![Dr Brett Paterson](/sites/default/files/profiles/33089.jpeg)
Overview
Background
After completing my undergraduate and postgraduate studies at the University of Melbourne, I had a Postdoctoral position at the University of Melbourne from 2011-2013 and held a Victorian Postdoctoral Resarch Fellowship at Kings College London (UK) from 2014-2015 and University of Melbourne in 2016. I took up an Australian Research Council DECRA Fellowship at Monash University from 2017-2019 and was a National Imaging Facility research fellow from 2020-2021. I joined The University of Queensland in 2022 as the Head of Radiochemistry at the Centre for Advanced Imaging.
Availability
- Dr Brett Paterson is:
- Available for supervision
Research impacts
Design and synthesis of radiopharmaceuticals for molecular imaging and targeted radiotherapy. In collaboration with industry, Associate Prof Paterson's research has contributed to the development and translation of new agents for the detection and treatment of cancer.
Works
Search Professor Brett Paterson’s works on UQ eSpace
2017
Journal Article
Frontispiece: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Frontispiece: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie International Edition, 56 (29). doi: 10.1002/anie.201782961
2017
Journal Article
Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie, 129 (29), 8490-8494. doi: 10.1002/ange.201701596
2017
Journal Article
Guest-induced assembly of bis(thiosemicarbazonato) zinc(II) coordination nanotubes
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest-induced assembly of bis(thiosemicarbazonato) zinc(II) coordination nanotubes. Angewandte Chemie - International Edition, 56 (29), 8370-8374. doi: 10.1002/anie.201701596
2016
Journal Article
Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets
Ziegler, Melanie, Alt, Karen, Paterson, Brett M., Kanellakis, Peter, Bobik, Alex, Donnelly, Paul S., Hagemeyer, Christoph E. and Peter, Karlheinz (2016). Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets. Scientific Reports, 6 (1) 38161. doi: 10.1038/srep38161
2016
Conference Publication
First-Time-in-Human Trial of Cu-64 MeCOSAR-octreotate (CuSARTATE) for Imaging and Dosimetry Estimation in Neuroendocrine Tumor (NET)
Hicks, Rodney, Jackson, Price, Ware, Robert, Drummond, Elizabeth, Roselt, Peter, Noonan, Wayne, Price, Roger, Jeffrey, Charmaine, Callahan, Jason, Hong, Emily, Hicks, Lauren, Hedt, Amos, Paterson, Brett, Kong, Grace and Donnelly, Paul (2016). First-Time-in-Human Trial of Cu-64 MeCOSAR-octreotate (CuSARTATE) for Imaging and Dosimetry Estimation in Neuroendocrine Tumor (NET). RESTON: SOC NUCLEAR MEDICINE INC.
2016
Book Chapter
Macrocyclic bifunctional chelators and conjugation strategies for copper-64 radiopharmaceuticals
Paterson, Brett M. and Donnelly, Paul S. (2016). Macrocyclic bifunctional chelators and conjugation strategies for copper-64 radiopharmaceuticals. Insights from Imaging in Bioinorganic Chemistry. (pp. 223-251) edited by Rudi van Eldik and Colin D. Hubbard. San Diego, CA United States: Academic Press. doi: 10.1016/bs.adioch.2015.09.005
2015
Journal Article
Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer
Gourni, Eleni, Del Pozzo, Luigi, Kheirallah, Emilie, Smerling, Christiane, Waser, Beatrice, Reubi, Jean-Claude, Paterson, Brett M., Donnelly, Paul S., Meyer, Philipp T. and Maecke, Helmut R. (2015). Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer. Molecular Pharmaceutics, 12 (8), 2781-2790. doi: 10.1021/mp500671j
2015
Journal Article
A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry
Alt, Karen, Paterson, Brett M., Westein, Erik, Rudd, Stacey E., Poniger, Stan S., Jagdale, Shweta, Ardipradja, Katie, Connell, Timothy U., Krippner, Guy Y., Nair, Ashish K. N., Wang, Xiaowei, Tochon-Danguy, Henri J., Donnelly, Paul S., Peter, Karlheinz and Hagemeyer, Christoph E. (2015). A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry. Angewandte Chemie - International Edition, 54 (26), 7515-7519. doi: 10.1002/anie.201411507
2015
Journal Article
The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution
Dearling, Jason L. J., Paterson, Brett M., Akurathi, Vamsidhar, Betanzos-Lara, Soledad, Treves, S. Ted, Voss, Stephan D., White, Jonathan M., Huston, James S., Smith, Suzanne V., Donnelly, Paul S. and Packard, Alan B. (2015). The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjugate Chemistry, 26 (4), 707-717. doi: 10.1021/acs.bioconjchem.5b00049
2015
Journal Article
Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: Comparison with desferrioxamine-B
Ma, Michelle T., Meszaros, Levente K., Paterson, Brett M., Berry, David J., Cooper, Maggie S., Ma, Yongmin, Hider, Robert C. and Blower, Philip J. (2015). Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: Comparison with desferrioxamine-B. Dalton Transactions, 44 (11), 4884-4900. doi: 10.1039/c4dt02978j
