Overview
Background
He is a Research Fellow with the Microbial Biology and Metagenomics group within the Immunology Program of the University of Queensland Frazer Institute and an honorary fellowship with The Commonwealth Scientific and Industrial Research Organisation (CSIRO, 2019-2021). His PhD research involved designing and applying DNA transfer systems for heterologous protein expression in Lactobacillus spp. He moved to The Ohio State University, USA to conduct postdoctoral research in gut microbiology, focusing on fibre-degrading bacteria and their production of multi-protein complexes supporting this process. He was recruited to join CSIRO (Brisbane) to undertake collaborative research projects for the “Colorectal Cancer and Gut Health” Theme of their Preventative Health Flagship Research Program. His contributions during this time were to develop further and use the DNA microarray technology he had pioneered to examine the stool and mucosa-associated microbiota communities in Crohn’s disease with French and Australian collaborators. These efforts led to several highly cited and high-impact publications in key medical journals, recognised for providing some of the first insights into the critical bacterial taxa that underpin the microbial “dysbiosis” now considered a hallmark of Crohn’s disease. In early 2019, he accepted a position with professor Morrison’s group as part of my ongoing collaborations with Melbourne University in Crohn’s disease research supported via the Helmsley Charitable Trust. He is providing leadership in using a novel ex-vivo combination of gut microbe culture and metagenomic sequencing for the first deep functional characterisation of the Crohn’s disease mucosa-associated microbiota. His development and implementation of innovative molecular biology and “omics” approach help better understand complex microbial gut systems relevant to human health.
Availability
- Dr Seungha Kang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Seoul National University
Works
Search Professor Seungha Kang’s works on UQ eSpace
2023
Conference Publication
The Secretomes Of Colonic Mucosa-associated Microbiota In Crohn's Disease And Health Identify Key Bacteria Driving Pro- And Anti-inflammatory Responses. The Enigma Study
Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). The Secretomes Of Colonic Mucosa-associated Microbiota In Crohn's Disease And Health Identify Key Bacteria Driving Pro- And Anti-inflammatory Responses. The Enigma Study. Digestive Disease Week (DDW) 2023, Chicago, IL United States, 6-9 May 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(23)03117-7
2023
Conference Publication
CHARACTERIZATION OF THE COLONIC MUCOSA-ASSOCIATED METAGENOME REVEALS NOVEL MICROBES AND GEOGRAPHICALLY DISTINCT COMMUNITIES IN HEALTH AND CROHN'S DISEASE. THE ENIGMA STUDY
Kang, Seungha, Teh, Jing Jie, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph J. Y., Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). CHARACTERIZATION OF THE COLONIC MUCOSA-ASSOCIATED METAGENOME REVEALS NOVEL MICROBES AND GEOGRAPHICALLY DISTINCT COMMUNITIES IN HEALTH AND CROHN'S DISEASE. THE ENIGMA STUDY. Digestive Disease Week (DDW), Chicago Il, May 06-09, 2023. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2023
Conference Publication
Characterization Of The Colonic Mucosa-associated Metagenome Reveals Novel Microbes And Geographically Distinct Communities In Health And Crohn's Disease. The Enigma Study
Kang, Seungha, Teh, Jing Jie, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Trakman, Gina L., Lin, Winnie Y., Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2023). Characterization Of The Colonic Mucosa-associated Metagenome Reveals Novel Microbes And Geographically Distinct Communities In Health And Crohn's Disease. The Enigma Study. Digestive Disease Week (DDW) 2023, Chicago, IL United States, 6-9 May 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(23)03125-6
2023
Conference Publication
IMPACT OF EPIDEMIOLOGIC EVOLUTION, DIET AND EARLY LIFE PROCESSED FOOD INTAKE ON MICROBIOME VARIANCE IN CROHN'S DISEASE. THE INTERNATIONAL ENIGMA STUDY
Zhang, Jingwan, Sun, Qianru, Teh, Jing Jie, Kang, Seungha, Hu, Jielun, Lin, Winnie Y., Trakman, Gina L., Sun, Yang, Hamilton, Amy L., Brien, Amy Wilson O', Ching, Jessica Y., Miao, Yinglei, Sung, Joseph J. Y., Yu, Jun, Morrison, Mark, Kamm, Michael A. and Ng, Siew C. (2023). IMPACT OF EPIDEMIOLOGIC EVOLUTION, DIET AND EARLY LIFE PROCESSED FOOD INTAKE ON MICROBIOME VARIANCE IN CROHN'S DISEASE. THE INTERNATIONAL ENIGMA STUDY. Digestive Disease Week (DDW), Chicago Il, May 06-09, 2023. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
2023
Journal Article
Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study
Loayza, J.J. Jimenez, Kang, S., Schooth, L., Teh, J. J., de Klerk, A., Noon, E. K., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O’Brien, A., Trakman, G. L., Lin, W., Ching, J., Or, L., Sung, J.J.Y., Yu, J., Ng, S.C., Kamm, M.A. and Morrison, M. (2023). Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study. Gut Microbes, 15 (1) 2172670, 1-18. doi: 10.1080/19490976.2023.2172670
