Development Grant
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Deploying next-generation adjuvants to enhance protection of a group A streptococcal vaccine candidate
    NHMRC Development Grant
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2019
    Worldwide molecular analysis of Streptococcus pyogenes scarlet fever outbreaks
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Facility for characterisation of bionanomaterials
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016 - 2020
    Epidemiology, pathogenesis and prevention of group A streptococcal infection
    NHMRC Research Fellowship
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015 - 2016
    Sequencing and bioinformatics analysis of circulating GAS strains for the CANVAS project (Subcontract to Murdoch Childrens Research Institute under NHMRC Special Initiative administered by UWA)
    Murdoch Childrens Research Institute
    Open grant
  • 2015 - 2020
    GAS Switch from Colonizing Bacterium to Invasive Pathogen (NIH application submitted by University of California, San Diego)
    University of California, San Diego
    Open grant
  • 2015 - 2019
    Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines (NHMRC Program Grant administered by The University of Adelaide)
    University of Adelaide
    Open grant
  • 2014 - 2017
    A pan-genome reverse vaccinology approach to disease prevention in farmed fish
    ARC Linkage Projects
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Evolution of bacterial pathogenesis
    ARC Discovery Projects
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2014
    Development and immunological evaluation of a broadly-protective Group A Streptococcal vaccine, incorporating six highly-conserved protective antigens, in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2013 - 2016
    Interaction of group A streptococci with intracellular innate immune defence
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    Post-genomic analysis of novel Streptococcus pyogenes virulence pathways
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Defining domains within Mycoplasma hyopneumaoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine
    ARC Linkage Projects
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    University of California, San Diego
    Open grant
  • 2010 - 2012
    Preclinical studies of group A Streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2010 - 2015
    NHMRC Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2012
    Does viral programming cause group A streptococcal invasive disease?
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Pathogenesis, treatment and prevention of bacterial infectious diseases (NHMRC Program Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2009 - 2011
    Mapping cell wall and surface structures of Gram-positive cocci
    ARC Discovery Projects
    Open grant

Availability

Professor Mark Walker is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni

    Principal Advisor

    Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK

    Principal Advisor

    Other advisors: Dr Stephan Brouwer

  • Doctor Philosophy

    Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens

    Principal Advisor

    Other advisors: Dr David De Oliveira

  • Doctor Philosophy

    Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection

    Principal Advisor

    Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price

  • Doctor Philosophy

    Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism

    Principal Advisor

    Other advisors: Professor Kate Schroder, Dr Stephan Brouwer

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model

    Associate Advisor

    Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith

Completed supervision

Enquiries

Contact Professor Mark Walker directly for media enquiries about:

  • Cellulitis
  • Disease
  • Impetigo
  • Invasive disease
  • Pharyngitis
  • Scarlet fever
  • Skin infections
  • Streptococcal toxic shock syndrome
  • Streptococcus
  • Toxic shock syndrome

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