Overview
Background
Prof Nestor joined the Queensland Brain Institute in October/2017 and has a conjoint appointment as a cognitive neurologist at Mater Misericordiae Ltd (Mater Hospital).
His particular interests include understanding the earliest stages of Alzheimer's disease (i.e. before dementia is established); atypical forms of dementia with a particular focus on primary progressive aphasia and dementias related to Parkinson's and Lewy body diseases; and improving differential diagnosis between the major categories of neurodegenerative diseases.
He works on development of neuropsychological tests of cognition, both to accurately track change over time and improve diagnostic accuracy between the major diseases causing dementia. He also uses multi-modal imaging (magnetic resonance imaging [MRI] and positron emission tomography [PET]) to understand the sequence of events occurring in degenerative brain diseases (particularly Alzheimer's disease, frontotemporal dementia, Parkinson's disease, motor neuron disease [ALS], progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]) and identify novel biomarkers. A major focus of his is on developing novel approaches to MR imaging for single subject pathological diagnoses that can be exported into the everyday clinical setting; recent examples include diffusion tensor imaging to identify PSP and CBD (Sajjadi et al, 2013) and quantitative susceptibility mapping in Parkinson's disease (Acosta-Cabornero et al, 2013).
Availability
- Professor Peter Nestor is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
- Doctor of Philosophy, University of Cambridge
Research interests
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Cognitive neurology
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frontotemporal lobar degeneration
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progressive aphasia
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Alzheimer's disease
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Neurodegenerative diseases
Works
Search Professor Peter Nestor’s works on UQ eSpace
2024
Conference Publication
Deciphering white-matter changes in Progressive Supranuclear Palsy using free-water diffusion MRI
Fazlollahi, Amir, Oestreich, Lena and Nestor, Peter (2024). Deciphering white-matter changes in Progressive Supranuclear Palsy using free-water diffusion MRI. Organization for Human Brain Mapping, Seoul, South Korea, 23-27 June 2024. doi: 10.52294/001c.120379
2024
Journal Article
A systematic review of cognitive and behavioral tools to differentiate behavioral variant frontotemporal dementia from other conditions
Flavell, Joshua and Nestor, Peter John (2024). A systematic review of cognitive and behavioral tools to differentiate behavioral variant frontotemporal dementia from other conditions. Psychiatry and Clinical Neurosciences Reports, 3 (2) e210. doi: 10.1002/pcn5.210
2024
Journal Article
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Chatterjee, Madhurima, Özdemir, Selcuk, Fritz, Christian, Möbius, Wiebke, Kleineidam, Luca, Mandelkow, Eckhard, Biernat, Jacek, Doğdu, Cem, Peters, Oliver, Cosma, Nicoleta Carmen, Wang, Xiao, Schneider, Luisa-Sophia, Priller, Josef, Spruth, Eike, Kühn, Andrea A., Krause, Patricia, Klockgether, Thomas, Vogt, Ina R., Kimmich, Okka, Spottke, Annika, Hoffmann, Daniel C., Fliessbach, Klaus, Miklitz, Carolin, McCormick, Cornelia, Weydt, Patrick, Falkenburger, Björn, Brandt, Moritz, Guenther, René, Dinter, Elisabeth ... Schneider, Anja (2024). Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nature Medicine, 30 (6), 1771-1783. doi: 10.1038/s41591-024-02937-4
2024
Journal Article
Quantitative susceptibility mapping through model-based deep image prior (MoDIP)
Xiong, Zhuang, Gao, Yang, Liu, Yin, Fazlollahi, Amir, Nestor, Peter, Liu, Feng and Sun, Hongfu (2024). Quantitative susceptibility mapping through model-based deep image prior (MoDIP). NeuroImage, 291 120583, 120583. doi: 10.1016/j.neuroimage.2024.120583
