Overview
Background
He is a Research Fellow with the Microbial Biology and Metagenomics group within the Immunology Program of the University of Queensland Frazer Institute and an honorary fellowship with The Commonwealth Scientific and Industrial Research Organisation (CSIRO, 2019-2021). His PhD research involved designing and applying DNA transfer systems for heterologous protein expression in Lactobacillus spp. He moved to The Ohio State University, USA to conduct postdoctoral research in gut microbiology, focusing on fibre-degrading bacteria and their production of multi-protein complexes supporting this process. He was recruited to join CSIRO (Brisbane) to undertake collaborative research projects for the “Colorectal Cancer and Gut Health” Theme of their Preventative Health Flagship Research Program. His contributions during this time were to develop further and use the DNA microarray technology he had pioneered to examine the stool and mucosa-associated microbiota communities in Crohn’s disease with French and Australian collaborators. These efforts led to several highly cited and high-impact publications in key medical journals, recognised for providing some of the first insights into the critical bacterial taxa that underpin the microbial “dysbiosis” now considered a hallmark of Crohn’s disease. In early 2019, he accepted a position with professor Morrison’s group as part of my ongoing collaborations with Melbourne University in Crohn’s disease research supported via the Helmsley Charitable Trust. He is providing leadership in using a novel ex-vivo combination of gut microbe culture and metagenomic sequencing for the first deep functional characterisation of the Crohn’s disease mucosa-associated microbiota. His development and implementation of innovative molecular biology and “omics” approach help better understand complex microbial gut systems relevant to human health.
Availability
- Dr Seungha Kang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Seoul National University
Works
Search Professor Seungha Kang’s works on UQ eSpace
2013
Journal Article
Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals
West, Nicholas P., Christophersen, Claus T., Pyne, David B., Cripps, Allan W., Conlon, Michael A., Topping, David L., Kang, Seungha, McSweeney, Chris S., Fricker, Peter A., Aguirre, Daniel and Clarke, Julie M. (2013). Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals. Exercise Immunology Review, 19, 102-119.
2013
Journal Article
Identification of metabolically active proteobacterial and archaeal communities in the rumen by DNA- and RNA-derived 16S rRNA gene
Kang S.H., Evans P., Morrison M. and Mcsweeney C. (2013). Identification of metabolically active proteobacterial and archaeal communities in the rumen by DNA- and RNA-derived 16S rRNA gene. Journal of Applied Microbiology, 115 (3), 644-653. doi: 10.1111/jam.12270
2013
Conference Publication
Escalating incidence of IBD in the East and West - Is the microbiota the key? impact of ethnicity, geography, and disease on the microbiota. The ENIGMA study
Prideaux, L., Kang, S., Wagner, J., Buckley, M., Mahar, J. E., De Cruz, P., Wen, Z., Chen, L., Xia, B., Van Langenberg, D. R., Lockett, T., Ng, S. C., Sung, J. J., Desmond, P., Mcsweeney, C., Morrison, M., Kirkwood, C. D. and Kamm, M. A. (2013). Escalating incidence of IBD in the East and West - Is the microbiota the key? impact of ethnicity, geography, and disease on the microbiota. The ENIGMA study. Australian Gastroenterology Week 2013, Melbourne Australia, 7-9 October 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_2
2013
Conference Publication
Tu1693 Indigenous Australians (IA) Have a Distinctive Gut Microbial Profile Compared to Patients With Inflammatory Bowel Disease (IBD) and Non Indigenous Controls
Iyngkaran, Guru, Kang, Seungha, McSweeney, Chris, Sivanesan, Suresh, Kangaharan, Nadarajah, Morrison, Mark and Macrae, Finlay A. (2013). Tu1693 Indigenous Australians (IA) Have a Distinctive Gut Microbial Profile Compared to Patients With Inflammatory Bowel Disease (IBD) and Non Indigenous Controls. 2013 Digestive Disease Week, Orlando, Florida, 18-21 May 2013. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(13)63057-7
2012
Conference Publication
Gut microbiota at the time of Crohn's resection predicts development of disease recurrence
De Cruz, Peter, Kang, Seungha, Sim, Winnie H., Buckley, Michael, Wagner, Josef, Prideaux, Lani, Morrison, Mark, Mcsweeney, Chris, Kirkwood, Carl and Kamm, Michael A. (2012). Gut microbiota at the time of Crohn's resection predicts development of disease recurrence.
