Overview
Background
Dr Gunn-Helen Moen was awarded her PhD on the "Genetic and environmental etiology of glucose metabolism and cardiometabolic traits during pregnancy and in later life" in 2019 from the Faculty of Medicine at the University of Oslo. After finishing her PhD, she was awarded a Mobility/Marie Sklodowska-Curie Fellowship from the Research Council of Norway and as part of that fellowship she spent two years as a visiting academic at the University of Queensland. She is currently an ARC DECRA fellow at IMB. Her research focus is on using Mendelian randomization to investigate the possible causal effects of maternal environmental exposures during pregnancy on offspring outcomes.
Availability
- Dr Gunn-Helen Moen is:
- Available for supervision
Works
Search Professor Gunn-Helen Moen’s works on UQ eSpace
2024
Journal Article
DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits
Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Yengo, Loic, Zeng, Jian, Toivonen, Jarkko, Arvas, Mikko, Beaumont, Robin N., Freathy, Rachel M., Moen, Gunn-Helen, Warrington, Nicole M. and Evans, David M. (2024). DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits. Nature Communications, 15 (1) 9255, 9255. doi: 10.1038/s41467-024-53495-9
2024
Journal Article
Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa)
D'Urso, Shannon, Wootton, Robyn E., Ask, Helga, Brito Nunes, Caroline, Andreassen, Ole A., Hwang, Liang-Dar, Moen, Gunn-Helen, Evans, David M. and Havdahl, Alexandra (2024). Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa). Psychological Medicine, 54 (12), 1-14. doi: 10.1017/S0033291724002216
2024
Conference Publication
Common Pitfalls In Mendelian Randomization Studies And How To Avoid Them
Moen, Gunn-Helen and Evans, David M. (2024). Common Pitfalls In Mendelian Randomization Studies And How To Avoid Them. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.030
2024
Journal Article
Understanding the genetic landscape of gestational diabetes: insights into the causes and consequences of elevated glucose levels in pregnancy
Brito Nunes, Caroline, Borges, Maria Carolina, Freathy, Rachel M., Lawlor, Deborah A., Qvigstad, Elisabeth, Evans, David M. and Moen, Gunn-Helen (2024). Understanding the genetic landscape of gestational diabetes: insights into the causes and consequences of elevated glucose levels in pregnancy. Metabolites, 14 (9) 508, 508. doi: 10.3390/metabo14090508
2024
Journal Article
Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis
Lee-Ødegård, Sindre, Hjorth, Marit, Olsen, Thomas, Moen, Gunn-Helen, Daubney, Emily, Evans, David M, Hevener, Andrea L, Lusis, Aldons J, Zhou, Mingqi, Seldin, Marcus M, Allayee, Hooman, Hilser, James, Viken, Jonas Krag, Gulseth, Hanne, Norheim, Frode, Drevon, Christian A and Birkeland, Kåre Inge (2024). Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis. eLife, 13 ARTN RP96535. doi: 10.7554/elife.96535
2024
Journal Article
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
Linares-Pineda, Teresa M., Fragoso-Bargas, Nicolas, Picón, María José, Molina-Vega, Maria, Jenum, Anne Karen, Sletner, Line, Lee-Ødegård, Sindre, Opsahl, Julia O., Moen, Gunn-Helen, Qvigstad, Elisabeth, Prasad, Rashmi B., Birkeland, Kåre I., Morcillo, Sonsoles and Sommer, Christine (2024). DNA methylation risk score for type 2 diabetes is associated with gestational diabetes. Cardiovascular Diabetology, 23 (1) 68. doi: 10.1186/s12933-024-02151-z
2024
Journal Article
Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain
Opsahl, J. O., Fragoso-Bargas, N., Lee, Y., Carlsen, E. Ø., Lekanova, N., Qvigstad, E., Sletner, L., Jenum, A. K., Lee-Ødegård, S., Prasad, R. B., Birkeland, K. I., Moen, G-H. and Sommer, C. (2024). Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain. International Journal of Obesity, 48 (4), 584-593. doi: 10.1038/s41366-024-01458-x
2023
Journal Article
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Oyvind, Sole-Navais, Pol, Banasik, Karina, Albinana, Clara, Ronkainen, Justiina, Fadista, Joao, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sanchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frederique, Jacques, Pierre-Etienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A. ... Njolstad, Pal R. (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics, 55 (11), 1807-1819+. doi: 10.1038/s41588-023-01520-w
2023
Journal Article
Intrauterine growth and offspring neurodevelopmental traits: a Mendelian randomization analysis of the Norwegian mother, father and child cohort study (MoBa)
D’Urso, Shannon, Moen, Gunn-Helen, Hwang, Liang-Dar, Hannigan, Laurie J., Corfield, Elizabeth C., Ask, Helga, Johannson, Stefan, Njølstad, Pål Rasmus, Beaumont, Robin N., Freathy, Rachel M., Evans, David M. and Havdahl, Alexandra (2023). Intrauterine growth and offspring neurodevelopmental traits: a Mendelian randomization analysis of the Norwegian mother, father and child cohort study (MoBa). JAMA Psychiatry, 81 (2), 144-156. doi: 10.1001/jamapsychiatry.2023.3872
2023
Journal Article
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Oyvind, Sole-Navais, Pol, Banasik, Karina, Albinana, Clara, Ronkainen, Justiina, Fadista, Joao, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sanchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frederique, Jacques, Pierre-etienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A. ... Njolstad, Pal R. (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics, 55 (11), 1807-1819. doi: 10.1038/s41588-023-01520-w
2023
Journal Article
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Oyvind, Sole-Navais, Pol, Banasik, Karina, Albinana, Clara, Ronkainen, Justiina, Fadista, Joao, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sanchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frederique, Jacques, Pierre-etienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A. ... Early Growth Genetics Consortium (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics, 1786-1787.
