Overview
Background
I am a clinician-academic whose interactions with patients have shaped my research questions and fuelled my enthusiasm for the importance of clinical research. I trained as a genetic counsellor and my research now focuses on the integration of genomics into clinical care. My research program has had three primary themes: evaluating the psychosocial impact of genetic conditions and/or genetic testing; evaluating genetics education preferences for patients and healthcare providers; and using next-generation sequencing to increase diagnostic yield for rare disorders.
Current research projects include:
- Exploring whether genetic fatalism affects sun-related health behaviours in high-risk individuals following genetic testing.
- Exploring the referral journey to genetic services for individuals with rare diseases
- Assessing Human Research Ethics Committee (HREC) members’ confidence in reviewing genomic research applications.
- Mainstreaming Genetic Testing for Melanoma into Dermatology Practice.
- Using Exome sequencing to identify new genes in families with inherited melanoma, negative for mutations in known genes.
Availability
- Associate Professor Aideen McInerney-Leo is:
- Available for supervision
Qualifications
- Masters (Coursework) of Science, The University of Manchester
- Doctor of Philosophy, The University of Queensland
Research interests
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Integrating genetic testing for melanoma into dermatology practice
Our study explores whether upskilling dermatologists to offer genetic testing for melanoma is acceptable to dermatologists and whether patient outcomes, as compared to when genetic testing is offered by a genetic counsellor.
Works
Search Professor Aideen McInerney-Leo’s works on UQ eSpace
2022
Journal Article
Evaluation of a genetics education program for health interpreters: A pilot study
Vidgen, Miranda E., Fowles, Lindsay F., Istiko, Satrio Nindyo, Evans, Erin, Cutler, Katrina, Sullivan, Kate, Bean, Jessica, Healy, Louise, Hondow, Gary, McInerney-Leo, Aideen M., Pratt, Gregory, Robins, Deborah, Best, Stephanie, Finlay, Keri, Ramarao-Milne, Priya and Waddell, Nicola (2022). Evaluation of a genetics education program for health interpreters: A pilot study. Frontiers in Genetics, 12 771892, 1-12. doi: 10.3389/fgene.2021.771892
2022
Journal Article
The future of precision prevention for advanced melanoma
Lee, Katie J., Betz-Stablein, Brigid, Stark, Mitchell S., Janda, Monika, McInerney-Leo, Aideen M., Caffery, Liam J., Gillespie, Nicole, Yanes, Tatiane and Soyer, H. Peter (2022). The future of precision prevention for advanced melanoma. Frontiers in Medicine, 8 818096, 818096. doi: 10.3389/fmed.2021.818096
2022
Journal Article
Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: a systematic review
Wallingford, Courtney K., Kovilpillai, Hannah, Jacobs, Chris, Turbitt, Erin, Primiero, Clare A., Young, Mary-Anne, Brockman, Deanna G., Soyer, H. Peter, McInerney-Leo, Aideen M. and Yanes, Tatiane (2022). Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: a systematic review. Genetics in Medicine, 25 (1), 1-11. doi: 10.1016/j.gim.2022.09.008
2021
Journal Article
Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis
McInerney-Leo, Aideen M., Chew, Hui Yi, Inglis, Po-Ling, Leo, Paul J., Joseph, Shannon R., Cooper, Caroline L., Okano, Satomi, Hassall, Tim, Anderson, Lisa, Bowman, Rayleen V., Gattas, Michael, Harris, Jessica E., Marshall, Mhairi S., Shaw, Janet G., Wheeler, Lawrie, Yang, Ian A., Brown, Matthew A., Fong, Kwun M., Simpson, Fiona and Duncan, Emma L. (2021). Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis. Human Molecular Genetics, 30 (24), 2393-2401. doi: 10.1093/hmg/ddab172
2021
Journal Article
The ethical protection of genetic information: procedure analysis for psychologists
Allen, Kelly-Ann, McInerney-Leo, Aideen M, Gamble, Nicholas, Wurf, Gerald and Boyle, Christopher (2021). The ethical protection of genetic information: procedure analysis for psychologists. Clinical Psychologist, 26 (1), 1-10. doi: 10.1080/13284207.2021.1985376
2021
Journal Article
A step forward, but still inadequate: Australian health professionals’ views on the genetics and life insurance moratorium
Tiller, Jane M., Keogh, Louise A., McInerney-Leo, Aideen M., Belcher, Andrea, Barlow-Stewart, Kristine, Boughtwood, Tiffany, Gleeson, Penny, Dowling, Grace, Prince, Anya, Bombard, Yvonne, Joly, Yann, Delatycki, Martin, Winship, Ingrid M., Otlowski, Margaret and Lacaze, Paul (2021). A step forward, but still inadequate: Australian health professionals’ views on the genetics and life insurance moratorium. Journal of Medical Genetics, 1-10. doi: 10.1136/jmedgenet-2021-107989
2021
Journal Article
