Overview
Background
Prof Nestor joined the Queensland Brain Institute in October/2017 and has a conjoint appointment as a cognitive neurologist at Mater Misericordiae Ltd (Mater Hospital).
His particular interests include understanding the earliest stages of Alzheimer's disease (i.e. before dementia is established); atypical forms of dementia with a particular focus on primary progressive aphasia and dementias related to Parkinson's and Lewy body diseases; and improving differential diagnosis between the major categories of neurodegenerative diseases.
He works on development of neuropsychological tests of cognition, both to accurately track change over time and improve diagnostic accuracy between the major diseases causing dementia. He also uses multi-modal imaging (magnetic resonance imaging [MRI] and positron emission tomography [PET]) to understand the sequence of events occurring in degenerative brain diseases (particularly Alzheimer's disease, frontotemporal dementia, Parkinson's disease, motor neuron disease [ALS], progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]) and identify novel biomarkers. A major focus of his is on developing novel approaches to MR imaging for single subject pathological diagnoses that can be exported into the everyday clinical setting; recent examples include diffusion tensor imaging to identify PSP and CBD (Sajjadi et al, 2013) and quantitative susceptibility mapping in Parkinson's disease (Acosta-Cabornero et al, 2013).
Availability
- Professor Peter Nestor is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
- Doctor of Philosophy, University of Cambridge
Research interests
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Cognitive neurology
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frontotemporal lobar degeneration
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progressive aphasia
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Alzheimer's disease
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Neurodegenerative diseases
Works
Search Professor Peter Nestor’s works on UQ eSpace
2021
Journal Article
A systematic review of apathy and depression in progressive supranuclear palsy
Flavell, Joshua and Nestor, Peter J. (2021). A systematic review of apathy and depression in progressive supranuclear palsy. Journal of Geriatric Psychiatry and Neurology, 35 (3), 891988721993545-292. doi: 10.1177/0891988721993545
2020
Conference Publication
Hippocampal volumetric variability is associated with memory in subjective cognitive decline : Neuroimaging / Optimal neuroimaging measures for early detection
Ziegler, Gabriel, Heinzinger, Nils, Metzger, Coraline D., Yakupov, Renat, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Brosseron, Frederic, Bürger, Katharina, Fließbach, Klaus, Heneka, Michael T., Laske, Christoph, Nestor, Peter J., Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Schneider, Anja, Speck, Oliver, Teipel, Stefan J., Wiltfang, Jens, Wagner, Michael, Düzel, Emrah and Jessen, Frank (2020). Hippocampal volumetric variability is associated with memory in subjective cognitive decline : Neuroimaging / Optimal neuroimaging measures for early detection. Alzheimer's Association International Conference (AAIC 2020), Online, 27-31 July 2020. Hoboken, NJ, United States: Wiley. doi: 10.1002/alz.043527
2020
Journal Article
Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline
Mak, Elijah, Grigorova, Monika, Beresford-Webb, Jessica, Malpetti, Maura, Walpert, Madeline, Brown, Stephanie, Jones, Elizabeth, Clare, Isabel, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Nestor, Peter J., Holland, Anthony J. and Zaman, Shahid H (2020). Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline. Brain Communications, 3 (1) fcaa198, fcaa198. doi: 10.1093/braincomms/fcaa198
2020
Journal Article
Minor neuropsychological deficits in patients with subjective cognitive decline
Wolfsgruber, Steffen, Kleineidam, Luca, Guski, Jannis, Polcher, Alexandra, Frommann, Ingo, Roeske, Sandra, Spruth, Eike Jakob, Franke, Christiana, Priller, Josef, Kilimann, Ingo, Teipel, Stefan, Buerger, Katharina, Janowitz, Daniel, Laske, Christoph, Buchmann, Martina, Peters, Oliver, Menne, Felix, Fuentes Casan, Manuel, Wiltfang, Jens, Bartels, Claudia, Düzel, Emrah, Metzger, Coraline, Glanz, Wenzel, Thelen, Manuela, Spottke, Annika, Ramirez, Alfredo, Kofler, Barbara, Fließbach, Klaus, Schneider, Anja ... Nestor, Peter (DELCODE Study Group member) (2020). Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology, 95 (9), e1134-e1143. doi: 10.1212/WNL.0000000000010142
2020
Journal Article