2023
Journal Article
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Øyvind, Solé-Navais, Pol, Banasik, Karina, Albiñana, Clara, Ronkainen, Justiina, Fadista, João, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sánchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frédérique, Jacques, Pierre-Étienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A. ... The Early Growth Genetics (EGG) Consortium (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics, 55 (11), 1807-1819. doi: 10.1038/s41588-023-01520-w
2023
Journal Article
Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight
Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina ... Danish Blood Donor Study Genomic Consortium (2023). Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics, 55 (7), 1250-1250. doi: 10.1038/s41588-023-01412-z
2023
Journal Article
Insulin and body mass index decrease serum soluble leptin receptor levels in humans
Sommer, Christine, Vangberg, Kjersti G., Moen, Gunn-Helen, Evans, David M., Lee-Ødegård, Sindre, Blom-Høgestøl, Ingvild K., Sletner, Line, Jenum, Anne K., Drevon, Christian A., Gulseth, Hanne L. and Birkeland, Kåre I. (2023). Insulin and body mass index decrease serum soluble leptin receptor levels in humans. The Journal of Clinical Endocrinology and Metabolism, 108 (5), 1110-1119. doi: 10.1210/clinem/dgac699
2023
Journal Article
Genetic effects on the timing of parturition and links to fetal birth weight
Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina ... Danish Blood Donor Study Genomic Consortium (2023). Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics, 55 (4), 1-9. doi: 10.1038/s41588-023-01343-9
2023
Conference Publication
Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths
Nunes, Caroline Brito, Hwang, Liang-Dar, Wang, Geng, Yengo, Loic, Leggatt, Graham, Moen, Gunn-Helen and Evans, David M. (2023). Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane Australia, Mar 21-25, 2023. HEIDELBERG: SPRINGER HEIDELBERG.
2023
Other Outputs
GWAS summary statistics of phenotypes generated for the journal article "Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk" published in 2022.
Moen, Gunn-Helen, Evans, David and D’Urso, Shannon (2023). GWAS summary statistics of phenotypes generated for the journal article "Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk" published in 2022.. The University of Queensland. (Dataset) doi: 10.48610/3381ffb
2023
Journal Article
Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes
Fragoso-Bargas, Nicolas, Page, Christian M., Joubert, Bonnie R., London, Stephanie J., Lee-Ødegård, Sindre, Opsahl, Julia O., Sletner, Line, Jenum, Anne K., Qvigstad, Elisabeth, Prasad, Rashmi B., Moen, Gunn-Helen, Birkeland, Kåre I. and Sommer, Christine (2023). Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes. Epigenomics, 15 (1), 39-52. doi: 10.2217/epi-2022-0427
2022
Journal Article
Cross-ancestry DNA methylation marks of insulin resistance in pregnancy: an integrative epigenome wide association study
Fragoso-Bargas, Nicolas, Elliott, Hannah R., Lee-Ødegård, Sindre, Opsahl, Julia O., Sletner, Line, Jenum, Anne Karen, Drevon, Christian A., Qvigstad, Elisabeth, Moen, Gunn-Helen, Birkeland, Kåre I., Prasad, Rashmi B. and Sommer, Christine (2022). Cross-ancestry DNA methylation marks of insulin resistance in pregnancy: an integrative epigenome wide association study. Diabetes, 72 (3), 415-426. doi: 10.2337/db22-0504
2022
Journal Article
Using genomic structural equation modeling to partition the genetic covariance between birthweight and cardiometabolic risk factors into maternal and offspring components in the Norwegian HUNT study
Moen, Gunn-Helen, Nivard, Michel, Bhatta, Laxmi, Warrington, Nicole M., Willer, Cristen, Åsvold, Bjørn Olav, Brumpton, Ben and Evans, David M. (2022). Using genomic structural equation modeling to partition the genetic covariance between birthweight and cardiometabolic risk factors into maternal and offspring components in the Norwegian HUNT study. Behavior Genetics, 53 (1), 1-13. doi: 10.1007/s10519-022-10116-9
Funding
Current funding
Supervision
Availability
- Dr Gunn-Helen Moen is:
- Available for supervision
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Available projects
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Testing effect of environmental exposures on subsequent human generations
Depending on the applicant’s level of experience, they will help develop and/or apply statistical genetics approaches to investigate the possible existence of transgenerational effects on human phenotypes, using cohorts such as the Norwegian HUNT cohort (which has a large number of parent-offspring pairs) and UK Biobank. A PhD is about learning new skills and learning how to do research. Our ideal candidate will have knowledge or keen interest in learning genetics, epidemiology, statistics, unix and shell scripting, and statistical software such as R. You will work closely with an experienced researcher on the project. There will also be possibility for a research stay in Norway during this PhD. The advertised projects are fundamentally quantitative and computer-based, and so evidence of aptitude in these areas is essential. The candidate should also have the ability to design, plan, and execute experiments and be proficient in English, both written and oral.
Supervision history
Current supervision
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Doctor Philosophy
Understanding the genetic epidemiology of women's reproductive health
Associate Advisor
Other advisors: Professor David Evans
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Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Associate Advisor
Other advisors: Dr Daniel Hwang, Professor David Evans
Completed supervision
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2024
Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Associate Advisor
Other advisors: Dr Daniel Hwang, Professor David Evans
Media
Enquiries
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