2023
Conference Publication
Deep functional assessment of the colonic mucosa-associated microbiota in Crohn's disease and health identifies pro- and anti- inflammatory secretomes and associated bacterial consortia. The ENIGMA study
Teh, J. J., Kang, S., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Deep functional assessment of the colonic mucosa-associated microbiota in Crohn's disease and health identifies pro- and anti- inflammatory secretomes and associated bacterial consortia. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.1055
2023
Conference Publication
Metagenomic characterisation of the colonic mucosa-associated microbiota reveals novel microbes and communities in health and Crohn’s disease. The ENIGMA study
Kang, S., Teh, J. J., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Metagenomic characterisation of the colonic mucosa-associated microbiota reveals novel microbes and communities in health and Crohn’s disease. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0089
2023
Conference Publication
Key anti-inflammatory Faecalibacterium prausnitzii is heterogeneous and diverse in the East and West and in health and Crohn’s disease. The ENIGMA study
Teh, J. J., Kang, S., Leonard, A., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Trakman, G. L., Lin, W., Ching, J., Sung, J. J. Y., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2023). Key anti-inflammatory Faecalibacterium prausnitzii is heterogeneous and diverse in the East and West and in health and Crohn’s disease. The ENIGMA study. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0088
2022
Journal Article
Increasing buffering capacity enhances rumen fermentation characteristics and alters rumen microbiota composition of high-concentrate fed Hanwoo steers
Ramos, Sonny C., Kim, Seon Ho, Jeong, Chang Dae, Mamuad, Lovelia L., Son, A-Rang, Kang, Seung Ha, Cho, Yong Il, Kim, Tae Gyu, Lee, Jin Sung, Cho, Kwang Keun, Lee, Sung Sill and Lee, Sang Suk (2022). Increasing buffering capacity enhances rumen fermentation characteristics and alters rumen microbiota composition of high-concentrate fed Hanwoo steers. Scientific Reports, 12 (1) 20739, 20739. doi: 10.1038/s41598-022-24777-3
2022
Journal Article
The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity
Shah, Ayesha, Kang, Seungha, Talley, Nicholas J., Do, Anh, Walker, Marjorie M., Shanahan, Erin R., Koloski, Natasha A., Jones, Michael P., Keely, Simon, Morrison, Mark and Holtmann, Gerald J. (2022). The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity. Gut Microbes, 14 (1) 2132078, 1-21. doi: 10.1080/19490976.2022.2132078
2022
Conference Publication
Diversity of Veillonella in cultures of the duodenal mucosa-associated microbiota suggests species-level differences between people with and without functional gastrointestinal symptoms
Schooth, L., Sid-Ahmed, A., Kang, S., Lim, Y., Fairlie, T., Shah, A., Holtmann, G. and Morrison, M. (2022). Diversity of Veillonella in cultures of the duodenal mucosa-associated microbiota suggests species-level differences between people with and without functional gastrointestinal symptoms. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
2022
Conference Publication
Elevated artificial sweetener levels are associated with Crohn's disease: The ENIGMA study
Hu, J., Ruan, Y., Lin, W., Trakman, G., Zhang, J., Teh, J. J., Kang, S., Hamilton, A., Wilson-O'Brien, A., Ching, J. Y. L., Sung, J. J. Y., Yu, J., Morrison, M., Kamm, M. A. and Ng, S. C. (2022). Elevated artificial sweetener levels are associated with Crohn's disease: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
2022
Conference Publication
The food additive carrageenan has differential effects on the growth of the mucosa-associated microbiota from Asian and Western people with Crohn's disease and healthy controls: The ENIGMA study
Kang, S., Teh, J. J., Schooth, L., Zhang, J., Hu, J., Hamilton, A. L., Wilson-O'Brien, A., Ching, J. Y. L., Lin, W., Trakman, G. L., Sung, J., Yu, J., Ng, S. C., Kamm, M. A. and Morrison, M. (2022). The food additive carrageenan has differential effects on the growth of the mucosa-associated microbiota from Asian and Western people with Crohn's disease and healthy controls: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
2022
Conference Publication
Deep metagenomic sequencing of the colonic mucosa-associated microbiota shows novel microbes and transnational differences in health and Crohn's disease: The ENIGMA study
Teh, J. J., Kang, S., Zhang, J., Hu, J., Hamilton, A., Wilson-O'Brien, A., Ching, J. Y. L., Lin, W., Trakman, G., Sung, J., Jun, Y., Ng, S., Kamm, M. and Morrison, M. (2022). Deep metagenomic sequencing of the colonic mucosa-associated microbiota shows novel microbes and transnational differences in health and Crohn's disease: The ENIGMA study. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons.
