Dr Brett Paterson
Dr

Brett Paterson

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Background

After completing my undergraduate and postgraduate studies at the University of Melbourne, I had a Postdoctoral position at the University of Melbourne from 2011-2013 and held a Victorian Postdoctoral Resarch Fellowship at Kings College London (UK) from 2014-2015 and University of Melbourne in 2016. I took up an Australian Research Council DECRA Fellowship at Monash University from 2017-2019 and was a National Imaging Facility research fellow from 2020-2021. I joined The University of Queensland in 2022 as the Head of Radiochemistry at the Centre for Advanced Imaging.

Availability

Dr Brett Paterson is:
Available for supervision
Media expert

Research impacts

Design and synthesis of radiopharmaceuticals for molecular imaging and targeted radiotherapy. In collaboration with industry, Associate Prof Paterson's research has contributed to the development and translation of new agents for the detection and treatment of cancer.

Search Professor Brett Paterson’s works on UQ eSpace

64 works between 2007 and 2025
All (64) Journal Article (58) Conference Publication (5) Book Chapter (1)

41 - 60 of 64 works

2014

Journal Article

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody

Paterson, Brett M., Alt, Karen, Jeffery, Charmaine M., Price, Roger I., Jagdale, Shweta, Rigby, Sheena, Williams, Charlotte C., Peter, Karlheinz, Hagemeyer, Christoph E. and Donnelly, Paul S. (2014). Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody. Angewandte Chemie - International Edition, 53 (24), 6115-6119. doi: 10.1002/anie.201402613

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody

2014

Journal Article

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation

Bica, Laura, Liddell, Jeffrey R., Donnelly, Paul S., Duncan, Clare, Caragounis, Aphrodite, Volitakis, Irene, Paterson, Brett M., Cappai, Roberto, Grubman, Alexandra, Camakaris, James, Crouch, Peter J. and White, Anthony R. (2014). Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. PLoS ONE, 9 (2) e90070, e90070. doi: 10.1371/journal.pone.0090070

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation

2014

Journal Article

PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

Paterson, Brett M., Roselt, Peter, Denoyer, Delphine, Cullinane, Carleen, Binns, David, Noonan, Wayne, Jeffery, Charmaine M., Price, Roger I., White, Jonathan M., Hicks, Rodney J. and Donnelly, Paul S. (2014). PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate. Dalton Transactions, 43 (3), 1386-1396. doi: 10.1039/c3dt52647j

PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

2014

Journal Article

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action

Djoko, Karrera Y., Paterson, Brett M., Donnelly, Paul S. and McEwan, Alastair G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, Advance Article (4), 1-10. doi: 10.1039/C3MT00348E

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action

2014

Journal Article

Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2014). Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 34 (23), 8021-8031. doi: 10.1523/JNEUROSCI.4196-13.2014

Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

2013

Journal Article

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

McAllum, Erin J., Lim, Nastasia K.-H., Hickey, James L., Paterson, Brett M., Donnelly, Paul S., Li, Qiao-Xin, Liddell, Jeffrey R., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2013). Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14 (7-8), 586-590. doi: 10.3109/21678421.2013.824000

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

2013

Journal Article

Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques

Hickey, James L., Lim, Sinchun, Hayne, David J., Paterson, Brett M., White, Jonathan M., Villemagne, Victor L., Roselt, Peter, Binns, David, Cullinane, Carleen, Jeffery, Charmaine M., Price, Roger I., Barnham, Kevin J. and Donnelly, Paul S. (2013). Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques. Journal of the American Chemical Society, 135 (43), 16120-16132. doi: 10.1021/ja4057807

Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques

2013

Journal Article

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

Cater, Michael A., Pearson, Helen B., Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal (2013). Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology, 8 (7), 1621-1631. doi: 10.1021/cb400198p

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

2013

Journal Article

Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Duncan, Clare, Bica, Laura, Crouch, Peter J., Caragounis, Aphrodite, Lidgerwood, Grace E., Parker, Sarah J., Meyerowitz, Jodi, Volitakis, Irene, Liddell, Jeffrey R., Raghupathi, Ravinarayan, Paterson, Brett M., Duffield, Michael D., Cappai, Roberto, Donnelly, Paul S., Grubman, Alexandra, Camakaris, James, Keating, Damien J. and White, Anthony R. (2013). Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics, 5 (6), 700-714. doi: 10.1039/c3mt20231c

