Overview
Background
After completing my undergraduate and postgraduate studies at the University of Melbourne, I had a Postdoctoral position at the University of Melbourne from 2011-2013 and held a Victorian Postdoctoral Resarch Fellowship at Kings College London (UK) from 2014-2015 and University of Melbourne in 2016. I took up an Australian Research Council DECRA Fellowship at Monash University from 2017-2019 and was a National Imaging Facility research fellow from 2020-2021. I joined The University of Queensland in 2022 as the Head of Radiochemistry at the Centre for Advanced Imaging.
Availability
- Dr Brett Paterson is:
- Available for supervision
Research impacts
Design and synthesis of radiopharmaceuticals for molecular imaging and targeted radiotherapy. In collaboration with industry, Associate Prof Paterson's research has contributed to the development and translation of new agents for the detection and treatment of cancer.
Works
Search Professor Brett Paterson’s works on UQ eSpace
2014
Journal Article
Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis
Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2014). Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 34 (23), 8021-8031. doi: 10.1523/JNEUROSCI.4196-13.2014
2013
Journal Article
Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
McAllum, Erin J., Lim, Nastasia K.-H., Hickey, James L., Paterson, Brett M., Donnelly, Paul S., Li, Qiao-Xin, Liddell, Jeffrey R., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2013). Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14 (7-8), 586-590. doi: 10.3109/21678421.2013.824000
2013
Journal Article
Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques
Hickey, James L., Lim, Sinchun, Hayne, David J., Paterson, Brett M., White, Jonathan M., Villemagne, Victor L., Roselt, Peter, Binns, David, Cullinane, Carleen, Jeffery, Charmaine M., Price, Roger I., Barnham, Kevin J. and Donnelly, Paul S. (2013). Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques. Journal of the American Chemical Society, 135 (43), 16120-16132. doi: 10.1021/ja4057807
2013
Journal Article
Increasing intracellular bioavailable copper selectively targets prostate cancer cells
Cater, Michael A., Pearson, Helen B., Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal (2013). Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology, 8 (7), 1621-1631. doi: 10.1021/cb400198p
2013
Journal Article
Copper modulates the large dense core vesicle secretory pathway in PC12 cells
Duncan, Clare, Bica, Laura, Crouch, Peter J., Caragounis, Aphrodite, Lidgerwood, Grace E., Parker, Sarah J., Meyerowitz, Jodi, Volitakis, Irene, Liddell, Jeffrey R., Raghupathi, Ravinarayan, Paterson, Brett M., Duffield, Michael D., Cappai, Roberto, Donnelly, Paul S., Grubman, Alexandra, Camakaris, James, Keating, Damien J. and White, Anthony R. (2013). Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics, 5 (6), 700-714. doi: 10.1039/c3mt20231c
2013
Journal Article
Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis
Kanninen, Katja M., Grubman, Alexandra, Meyerowitz, Jodi, Duncan, Clare, Tan, Jiang-Li, Parker, Sarah J., Crouch, Peter J., Paterson, Brett M., Hickey, James L., Donnelly, Paul S., Volitakis, Irene, Tammen, Imke, Palmer, David N. and White, Anthony R. (2013). Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis. PLoS ONE, 8 (3) e58644, e58644. doi: 10.1371/journal.pone.0058644
2012
Journal Article
Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes
Parker, Sarah J., Meyerowitz, Jodi, James, Janine L., Liddell, Jeffrey R., Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Lim, SinChun, Paterson, Brett M., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2012). Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes. PLoS ONE, 7 (8) e42277. doi: 10.1371/journal.pone.0042277
2012
Journal Article
An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II
Donnelly, Paul S., Liddell, Jeffrey R., Lim, SinChun, Paterson, Brett M., Cater, Michael A., Savva, Maria S., Mot, Alexandra I., James, Janine L., Trounce, Ian A., White, Anthony R. and Crouch, Peter J. (2012). An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II . Proceedings of the National Academy of Sciences of the United States of America, 109 (1), 47-52. doi: 10.1073/pnas.1116227108
2011
Journal Article
Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm)
Price, Katherine Ann, Crouch, Peter J., Lim, Sinchun, Paterson, Brett M., Liddell, Jeffrey R., Donnelly, Paul S. and White, Anthony R. (2011). Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm). Metallomics, 3 (12), 1280-1290. doi: 10.1039/c1mt00092f