The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI
Wimmer, Thomas, Schreiber, Frank, Hensiek, Nathalie, Garz, Cornelia, Kaufmann, Jörn, Machts, Judith, Vogt, Susanne, Prudlo, Johannes, Dengler, Reinhard, Petri, Susanne, Heinze, Hans-Jochen, Nestor, Peter J., Vielhaber, Stefan and Schreiber, Stefanie (2020). The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI. Scientific Reports, 10 (1) 1783, 1783. doi: 10.1038/s41598-020-58687-z
2020
Journal Article
7T MR neurography-ultrasound fusion for peripheral nerve imaging
Schreiber, Stefanie, Schreiber, Frank, Peter, Alica, Isler, Eser, Doerner, Marc, Heinze, Hans-Jochen, Petri, Suanne, Tempelmann, Claus, Nestor, Peter J., Grimm, Alexander and Vielhaber, Stefan (2020). 7T MR neurography-ultrasound fusion for peripheral nerve imaging. Muscle and Nerve, 61 (4) mus.26800, 1-6. doi: 10.1002/mus.26800
2020
Journal Article
A multi-contrast MRI approach to thalamus segmentation
Corona, Veronica, Lellmann, Jan, Nestor, Peter, Schoenlieb, Carola-Bibiane and Acosta-Cabronero, Julio (2020). A multi-contrast MRI approach to thalamus segmentation. Human Brain Mapping, 41 (8) hbm.24933, 2104-2120. doi: 10.1002/hbm.24933
2020
Journal Article
Prominent white matter involvement in multiple system atrophy of cerebellar type
Faber, Jennifer, Giordano, Ilaria, Jiang, Xueyan, Kindler, Christine, Spottke, Annika, Acosta-Cabronero, Julio, Nestor, Peter J., Machts, Judith, Düzel, Emrah, Vielhaber, Stefan, Speck, Oliver, Dudesek, Ales, Kamm, Christoph, Scheef, Lukas and Klockgether, Thomas (2020). Prominent white matter involvement in multiple system atrophy of cerebellar type. Movement Disorders, 35 (5) mds.27987, 816-824. doi: 10.1002/mds.27987
2020
Journal Article
Sonographic and 3T-MRI-based evaluation of the tongue in ALS
Hensiek, Nathalie, Schreiber, Frank, Wimmer, Thomas, Kaufmann, Jörn, Machts, Judith, Fahlbusch, Laura, Garz, Cornelia, Vogt, Susanne, Prudlo, Johannes, Dengler, Reinhard, Petri, Susanne, Nestor, Peter J., Vielhaber, Stefan and Schreiber, Stefanie (2020). Sonographic and 3T-MRI-based evaluation of the tongue in ALS. NeuroImage: Clinical, 26 102233, 102233. doi: 10.1016/j.nicl.2020.102233
2019
Journal Article
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report
Mak, Elijah, Bickerton, Anastasia, Padilla, Concepcion, Walpert, Madeleine J., Annus, Tiina, Wilson, Liam R., Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Aigbirhio, Franklin I., Christian, Bradley T., Handen, Benjamin L., Klunk, William E., Menon, David K., Nestor, Peter J., Zaman, Shahid H. and Holland, Anthony J. (2019). Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11 (C), 654-658. doi: 10.1016/j.dadm.2019.04.006
2019
Journal Article
Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System
van Eimeren, Thilo, Antonini, Angelo, Berg, Daniela, Bohnen, Nico, Ceravolo, Roberto, Drzezga, Alexander, Höglinger, Günter U., Higuchi, Makoto, Lehericy, Stephane, Lewis, Simon, Monchi, Oury, Nestor, Peter, Ondrus, Matej, Pavese, Nicola, Peralta, María Cecilia, Piccini, Paola, Pineda-Pardo, José Ángel, Rektorová, Irena, Rodríguez-Oroz, María, Rominger, Axel, Seppi, Klaus, Stoessl, A. Jon, Tessitore, Alessandro, Thobois, Stephane, Kaasinen, Valtteri, Wenning, Gregor, Siebner, Hartwig R., Strafella, Antonio P. and Rowe, James B. (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11 (C), 301-309. doi: 10.1016/j.dadm.2019.01.011
2019
Journal Article
Diffusion tensor MRI to distinguish progressive supranuclear palsy from α-synucleinopathies
Spotorno, Nicola, Hall, Sara, Irwin, David J., Rumetshofer, Theodor, Acosta-Cabronero, Julio, Deik, Andres F., Spindler, Meredith A., Lee, Edward B., Trojanowski, John Q., van Westen, Danielle, Nilsson, Markus, Grossman, Murray, Nestor, Peter J., McMillan, Corey T. and Hansson, Oskar (2019). Diffusion tensor MRI to distinguish progressive supranuclear palsy from α-synucleinopathies. Radiology, 293 (3), 190406-653. doi: 10.1148/radiol.2019190406
2019
Journal Article
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity
Wilson, Liam R., Vatansever, Deniz, Annus, Tiina, Williams, Guy B., Hong, Young T., Fryer, Tim D., Nestor, Peter J., Holland, Anthony J. and Zaman, Shahid H. (2019). Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity. Human Brain Mapping, 40 (15) hbm.24720, 4551-4563. doi: 10.1002/hbm.24720
2019
Journal Article
The atrophy pattern in Alzheimer-related PPA is more widespread than that of the frontotemporal lobar degeneration associated variants
