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2012 Journal Article INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cellsMorris, Christelle, Tomimatsu, Nozomi, Richard, Derek J., Cluet, David, Burma, Sandeep, Khanna, Kum Kum and Jalinot, Pierre (2012). INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Research, 72 (8), 2006-2016. doi: 10.1158/0008-5472.CAN-11-2562 |
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2012 Journal Article Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisionsTomimatsu, Nozomi, Mukherjee, Bipasha, Deland, Katherine, Kurimasa, Akihiro, Bolderson, Emma, Khanna, Kum Kum and Burma, Sandeep (2012). Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair, 11 (4), 441-448. doi: 10.1016/j.dnarep.2012.01.006 |
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2012 Journal Article Tocotrienol as a potential anticancer agentLing, Ming T., Luk, Sze U., Al-Ejeh, Fares and Khanna, Kum K. (2012). Tocotrienol as a potential anticancer agent. Carcinogenesis, 33 (2), 233-239. doi: 10.1093/carcin/bgr261 |
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2012 Conference Publication Uncovering molecular mechanisms involved in metastasis to the brainSaunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Vargas, Ana Cristina, Al-Ejeh, Fares, Morrison, Brian, Khanna, Kum Kum, Grimmond, Sean, Chenevix-Trench, Georgia, Jeffree, Rosalind L., Waddell, Nicola, Simpson, Peter T. and Lakhani, Sunil R. (2012). Uncovering molecular mechanisms involved in metastasis to the brain. 14th International Biennial Congress of the Metastasis Research Society, Brisbane, QLD, Australia, 2-5 September 2012. |
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2012 Journal Article Potential roles for prions and protein-only inheritance in cancerAntony, H., Wiegmans, A. P., Wei, M. Q., Chernoff, Y. O., Khanna, K. K. and Munn, A. L. (2012). Potential roles for prions and protein-only inheritance in cancer. Cancer metastasis reviews, 31 (1-2), 1-19. doi: 10.1007/s10555-011-9325-9 |
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2012 Conference Publication Role of HER3 in brain metastases from primary breast cancerSaunus, Jodi M., Da Silva, Leonard, Momeny, Majid, Morrison, Brian, Lane, Annette, Smart, Chanel, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2012). Role of HER3 in brain metastases from primary breast cancer. 24th Lorne Cancer Conference, Lorne, VIC, Australia, 9-12 February 2012. |
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2011 Journal Article ATM protein kinase: The linchpin of cellular defenses to stressBhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9 |
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2011 Journal Article Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neuronsJung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011). Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 (47) 47, 1-14. doi: 10.1186/1750-1326-6-47 |
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2011 Journal Article Rare variants in the ATM gene and risk of breast cancerGoldgar, David E., Healey, Sue, Dowty, James G., Da Silva, Leonard, Chen, Xiaoqing, Spurdle, Amanda B., Terry, Mary B., Daly, Mary J., Buys, Saundra M., Southey, Melissa C., Andrulis, Irene, John, Esther M., Breast Cancer Family Registry, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna, Kum K., Hopper, John L., Oefner, Peter J., Lakhani, Sunil and Chenevix-Trench, Georgia (2011). Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Research, 13 (4) R73, R73-1-R73-9. doi: 10.1186/bcr2919 |
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2011 Journal Article hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activityRichard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F. and Khanna, Kum Kum (2011). hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research, 39 (9), 3643-3651. doi: 10.1093/nar/gkq1340 |
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2011 Journal Article Breast cancer stem cells: Treatment resistance and therapeutic opportunitiesAL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011). Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 (5), 650-658. doi: 10.1093/carcin/bgr028 |
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2011 Journal Article A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in miceYoungson, N. A., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J. S., Khanna, K. K., de Kretser, D. M. and Whitelaw, Emma (2011). A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mammalian Genome, 22 (3-4), 235-248. doi: 10.1007/s00335-011-9317-7 |
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2011 Journal Article hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complexRichard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, Chen, David J., White, Malcolm F., Richard, Kerry, Prise, Kevin M., Schettino, Giuseppe and Khanna, Kum Kum (2011). hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research, 39 (5), 1692-1702. doi: 10.1093/nar/gkq1098 |
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2011 Journal Article Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challengesSimpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011). Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 (2), 153-165. doi: 10.1016/j.humpath.2010.07.008 |
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2011 Journal Article Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer familiesJohnson, Julie, Healey, Sue, Khanna, Kum Kum, kConFab and Chenevix-Trench, Georgia (2011). Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families. Breast Cancer Research and Treatment, 129 (1), 255-263. doi: 10.1007/s10549-011-1539-6 |
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2010 Journal Article Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humansSchoenmakers, Erik, Agostini, Maura, Mitchell, Catherine, Schoenmakers, Nadia, Papp, Laura, Rajanayagam, Odelia, Padidela, Raja, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Prevosto, Claudia, Luan, Jian'an, Montano, Sergio, Lu, Jun, Castanet, Mireille, Clemons, Nick, Groeneveld, Matthijs, Castets, Perrine, Karbaschi, Mahsa, Aitken, Sri, Dixon, Adrian, Williams, Jane, Campi, Irene, Blount, Margaret, Burton, Hannah, Muntoni, Francesco, O'Donovan, Dominic, Dean, Andrew, Warren, Anne, Brierley, Charlotte ... Chatterjee, Krishna (2010). Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Journal of Clinical Investigation, 120 (12), 4220-4235. doi: 10.1172/JCI43653 |
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2010 Journal Article Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomesAl-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010). Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29 (46), 6085-6098. doi: 10.1038/onc.2010.407 |
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2010 Journal Article The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stressKim, TS, Kawaguchi, M, Suzuki, M, Jung, CG, Asai, K, Shibamoto, Y, Lavin, MF, Khanna, KK and Miura, Y (2010). The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. DMM Disease Models and Mechanisms, 3 (11-12), 752-762. doi: 10.1242/dmm.004689 |
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2010 Journal Article A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activationHinz, Michael, Stilmann, Michael, Arslan, Seda Çöl, Khanna, Kum Kum, Dittmar, Gunnar and Scheidereit, Claus (2010). A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular Cell, 40 (1), 63-74. doi: 10.1016/j.molcel.2010.09.008 |
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2010 Journal Article Subtypes of familial breast tumours revealed by expression and copy number profilingWaddell, N, Arnold, J, Cocciardi, S, da Silva, L, Marsh, A, Riley, J, Johnstone, CN, Orloff, M, Assie, G, Eng, C, Reid, L, Keith, P, Yan, M, Fox, S, Devilee, P, Godwin, AK, Hogervorst, FBL, Couch, F, Grimmond, S, Flanagan, JM, Khanna, K, Simpson, PT, Lakhani, SR, Chenevix-Trench, G and kConFab Investigators (2010). Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Research And Treatment, 123 (3), 661-677. doi: 10.1007/s10549-009-0653-1 |