Copper modulates the large dense core vesicle secretory pathway in PC12 cells

2013

Journal Article

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Kanninen, Katja M., Grubman, Alexandra, Meyerowitz, Jodi, Duncan, Clare, Tan, Jiang-Li, Parker, Sarah J., Crouch, Peter J., Paterson, Brett M., Hickey, James L., Donnelly, Paul S., Volitakis, Irene, Tammen, Imke, Palmer, David N. and White, Anthony R. (2013). Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis. PLoS ONE, 8 (3) e58644, e58644. doi: 10.1371/journal.pone.0058644

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

2012

Journal Article

Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes

Parker, Sarah J., Meyerowitz, Jodi, James, Janine L., Liddell, Jeffrey R., Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Lim, SinChun, Paterson, Brett M., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2012). Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes. PLoS ONE, 7 (8) e42277. doi: 10.1371/journal.pone.0042277

Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes

2012

Journal Article

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II

Donnelly, Paul S., Liddell, Jeffrey R., Lim, SinChun, Paterson, Brett M., Cater, Michael A., Savva, Maria S., Mot, Alexandra I., James, Janine L., Trounce, Ian A., White, Anthony R. and Crouch, Peter J. (2012). An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II . Proceedings of the National Academy of Sciences of the United States of America, 109 (1), 47-52. doi: 10.1073/pnas.1116227108

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II

2011

Journal Article

Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm)

Price, Katherine Ann, Crouch, Peter J., Lim, Sinchun, Paterson, Brett M., Liddell, Jeffrey R., Donnelly, Paul S. and White, Anthony R. (2011). Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm). Metallomics, 3 (12), 1280-1290. doi: 10.1039/c1mt00092f

Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm)

2011

Journal Article

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes

Price, Katherine Ann, Crouch, Peter J., Volitakis, Irene, Paterson, Brett M., Lim, Sinchun, Donnelly, Paul S. and White, Anthony R. (2011). Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes. Inorganic Chemistry, 50 (19), 9594-9605. doi: 10.1021/ic201334q

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes

2011

Journal Article

Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

Paterson, Brett M. and Donnelly, Paul S. (2011). Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals. Chemical Society Reviews, 40 (5), 3005-3018. doi: 10.1039/c0cs00215a

Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

2011

Journal Article

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

Bica, Laura, Meyerowitz, Jodi, Parker, Sarah J., Caragounis, Aphrodite, Du, Tai, Paterson, Brett M., Barnham, Kevin J., Crouch, Peter J., White, Anthony R. and Donnelly, Paul S. (2011). Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex. BioMetals, 24 (1), 117-133. doi: 10.1007/s10534-010-9380-7

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

2010

Journal Article

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

Lim, Sinchun, Paterson, Brett M., Fodero-Tavoletti, Michelle T., O'Keefe, Graeme J., Cappai, Roberto, Barnham, Kevin J., Villemagne, Victor L. and Donnelly, Paul S. (2010). A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques. Chemical Communications, 46 (30), 5437-5439. doi: 10.1039/c0cc01175d

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

2010

Journal Article

A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

Buncic, Gojko, Donnelly, Paul S., Paterson, Brett M., White, Jonathan M., Zimmermann, Matthias, Xiao, Zhiguang and Wedd, Anthony G. (2010). A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc. Inorganic Chemistry, 49 (7), 3071-3073. doi: 10.1021/ic902370a

A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc

2010

Journal Article

A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes

Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2010). A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes. Dalton Transactions, 39 (11), 2831-2837. doi: 10.1039/b922127a

A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes

2010

Journal Article

Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling

Brett M. Paterson, M. Paterson, John A. Karas, A. Karas, Denis B. Scanlon, B. Scanlon, Jonathan M. White, M. White and Donnelly, Paul S. (2010). Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling. Inorganic Chemistry, 49 (4), 1884-1893. doi: 10.1021/ic902204e

Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling

Current funding

  • 2024 - 2027
    Understanding production and application of alpha emitting radionuclides
    ARC Linkage Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant

Past funding

  • 2017 - 2024
    ARC Training Centre for Innovation in Biomedical Imaging Technology
    ARC Industrial Transformation Training Centres
    Open grant

Availability

Dr Brett Paterson is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Brett Paterson directly for media enquiries about:

  • Inorganic
  • Radioactivity
  • Radiopharmaceutical

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