2012
Conference Publication
Indigenous Australians (IA) have a distinctive gut microbial profile compared to patient's with inflammatory bowel disease (IBD) and non indigenous controls
Iyngkaran, Guru, Mcsweeney, Chris, Kang, Seungha, Sivanesan, Suresh, Morrison, Mark and Macrae, Finlay (2012). Indigenous Australians (IA) have a distinctive gut microbial profile compared to patient's with inflammatory bowel disease (IBD) and non indigenous controls. Digestive Disease Week, Orlando Fl, May 18-21, 2013. W B SAUNDERS CO-ELSEVIER INC.
2012
Journal Article
An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs
Belobrajdic, Damien P., Bird, Anthony R., Conlon, Michael A., Williams, Barbara A., Kang, Seungha, McSweeney, Christopher S., Zhang, Dagong, Bryden, Wayne L., Gidley, Michael J. and Topping, David L. (2012). An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs. British Journal of Nutrition, 107 (9), 1274-1282. doi: 10.1017/S0007114511004338
2012
Journal Article
Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet
Conlon, Michael A., Kerr, Caroline A., McSweeney, Christopher S., Dunne, Robert A., Shaw, Janet M., Kang, Seungha, Bird, Anthony R., Morell, Matthew K., Lockett, Trevor J., Molloy, Peter L., Regina, Ahmed, Toden, Shusuke, Clarke, Julie M. and Topping, David L. (2012). Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet. The Journal of Nutrition, 142 (5), 832-840. doi: 10.3945/jn.111.147660
2011
Journal Article
Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon
de Carcer, Daniel Aguirre, Ó Cuív, Páraic, Wang, Tingting, Kang, Seungha, Worthley, Daniel, Whitehall, Vicki, Gordon, Iain, McSweeney, Chris, Leggett, Barbara and Morrison, Mark (2011). Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon. ISME Journal, 5 (5), 801-809. doi: 10.1038/ismej.2010.177
2011
Journal Article
The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue
Ó Cuív, Páraic, de Carcer, Daniel Aguirre, Jones, Michelle, Klaassens, Eline S., Worthley, Daniel L., Whitehall, Vicki L. J., Kang, Seungha, McSweeney, Christopher S., Leggett, Barbara A. and Morrison, Mark (2011). The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue. Microbial Ecology, 61 (2), 353-362. doi: 10.1007/s00248-010-9771-x
2011
Conference Publication
Prospective Evaluation of the Mucosa-Associated Microbiota After “Curative” Crohn's Resection Reveals Incomplete Return to “Normal” and Association of Bacteroides With Protection From Disease Recurrence
De Cruz, Peter P., Kang, Seungha, Prideaux, Lani, McSweeney, Chris, Morrison, Mark and Kamm, Michael A. (2011). Prospective Evaluation of the Mucosa-Associated Microbiota After “Curative” Crohn's Resection Reveals Incomplete Return to “Normal” and Association of Bacteroides With Protection From Disease Recurrence. 2011 Digestive Disease Week , Chicago, Illinois, 7-10 May 2011. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(11)61325-5
2011
Journal Article
Highlighting new phylogenetic specificities of Crohn's disease microbiota
Mondot, S., Kang, S., Furet, J.P., Aguirre De Carcer, D., McSweeney, C., Morrison, M., Marteau, P., Dore, J. and Leclerc, M. (2011). Highlighting new phylogenetic specificities of Crohn's disease microbiota. Inflammatory Bowel Diseases, 17 (1), 185-192. doi: 10.1002/ibd.21436
2010
Conference Publication
T1805 Analysis of the Mucosal Microbiota From Inflammatory Bowel Disease Biopsy Tissues Using a Custom 16s rRNA Based Phylogenetic Microarray
Kang, Seungha, Gupta, Arun, Wagner, Josef, Macrae, Finlay A., Morrison, Mark and McSweeney, Chris (2010). T1805 Analysis of the Mucosal Microbiota From Inflammatory Bowel Disease Biopsy Tissues Using a Custom 16s rRNA Based Phylogenetic Microarray. 2010 Digestive Disease Week, New Orleans, Louisiana, 1-5 May 2010. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(10)62683-2
