Overview
Background
Prof Nestor joined the Queensland Brain Institute in October/2017 and has a conjoint appointment as a cognitive neurologist at Mater Misericordiae Ltd (Mater Hospital).
His particular interests include understanding the earliest stages of Alzheimer's disease (i.e. before dementia is established); atypical forms of dementia with a particular focus on primary progressive aphasia and dementias related to Parkinson's and Lewy body diseases; and improving differential diagnosis between the major categories of neurodegenerative diseases.
He works on development of neuropsychological tests of cognition, both to accurately track change over time and improve diagnostic accuracy between the major diseases causing dementia. He also uses multi-modal imaging (magnetic resonance imaging [MRI] and positron emission tomography [PET]) to understand the sequence of events occurring in degenerative brain diseases (particularly Alzheimer's disease, frontotemporal dementia, Parkinson's disease, motor neuron disease [ALS], progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]) and identify novel biomarkers. A major focus of his is on developing novel approaches to MR imaging for single subject pathological diagnoses that can be exported into the everyday clinical setting; recent examples include diffusion tensor imaging to identify PSP and CBD (Sajjadi et al, 2013) and quantitative susceptibility mapping in Parkinson's disease (Acosta-Cabornero et al, 2013).
Availability
- Professor Peter Nestor is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
- Doctor of Philosophy, University of Cambridge
Research interests
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Cognitive neurology
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frontotemporal lobar degeneration
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progressive aphasia
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Alzheimer's disease
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Neurodegenerative diseases
Works
Search Professor Peter Nestor’s works on UQ eSpace
2017
Journal Article
Can MRI visual assessment differentiate the variants of primary-progressive aphasia?
Sajjadi, S. A., Sheikh-Bahaei, N., Cross, J., Gillard, J. H., Scoffings, D. and Nestor, P. J. (2017). Can MRI visual assessment differentiate the variants of primary-progressive aphasia?. American Journal of Neuroradiology, 38 (5), 954-960. doi: 10.3174/ajnr.A5126
2017
Journal Article
The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis
Annus, Tiina, Wilson, Liam R., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Menon, David K., Zaman, Shahid H., Holland, Anthony J. and Nestor, Peter J. (2017). The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiology of Aging, 53, 11-19. doi: 10.1016/j.neurobiolaging.2017.01.009
2017
Journal Article
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis
Smith, Bradley N., Topp, Simon D., Fallini, Claudia, Shibata, Hideki, Chen, Han-Jou, Troakes, Claire, King, Andrew, Ticozzi, Nicola, Kenna, Kevin P., Soragia-Gkazi, Athina, Miller, Jack W., Sato, Akane, Dias, Diana Marques, Jeon, Maryangel, Vance, Caroline, Wong, Chun Hao, de Majo, Martina, Kattuah, Wejdan, Mitchell, Jacqueline C., Scotter, Emma L., Parkin, Nicholas W., Sapp, Peter C., Nolan, Matthew, Nestor, Peter J., Simpson, Michael, Weale, Michael, Lek, Monkel, Baas, Frank, de Jong, J. M. Vianney ... Shaw, Christopher E. (2017). Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Science Translational Medicine, 9 (388) aad9157, eaad9157. doi: 10.1126/scitranslmed.aad9157
2017
Journal Article
The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: Consensus document of the Joint Program for Neurodegenerative Diseases Working Group
Costa, Alberto, Bak, Thomas, Caffarra, Paolo, Caltagirone, Carlo, Ceccaldi, Mathieu, Collette, Fabienne, Crutch, Sebastian, Della Sala, Sergio, Demonet, Jean Francois, Dubois, Bruno, Duzel, Emrah, Nestor, Peter, Papageorgiou, Sokratis G., Salmon, Eric, Sikkes, Sietske, Tiraboschi, Pietro, van der Flier, Wiesje M., Visser, Pieter Jelle and Cappa, Stefano F. (2017). The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: Consensus document of the Joint Program for Neurodegenerative Diseases Working Group. Alzheimers Research & Therapy, 9 (1) 27. doi: 10.1186/s13195-017-0254-x
