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2001 Journal Article Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasiaGueven, Nuri, Keating, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001). Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. Journal of Biological Chemistry, 276 (12), 8884-8891. doi: 10.1074/jbc.M006190200 |
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2001 Journal Article Chk2 activation dependence on Nbs1 after DNA damageBuscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001). Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 (15), 5214-5222. doi: 10.1128/MCB.21.15.5214-5222.2001 |
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2001 Journal Article The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerYe, R. Q., Bodero, A., Zhou, B. B., Khanna, K. K., Lavin, M. F. and Lees-Miller, S. P. (2001). The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. Journal of Biological Chemistry, 276 (7), 4828-4833. doi: 10.1074/jbc.M004894200 |
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2001 Journal Article Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acidGatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001). Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 (3), 289-294. doi: 10.1038/sj.onc.1204111 |
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2001 Journal Article DNA double-strand breaks: signaling, repair and the cancer connectionJackson, S.P. and Khanna, K. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 (3), 247-254. doi: 10.1038/85798 |
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2001 Journal Article Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118 |
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2001 Journal Article ATM, a central controller of cellular responses to DNA damageKhanna, K. K., Lavin, M. F., Jackson, S. P. and Mulhern, T. D. (2001). ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 (11), 1052-1065. doi: 10.1038/sj.cdd.4400874 |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. |
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2000 Journal Article Purification and characterization of ATM from human placentaChan, D., Son, S-C., Block, W., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P. J. G., Goodarzi, A. A., Pelley, J., Taya, Y., Lavin, M. F. and Lees-Miller, S. P. (2000). Purification and characterization of ATM from human placenta. Journal of Biological Chemistry, 275 (11), 7803-7810. doi: 10.1074/jbc.275.11.7803 |
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2000 Journal Article Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1)Dicker, A., Serewko, M. S., Dahler, A. L., Khanna, K. K., Kaur, P., Li, A., Strutton, G. and Saunders, N. A. (2000). Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). Experimental Cell Research, 258 (2), 352-360. doi: 10.1006/excr.2000.4944 |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497 |
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2000 Journal Article Cancer risk and the ATM gene: a continuing debateKhanna, Kum Kum (2000). Cancer risk and the ATM gene: a continuing debate. Journal of the National Cancer Institute, 92 (10), 795-802. doi: 10.1093/jnci/92.10.795 |
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2000 Journal Article Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activityZhou, B., Chaturvedi, P.S., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R.G., Mattern, M. R., Winkler, J. D. and Khanna, K. K. (2000). Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. Journal of Biological Chemistry, 275 (14), 10342-10348. doi: 10.1074/jbc.275.14.10342 |
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2000 Journal Article p73 is up-regulated in a subset of hepatocellular carcinomasHerath, NI, Kew, MC, Whitehall, VLJ, Walsh, MD, Jass, JR, Khanna, KK, Young, J, Powell, LW, Leggett, BA and Macdonald, GA (2000). p73 is up-regulated in a subset of hepatocellular carcinomas. Hepatology, 31 (3), 601-605. doi: 10.1002/hep.510310309 |
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2000 Conference Publication Sensing damage in DNA: ATM and cellular signallingLavin, M.F., Khanna, K.K., Watters, D., Spring, K., Scott, S., Keating, K., Gatei, M., Kaneko, H. and Kozlov, S. (2000). Sensing damage in DNA: ATM and cellular signalling. 11th International Congress of Radiation Research, Dublin, Ireland, 18-23 July 1999. Lawrence, KS United States: Allen Press. |
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2000 Journal Article ATM-dependent phosphorylation of nibrin in response to radiation exposureGatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 (1), 115-119. doi: 10.1038/75508 |
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1999 Journal Article ATM is upregulated during the mitogenic response in peripheral blood mononuclear cellsFukao, Toshiyuki, Kaneko, Hideo, Birrell, Geoff, Gatei, Magtouf, Tashita, Hideaki, Yoshida, Toko, Cross, Simone, Kedar, Padmini, Watters, Dianne, Khanna, Kum Kum, Misko, Ihor, Kondo, Naomi and Lavin, Martin F. (1999). ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells. Blood, 94 (6), 1998-2006. doi: 10.1182/blood.v94.6.1998.418k01_1998_2006 |
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1999 Journal Article Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the targetImyanitov, Evgeny N., Birrell, Geoff W., Filippovich, Igor, Sorokina, Natasha, Arnold, Jeremy, Mould, Michelle A., Wright, Kim, Walsh, Michael, Mok, Samuel C ., Lavin, Martin F., Chenevix-Trench, Georgia and Khanna, Kum Kum (1999). Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target. Oncogene, 18 (32), 4640-4642. doi: 10.1038/sj.onc.1202863 |
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1999 Journal Article CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasiaChen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999). CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 (1), 249-256. doi: 10.1038/sj.onc.1202257 |
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1999 Journal Article ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasiaLavin, M. F. and Khanna, K. K. (1999). ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia. International Journal of Radiation Biology, 75 (10), 1201-1214. |