2023
Journal Article
Pareidolias are a function of visuoperceptual impairment
McCann, Emily, Lee, Soohyun, Coleman, Felicia, O’Sullivan, John D. and Nestor, Peter J. (2023). Pareidolias are a function of visuoperceptual impairment. PLoS One, 18 (11) e0293942, 1-11. doi: 10.1371/journal.pone.0293942
2023
Journal Article
Increased resolution of structural MRI at 3T improves estimation of regional cortical degeneration in individual dementia patients using surface thickness maps
Fazlollahi, Amir, Lee, Soohyun, Coleman, Felicia, McCann, Emily, Cloos, Martijn A., Bourgeat, Pierrick and Nestor, Peter J. (2023). Increased resolution of structural MRI at 3T improves estimation of regional cortical degeneration in individual dementia patients using surface thickness maps. Journal of Alzheimer's Disease, 95 (3), 1-10. doi: 10.3233/jad-230030
2023
Conference Publication
QSM from the raw phase using an end-to-end neural network
Gao, Yang, Xiong, Zhuang, Fazlollahi, Amir, Nestor, Peter, Vegh, Viktor, Pike, G. Bruce, Crozier, Stuart, Liu, Feng and Sun, Hongfu (2023). QSM from the raw phase using an end-to-end neural network. ISMRM Annual Meeting, London, United Kingdom, 7-12 May 2022. Berkeley, CA, United States: International Society for Magnetic Resonance in Medicine. doi: 10.58530/2022/4740
2022
Journal Article
Management-induced distress syndrome
Nestor, Peter J. (2022). Management-induced distress syndrome. Brain, 145 (11), e104-e104. doi: 10.1093/brain/awac287
2022
Journal Article
Instant tissue field and magnetic susceptibility mapping from MRI raw phase using Laplacian enhanced deep neural networks
Gao, Yang, Xiong, Zhuang, Fazlollahi, Amir, Nestor, Peter J., Vegh, Viktor, Nasrallah, Fatima, Winter, Craig, Pike, G. Bruce, Crozier, Stuart, Liu, Feng and Sun, Hongfu (2022). Instant tissue field and magnetic susceptibility mapping from MRI raw phase using Laplacian enhanced deep neural networks. NeuroImage, 259 119410, 1-13. doi: 10.1016/j.neuroimage.2022.119410
2022
Journal Article
A systematic review of fragile X-associated neuropsychiatric disorders
Flavell, Joshua, Franklin, Catherine and Nestor, Peter J. (2022). A systematic review of fragile X-associated neuropsychiatric disorders. The Journal of Neuropsychiatry and Clinical Neurosciences, 35 (2), 110-120. doi: 10.1176/appi.neuropsych.21110282
2022
Journal Article
Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome
Brown, Stephanie S.G., Mak, Elijah, Clare, Isabel, Grigorova, Monika, Beresford-Webb, Jessica, Walpert, Madeline, Jones, Elizabeth, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Aigbirhio, Franklin I., Tudorascu, Dana, Cohen, Annie, Christian, Bradley T., Handen, Benjamin L., Klunk, William E., Menon, David K., Nestor, Peter J., Holland, Anthony J. and Zaman, Shahid H. (2022). Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome. Neurobiology of Aging, 115, 112-121. doi: 10.1016/j.neurobiolaging.2022.02.013
2022
Conference Publication
Fragile X-Associated Neuropsychiatric Conditions (FXANC)
Flavell, J., Franklin, C. and Nestor, P. (2022). Fragile X-Associated Neuropsychiatric Conditions (FXANC). RANZCP Congress 2022, Sydney, NSW Australia, 15-19 May 2022. London, United Kingdom: SAGE Publications. doi: 10.1177/00048674221088686
2021
Journal Article
Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury
Hermanides, Jeroen, Hong, Young T., Trivedi, Monica, Outtrim, Joanne, Aigbirhio, Franklin, Nestor, Peter J., Guilfoyle, Matthew, Winzeck, Stefan, Newcombe, Virginia F. J., Das, Tilak, Correia, Marta M., Carpenter, Keri L. H., Hutchinson, Peter J. A., Gupta, Arun K., Fryer, Tim D., Pickard, John D., Menon, David K. and Coles, Jonathan P. (2021). Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury. Brain, 144 (11), 3492-3504. doi: 10.1093/brain/awab255
2021
Journal Article
What Lies Behind the Construct of Primary Progressive Aphasia?