2010
Journal Article
Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray
Kang, Seungha, Denman, Stuart E., Morrison, Mark, Yu, Zhongtang, Dore, Joel, Leclerc, Marion and McSweeney, Chris S. (2010). Dysbiosis of fecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray. Inflammatory Bowel Diseases, 16 (12), 2034-2042. doi: 10.1002/ibd.21319
2009
Conference Publication
The gut microflora of individuals with ulcerative colitis (remission or mild) differs from healthy individuals
Christophersen, C. T., Kang, S., Mcsweeney, C., Morrison, M., Roberts-Thomson, I. and Conlon, M. A. (2009). The gut microflora of individuals with ulcerative colitis (remission or mild) differs from healthy individuals. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
2009
Journal Article
Recent developments in nucleic acid based techniques for use in rumen manipulation
McSweeney, Christopher, Kang, Seungha, Gagen, Emma, Davis, Carl, Morrison, Mark and Denman, Stuart (2009). Recent developments in nucleic acid based techniques for use in rumen manipulation. Revista Brasileira De Zootecnia-Brazilian Journal of Animal Science, 38 (spe), 341-351. doi: 10.1590/S1516-35982009001300034
2009
Journal Article
An efficient RNA extraction method for estimating gut microbial diversity by polymerase chain reaction
Kang, Seungha, Denham, Stuart E., Morrison, Mark, Zhongtang, Yu and McSweeney, Chris S. (2009). An efficient RNA extraction method for estimating gut microbial diversity by polymerase chain reaction. Current Microbiology, 58 (5), 464-471. doi: 10.1007/s00284-008-9345-z
2009
Conference Publication
Arabinoxylan improves indices of gut health and reduces DNA damage in pigs consuming a high risk “Western diet”: a pilot study
Gidley, M. J., Williams, B. A., Zhang, D., Gunness, P., Mikkelsen, D., Gorham, B., Keates, H., Bryden, W. L., Belobrajdic, D., Conlon, M. A., Kang, S., McSweeney, C., Bird, A. R. and Topping, D. L. (2009). Arabinoxylan improves indices of gut health and reduces DNA damage in pigs consuming a high risk “Western diet”: a pilot study. American Association of Cereal Chemists International 2009 Annual Meeting, Baltimore, MD, United States, 13-16 September 2009.
2009
Conference Publication
Application of numerical ecology methods to microarray data reveals obscured patterns in the mucosa-associated microbial community of the human colorectum
De Carcer, D. Aguirre, O Cuiv, P., Wang, T., Reverter, T., Worthley, D., Whitehall, V., Klaassens, E. S., Kang, S., Denman, S., Young, G., Legget, B., McSweeney, C. and Morrison, M. (2009). Application of numerical ecology methods to microarray data reveals obscured patterns in the mucosa-associated microbial community of the human colorectum. Australia and New Zealand Medical and Surgical Gastrointestinal Week 2009, Sydney, NSW Australia, 21‐24 October 2009. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
2007
Journal Article
Expression and characterization of human growth hormone–Fc fusion proteins for transcytosis induction
Woo, Jung Hee, Lee, Chang Hoon, Cho, Kwang Keun, Kang, Seung Ha, Kang, Sang Kee and Choi, Yun Jaie (2007). Expression and characterization of human growth hormone–Fc fusion proteins for transcytosis induction. Biotechnology and Applied Biochemistry, 46 (4), 211-217. doi: 10.1042/ba20060083
Funding
Current funding
Supervision
Availability
- Dr Seungha Kang is:
- Available for supervision
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