Preiß, Daniel, Billette, Ornella V., Schneider, Anja, Spotorno, Nicola and Nestor, Peter J. (2019). The atrophy pattern in Alzheimer-related PPA is more widespread than that of the frontotemporal lobar degeneration associated variants. NeuroImage: Clinical, 24 101994, 101994. doi: 10.1016/j.nicl.2019.101994
2019
Journal Article
Delineating the topography of amyloid-associated cortical atrophy in Down syndrome
Mak, Elijah, Padilla, Concepcion, Annus, Tiina, Wilson, Liam R., Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Nestor, Peter J., Zaman, Shahid H. and Holland, Anthony J. (2019). Delineating the topography of amyloid-associated cortical atrophy in Down syndrome. Neurobiology of Aging, 80, 196-202. doi: 10.1016/j.neurobiolaging.2019.02.018
2019
Journal Article
Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis
Schreiber, Stefanie, Schreiber, Frank, Garz, Cornelia, Debska-Vielhaber, Grazyna, Assmann, Anne, Perosa, Valentina, Petri, Susanne, Dengler, Reinhard, Nestor, Peter and Vielhaber, Stefan (2019). Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis. Muscle and Nerve, 59 (5), 567-576. doi: 10.1002/mus.26444
2019
Journal Article
The BDNF Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease
Franzmeier, Nicolai, Ren, Jinyi, Damm, Alexander, Monté-Rubio, Gemma, Boada, Mercè, Ruiz, Agustín, Ramirez, Alfredo, Jessen, Frank, Düzel, Emrah, Rodríguez Gómez, Octavio, Benzinger, Tammie, Goate, Alison, Karch, Celeste M., Fagan, Anne M., McDade, Eric, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Suárez-Calvet, Marc, Haass, Christian, Gordon, Brian A., Lim, Yen Ying, Masters, Colin L., Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Milz, Esther ... Ewers, Michael (2019). The BDNF Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Molecular Psychiatry, 26 (2), 614-628. doi: 10.1038/s41380-019-0404-6
2019
Journal Article
The concept of regularization: resolving the problem of surface dyslexia in semantic variant primary progressive aphasia across different languages
Billette, Ornella V., Preib, Daniel and Nestor, Peter J. (2019). The concept of regularization: resolving the problem of surface dyslexia in semantic variant primary progressive aphasia across different languages. Neuropsychology, 34 (3), 298-307. doi: 10.1037/neu0000611
2018
Journal Article
Significance of CSF NfL and tau in ALS
Schreiber, Stefanie, Spotorno, Nicola, Schreiber, Frank, Acosta-Cabronero, Julio, Kaufmann, Jörn, Machts, Judith, Debska-Vielhaber, Grazyna, Garz, Cornelia, Bittner, Daniel, Hensiek, Nathalie, Dengler, Reinhard, Petri, Susanne, Nestor, Peter J. and Vielhaber, Stefan (2018). Significance of CSF NfL and tau in ALS. Journal of Neurology, 265 (11), 2633-2645. doi: 10.1007/s00415-018-9043-0
2018
Journal Article
European Association of Nuclear Medicine and European Academy of Neurology recommendations for the use of brain 18 F-fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: Delphi consensus
Nobili, F., Arbizu, J., Bouwman, F., Drzezga, A., Agosta, F., Nestor, P., Walker, Z., Boccardi, M. and for the EANM-EAN Task Force for the Prescription of FDG-PET for DementingNeurodegenerative Disorders (2018). European Association of Nuclear Medicine and European Academy of Neurology recommendations for the use of brain 18 F-fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: Delphi consensus. European Journal of Neurology, 25 (10), 1201-1217. doi: 10.1111/ene.13728
Supervision
Availability
- Professor Peter Nestor is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Clinical utility of autobiographical memory in dementia diagnoses
Principal Advisor
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Doctor Philosophy
Diagnostic specificity in frontotemporal dementia
Principal Advisor
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Doctor Philosophy
The evolution of cognitive deficits in Lewy body disorders and related degenerative diseases.
Principal Advisor
Other advisors: Associate Professor John O'Sullivan, Dr Amir Fazlollahi
Completed supervision
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2024
Doctor Philosophy
The `What' and `Where' of Visual Processing in Neurodegeneration: The essential yet overlooked component of diagnostic testing in dementia
Principal Advisor
Other advisors: Professor Jason Mattingley
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2025
Doctor Philosophy
Attentional Switching in Healthy Ageing and Neurodegenerative Disorders
Associate Advisor
Other advisors: Professor Gail Robinson
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2021
Doctor Philosophy
Neuroimaging of Traumatic Brain Injury and Dementia: Bridging the link
Associate Advisor
Other advisors: Professor Fatima Nasrallah
Media
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