Professor David Evans
Professor

David Evans

Email: 
Phone: 
+61 7 334 62617

Background

David Evans is an NHMRC Leadership Fellow and Professor of Statistical Genetics at the University of Queensland Institute for Molecular Bioscience. He is a winner of the NHMRC Marshall and Warren Award.

He completed his PhD in Statistical Genetics at the University of Queensland in 2003, before undertaking a four-year post-doctoral fellowship at the Wellcome Trust Centre for Human Genetics, University of Oxford where he worked as part of the The International HapMap Consortium and co-led the analysis of four diseases within the first Wellcome Trust Case Control Consortium. In 2007 he moved to take up a Senior Lecturer position at the University of Bristol where he led much of the genome-wide association studies work in the Avon Longitudinal Study of Parents and Children (ALSPAC). In 2013 he returned to take up a chair at the University of Queensland whilst continuing to lead an MRC Programme in statistical genetics at the University of Bristol.

His research interests include the genetic mapping of complex traits and diseases (including birthweight and other perinatal traits, osteoporosis, ankylosing spondylitis, sepsis, laterality) and the development of statistical methodologies in genetic epidemiology including approaches for gene mapping, individual risk prediction, causal modelling and dissecting the genetic architecture of complex traits. He has a particular interest in Mendelian randomization and has used it and other causal methods to investigate the Developmental Origins of Health and Disease (DOHaD)- the idea that adverse intrauterine exposures lead to increased risk of disease in later life.

He is Academic Codirector at the NIH funded International Workshop on Statistical Genetics Methods and is faculty on the European Programme in Educational Epidemiology.

He is Associate Editor at the International Journal of Epidemiology and Behavior Genetics journals.

Availability

Professor David Evans is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Epidemiology Gene mapping Genetics Health Sciences

Qualifications

  • Bachelor (Honours), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Mendelian randomization

  • Genome-wide association studies

  • Causal Modeling

  • Developmental Origins of Health and Disease (DOHaD)

  • Laterality

  • Sepsis

  • Osteoporosis

  • Ankylosing Spondylitis

Search Professor David Evans’s works on UQ eSpace

445 works between 1933 and 2024
All (445) Journal Article (381) Book Chapter (4) Conference Publication (59) Other Outputs (1)

141 - 160 of 445 works

2018

Journal Article

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties

St Pourcain, B., Robinson, E. B., Anttila, V., Sullivan, B. B., Maller, J., Golding, J., Skuse, D., Ring, S., Evans, D. M., Zammit, S., Fisher, S. E., Neale, B. M., Anney, R. J. L., Ripke, S., Hollegaard, M. V., Werge, T., Ronald, A., Grove, J., Hougaard, D. M., Børglum, A. D., Mortensen, P. B., Daly, M. J. and Davey Smith, G. (2018). ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties. Molecular Psychiatry, 23 (2), 263-270. doi: 10.1038/mp.2016.198

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties

2018

Journal Article

Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study

Trajanoska, Katerina, Morris, John A., Oei, Ling, Zheng, Hou-Feng, Evans, David M., Kiel, Douglas P., Ohlsson, Claes, Richards, J. Brent and Rivadeneira, Fernando (2018). Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. BMJ, 362 k3225, k3225. doi: 10.1136/bmj.k3225

Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study

2018

Conference Publication

The genetic architecture of hip statistical shape models suggests that endochondral bone formation makes an important contribution to hip shape

Baird, D., Evans, D. S., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Kamanu, F. K., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullins, B. H., Williams, F. M., Richards, B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A., Beck, T. J., Evans, D. M., Paternoster, L., Karasikl, D. and Tobias, J. H. (2018). The genetic architecture of hip statistical shape models suggests that endochondral bone formation makes an important contribution to hip shape. OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, England, 26-29 April 2018. London, United Kingdom: Elsevier.

