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2003 Journal Article Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiationGatei, Magtouf, Sloper, Katie, Sorensen, Claus, Syljuasen, Randi, Falck, Jacob, Hobson, Karen, Savage, Kienan, Lukas, Jiri, Zhou, Bin-Bing, Bartek, Jiri and Khanna, Kum Kum (2003). Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278 (17), 14806-14811. doi: 10.1074/jbc.M210862200 |
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2003 Journal Article Role of tumor suppressors in DNA damage responseZhou, Bin-Bing S., Mattern, Michael R. and Khanna, Kum Kum (2003). Role of tumor suppressors in DNA damage response. Methods in Molecular Biology, 223, 39-50. doi: 10.1385/1592593291 |
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2003 Journal Article Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25ASorensen, Claus Storgaard, Syluasen, Randi G., Falck, Jacob, Schroeder, Tine, Ronnstrand, Lars, Khanna, Kum Kum, Zhou, Bin-Bing, Bartek, Jiri and Lukas, Jiri (2003). Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3 (3), 247-258. doi: 10.1016/S1535-6108(03)00048-5 |
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2002 Journal Article Dominant negative ATM mutations in breast cancer familiesChenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret C., Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R. E., Hopper, John L., Sambrook, Joseph, Mann, Graham J. and Khanna, Kum Kum (2002). Dominant negative ATM mutations in breast cancer families. Journal of the National Cancer Institute, 94 (3), 205-215. doi: 10.1093/jnci/94.3.205 |
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2002 Journal Article Expression of a truncated Brca1 protein delays lactational mammary development in transgenic miceBrown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002). Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 (5), 467-478. doi: 10.1023/A:1020348025139 |
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2002 Journal Article No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancerSpurdle, Amanda B., Hopper, John L., Chen, Xiaoqing, McCredie, Margaret R. E., Giles, Graham G., Newmann, Beth, Chenevix-Trench, Georgia and Khanna, KumKum (2002). No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer. Breast Cancer Research, 4 (6) R15, R15/1-R15/6. doi: 10.1186/bcr534 |
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2001 Journal Article Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodiesGatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001). Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 (20), 17276-17280. doi: 10.1074/jbc.M011681200 |
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2001 Journal Article UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM proteinOakley, G. G., Loberg, L. I., Yao, J. Q., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P. and Dixon, K. (2001). UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM protein. Molecular Biology of The Cell, 12 (5), 1199-1213. doi: 10.1091/mbc.12.5.1199 |
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2001 Journal Article Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasiaGueven, Nuri, Keating, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001). Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. Journal of Biological Chemistry, 276 (12), 8884-8891. doi: 10.1074/jbc.M006190200 |
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2001 Journal Article ATM, a central controller of cellular responses to DNA damageKhanna, K. K., Lavin, M. F., Jackson, S. P. and Mulhern, T. D. (2001). ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 (11), 1052-1065. doi: 10.1038/sj.cdd.4400874 |
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2001 Journal Article Chk2 activation dependence on Nbs1 after DNA damageBuscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001). Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 (15), 5214-5222. doi: 10.1128/MCB.21.15.5214-5222.2001 |
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2001 Journal Article The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerYe, R. Q., Bodero, A., Zhou, B. B., Khanna, K. K., Lavin, M. F. and Lees-Miller, S. P. (2001). The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. Journal of Biological Chemistry, 276 (7), 4828-4833. doi: 10.1074/jbc.M004894200 |
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2001 Journal Article Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acidGatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001). Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 (3), 289-294. doi: 10.1038/sj.onc.1204111 |
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2001 Journal Article DNA double-strand breaks: signaling, repair and the cancer connectionJackson, S.P. and Khanna, K. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 (3), 247-254. doi: 10.1038/85798 |
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2001 Journal Article Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118 |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. |
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2000 Journal Article Purification and characterization of ATM from human placentaChan, D., Son, S-C., Block, W., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P. J. G., Goodarzi, A. A., Pelley, J., Taya, Y., Lavin, M. F. and Lees-Miller, S. P. (2000). Purification and characterization of ATM from human placenta. Journal of Biological Chemistry, 275 (11), 7803-7810. doi: 10.1074/jbc.275.11.7803 |
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2000 Journal Article Role for ATM in DNA damage-induced phosphorylation of BRCA1Gatei, M., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. and Khanna, K. (2000). Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Research, 60 (12), 3299-3304. |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497 |
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2000 Journal Article Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1)Dicker, A., Serewko, M. S., Dahler, A. L., Khanna, K. K., Kaur, P., Li, A., Strutton, G. and Saunders, N. A. (2000). Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). Experimental Cell Research, 258 (2), 352-360. doi: 10.1006/excr.2000.4944 |