2017
Journal Article
The whole-brain pattern of magnetic susceptibility perturbations in Parkinson's disease
Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Betts, Matthew J., Butryn, Michaela, Valdes-Herrera, Jose P., Galazky, Imke and Nestor, Peter J. (2017). The whole-brain pattern of magnetic susceptibility perturbations in Parkinson's disease. Brain, 140 (1), 118-131. doi: 10.1093/brain/aww278
2017
Journal Article
The European DTI study on dementia — a multicenter DTI and MRI study on Alzheimer's disease and mild cognitive impairment
Brueggen, Katharina, Grothe, Michel J., Dyrba, Martin, Fellgiebel, Andreas, Fischer, Florian, Filippi, Massimo, Agosta, Federica, Nestor, Peter, Meisenzahl, Eva, Blautzik, Janusch, Froelich, Lutz, Hausner, Lucrezia, Bokde, Arun L. W., Frisoni, Giovanni, Pievani, Michela, Kloeppel, Stefan, Prvulovic, David, Barkhof, Frederik, Pouwels, Petra J. W., Schroeder, Johannes, Hampel, Harald, Hauenstein, Karlheinz and Teipel, Stefan (2017). The European DTI study on dementia — a multicenter DTI and MRI study on Alzheimer's disease and mild cognitive impairment. NeuroImage, 144 (B), 305-308. doi: 10.1016/j.neuroimage.2016.03.067
2017
Book Chapter
Frontotemporal dementia
Nestor, Peter J. (2017). Frontotemporal dementia. Dementia. (pp. 749-758) edited by David Ames, John T. O'Brien and Alistair Burns. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9781315381572
2016
Journal Article
High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T
Betts, Matthew J., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Nestor, Peter J. and Duezel, Emrah (2016). High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T. NeuroImage, 138, 43-63. doi: 10.1016/j.neuroimage.2016.05.024
2016
Journal Article
Quantifying disease progression in ALS using peripheral nerve sonography
Schreiber, S., Dannhardt-Stieger, V., Henkel, D., Debska-Vielhaber, G., Machts, J., Abdulla, S., Kropf, S., Kollewe, K., Petri, S., Heinze, H. J., Dengler, R., Nestor, P. J. and Vielhaber, S. (2016). Quantifying disease progression in ALS using peripheral nerve sonography. Muscle and Nerve, 54 (3), 391-397. doi: 10.1002/mus.25066
2016
Journal Article
The pattern of amyloid accumulation in the brains of adults with Down syndrome
Annus, Tiina, Wilson, Liam R., Hong, Young T., Acosta-Cabronero, Julio, Fryer, Tim D., Cardenas-Blanco, Arturo, Smith, Robert, Boros, Istvan, Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Zaman, Shahid H., Nestor, Peter J. and Holland, Anthony J. (2016). The pattern of amyloid accumulation in the brains of adults with Down syndrome. Alzheimers & Dementia, 12 (5), 538-545. doi: 10.1016/j.jalz.2015.07.490
2016
Book Chapter
Bedside assessment of cognition
Sajjadi, S. A. and Nestor, P. J. (2016). Bedside assessment of cognition. Oxford Textbook of Cognitive Neurology and Dementia. (pp. 105-112) edited by Hussain, M. and Schott, J. M.. Oxford University Press, Oxford, UK: OUP. doi: 10.1093/med/9780199655946.003.0010
2016
Journal Article
Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis
Cardenas-Blanco, Arturo, Machts, Judith, Acosta-Cabronero, Julio, Kaufmann, Joern, Abdulla, Susanne, Kollewe, Katja, Petri, Susanne, Schreiber, Stefanie, Heinze, Hans-Jochen, Dengler, Reinhard, Vielhaber, Stefan and Nestor, Peter J. (2016). Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis. Neuroimage: Clinical, 11, 408-414. doi: 10.1016/j.nicl.2016.03.011
2016
Journal Article
In vivo MRI mapping of brain iron deposition across the adult lifespan
Acosta-Cabronero, Julio, Betts, Matthew J., Cardenas-Blanco, Arturo, Yang, Shan and Nestor, Peter J. (2016). In vivo MRI mapping of brain iron deposition across the adult lifespan. Journal of Neuroscience, 36 (2), 364-374. doi: 10.1523/JNEUROSCI.1907-15.2016
2015
Journal Article
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) with a novel CSF1R mutation and spinal cord involvement