The genetic architecture of hip statistical shape models suggests that endochondral bone formation makes an important contribution to hip shape

2018

Conference Publication

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease

Beaumont, Robin N., Warrington, Nicole M., Horikoshi, Momoko, Day, Felix R., Ong, Ken K., McCarthy, Mark I., Perry, John R. B., Freathy, Rachel M. and Evans, David M. (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease. 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), San Diego, Ca, United States, 14-16 October 2018. Hoboken, NJ, United States: John Wiley & Sons.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease

2017

Journal Article

Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

Hendricks, Audrey E., Bochukova, Elena G., Marenne, Gaelle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Koerner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M., Butterworth, Adam S., Danesh, John, Nordestgaard, Borge G., Nielsen, Sune F., Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I. ... Yang, Jian (2017). Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports, 7 (1) 4394, 4394.1-4394.14. doi: 10.1038/s41598-017-03054-8

Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

2017

Journal Article

Recent Developments in Mendelian Randomization Studies

Zheng, Jie, Baird, Denis, Borges, Maria-Carolina, Bowden, Jack, Hemani, Gibran, Haycock, Philip, Evans, David M and Smith, George Davey (2017). Recent Developments in Mendelian Randomization Studies. Current epidemiology reports, 4 (4), 330-345. doi: 10.1007/s40471-017-0128-6

Recent Developments in Mendelian Randomization Studies

2017

Journal Article

Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts

Paternoster, Lavinia, Savenije, Olga E.M., Heron, Jon, Evans, David M., Vonk, Judith M., Brunekreef, Bert, Wijga, Alet H., Henderson, A. John, Koppelman, Gerard H. and Brown, Sara J. (2017). Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts. Journal of Allergy and Clinical Immunology, 141 (3), 964-971. doi: 10.1016/j.jaci.2017.09.044

Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts

2017

Journal Article

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, Liz, Streit, Fabian, Zhu, Gu, McAloney, Kerrie, Frank, Josef, Couvy-Duchesne, Baptiste, Witt, Stephanie H., Binz, Tina M., Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika ... Rietschel, Marcella (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7 (1) 15351, 15351. doi: 10.1038/s41598-017-11852-3

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

2017

Journal Article

Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices

Laurin, Charles, Cuellar-Partida, Gabriel, Hemani, Gibran, Smith, George Davey, Yang, Jian and Evans, David M. (2017). Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices. Behavior Genetics, 48 (1), 67-79. doi: 10.1007/s10519-017-9880-0

Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices

2017

Journal Article

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T., Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J. ... Lawlor, D. A. (2017). Maternal and fetal genetic contribution to gestational weight gain. International Journal of Obesity (2005), 42 (4), 775-784. doi: 10.1038/ijo.2017.248

Maternal and fetal genetic contribution to gestational weight gain

2017

Journal Article

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

Hackinger, Sophie, Trajanoska, Katerina, Styrkarsdottir, Unnur, Zengini, Eleni, Steinberg, Julia, Ritchie, Graham R.S., Hatzikotoulas, Konstantinos, Gilly, Arthur, Evangelou, Evangelos, Kemp, John P., Evans, David, Ingvarsson, Thorvaldur, Jonsson, Helgi, Thorsteinsdottir, Unnur, Stefansson, Kari, McCaskie, Andrew W., Brooks, Roger A., Wilkinson, Jeremy M., Rivadeneira, Fernando and Zeggini, Eleftheria (2017). Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus. Human Molecular Genetics, 26 (19), 3850-3858. doi: 10.1093/hmg/ddx285

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

2017

Journal Article

Developmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals

St Pourcain, Beate, Eaves, Lindon J, Ring, Susan M, Fisher, Simon E, Medland, Sarah, Evans, David M and Davey Smith, George (2017). Developmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals. Biological psychiatry, 83 (7), 598-606. doi: 10.1016/j.biopsych.2017.09.020

Developmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals

2017

Journal Article

Collider scope: when selection bias can substantially influence observed associations

Munafò, Marcus R, Tilling, Kate, Taylor, Amy E, Evans, David M and Davey Smith, George (2017). Collider scope: when selection bias can substantially influence observed associations. International journal of epidemiology, 47 (1) dyx217, 226-235. doi: 10.1093/ije/dyx206

Collider scope: when selection bias can substantially influence observed associations

2017

Journal Article

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Kemp, John P., Morris, John A., Medina-Gomez, Carolina, Forgetta, Vincenzo, Warrington, Nicole M., Youlten, Scott E., Zheng, Jie, Gregson, Celia L., Grundberg, Elin, Trajanoska, Katerina, Logan, John G., Pollard, Andrea S., Sparkes, Penny C., Ghirardello, Elena J., Allen, Rebecca, Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Adoum, Anne-Tounsia, Curry, Katharine F., White, Jacqueline K., Kussy, Fiona, Greenlaw, Keelin M., Xu, Changjiang, Harvey, Nicholas C., Cooper, Cyrus, Adams, David J., Greenwood, Celia M. T., Maurano, Matthew T. ... Evans, David M. (2017). Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics, 49 (10), 1468-1475. doi: 10.1038/ng.3949

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

2017

Journal Article

Back to school to protect against coronary heart disease?

