
Overview
Availability
- Professor Mark Walker is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Mark Walker’s works on UQ eSpace
2022
Journal Article
The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection
Li, Gen, De Oliveira, David M.P. and Walker, Mark J. (2022). The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection. Journal of Inorganic Biochemistry, 227 111661, 111661. doi: 10.1016/j.jinorgbio.2021.111661
2022
Journal Article
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection
De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21
2022
Journal Article
Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W. and McDevitt, Christopher A. (2022). Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model. Cell Reports, 38 (2) 110202, 1-18. doi: 10.1016/j.celrep.2021.110202
2021
Journal Article
Streptococcal superantigens and the return of scarlet fever
Hurst, Jacklyn R., Brouwer, Stephan, Walker, Mark J. and McCormick, John K. (2021). Streptococcal superantigens and the return of scarlet fever. PLOS Pathogens, 17 (12) e1010097, e1010097. doi: 10.1371/journal.ppat.1010097
2021
Journal Article
A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides
Jen, Freda E. -C., El-Deeb, Ibrahim M., Zalucki, Yaramah M., Edwards, Jennifer L., Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2021). A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides. Journal of Antimicrobial Chemotherapy, 76 (11), 2850-2853. doi: 10.1093/jac/dkab291
2021
Journal Article
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection
Richter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499
2021
Journal Article
Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease
Richter, Johanna, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease. Cellular Microbiology, 23 (9) e13373, 1-9. doi: 10.1111/cmi.13373
2021
Journal Article
A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study
Osowicki, Joshua, Azzopardi, Kristy I, Fabri, Loraine, Frost, Hannah R, Rivera-Hernandez, Tania, Neeland, Melanie R, Whitcombe, Alana L, Grobler, Anneke, Gutman, Sarah J, Baker, Ciara, Wong, Janet M F, Lickliter, Jason D, Waddington, Claire S, Pandey, Manisha, Schuster, Tibor, Cheng, Allen C, Pollard, Andrew J, McCarthy, James S, Good, Michael F, Dale, James B, Batzloff, Michael, Moreland, Nicole J, Walker, Mark J, Carapetis, Jonathan R, Smeesters, Pierre R and Steer, Andrew C (2021). A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study. The Lancet Microbe, 2 (7), e291-e299. doi: 10.1016/S2666-5247(20)30240-8
2021
Journal Article
A multivalent T-antigen-based vaccine for Group A Streptococcus
Loh, Jacelyn M. S., Rivera-Hernandez, Tania, McGregor, Reuben, Khemlani, Adrina Hema J., Tay, Mei Lin, Cork, Amanda J., M. Raynes, Jeremy, Moreland, Nicole J., Walker, Mark J. and Proft, Thomas (2021). A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Reports, 11 (1) 4353, 1-10. doi: 10.1038/s41598-021-83673-4
2021
Journal Article
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280
2020
Journal Article
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M. P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nature Communications, 11 (1) 5018, 5018. doi: 10.1038/s41467-020-18700-5
2020
Journal Article
Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes
Stewart, Louisa J., Ong, Cheryl-Lynn Y., Zhang, May M., Brouwer, Stephan, McIntyre, Liam, Davies, Mark R., Walker, Mark J., McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2020). Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio, 11 (6) e02804-20, 1-19. doi: 10.1128/mBio.02804-20
2020
Journal Article
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis
De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791
2020
Journal Article
Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19)
Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2020). Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19). mBio, 11 (6) e02995-20, 1-1. doi: 10.1128/mBio.02995-20
2020
Journal Article
Antimicrobial resistance in ESKAPE pathogens
De Oliveira, David M. P., Forde, Brian M., Kidd, Timothy J., Harris, Patrick N. A., Schembri, Mark A., Beatson, Scott A., Paterson, David L. and Walker, Mark J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical Microbiology Reviews, 33 (3) e00181-19, e00181-19. doi: 10.1128/cmr.00181-19
2020
Journal Article
Update on group A streptococcal vaccine development
Dale, James B. and Walker, Mark J. (2020). Update on group A streptococcal vaccine development. Current Opinion in Infectious Diseases, 33 (3), 244-250. doi: 10.1097/QCO.0000000000000644
2020
Journal Article
All major cholesterol-dependent cytolysins use glycans as cellular receptors
Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926
2020
Other Outputs
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M.P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. doi: 10.1101/2020.05.17.095000
2020
Journal Article