Preiss, Daniel, Billette, Ornella and Nestor, Peter J. (2021). What Lies Behind the Construct of Primary Progressive Aphasia?. Sprache-Stimme-Gehor, 45 (04), 173-178. doi: 10.1055/a-1557-8330
2021
Journal Article
What’s “up”?: impaired spatial preposition processing in posterior cortical atrophy
Shebani, Zubaida, Nestor, Peter J. and Pulvermüller, Friedemann (2021). What’s “up”?: impaired spatial preposition processing in posterior cortical atrophy. Frontiers in Human Neuroscience, 15 731104, 731104. doi: 10.3389/fnhum.2021.731104
2021
Journal Article
Traumatic brain injury fast-forwards Alzheimer’s pathology: evidence from amyloid positron emission tomorgraphy imaging
Mohamed, Abdalla Z., Nestor, Peter J., Cumming, Paul, Nasrallah, Fatima A. and for the Alzheimer’s Disease Neuroimaging Initiative (2021). Traumatic brain injury fast-forwards Alzheimer’s pathology: evidence from amyloid positron emission tomorgraphy imaging. Journal of Neurology, 269 (2), 873-884. doi: 10.1007/s00415-021-10669-5
2021
Journal Article
A systematic review of apathy and depression in progressive supranuclear palsy
Flavell, Joshua and Nestor, Peter J. (2021). A systematic review of apathy and depression in progressive supranuclear palsy. Journal of Geriatric Psychiatry and Neurology, 35 (3), 891988721993545-292. doi: 10.1177/0891988721993545
2020
Conference Publication
Hippocampal volumetric variability is associated with memory in subjective cognitive decline : Neuroimaging / Optimal neuroimaging measures for early detection
Ziegler, Gabriel, Heinzinger, Nils, Metzger, Coraline D., Yakupov, Renat, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Brosseron, Frederic, Bürger, Katharina, Fließbach, Klaus, Heneka, Michael T., Laske, Christoph, Nestor, Peter J., Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Schneider, Anja, Speck, Oliver, Teipel, Stefan J., Wiltfang, Jens, Wagner, Michael, Düzel, Emrah and Jessen, Frank (2020). Hippocampal volumetric variability is associated with memory in subjective cognitive decline : Neuroimaging / Optimal neuroimaging measures for early detection. Alzheimer's Association International Conference (AAIC 2020), Online, 27-31 July 2020. Hoboken, NJ, United States: Wiley. doi: 10.1002/alz.043527
2020
Journal Article
Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline
Mak, Elijah, Grigorova, Monika, Beresford-Webb, Jessica, Malpetti, Maura, Walpert, Madeline, Brown, Stephanie, Jones, Elizabeth, Clare, Isabel, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Nestor, Peter J., Holland, Anthony J. and Zaman, Shahid H (2020). Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline. Brain Communications, 3 (1) fcaa198, fcaa198. doi: 10.1093/braincomms/fcaa198
2020
Journal Article
The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI
Wimmer, Thomas, Schreiber, Frank, Hensiek, Nathalie, Garz, Cornelia, Kaufmann, Jörn, Machts, Judith, Vogt, Susanne, Prudlo, Johannes, Dengler, Reinhard, Petri, Susanne, Heinze, Hans-Jochen, Nestor, Peter J., Vielhaber, Stefan and Schreiber, Stefanie (2020). The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI. Scientific Reports, 10 (1) 1783, 1783. doi: 10.1038/s41598-020-58687-z
Supervision
Availability
- Professor Peter Nestor is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The `What¿ and `Where¿ of Visual Processing in Neurodegeneration: The essential yet overlooked component of diagnostic testing in dementia
Principal Advisor
Other advisors: Professor Jason Mattingley
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Doctor Philosophy
The evolution of cognitive deficits in Lewy body disorders and related degenerative diseases.
Principal Advisor
Other advisors: Associate Professor John O'Sullivan
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Doctor Philosophy
Diagnostic specificity in frontotemporal dementia
Principal Advisor
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Doctor Philosophy
Cognitive switching in ageing and preclinical neurodegenerative disorders
Associate Advisor
Other advisors: Professor Gail Robinson
Completed supervision
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2021
Doctor Philosophy
Neuroimaging of Traumatic Brain Injury and Dementia: Bridging the link
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Media
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