Richards, J. Brent and Evans, David M. (2017). Back to school to protect against coronary heart disease?. BMJ, 358 j3849, j3849. doi: 10.1136/bmj.j3849

Back to school to protect against coronary heart disease?

2017

Journal Article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben ... Ohlsson, Claes (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 (1) 16015, 16015. doi: 10.1038/ncomms16015

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

2017

Journal Article

Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes

Luciano, Michelle, Hagenaars, Saskia P. , Cox, Simon R. , Hill, William David , Davies, Gail , Harris, Sarah E. , Deary, Ian J. , Evans, David M. , Martin, Nicholas G. , Wright, Margaret J.  and Bates, Timothy C.  (2017). Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes. Behavior Genetics, 47 (5), 469-479. doi: 10.1007/s10519-017-9859-x

Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes

2017

Journal Article

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Medina-Gomez, Carolina, Kemp, John P., Dimou, Niki L., Kreiner, Eskil, Chesi, Alessandra, Zemel, Babette S., Bonnelykke, Klaus, Boer, Cindy G., Ahluwalia, Tarunveer S., Bisgaard, Hans, Evangelou, Evangelos, Heppe, Denise H. M., Bonewald, Lynda F., Gorski, Jeffrey P., Ghanbari, Mohsen, Demissie, Serkalem, Duque, Gustavo, Maurano, Matthew T., Kiel, Douglas P., Hsu, Yi-Hsiang, Van Der Eerden, Bram C. J., Ackert-Bicknell, Cheryl, Reppe, Sjur, Gautvik, Kaare M., Raastad, Truls, Karasik, David, Van De Peppel, Jeroen, Jaddoe, Vincent W. V., Uitterlinden, André G. ... Rivadeneira, Fernando (2017). Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nature Communications, 8 (1) 121, 121. doi: 10.1038/s41467-017-00108-3

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

2017

Journal Article

Constructing and mobilizing "the consumer': Responsibility, consumption and the politics of sustainability

Evans, David, Welch, Daniel and Swaffield, Joanne (2017). Constructing and mobilizing "the consumer': Responsibility, consumption and the politics of sustainability. Environment and Planning A-Economy and Space, 49 (6), 1396-1412. doi: 10.1177/0308518X17694030

Constructing and mobilizing "the consumer': Responsibility, consumption and the politics of sustainability

2017

Journal Article

Association between telomere length and risk of cancer and non-neoplastic diseases a Mendelian randomization study

Haycock, Philip C., Burgess, Stephen, Nounu, Aayah, Zheng, Jie, Okoli, George N., Bowden, Jack, Wade, Kaitlin Hazel, Timpson, Nicholas J., Evans, David M., Willeit, Peter, Aviv, Abraham, Gaunt, Tomr., Hemani, Gibran, Mangino, Massimo, Ellis, Hayley Patricia, Kurian, Kathreena M., Pooley, Karen A., Eeles, Rosalind A., Lee, Jeffrey E., Fang, Shenying, Chen, Wei V., Law, Matthew H., Bowdler, Lisa M., Iles, Mark M., Yang, Qiong, Worrall, Bradford B., Markus, Hugh Stephen, Hung, Rayjean J., Amos, Chris I. ... Smith, George Davey (2017). Association between telomere length and risk of cancer and non-neoplastic diseases a Mendelian randomization study. JAMA Oncology, 3 (5), 636-651. doi: 10.1001/jamaoncol.2016.5945

Association between telomere length and risk of cancer and non-neoplastic diseases a Mendelian randomization study

Current funding

  • 2023 - 2027
    Developing and Applying Mendelian Randomization Methods to Facilitate Drug Discovery and Solve Intractable Problems in Medical Research
    NHMRC Investigator Grants
    Open grant
  • 2018 - 2024
    The role of size, shape and structure of bones and joints, in explaining common musculoskeletal diseases (Wellcome Trust Grant administered by University of Bristol)
    University of Bristol
    Open grant