2015
Journal Article
Engineering poly(ethylene glycol) particles for improved biodistribution
Cui, Jiwei, De Rose, Robert, Alt, Karen, Alcantara, Sheilajen, Paterson, Brett M., Liang, Kang, Hu, Ming, Richardson, Joseph J., Yan, Yan, Jeffery, Charmaine M., Price, Roger I., Peter, Karlheinz, Hagemeyer, Christoph E., Donnelly, Paul S., Kent, Stephen J. and Caruso, Frank (2015). Engineering poly(ethylene glycol) particles for improved biodistribution. ACS Nano, 9 (2), 1571-1580. doi: 10.1021/nn5061578
2015
Journal Article
Bifunctional 64Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography
Paterson, Brett M., Buncic, Gojko, McInnes, Lachlan E., Roselt, Peter, Cullinane, Carleen, Binns, David S., Jeffery, Charmaine M., Price, Roger I., Hicks, Rodney J. and Donnelly, Paul S. (2015). Bifunctional 64Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography. Dalton Transactions, 44 (11), 4901-4909. doi: 10.1039/c4dt02983f
2014
Journal Article
+ complexes of exo-functionalized tridentate "click" macrocycles: Synthesis, stability, photophysical properties, bioconjugation, and antibacterial activity
Noor, Asif, Huff, Gregory S., Kumar, Sreedhar V., Lewis, James E. M., Paterson, Brett M., Schieber, Christine, Donnelly, Paul S., Brooks, Heather J. L., Gordon, Keith C., Moratti, Stephen C. and Crowley, James D. (2014). + complexes of exo-functionalized tridentate "click" macrocycles: Synthesis, stability, photophysical properties, bioconjugation, and antibacterial activity. Organometallics, 33 (24), 7031-7043. doi: 10.1021/om500664v
2014
Journal Article
Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets
Alt, Karen, Paterson, Brett M., Ardipradja, Katie, Schieber, Christine, Buncic, Gojko, Lim, Bock, Poniger, Stan S., Jakoby, Bjoern, Wang, Xiaowei, Okeefe, Graeme J., Tochon-Danguy, Henri J., Scott, Andrew M., Ackermann, Uwe, Peter, Karlheinz, Donnelly, Paul S. and Hagemeyer, Christoph E. (2014). Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets. Molecular Pharmaceutics, 11 (8), 2855-2863. doi: 10.1021/mp500209a
2014
Journal Article
Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody
Paterson, Brett M., Alt, Karen, Jeffery, Charmaine M., Price, Roger I., Jagdale, Shweta, Rigby, Sheena, Williams, Charlotte C., Peter, Karlheinz, Hagemeyer, Christoph E. and Donnelly, Paul S. (2014). Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody. Angewandte Chemie - International Edition, 53 (24), 6115-6119. doi: 10.1002/anie.201402613
2014
Journal Article
Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation
Bica, Laura, Liddell, Jeffrey R., Donnelly, Paul S., Duncan, Clare, Caragounis, Aphrodite, Volitakis, Irene, Paterson, Brett M., Cappai, Roberto, Grubman, Alexandra, Camakaris, James, Crouch, Peter J. and White, Anthony R. (2014). Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. PLoS ONE, 9 (2) e90070, e90070. doi: 10.1371/journal.pone.0090070
2014
Journal Article
PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate
Paterson, Brett M., Roselt, Peter, Denoyer, Delphine, Cullinane, Carleen, Binns, David, Noonan, Wayne, Jeffery, Charmaine M., Price, Roger I., White, Jonathan M., Hicks, Rodney J. and Donnelly, Paul S. (2014). PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate. Dalton Transactions, 43 (3), 1386-1396. doi: 10.1039/c3dt52647j
2014
Journal Article
Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action
Djoko, Karrera Y., Paterson, Brett M., Donnelly, Paul S. and McEwan, Alastair G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, Advance Article (4), 1-10. doi: 10.1039/C3MT00348E
2014
Journal Article
Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis
Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2014). Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 34 (23), 8021-8031. doi: 10.1523/JNEUROSCI.4196-13.2014
2013
Journal Article
Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
McAllum, Erin J., Lim, Nastasia K.-H., Hickey, James L., Paterson, Brett M., Donnelly, Paul S., Li, Qiao-Xin, Liddell, Jeffrey R., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2013). Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14 (7-8), 586-590. doi: 10.3109/21678421.2013.824000
Funding
Current funding
Supervision
Availability
- Dr Brett Paterson is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
PET imaging agents for osteosarcoma
Associate Advisor
-
Doctor Philosophy
Gel-based drug delivery monitored via medical imaging
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Karnaker Reddy Tupally, Dr Viktor Vegh
Completed supervision
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2024
Doctor Philosophy
Development of PET Radioligands targeting the Aryl Hydrocarbon Receptor in Glioblastoma
Associate Advisor
Media
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