Australian human research ethics committee members’ confidence in reviewing genomic research applications
Pysar, Ryan, Wallingford, Courtney K., Boyle, Jackie, Campbell, Scott B., Eckstein, Lisa, McWhirter, Rebekah, Terrill, Bronwyn, Jacobs, Chris and McInerney-Leo, Aideen M. (2021). Australian human research ethics committee members’ confidence in reviewing genomic research applications. European Journal of Human Genetics, 29 (12), 1-8. doi: 10.1038/s41431-021-00951-5
2021
Journal Article
Anatomic distribution of cherry angiomas in the general population
Betz-Stablein, Brigid, Koh, Uyen, Edwards, Harrison A., McInerney-Leo, Aideen, Janda, Monika and Soyer, H. Peter (2021). Anatomic distribution of cherry angiomas in the general population. Dermatology, 238 (1), 1-9. doi: 10.1159/000517172
2021
Journal Article
A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young
Graff, Sarah M., Johnson, Stephanie R., Leo, Paul J., Dadi, Prasanna K., Dickerson, Matthew T., Nakhe, Arya Y., McInerney-Leo, Aideen M., Marshall, Mhairi, Zaborska, Karolina E., Schaub, Charles M., Brown, Matthew A., Jacobson, David A. and Duncan, Emma L. (2021). A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young. JCI Insight, 6 (13) 138057, 1-13. doi: 10.1172/jci.insight.138057
2021
Journal Article
Study protocol: the Australian genetics and life insurance moratorium-monitoring the effectiveness and response (A-GLIMMER) project
Tiller, Jane, McInerney-Leo, Aideen, Belcher, Andrea, Boughtwood, Tiffany, Gleeson, Penny, Delatycki, Martin, Barlow-Stewart, Kristine, Winship, Ingrid, Otlowski, Margaret, Keogh, Louise and Lacaze, Paul (2021). Study protocol: the Australian genetics and life insurance moratorium-monitoring the effectiveness and response (A-GLIMMER) project. BMC Medical Ethics, 22 (1) 63, 1-14. doi: 10.1186/s12910-021-00634-2
2021
Journal Article
A family with partially penetrant multicentric carpotarsal osteolysis due to gonadal mosaicism: first reported case
Närhi, Anu, Fernandes, Andrea, Toiviainen‐Salo, Sanna, Harris, Jessica, McInerney‐Leo, Aideen, Lazarus, Syndia, Avela, Kristiina and Duncan, Emma L. (2021). A family with partially penetrant multicentric carpotarsal osteolysis due to gonadal mosaicism: first reported case. American Journal of Medical Genetics Part A, 185 (8), 2477-2481. doi: 10.1002/ajmg.a.62257
2021
Journal Article
Genomic risk score for melanoma in a prospective study of older individuals
Bakshi, Andrew, Yan, Mabel, Riaz, Moeen, Polekhina, Galina, Orchard, Suzanne G., Tiller, Jane, Wolfe, Rory, Joshi, Amit, Cao, Yin, McInerney-Leo, Aideen M., Yanes, Tatiane, Janda, Monika, Soyer, H. Peter, Cust, Anne E., Law, Matthew H., Gibbs, Peter, McLean, Catriona, Chan, Andrew T., McNeil, John J., Mar, Victoria J. and Lacaze, Paul (2021). Genomic risk score for melanoma in a prospective study of older individuals. Journal of the National Cancer Institute, 113 (10) ARTN djab076, 1379-1385. doi: 10.1093/jnci/djab076
2021
Journal Article
Communicating polygenic risk scores in the familial breast cancer clinic
Das Gupta, Kuheli, Gregory, Gillian, Meiser, Bettina, Kaur, Rajneesh, Scheepers-Joynt, Maatje, McInerny, Simone, Taylor, Shelby, Barlow-Stewart, Kristine, Antill, Yoland, Salmon, Lucinda, Smyth, Courtney, McInerney-Leo, Aideen, Young, Mary-Anne, James, Paul A. and Yanes, Tatiane (2021). Communicating polygenic risk scores in the familial breast cancer clinic. Patient Education and Counseling, 104 (10), 2512-2521. doi: 10.1016/j.pec.2021.02.046
2021
Journal Article
Massively parallel sequencing for rare genetic disorders: potential and pitfalls
McInerney-Leo, Aideen M. and Duncan, Emma L. (2021). Massively parallel sequencing for rare genetic disorders: potential and pitfalls. Frontiers in Endocrinology, 11 628946, 628946. doi: 10.3389/fendo.2020.628946
2021
Journal Article
A systematic review on the impact of genetic testing for familial melanoma I: primary and secondary preventative behaviours
Primiero, Clare A., Yanes, Tatiane, Finnane, Anna, Soyer, H. Peter and McInerney-Leo, Aideen M. (2021). A systematic review on the impact of genetic testing for familial melanoma I: primary and secondary preventative behaviours. Dermatology , 237 (5), 1-10. doi: 10.1159/000513919
2021
Journal Article
A systematic review on the impact of genetic testing for familial melanoma II: psychosocial outcomes and attitudes
Primiero, Clare A., Yanes, Tatiane, Finnane, Anna, Soyer, H. Peter and McInerney-Leo, Aideen M. (2021). A systematic review on the impact of genetic testing for familial melanoma II: psychosocial outcomes and attitudes. Dermatology, 237 (5), 1-11. doi: 10.1159/000513576
2020
Journal Article
Multiple endocrine tumors associated with germline MAX mutations: multiple endocrine neoplasia type 5?