Multiple bactericidal mechanisms of the zinc ionophore PBT2
Harbison-Price, Nichaela, Ferguson, Scott A., Heikal, Adam, Taiaroa, George, Hards, Kiel, Nakatani, Yoshio, Rennison, David, Brimble, Margaret A., El-Deeb, Ibrahim M., Bohlmann, Lisa, McDevitt, Christopher A., von Itzstein, Mark, Walker, Mark J. and Cook, Gregory M. (2020). Multiple bactericidal mechanisms of the zinc ionophore PBT2. mSphere, 5 (2) e00157-20. doi: 10.1128/msphere.00157-20
2020
Journal Article
Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies
Rivera-Hernandez, Tania, Rhyme, Mira Syahira, Cork, Amanda J., Jones, Scott, Segui-Perez, Celia, Brunner, Livia, Richter, Johanna, Petrovsky, Nikolai, Lawrenz, Maria, Goldblatt, David, Collin, Nicolas and Walker, Mark J. (2020). Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies. mBio, 11 (2) e00122-20. doi: 10.1128/mbio.00122-20
Funding
Current funding
Past funding
Supervision
Availability
- Professor Mark Walker is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens
Principal Advisor
Other advisors: Dr David De Oliveira
-
Doctor Philosophy
Investigating the efficacy of ionophores as antimicrobials against multidrug-resistant Gram-positive bacteria
Principal Advisor
Other advisors: Dr David De Oliveira
-
Doctor Philosophy
The contribution of superantigens to the pathogenesis of Streptococcus pyogenes M1UK
Principal Advisor
Other advisors: Dr Stephan Brouwer
-
Doctor Philosophy
Repurposing PBT-2 as a therapeutic to reverse antibiotic resistance in Gram-positive bacterial pathogens
Principal Advisor
Other advisors: Dr David De Oliveira
-
Doctor Philosophy
Preclinical refinement of a UQ-Moderna vaccine developed to prevent StrepA infection
Principal Advisor
Other advisors: Professor Gabrielle Belz, Dr Nichaela Harbison-Price
-
Doctor Philosophy
Studying the synergistic effects of streptococcal SLO and NADase on toxification of the host redox metabolism
Principal Advisor
Other advisors: Professor Kate Schroder, Dr Stephan Brouwer
-
Doctor Philosophy
Deploying ex vivo intranasal and tonsillar epithelial models to investigate Streptococcus pyogenes colonisation
Principal Advisor
Other advisors: Dr Stephan Brouwer
-
Doctor Philosophy
Breaking antibiotic resistance in multi-drug resistant Acinetobacter baumanni
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr David De Oliveira
-
Doctor Philosophy
Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
Associate Advisor
Other advisors: Professor Gabrielle Belz
-
Doctor Philosophy
Understanding development of an mRNA vaccine to prevent Group A Streptococcus pharyngeal infection
Associate Advisor
Other advisors: Professor Gabrielle Belz
-
Doctor Philosophy
Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model
Associate Advisor
Other advisors: Dr Andy Kuo, Dr David De Oliveira, Emeritus Professor Maree Smith
Completed supervision
-
2023
Doctor Philosophy
Characterisation of the interaction of M1 Group A Streptococcus with the inflammasome pathway
Principal Advisor
Other advisors: Professor Kate Schroder
-
2018
Doctor Philosophy
The Group A Streptococcus M1T1 clone post-transcriptionally modifies innate immune signalling to promote infection
Principal Advisor
Other advisors: Professor Matt Sweet
-
2018
Doctor Philosophy
Investigation of metal stress response and regulation in Group A Streptococcus
Principal Advisor
Other advisors: Professor Matt Sweet
-
2017
Doctor Philosophy
Understanding the role of caveolae in the uptake process of Streptococcus pyogenes into non-phagocytic host cells
Principal Advisor
Other advisors: Professor Robert Parton
-
2012
Doctor Philosophy
Evolution of group A streptococci: impact on virulence capacity
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2022
Doctor Philosophy
Disseminated Tuberculosis; Defining Pathogen Encoded Mechanisms
Associate Advisor
Other advisors: Professor Nick West
-
2022
Doctor Philosophy
A bitter taste in your heart: the role of T2Rs in cardiovascular physiology and pathophysiology
Associate Advisor
Other advisors: Professor Mark Schembri, Professor Wally Thomas
-
2020
Doctor Philosophy
Site-specific Bioconjugation of Toll-like Receptor Ligands onto Folded Recombinant Protein Antigens Using Enzyme-mediated Ligation
Associate Advisor
Other advisors: Associate Professor Peter Moyle
-
2019
Doctor Philosophy
A pan genome reverse vaccinology approach to prevent Streptococcus agalactiae infection in farmed tilapia
Associate Advisor
Other advisors: Professor Andrew Barnes
-
2016
Doctor Philosophy
Evolution of Streptococcus iniae after vaccination and molecular underpinnings of capsular antigenicity
Associate Advisor
Other advisors: Professor Andrew Barnes
Media
Enquiries
Contact Professor Mark Walker directly for media enquiries about:
- Cellulitis
- Disease
- Impetigo
- Invasive disease
- Pharyngitis
- Scarlet fever
- Skin infections
- Streptococcal toxic shock syndrome
- Streptococcus
- Toxic shock syndrome
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