Past funding

  • 2020 - 2024
    Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2022
    Identifying maternal and fetal genetic determinants of infant birthweight and their relationship to offspring cardiometabolic risk
    NHMRC Project Grant
    Open grant
  • 2018 - 2022
    Developing and applying statistical genetics methods to identify genes, molecular biomarkers and environmental agents that causally affect risk of complex musculoskeletal diseases
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Enhancing host defence mechanisms in severe bacterial infections
    NHMRC Project Grant
    Open grant
  • 2017 - 2021
    Development and application of a Mendelian randomization framework aimed at dissecting the biological basis of ankylosing spondylitis and other complex diseases
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
    NHMRC Project Grant
    Open grant
  • 2016
    Establishing a gnotobiotic germ-free mouse facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    A biomarker for sepsis to thwart antibiotic overuse in the intensive care unit
    Royal Brisbane and Women's Hospital
    Open grant
  • 2015
    Bivariate genome-wide association study of birth weight and endophenotypes related to five diseases in later life
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2015 - 2017
    Finding novel genetic associations in Ankylosing Spondylitis
    University of Oxford
    Open grant
  • 2015 - 2018
    Gene expression profiling in critically ill patients with septic shock: The ADRENAL-GEPS Study
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology
    NHMRC Project Grant
    Open grant
  • 2014
    Calibration of single channel and liquid handling robots
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Dissecting the great ophthalmic masquerade: The Global Giant Cell Arteritis Genomics Consortium (NHMRC Project Grant administered by the Centre for Eye Research Australia)
    Centre for Eye Research Australia
    Open grant
  • 2014
    Multiplex High Throughput Bio-plex Protein Assay Platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2018
    Clinical Researcher Training
    Research Donation Generic
    Open grant

Availability

Professor David Evans is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Sometimes Correlation does Equal Causation: Developing Statistical Methods to Determine Causality Using Genetic Data

    There is a well-known mantra that correlation does not necessarily equal causation. This is why randomized controlled trials in which participants are physically randomized into treatment and placebo groups are the gold standard for assessing causality in epidemiological investigations. However, what is less appreciated is that strong evidence for causality can sometimes be obtained using observational data only. In particular, genotypes are randomly transmitted from parents to their offspring independent of the environment and other confounding factors, meaning that genotypes associated with particular traits can be used like natural “randomized controlled trials” to examine whether these traits causally affect risk of disease.

    The aim of this PhD project is to develop statistical methods to assess causality using observational data alone. The successful candidate will gain experience across a wide range of advanced statistical genetics methodologies including Mendelian randomization (a way of using genetic variants to investigate putatively causal relationships), structural equation modelling, genome-wide association analysis (GWAS), genetic restricted maximum likelihood (G-REML) analysis of genome-wide data which can be used to partition variation in phenotypes into genetic and environmental sources of variation, and instrumental variables analysis (using natural “experiments” to obtain information on causality from observational data). The candidate will apply the new statistical methods that they develop to large genetically informative datasets like the UK Biobank (500,000 individuals with genome-wide SNP data).

Supervision history

Current supervision

  • Doctor Philosophy

    Multi-omic Approaches to Understanding Septic Shock

    Principal Advisor

    Other advisors: Dr Daniel Hwang

  • Doctor Philosophy

    Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease

    Principal Advisor

    Other advisors: Dr Nicole Warrington

  • Doctor Philosophy

    Investigating the association between maternal and fetal HLA-KIR genotypes and offspring birth weight

    Principal Advisor

  • Doctor Philosophy

    Understanding the genetic epidemiology of women's reproductive health

    Principal Advisor

    Other advisors: Dr Gunn-Helen Moen

  • Doctor Philosophy

    Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes

    Principal Advisor

    Other advisors: Dr Daniel Hwang, Dr Gunn-Helen Moen

  • Doctor Philosophy

    Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health

    Associate Advisor

    Other advisors: Honorary Professor Jake Gratten, Dr Nicole Warrington

Completed supervision

Enquiries

Contact Professor David Evans directly for media enquiries about:

  • Genetics
  • Genome-wide association
  • Mendelian randomization
  • Twin Studies

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