Seabrook, Amanda J., Harris, Jessica E., Velosa, Sofia B., Kim, Edward, McInerney-Leo, Aideen M., Dwight, Trisha, Hockings, Jason I., Hockings, Nicholas G., Kirk, Judy, Leo, Paul J., Love, Amanda J., Luxford, Catherine, Marshall, Mhairi, Mete, Ozgur, Pennisi, David J., Brown, Matthew A., Gill, Anthony J., Hockings, Gregory I., Clifton-Bligh, Roderick J. and Duncan, Emma L. (2020). Multiple endocrine tumors associated with germline MAX mutations: multiple endocrine neoplasia type 5?. Journal of Clinical Endocrinology and Metabolism, 106 (4), 1163-1182. doi: 10.1210/clinem/dgaa957
2020
Journal Article
Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice
Martin, Ella M. M. A., Enriquez, Annabelle, Sparrow, Duncan B., Humphreys, David T., McInerney-Leo, Aideen M., Leo, Paul J., Duncan, Emma L., Iyer, Kavitha R., Greasby, Joelene A., Ip, Eddie, Giannoulatou, Eleni, Sheng, Delicia, Wohler, Elizabeth, Dimartino, Clémantine, Amiel, Jeanne, Capri, Yline, Lehalle, Daphné, Mory, Adi, Wilnai, Yael, Lebenthal, Yael, Gharavi, Ali G., Krzemień, Grażyna G., Miklaszewska, Monika, Steiner, Robert D., Raggio, Cathy, Blank, Robert, Baris Feldman, Hagit, Milo Rasouly, Hila, Sobreira, Nara L. M. ... Chapman, Gavin (2020). Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice. Human Molecular Genetics, 29 (22), 3662-3678. doi: 10.1093/hmg/ddaa258
2020
Journal Article
CDKN2A testing threshold in a high-risk Australian melanoma cohort: number of primaries, family history and young age of onset impact risk
McMeniman, E. K., McInerney-Leo, A. M., Peach, E., Lee, K. J., Yanes, T., Jagirdar, K., Stark, M. S., Soyer, H. P., Duffy, D. L. and Sturm, R. A. (2020). CDKN2A testing threshold in a high-risk Australian melanoma cohort: number of primaries, family history and young age of onset impact risk. Journal of the European Academy of Dermatology and Venereology, 34 (12) jdv.16627, e797-e798. doi: 10.1111/jdv.16627
2020
Journal Article
Factors influencing cancer genetic somatic mutation test ordering by cancer physician
Demeshko, Anastassia, Pennisi, David J., Narayan, Sushil, Gray, Stacy W., Brown, Matthew A. and McInerney-Leo, Aideen M. (2020). Factors influencing cancer genetic somatic mutation test ordering by cancer physician. Journal of Translational Medicine, 18 (1) 431, 1-7. doi: 10.1186/s12967-020-02610-7
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Aideen McInerney-Leo is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Unusual suspects in hereditary melanoma: phenotype-genotype characterisation of POT1, POLE, BAP1 and CDKN2A carriers
Principal Advisor
Other advisors: Professor Peter Soyer, Dr Brigid Betz-Stablein
-
Doctor Philosophy
Integrating genomics and deep phenotyping to optimise care for paediatric hearing loss
Principal Advisor
-
Doctor Philosophy
Mainstreaming polygenic risk testing for common cancers into clinical practice
Associate Advisor
Other advisors: Dr Tatiane Yanes
-
Doctor Philosophy
Artificial Intelligence Tools for Automated Melanoma Risk Assessment: Potential Utility and Validation
Associate Advisor
Other advisors: Dr Brigid Betz-Stablein, Professor Peter Soyer
-
Doctor Philosophy
Translating polygenic and personalised risk scores: Acceptability and impact of providing polygenic and personalised risk information for melanoma
Associate Advisor
Other advisors: Professor Peter Soyer, Dr Tatiane Yanes
-
Doctor Philosophy
Development and evaluation of model of care for implementation of genomic testing for paediatric healthcare
Associate Advisor
Other advisors: Dr Tatiane Yanes
Completed supervision
-
2023
Doctor Philosophy
Mainstreaming Genetic Testing for Familial Melanoma: evaluating whether psycho-behavioural outcomes differ depending on provider type
Principal Advisor
Other advisors: Dr Anna Finnane, Professor Peter Soyer
Media
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