2022
Conference Publication
Deep characterization of the mucosa-associated microbiota in asian and western populations reveals acidaminococcus occupies a key niche in the nitrogen economy of Crohn's disease. The ENIGMA study
Drljaca, Sonja, Vollenbroich, Valeria, Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Lin, Winnie Y., Trakman, Gina L., Sung, Joseph, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2022). Deep characterization of the mucosa-associated microbiota in asian and western populations reveals acidaminococcus occupies a key niche in the nitrogen economy of Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60319-6
2022
Conference Publication
Food additives intake is associated with microbiome dysbiosis and specific pro-inflammatory bacterial changes in Crohn's disease. The ENIGMA study
Zhang, Jingwan, Sun, Qianru, Teh, Jing Jie, Kang, Seungha, Hu, Jielun, Lin, Winnie Y., Trakman, Gina L., Hamilton, Amy L., Brien, Amy Wilson O’, Ching, Jessica Y., Sung, Joseph JY, Yu, Jun, Morrison, Mark, Kamm, Michael A. and Ng, Siew C. (2022). Food additives intake is associated with microbiome dysbiosis and specific pro-inflammatory bacterial changes in Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60218-x
2022
Conference Publication
Strain-level resolution of the colonic mucosa-associated microbiota reveals novel trans-ethnic differences in health and Crohn's disease. The ENIGMA study
Teh, Jing Jie, Kang, Seungha, Zhang, Jingwan, Hu, Jielun, Hamilton, Amy L., Wilson-O'Brien, Amy, Ching, Jessica Y., Lin, Winnie Y., Trakman, Gina L., Sung, Joseph, Yu, Jun, Ng, Siew C., Kamm, Michael A. and Morrison, Mark (2022). Strain-level resolution of the colonic mucosa-associated microbiota reveals novel trans-ethnic differences in health and Crohn's disease. The ENIGMA study. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)62327-8
2022
Conference Publication
Influence of proton pump inhibitors on the mucosa associated microbiome in the small intestine and colon
Shah, Ayesha, Sternes, Peter R., Pintos, Camila Ayala, Kang, Seungha, Jones, Michael P., Tyson, Gene, Morrison, Mark and Holtmann, Gerald J. (2022). Influence of proton pump inhibitors on the mucosa associated microbiome in the small intestine and colon. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)62401-6
2022
Conference Publication
Strain-level functional and phenotypic resolution of the duodenal mucosa-associated microbiota in functional dyspepsia and healthy control subjects via a novel ex vivo combination of microbe culture and metagenomic sequencing
Schooth, Lauren F., Ahmed, Ahmed Sid, Kang, Seungha, Shah, Ayesha, Fairlie, Thomas, Teh, Jing Jie, Lim, Yenkai, Hoedt, Emily C., Talley, Nicholas J., Keely, Simon, Holtmann, Gerald J. and Morrison, Mark (2022). Strain-level functional and phenotypic resolution of the duodenal mucosa-associated microbiota in functional dyspepsia and healthy control subjects via a novel ex vivo combination of microbe culture and metagenomic sequencing. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)61208-3
2021
Conference Publication
Differentiation and capture of the human duodenal mucosa-associated microbiota by a novel ex vivo combination of microbe culture and metagenomic sequencing
Schooth, L., Kang, S., Lim, Y., Shah, A., Fairlie, T., Jimenez-Loayza, J., Teh, J.-J., Holtmann, G. and Morrison, M. (2021). Differentiation and capture of the human duodenal mucosa-associated microbiota by a novel ex vivo combination of microbe culture and metagenomic sequencing. GESA AGW 2021, Online, 4-12 September 2021. Richmond, VIC Australia: Wiley-Blackwell.
Funding
Current funding
Supervision
Availability
- Dr Seungha Kang is:
- Available for supervision
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