Koertvelyessy, Peter, Kraegeloh-Mann, Ingeborg, Mawrin, Christian, Heinze, Hans-Jochen, Bittner, Daniel, Wieland, Ilse, Zenker, Martin and Nestor, Peter (2015). Hereditary diffuse leukoencephalopathy with spheroids (HDLS) with a novel CSF1R mutation and spinal cord involvement. Journal of the Neurological Sciences, 358 (1-2), 515-517. doi: 10.1016/j.jns.2015.09.370
2015
Journal Article
SECT and MAST: new tests to assess grammatical abilities in primary progressive aphasia
Billette, Ornella V., Sajjadi, Seyed A., Patterson, Karalyn and Nestor, Peter J. (2015). SECT and MAST: new tests to assess grammatical abilities in primary progressive aphasia. Aphasiology, 29 (10), 1135-1151. doi: 10.1080/02687038.2015.1037822
2015
Journal Article
Basal forebrain and hippocampus as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment-a multicenter DTI and volumetry study
Brueggen, Katharina, Dyrba, Martin, Barkhof, Frederik, Hausner, Lucrezia, Filippi, Massimo, Nestor, Peter J., Hauenstein, Karlheinz, Kloeppel, Stefan, Grothe, Michel J., Kasper, Elisabeth and Teipel, Stefan J. (2015). Basal forebrain and hippocampus as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment-a multicenter DTI and volumetry study. Journal of Alzheimers Disease, 48 (1), 197-204. doi: 10.3233/JAD-150063
2015
Journal Article
Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes
Schreiber, Stefanie, Abdulla, Susanne, Debska-Vielhaber, Grazyna, Machts, Judith, Dannhardt-Stieger, Verena, Feistner, Helmut, Oldag, Andreas, Goertler, Michael, Petri, Susanne, Kollewe, Katja, Kropf, Siegfried, Schreiber, Frank, Heinze, Hans-Jochen, Dengler, Reinhard, Nestor, Peter J. and Vielhaber, Stefan (2015). Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes. Muscle & Nerve, 51 (5), 669-675. doi: 10.1002/mus.24431
2014
Journal Article
A new fast accurate nonlinear medical image registration program including surface preserving regularization
Gruslys, Audrunas, Acosta-Cabronero, Julio, Nestor, Peter J., Williams, Guy B. and Ansorge, Richard E. (2014). A new fast accurate nonlinear medical image registration program including surface preserving regularization. IEEE Transactions on Medical Imaging, 33 (11) A6, 2118-2127. doi: 10.1109/TMI.2014.2332370
2014
Journal Article
Hippocampal degeneration in patients with amyotrophic lateral sclerosis
Abdulla, Susanne, Machts, Judith, Kaufmann, Joern, Patrick, Karina, Kollewe, Katja, Dengler, Reinhard, Heinze, Hans-Jochen, Petri, Susanne, Vielhaber, Stefan and Nestor, Peter J. (2014). Hippocampal degeneration in patients with amyotrophic lateral sclerosis. Neurobiology of Aging, 35 (11), 2639-2645. doi: 10.1016/j.neurobiolaging.2014.05.035
2014
Journal Article
Comparing voxel-based iterative sensitivity and voxel-based morphometry to detect abnormalities in T2-weighted MRI
Diaz-de-Grenu, Lara Z., Acosta-Cabronero, Julio, Williams, Guy B. and Nestor, Peter J. (2014). Comparing voxel-based iterative sensitivity and voxel-based morphometry to detect abnormalities in T2-weighted MRI. NeuroImage, 100, 379-384. doi: 10.1016/j.neuroimage.2014.06.030
Supervision
Availability
- Professor Peter Nestor is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The evolution of cognitive deficits in Lewy body disorders and related degenerative diseases.
Principal Advisor
Other advisors: Associate Professor John O'Sullivan
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Doctor Philosophy
The `What¿ and `Where¿ of Visual Processing in Neurodegeneration: The essential yet overlooked component of diagnostic testing in dementia
Principal Advisor
Other advisors: Professor Jason Mattingley
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Doctor Philosophy
Diagnostic specificity in frontotemporal dementia
Principal Advisor
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Doctor Philosophy
Cognitive switching in ageing and preclinical neurodegenerative disorders
Associate Advisor
Other advisors: Professor Gail Robinson
Completed supervision
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2021
Doctor Philosophy
Neuroimaging of Traumatic Brain Injury and Dementia: Bridging the link
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Media
Enquiries
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