2011
Journal Article
Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes
Price, Katherine Ann, Crouch, Peter J., Volitakis, Irene, Paterson, Brett M., Lim, Sinchun, Donnelly, Paul S. and White, Anthony R. (2011). Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes. Inorganic Chemistry, 50 (19), 9594-9605. doi: 10.1021/ic201334q
2011
Journal Article
Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals
Paterson, Brett M. and Donnelly, Paul S. (2011). Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals. Chemical Society Reviews, 40 (5), 3005-3018. doi: 10.1039/c0cs00215a
2011
Journal Article
Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex
Bica, Laura, Meyerowitz, Jodi, Parker, Sarah J., Caragounis, Aphrodite, Du, Tai, Paterson, Brett M., Barnham, Kevin J., Crouch, Peter J., White, Anthony R. and Donnelly, Paul S. (2011). Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex. BioMetals, 24 (1), 117-133. doi: 10.1007/s10534-010-9380-7
2010
Journal Article
A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques
Lim, Sinchun, Paterson, Brett M., Fodero-Tavoletti, Michelle T., O'Keefe, Graeme J., Cappai, Roberto, Barnham, Kevin J., Villemagne, Victor L. and Donnelly, Paul S. (2010). A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques. Chemical Communications, 46 (30), 5437-5439. doi: 10.1039/c0cc01175d
2010
Journal Article
A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc
Buncic, Gojko, Donnelly, Paul S., Paterson, Brett M., White, Jonathan M., Zimmermann, Matthias, Xiao, Zhiguang and Wedd, Anthony G. (2010). A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc. Inorganic Chemistry, 49 (7), 3071-3073. doi: 10.1021/ic902370a
2010
Journal Article
A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes
Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2010). A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes. Dalton Transactions, 39 (11), 2831-2837. doi: 10.1039/b922127a
2010
Journal Article
Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling
Brett M. Paterson, M. Paterson, John A. Karas, A. Karas, Denis B. Scanlon, B. Scanlon, Jonathan M. White, M. White and Donnelly, Paul S. (2010). Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling. Inorganic Chemistry, 49 (4), 1884-1893. doi: 10.1021/ic902204e
2010
Journal Article
Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: Synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies
Lim, Sinchun, Price, Katherine A., Chong, Siow-Feng, Paterson, Brett M., Caragounis, Aphrodite, Barnham, Kevin J., Crouch, Peter J., Peach, Josephine M., Dilworth, Jonathan R., White, Anthony R. and Donnelly, Paul S. (2010). Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: Synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies. Journal of Biological Inorganic Chemistry, 15 (2), 225-235. doi: 10.1007/s00775-009-0587-4
2010
Journal Article
Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease
Fodero-Tavoletti, Michelle T., Villemagne, Victor L., Paterson, Brett M., White, Anthony R., Li, Qiao-Xin, Camakaris, James, O'keefe, Graeme, Cappai, Roberto, Barnham, Kevin J. and Donnelly, Paul S. (2010). Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. Journal of Alzheimer's Disease, 20 (1), 49-55. doi: 10.3233/JAD-2010-1359
2009
Journal Article
Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
Price, Katherine Ann, Caragounis, Aphrodite, Paterson, Brett M., Filiz, Gulay, Volitakis, Irene, Masters, Colin L., Barnham, Kevin J., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2009). Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity. Journal of Medicinal Chemistry, 52 (21), 6606-6620. doi: 10.1021/jm9007938
2007
Journal Article
New bimetallic compounds based on the bis(thiosemicarbazonato) motif
Christlieb, Martin, Cowley, Andrew R., Dilworth, Jonathan R., Donnelly, Paul S., Paterson, Brett M., Struthers, Harriet S. R. and White, Jonathan M. (2007). New bimetallic compounds based on the bis(thiosemicarbazonato) motif. Dalton Transactions (3), 327-331. doi: 10.1039/b612907b
Funding
Current funding
Supervision
Availability
- Dr Brett Paterson is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
PET imaging agents for osteosarcoma
Associate Advisor
-
Doctor Philosophy
Gel-based drug delivery monitored via medical imaging
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Karnaker Reddy Tupally, Dr Viktor Vegh
Completed supervision
-
2024
Doctor Philosophy
Development of PET Radioligands targeting the Aryl Hydrocarbon Receptor in Glioblastoma
Associate Advisor
Media
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